Bone pluripotent stem cells adult mammalian cells. Medical search. Frequent questions

Instead, germ cells can arise from somatic cells in the adult, such as the floral meristem of flowering plants. (wikipedia.org)
Multicellular eukaryotes are made of two fundamental cell types: germ and somatic. (wikipedia.org)
Somatic cells are all the other cells that form the building blocks of the body and they only divide by mitosis. (wikipedia.org)
Repair of mitomycin-C-induced chromosomal aberrations was impaired in RAD51B/Rad51b-c.92delT human and mouse somatic cells in vitro and in explanted mouse bone marrow cells. (nature.com)
Yamanaka and others hypothesized that retroviruses could influence somatic cells to become stem cells. (asu.edu)
The Dolly experiment showed that scientists could reprogram the nucleus of somatic cells by transferring the contents of the nucleus into oocytes that have had their nuclei removed, a technique called somatic cell nuclear transfer (SCNT). (asu.edu)
Other research groups such as Masako Tada's group in Japan in 2001 and Chad CowanÆs group in Massachusetts in 2005 combined embryonic stem cells with somatic cells to produce pluripotent cells. (asu.edu)
After these experiments with somatic cells, Takahashi and Yamanaka hypothesized that there were common factors, genes in particular, which caused somatic cells to become pluripotent stem cells. (asu.edu)
In 2006, Takahashi and Yamanaka selected twenty-four candidate genes as factors that they hypothesized could possibly induce somatic cells to become pluripotent, and they began to test them one at a time. (asu.edu)
In 2007, a team at Kyoto University created pluripotent stem cells from adult human somatic cells (4). (the-scientist.com)
During differentiation the expression of stem cell specific genes and markers are often lost and cells acquire gene expression profiles of somatic cells or their precursors. (justia.com)
In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)
That is to say, one type of stem cell may be capable of differentiating into all adult cell types, while another may only be capable of maturing into one specific somatic cell type. (papersowl.com)
This pluripotency enables these cells to produce daughter cells of all differentiated somatic cell types, germ cells, and cells of all three embryonic germ layers (Can/Hematol 2008). (papersowl.com)
In contrast, adult stem cells can only give rise to differentiated somatic cells of the particular tissue from which these cells originated (Can/Hematol 2008). (papersowl.com)
The methodology included inducing differentiated somatic cells with the primary genes responsible for embryonic stem cell potency. (papersowl.com)
A single migratory somatic cell termed the distal tip cell (DTC),which is positioned at the tip of each arm, acts as a specialised signalling centre to control the development and the shape of the gonad through a series of inductive events. (silverchair.com)
Metabolomic profiles of somatic cells, embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) reflect their metabolic phenotypes. (shengsci.com)
The comparative study of metabolomes of these cells is important for understanding the differences in metabolism between somatic and pluripotent cells, and also the possibl. (shengsci.com)

They called the pluripotent stem cells that they produced induced pluripotent stem cells (iPSCs) because they had induced the adult cells, called differentiated cells, to become pluripotent stem cells through genetic manipulation. (asu.edu)

