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  • resorption
  • This book introduces the subject of apoptosis to the uninitiated, looks at apoptosis in normal physiology during bone resorption under mechanical stress, and reviews apoptosis in a number of pathological conditions with an emphasis on cancer. (e-booksdirectory.com)
  • In cases where augmentation materials used are autografts or allografts the bone density is quite low and resorption of the grafted site in these cases can reach up to 30% of original volume. (wikipedia.org)
  • Bone resorption caused by metabolism of acidic substances produced by cysts contributes to cyst growth. (wikipedia.org)
  • While bone marrow expresses low levels of RANKL, it plays a critical role for adequate bone metabolism, this surface-bound molecule (also known as CD254) found on osteoblasts serves to activate osteoclasts, which are critically involved in bone resorption. (wikipedia.org)
  • Collagen
  • rMAPCs were cultivated as single cells or as 3D aggregates in osteogenic media for up to 38 days, and their differentiation to bone lineage was then assessed by immunostaining of osteocalcin and collagen type I and by mineralization assays. (hindawi.com)
  • Collagenase (breakdown of collagen) in the jaw bone leads to bone degeneration, providing room for cysts to develop. (wikipedia.org)
  • The use of dual tapered threaded fusion cages and recombinant human bone morphogenetic protein-2 on an absorbable collagen sponge obtained and maintained intervertebral spinal fusion, improved clinical outcomes, and reduced pain after anterior lumbar interbody arthrodesis in patients with degenerative lumbar disc disease. (wikipedia.org)
  • induce
  • But the high concentrations needed to induce human bone formation may have serious side effects, including life-threatening cervical swelling and abnormal and inconsistent bone growth. (ucla.edu)
  • It also showed that BMP2 can induce non-bone cells to form bone, with the potential risk for ectopic bone growth - bone formation in undesirable locations. (ucla.edu)
  • NELL-1, when given systemically, does not appear to induce ectopic bone. (ucla.edu)
  • In contrast, because of its known capacity to induce unwanted bone, BMP2 may not be as appropriate for systemic administration. (ucla.edu)
  • T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. (wikipedia.org)
  • autograft
  • Though PDGF is synthesized, stored (in the alpha granules of platelets), and released by platelets upon activation, it is also produced by other cells including smooth muscle cells, activated macrophages, and endothelial cells Recombinant PDGF is used in medicine to help heal chronic ulcers and in orthopedic surgery and periodontistry as an alternative to bone autograft to stimulate bone regeneration and repair. (wikipedia.org)
  • stimulate bone
  • Used together, the two proteins stimulate bone production more dramatically than either does alone. (ucla.edu)
  • In contrast to BMP2, the novel ability of NELL-1 to stimulate bone growth and repress the formation of fat may highlight new treatment approaches for osteoporosis and other therapies for bone loss," Soo said. (ucla.edu)
  • grafts
  • The researchers monitored the grafts for bone volume and bone mineral density every two weeks up until 10 weeks. (news-medical.net)
  • However, although the rate of new bone formation was faster in group 3, when the researchers examined the grafts at the end of the study, they found that grafts involving the synthetic material did not form a strong connection with the natural bone. (news-medical.net)
  • therapies
  • Hydrogels and Cell Based Therapies in Spinal Cord Injury Regeneration. (rutgers.edu)
  • The following therapies do not rely on autologous cells: A vibration technique developed by Ellen L. Barnard and Myrtile Wilhite claims to promote regeneration in the vaginal cell lining. (wikipedia.org)
  • regenerative
  • This book concentrates on such procedures that may well be counted among the recent outstanding breakthroughs in bone regenerative therapy. (e-booksdirectory.com)
  • The feasibility and bone-regenerative capacity of intraoperative constructs were determined histologically and histomorphometrically in a rat femoral condyle bone defect model. (rutgers.edu)
  • In conclusion, we here demonstrate the feasibility of intraoperative SVF construct preparation and superior bone-regenerative capacity thereof compared to donor-matched ADMSC constructs. (rutgers.edu)
  • Some organizations which perform research into, or conduct regeneration procedures, include the Wake Forest Institute for Regenerative Medicine, the United States Department of Defense, and the California Institute for Regenerative Medicine. (wikipedia.org)
  • osteogenic
  • described that osseous regeneration by GBR depends on the migration of pluripotential and osteogenic cells (e.g., osteoblasts derived from the periosteum and/or adjacent bone and/or bone marrow) to the bone defect site and exclusion of cells impeding bone formation (e.g., epithelial cells and fibroblasts) [ 3 ]. (hindawi.com)
