Loading...
  • Osteoclast
  • Osteoclast, with bone below it, showing typical distinguishing characteristics: a large cell with multiple nuclei and a "foamy" cytosol. (wikipedia.org)
  • The maintenance of bone mass mainly depends on the balance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption [ 15 ]. (hindawi.com)
  • Osteoclast formation and activity are promoted by factors, including cytokines, hormones, growth factors, and free radicals, and require expression of macrophage-colony stimulating factor (M-CSF) and receptor activator of NF-κB ligand (RANKL) by accessory cells in the bone marrow, including osteoblastic and immune cells. (frontiersin.org)
  • Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo. (sigmaaldrich.com)
  • Sphingosine-1-phosphate (S1P), a lipid mediator enriched in blood, controls the dynamic migration of osteoclast (OC) precursors (OPs) between the blood and bone, in part via the S1P receptor 1 (S1PR1) which directs positive chemotaxis toward S1P. (sigmaaldrich.com)
  • marrow-derived
  • These controls include the action of several hormones, including parathyroid hormone (PTH), vitamin D, growth hormone, steroids, and calcitonin, as well as several bone marrow-derived membrane and soluble cytokines and growth factors (ex. (wikipedia.org)
  • metabolism
  • In the present study, we try to investigate the effects of iron disorder on bone metabolism using Irp 2 knockout ( Irp 2 −/− ) mice. (springer.com)
  • microscopic
  • In other words, what this formula means is that the bone remodeling period is equivalent to the thickness of the microscopic segment of bone being formed divided by the rate at which it forms. (wikipedia.org)
  • molecular
  • Although mechanotransduction-induced de novo gene expression is required for bone remodeling, the molecular mechanism of intracellular signaling, which leads to regulation of gene expression, is not fully understood. (springer.com)
  • Nevertheless, there is evidence that CDTs can also perturb the innate immune responses, by regulating inflammatory cytokine production and molecular mediators of bone remodeling in various cell types. (mdpi.com)
  • mineral
  • Bone mineral density (BMD) was measured by Micro-CT. (springer.com)
  • Guggenbuhl P, Deugnier Y, Boisdet JF et al (2005) Bone mineral density in men with genetic hemochromatosis and HFE gene mutation. (springer.com)
  • genes
  • Furthermore, we observed that ASK1-activated JNK and p38 induced the expression of two bone remodeling related genes, Fn14 and MCP-3 , respectively. (springer.com)
  • postmenopausal women
  • Meanwhile, the results from our and other research groups showed that the expression profiles of microRNAs in the serum and bone tissues are significantly different in postmenopausal women with or without fractures compared to the control. (hindawi.com)
  • calcium
  • The structure of bones as well as adequate supply of calcium requires close cooperation between these two cell types and other cell populations present at the bone remodeling sites (ex. (wikipedia.org)
  • Immobilization of humans causes loss of bone and excretion of calcium and phosphorus (4.1.10). (biology-online.org)
  • the calcium is released from bone. (sophia.org)
  • It is also a repository for calcium and other elements that get deposited in bone as it mineralizes during bone formation and are released from bone when it is being remodeled. (frontiersin.org)
  • cartilage
  • Genome-wide DNA methylation study identifies significant epigenomic changes in osteoarthritic subchondral bone and similarity to overlying cartilage. (springer.com)
  • The preceding chapter provided a general description of the structure and biology of bone and cartilage. (springer.com)
  • rate of bone
  • Each vertebrate species exhibits a distinct duration of bone regeneration and remodeling, and it appears as though there is an inversely proportional relationship between the rate of bone regeneration and the phylogenetic evolution of the animal. (wikipedia.org)
  • cells
  • Whenever there is a tiny crack inside the bones, for example, after landing from a high jump, the bone cells will dissolve the area around the crack and fill it in with new bone. (washington.edu)
  • process
  • The second movie shows this process on a larger section of bone where at least ten places are getting remodelled. (washington.edu)
  • Researchers have known for some time that bone resorption - the process by which bone minerals are broken down - operates on a circadian rhythm, peaking during the night and decreasing over the course of the day. (endocrineweb.com)
  • role
  • It is therefore the aim of this review to identify and present the current state of the literature with regards to the role of CDTs on host inflammatory responses, as well as the associated effects on bone remodeling. (mdpi.com)
  • Sinigaglia L, Fargion S, Fracanzani AL et al (1997) Bone and joint involvement in genetic hemochromatosis: role of cirrhosis and iron overload. (springer.com)
  • markers
  • In the new study, rheumatologists and endocrinologists from Prague tested the blood levels of a number of bone resorption indicators to see how the markers responded to injections of teriparatide, which were applied either in the evening or the morning. (endocrineweb.com)
  • peak
  • New bone was added until, after three months, the peak strain was about the same as on the normal leg bones. (biology-online.org)
  • Their results, which appear in the European Journal of Endocrinology , indicate that administration of the drug teriparatide in the morning, rather than in the evening, significantly decreased peak circadian levels of C-terminal telopeptide of type 1 collagen (beta-CTx), a marker for bone resorption. (endocrineweb.com)
  • surfaces
  • 3. Dynamic flexure causes all affected bone surfaces to drift towards the concavity which arises during the act of dynamic flexure. (biology-online.org)