Under special conditions in vitro germ cells can acquire properties similar to those of embryonic stem cells (ESCs). (wikipedia.org)
Both cell types are pluripotent in vitro, but only ESCs have proven pluripotency in vivo. (wikipedia.org)
2018). Development of bovine embryos in vitro in coculture with murine mesenchymal stem clls and embryonic fibroblasts. (sciendo.com)
Gey developed new techniques for in vitro, or laboratory-based, maintenance of organs and hormonal tissue, created new methods for cell cultivation, and researched nutritional media, or cell food. (asu.edu)
Therefore, the implantation of human cells reprogrammed in vitro represents an alternative strategy [ 16 - 19 ]. (thno.org)
Some researchers are attempting to use stem cells to bioengineer human organs in the lab in vitro , rather than inside another species (5). (the-scientist.com)
The induction of a specific differentiated cell type can be useful for transplantation or drug screening and drug discovery in vitro. (justia.com)
Differentiation is triggered by various factors in vivo , some of which can be replicated in in vitro stem cell cultures. (sigmaaldrich.com)
These protocols, such as organoid cell culture methods, have provided more predictive in vitro cellular "Disease-in-a-Dish" models. (sigmaaldrich.com)
The ability to expand pluripotent cells in vitro and subject them to direct differentiation to produce specific cell types is crucial to the development of cell-based therapies to replace or restore tissue that has been damaged by disease or injury. (sigmaaldrich.com)
Hematopoietic Stem Cell and Leukaemic Stem Cell environmental stress responses (In vitro biomimicry of hypoxia, normoxia, hypothermia, hyperthermia, hypoglycemia and hyperglycemia): Effect on cellular growth, cell cycle distribution, apoptosis and cellular metabolism. (imperial.ac.uk)
Until recently, it was believed that they were tissue-specific…however, this concept has been challenged… (multipotent cells) can differentiate in vitro and in vivo into various cell types not only from the tissue of origin" (Can/Hematol 2008). (papersowl.com)
Marking a vast leap in reproductive therapy, it became possible to isolate these human embryonic stem cells for reproductive purposes, such as in vitro fertilization. (papersowl.com)
The requirements for the successful culture of organoids in vitro differ significantly from those of traditional monolayer cell cultures. (mdpi.com)
Some of these techniques include novel tools for genetic manipulation, 4,5 approaches for in vitro disease modelling 6-9 and innovative co-culture system with autologous cell types 10,11 or bacteria, 12-14 as well as viral infection models. (stemcell.com)
Comparing the potential of neural stem cells derived from the forebrain and cerebellum, we find that progeny derived from each of these brain regions retain regional character in vitro as well as after homotopic transplantation. (silverchair.com)

Human pluripotent stem cells harbor the potential to provide an inexhaustible supply of donor cells or tissues or organs for transplantation," Wu wrote in an email. (the-scientist.com)
Transplantation of human NSCs (hNSCs) derived from human pluripotent stem cells at the SCI sites has been considered a promising therapeutic strategy to compensate for the loss of spinal neurons, and could feasibly enable their connectivity with host neurons, leading to spinal cord recovery. (genengnews.com)
In particular, the induction of stem cells to differentiate into muscle cells (myocytes) is useful for muscle transplantation and therapeutic purposes, as well as providing potential human disease models in culture (e.g. for testing pharmaceuticals). (justia.com)
Human induced pluripotent stem cells differentiation into oligodendrocyte progenitors and transplantation in a rat model of optic chiasm demyelination. (1library.org)
To take human organ generation via BC and transplantation to the next step, we reviewed current emerging organ generation technologies and the associated efficiency of chimera formation in human cells from the standpoint of developmental biology. (frontiersin.org)
Impact of Diabetes Mellitus on Human Mesenchymal Stromal Cell Biology and Functionality: Implications for Autologous Transplantation. (shengsci.com)
WO 2001/046401 discloses embryonic or stem-like cells produced by cross species nuclear transplantation. (justia.com)
Treatment of complete spinal cord injury patients by autologous bone marrow cell transplantation and administration of granulocyte-macrophage colony stimulating factor. (ui.ac.id)
Most notably, upon transplantation to the perinatal cerebellum, cerebellar stem cells from all ages are able to acquire the position and mature electrophysiological properties of cerebellar granule cells. (silverchair.com)

Induced pluripotent stem cells (iPSCs) are a type of stem cells that can be generated directly from adult cells and pioneered by Yamanaka in 2006 who discovered that only 4 genes were required to re-programme adult cells into iPSCs. (mastercellbank.com)
Step-by-step stem cell culture protocols for human induced pluripotent stem cells (iPSCs) including ips cell thawing, expanding, freezing and characterizing. (sigmaaldrich.com)
We offer a large collection of cell culture media, supplements, bioactive small molecules, and growth factors used to control the cell fate of human iPSCs. (sigmaaldrich.com)
This article provides an extensive step-wise overview of CRISPR Cas9 protocol that can be used to perform gene editing in human induced pluripotent stem cells (iPSCs). (sigmaaldrich.com)
Combining our CRISPR, ZFN gene editing , and stem cell expertise, we now offer novel stem cell lines, optimized media, and innovative kits for all areas of stem cell biology, including induced pluripotent stem cells (iPSCs), neural, mesenchymal and hematopoietic stem cell culture. (sigmaaldrich.com)
Pluripotent stem cells, including embryonic stem cells (ES cells) and induced pluripotent stem cells (iPSCs), have the capacity to give rise to differentiated progeny representative of all three germ layers (ectoderm, endoderm, and mesoderm). (sigmaaldrich.com)