  • Osteogenic cells derived from rat multipotent adult progenitor cells (rMAPCs) were investigated for their potential use in bone regeneration. (hindawi.com)
  • Results showed that rMAPCs successfully differentiated into osteogenic lineage by demonstrating mineralized extracellular matrix formation in vitro and induced new bone formation by the effect of rMAPC aggregates in vivo . (hindawi.com)
  • An ideal cell source for bone tissue engineering should have readily available cells, high proliferative potential in vitro , and a high osteogenic differentiation potential under in vitro culture condition. (hindawi.com)
  • Together with Nuno Pires he won the prize for the Altis Osteogenic Bone Matrix. (wikipedia.org)
  • defect
  • Statistical evaluation was done to evaluate percentage of bone defect filled by new bone. (hindawi.com)
  • Higher and highly statistically significant differences were found in the percentages of bone defect filled by new bone in group filled with corticocancellous 250-1000 microns particulate porcine bone mix. (hindawi.com)
  • To evaluate the different potentially regenerating biomaterials, a histological analysis to find the percentage of the bone fill of the defect (partial or complete) and the percentage of the contact between the newly formed bone and the surface of the implant is necessary. (hindawi.com)
  • autologous
  • Many have reported the aging effects of donor source for MSC, and this effect may have implications in the potential use of autologous MSCs for bone regeneration [ 11 , 12 ]. (hindawi.com)
  • proteins
  • A UCLA research team has found a combination of proteins that could significantly improve clinical bone restoration. (ucla.edu)
  • The two proteins complement each other in that BMP2 helps to turn non-bone cells into bone-forming cells, and NELL-1 then increases the bone-forming ability of bone cells. (ucla.edu)
  • rats
  • The researchers carried out their experiments in the skull bones of rats, which are thought to act as a model for the bones of the oral and maxillofacial region in humans. (news-medical.net)
  • efficacy
  • The combination of NELL-1 and BMP2 resulted in improved safety and efficacy of bone regeneration in animal models - and may, one day, offer patients significantly better bone healing. (ucla.edu)
  • Previous and present studies demonstrate a strong rationale for combining NELL-1 with BMP2 to significantly improve the safety and efficacy of current bone regeneration options. (ucla.edu)
  • Efficacy of intraoperatively prepared cell-based constructs for bone regeneration. (rutgers.edu)
  • surgical
  • There are limitations in treating patients with advanced disease but GTR may be able to achieve regeneration and therefore improve upon conventional surgical results. (wikipedia.org)
  • May 2012 Barnard, E. and Wilhite M. Patent application number: 20120136287 "Regeneration of Vaginal Tissue with non-systemic vaginal administration of Estrogen" May 2009 Lyle, J. Patent application number: 20090124584 "Surgical Techniques: Reconstructive Surgery of the Clitoris after Ritual Excision. (wikipedia.org)
  • procedure
  • Guided bone regeneration (GBR) is a procedure that has been used in dental surgery for over 20 years for the treatment of bone loss. (news-medical.net)
  • Previous research had only been able to say that new bone has begun to form within 4-8 weeks of the procedure. (news-medical.net)
  • Bone volume obtained following a GBR procedure will be detemined through a comparison of a 3 dimensional analysis of computed tomography images done before and after the GBR procedure. (clinicaltrials.gov)
  • Bone quality [ Time Frame: Bone quality will be assesed through histological analysis that will be carried out at the time of implants insertion 7-8 months after the GBR procedure. (clinicaltrials.gov)
  • 1965
  • In 1965, Gavriil Ilizarov determined that bone fragments could be carefully pulled apart without disrupting their alignment. (wikipedia.org)
  • synthetic
  • Dr Leandro Bolzoni from the University of Waikato's School of Engineering has been awarded a Health Research Council explorer grant worth $150,000 to research bone regeneration using alternative synthetic materials for joint replacements. (waikato.ac.nz)
  • bony
  • The collected bone sample will be subjected to histo-morphometric analysis in order to determine the size, shape and orientation of the bony trabeculae,the size and porosity of the bony cortex in addition to the new bone/ bone substitute ratio. (clinicaltrials.gov)
  • Tissue Engineering
  • These results are quite promising because they can allow for the production of bioactive and biodegradable 3D porous scaffolds to be used in bone tissue engineering applications. (scientific.net)