The second way is found in mammals, where germ cells are not specified by such determinants but by signals controlled by zygotic genes. (wikipedia.org)
If one of the infected cells showed G418 resistance, then the scientists would know that one of the twenty-four genes influenced the cell to become an embryonic stem cell-like cell. (asu.edu)
Transcription factor GATA4-targeted compounds that have previously shown in vivo efficacy in cardiac injury models were tested for stage-specific activation of atrial and ventricular reporter genes in differentiating pluripotent stem cells using a dual reporter assay. (biomedcentral.com)
In an adult organism, the genes on the Y-chromosome help produce the male gamete, the sperm cell. (asu.edu)
After treatment with chemical signals, the gastruloids were seen to lengthen along a head to tail axis, known as the anteroposterior axis, turning on genes in specific patterns along this axis that reflect elements of a mammalian body plan. (scitechdaily.com)
By looking at which genes were expressed in these human gastruloids at 72 hours of development, the researchers found a clear signature of the event that gives rise to important body structures such as thoracic muscles, bone, and cartilage, but they do not develop brain cells. (scitechdaily.com)
Generally, when a stem cell culture is induced to differentiate, the differentiated population is analysed for particular cell types by expression of genes, markers or phenotypic analysis. (justia.com)
Methods of inducing differentiation in stem cells and muscle cells produced therefrom may be used for the study of cellular and molecular biology of tissue development, for the discovery of genes and proteins such as differentiation factors that play a role in tissue development and regeneration. (justia.com)
With roughly 30,000 genes in mammalian genomes, fection with a vector encoding MyoD (Tapscott et al. (lu.se)
explosion further, consider that a fictitious small genome with 2002) More recently and more dramatically, the potential for 260 genes would host the same number of combinations as cell state conversions is exemplified by the reprogramming of the number of atoms in the visible universe! (lu.se)
Cells become cancerous by accumulating, stepwise, a series of several mutations that alter the function of genes important for cell growth. (agemed.org)
The mtDNA contains only 37 genes, thus most of the gene products in the mammalian body are encoded by nuclear DNA. (justia.com)

In many animals, the germ cells originate in the primitive streak and migrate via the gut of an embryo to the developing gonads. (wikipedia.org)
There are two mechanisms to establish the germ cell lineage in the embryo. (wikipedia.org)
In mammals, a few cells of the early embryo are induced by signals of neighboring cells to become primordial germ cells. (wikipedia.org)
In the model organism Drosophila, pole cells passively move from the posterior end of the embryo to the posterior midgut because of the infolding of the blastoderm. (wikipedia.org)
Embryonic stem cell research garnered great controversy because it derives cells from human embryos through the process of disassembling the embryo. (firebaseapp.com)
The researchers used cryopreserved gaur skin cells combined with an embryo of a domestic cow (Bos taurus). (asu.edu)
Green is posterior part similar to tail-end of an embryo, magenta is anterior part similar to developing heart cells, grey marks DNA. (scitechdaily.com)
During gastrulation, three distinct layers of cells are formed in the embryo that will later give rise to all the body's major systems: the ectoderm will make the nervous system, mesoderm the muscles, and endoderm the gut. (scitechdaily.com)
We think that the developmental cues that exist in the pig will help to guide the human cells inside the porcine embryo. (the-scientist.com)
Embryonic stem (ES) cells are derived from the embryo and are pluripotent, thus possessing the capability of developing into any organ, cell type or tissue type. (justia.com)
The early mammalian embryo consists of the extra-embryonic cell layers-the trophoblast and a body of cells called the inner cell mass (ICM), which eventually become the embryo proper. (thefutureofthings.com)
A pluripotent stem cell has the potential to form all cells of the embryo, but cannot form a placenta. (papersowl.com)
This process gets rid of unneeded cells and is particularly important for "sculpting" tissue and organ structure during development of the embryo (or larval metamorphosis in insects), but may occur at any time even in adult cells when a tissue needs to be remodeled. (agemed.org)
Revealing cell populations catching the early stages of the human embryo development in naïve pluripotent stem cells. (axonmedchem.com)

Chemical compounds that modulate atrial and ventricular cell fate could be used to improve subtype-specific differentiation of endogenous or exogenously delivered progenitor cells in order to promote cardiac regeneration. (biomedcentral.com)
Thus, small molecules capable of influencing the fate decisions and differentiation programs of multipotent progenitor cells could facilitate therapeutic regeneration of lost myocardium. (biomedcentral.com)
MicroRNAs regulate target gene expression post-transcriptionally in a myriad of cell types and play critical roles in diverse physiological and pathological processes, including cardiomyocyte development, differentiation, and regeneration. (biomedcentral.com)
Teleost fishes and amphibians show robust regeneration abilities of heart tissues, whereas the adult mammalian heart poorly renews itself, showing extremely limited regenerative capacity. (biomedcentral.com)
Identifying molecular regulators and critical mediators of cardiac cell type development, proliferation, and differentiation is of great clinical importance, and unraveling such molecular horizons could lead to the development of therapeutic strategies for successful regeneration of the human adult heart. (biomedcentral.com)
During limb epimorphic regeneration: committed mesenchymal cells at the stump site dedifferentiate, forming a cluster of heterogeneous population of stem cells, known as the blastema. (eurekaselect.com)
Epimorphic regeneration and retrodifferentiation both have the capacity to recreate and reconstruct tissue with precise positional integration of cells in such a way that will enable us to heal without scars and to understand how to maintain tissue integrity and architecture in the face of a hostile environment. (eurekaselect.com)
Direct cardiac reprogramming of fibroblasts is an attractive therapeutic strategy for treating cardiovascular diseases because the adult heart has a low regeneration capacity [ 1 ]. (thno.org)
This review considers the genetic and epigenetic control of nephrogenesis, together with the epigenetic mechanisms that accompany kidney development and recent advances in induced reprogramming and kidney cell regeneration in the context of DN. (emjreviews.com)
These properties provide stem cells with powerful capabilities for tissue repair, replacement, and regeneration, so human stem cells are of special interest in medical research. (sigmaaldrich.com)
These cells play a critical role in the regeneration and restoration of injured sites. (shengsci.com)
17 This property of rapid regeneration at intestinal stasis makes the intestine a uniquely convenient model system for epithelial cell biology and adult stem cell biology studies both inside and outside the specific context of intestinal function. (stemcell.com)

whereas, adult stem cells are isolated from adult tissues. (firebaseapp.com)
Comparison of human mesenchymal stromal cells from four neonatal tissues: Amniotic membrane, chorionic membrane, placental decidua and umbilical cord. (sciendo.com)
Unlike some other tissues, it has not been possible to identify or purify neural stem cells directly from the tissue. (elifesciences.org)
They do not have brain cells or any of the tissues needed for implantation in the womb. (scitechdaily.com)
Their team focuses on using human induced pluripotent stem cells to grow human tissues inside pigs. (the-scientist.com)
This can range from the relatively pedestrian, such as a person who received a bone marrow transplant, to creatures that seem more at home in science fiction, such as animals containing cells or tissues belonging to other species. (the-scientist.com)
In the 1960s and 1970s, scientists discovered that there are cells within adult tissues of the body that harbor many of the same special properties as embryonic stem cells. (pas.va)
However, these adult stem cells have more restricted potential - they are specialized to replenish, rejuvenate, and repair the tissues in which they reside. (pas.va)
embryonic stem cells , resulting from the early divisions of the egg, characterized by their "pluripotency", i.e. the capacity, that they share with the egg cell itself, to produce all the cell types found in the adult organism, and the tissue-specific stem cells present in the tissues and organs of the adult. (pas.va)
They are particularly active in tissues and organs in which the lifespan of the differentiated cells is short, like blood, skin and the inner cell layer covering the intestinal cavity, as well as in the repair of skeletal muscle after exercise of injury. (pas.va)
Significant advances have been made in isolating, culturing and reintroducing adult stem cells into tissues. (pas.va)
In addition to their ability to supply cells at the turnover rate of their respective tissues, they can be stimulated to repair injured tissue caused by liver damage, skin abrasions and blood loss. (thefutureofthings.com)
The ability of our body to regenerate some of its tissues is largely owed to the reserves of adult stem cells. (thefutureofthings.com)
Totipotent stem cells contain all the constituents necessary to produce a living being, given that these cells can supply all embryonic and extraembryonic tissues required for proper growth (Can/Hematol 2008). (papersowl.com)
The most obvious of the recurrent concepts to emerge from the meeting was the central role that similar inductive cues play across a variety of organisms and tissues in specifying cell fate. (silverchair.com)
Stem cells represent a small fraction of cells located in different tissues. (shengsci.com)
Multipotent mesenchymal stem/stromal cells (MSCs) have regenerative and immunomodulatory properties to restore and repair injured tissues, making them attractive candidates for cell-based therapies. (shengsci.com)