  • As is the case in most scientific pursuits, these accomplishments might be applied to other forms of regeneration and vice versa as scientists continue to study tissue engineering. (wikipedia.org)
  • January 1998) Tissue Engineering of Bne, From Concept To Market (April 2, 2008) High yield isolation of BMP-2 from bone and in vivo activity of a combination of BMP-2/TGF-β1. (wikipedia.org)
  • commonly
  • Currently metallic implants are most commonly used, but due to being a much stiffer material than human bones, the implants causes osteoporosis and eventual loosening of the implant. (waikato.ac.nz)
  • Conventional
  • Conventional cell-based bone regeneration suffers from the major disadvantage of limited cell supply, time-consuming in vitro expansion cultures, and limited patient-friendliness related to cell isolation and multiple visits to the clinic. (rutgers.edu)
  • types of bone
  • In a study, researchers at King Saud University in Riyadh, Saudi Arabia, showed how 3D micro-CT could help advance the study of GBR, by more precisely revealing the first instance of new bone formation, and how it could be used to test alternative types of bone graft material. (news-medical.net)
  • cartilage
  • This particular type of stem cell has the future potential to differentiate into a variety of other cell types including: Myocardiocytes to repair damaged cardiac tissue following a heart attack Neuronal to generate nerve and brain tissue Myocytes to repair muscle Osteocytes to generate bone Chondrocytes to generate cartilage Adipocytes to generate fat Bone and tissue from the oral cavity. (wikipedia.org)
  • These molecules have revolutionized the field of bioactive materials for regenerative medicine, with potential applications in bone and cartilage regeneration, angiogenesis for ischemia or peripheral artery disease, cancer therapy, novel therapies for neurodegenerative diseases, stem cell differentiation, spinal cord injury, diabetes, and many other areas. (wikipedia.org)
  • membrane
  • Barrier membrane is utilized in GBR technique to cover the bone defect and create a secluded space, which prevents the connective tissue from growing into the space and facilitates the growth priority of bone tissue. (wikipedia.org)
  • A barrier membrane is a device used in oral surgery and periodontal surgery to prevent epithelium, which regenerates relatively quickly, from growing into an area in which another, more slowly growing tissue type, such as bone, is desired. (wikipedia.org)
  • marrow
  • Bone marrow transplant is the most widely used stem-cell therapy, but some therapies derived from umbilical cord blood are also in use. (wikipedia.org)
  • citation needed] Possible mechanisms of recovery include: Generation of heart muscle cells Stimulation of growth of new blood vessels to repopulate damaged heart tissue Secretion of growth factors Assistance via some other mechanism It may be possible to have adult bone-marrow cells differentiate into heart muscle cells. (wikipedia.org)
  • conventional
  • There are limitations in treating patients with advanced disease but GTR may be able to achieve regeneration and therefore improve upon conventional surgical results. (wikipedia.org)
  • cages
  • Additional hardware (screws, plates, or cages) is often used to hold the bones in place while the graft fuses the two vertebrae together. (wikipedia.org)
  • patient
  • In anthropometric correction (extension), the alignment of the legs takes about 17 days after the initial operation, followed by a period of bone fixation during which time the patient wears the apparatus continuously until advised otherwise. (wikipedia.org)
  • particularly
  • Variation in concentration levels of RANKL throughout several organs, reconfirm the uses and importance of growth (particularly bone growth) and immune functions within the body. (wikipedia.org)
  • types
  • RANKL derived from other cell types contributes to bone loss in conditions involving inflammation such as rheumatoid arthritis, and in lytic lesions caused by cancer, such as in multiple myeloma. (wikipedia.org)
  • technique
  • The following therapies do not rely on autologous cells: A vibration technique developed by Ellen L. Barnard and Myrtile Wilhite claims to promote regeneration in the vaginal cell lining. (wikipedia.org)
  • activity
  • January 1998) Tissue Engineering of Bne, From Concept To Market (April 2, 2008) High yield isolation of BMP-2 from bone and in vivo activity of a combination of BMP-2/TGF-β1. (wikipedia.org)
  • study
  • As is the case in most scientific pursuits, these accomplishments might be applied to other forms of regeneration and vice versa as scientists continue to study tissue engineering. (wikipedia.org)
  • 2008 DPSC 1st advanced animal study for bone grafting announced. (wikipedia.org)
  • often
  • There are rudimentary techniques of promoting cellular division to alter the structure of the penis, often referred to as foreskin restoration, and are not to be confused with regeneration. (wikipedia.org)