Neurons that arise in the adult nervous system originate from neural stem cells and neural progenitor cells. (elifesciences.org)
Neural stem cells can also give rise to neural progenitor cells, which proliferate rapidly during their short lives and then 'differentiate' into neurons or glia. (elifesciences.org)
Consequently, neural stem and progenitor cells have usually been studied retrospectively, based on their ability to form colonies in laboratory cell cultures. (elifesciences.org)
A region of the brain called the subventricular zone contains both neural stem cells and neural progenitor cells, and is one of only two regions of the brain where neural stem cells are found in adult mammals. (elifesciences.org)
Collectively, these results indicate the potential for therapeutic alteration of cell fate decisions and pathological gene regulatory networks by GATA4-targeted compounds modulating chamber-specific transcriptional programs in multipotent cardiac progenitor cells and cardiomyocytes. (biomedcentral.com)
Efficient commitment to functional CD34+ progenitor cells from human bone marrow mesenchymal stem-cell-derived induced pluripotent stem cells. (1library.org)
Cord blood is now being enriched with functional stem and progenitor cells and also immune modulatory cells. (mastercellbank.com)
allogenic natural killer cells (NK-cells) generated ex vivo from umbilical cord blood progenitor cells in cancer immunotherapy. (mastercellbank.com)
Adult stem cells can be used to accelerate bone or tendon healing , and they can induce cartilage progenitor cells to produce a better matrix and repair cartilage damage . (thefutureofthings.com)
Derivation and characterization of functional human neural stem cell derived oligodendrocyte progenitor cells (OPCs) that efficiently myelinate primary neurons in culture. (sigmaaldrich.com)
Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. (lu.se)
To varying degrees, these fates also extend to the Such state stability is required in stem and progenitor cells to immediate progeny of stem cells, known as progenitor or support self-renewal and maintenance of the uncommitted transit-amplifying cells. (lu.se)
A key challenge is to understand how state, but must also afford flexibility in cell-fate choice to permit the different cell-fate options confronting stem and progenitor cell-type diversification and differentiation in response to cells are selected and coordinated such that adoption of a given intrinsic cues or extrinsic signals. (lu.se)

The efficient derivation of specialized and functional cardiomyocytes (CMs) from pluripotent stem cells is a primary goal for stem cell-based cardiac regenerative therapies. (biomedcentral.com)
Atta-ur-Rahman, Shazia Anjum , " Frontiers in Stem Cell and Regenerative Medicine Research ", Bentham Science Publishers (2017). (eurekaselect.com)
Cardiovascular diseases often cause substantial heart damage and even heart failure due to the limited regenerative capacity of adult cardiomyocytes. (thno.org)
Spinal neurons around the scar cannot be restored due to the low intrinsic regenerative ability of undamaged neurons and the lack of neural stem cells in the adult spinal cord. (genengnews.com)
spinal composition and architectures within and around the scar cannot be restored due to low intrinsic regenerative ability of neurons in the adult mammalian central nervous system (CNS) and the postinjury environment. (genengnews.com)
Cell therapy, cytotherapy, cytotherapeutics has the potential to provide cures for many significant ailments and disorders by repairing and reversing disease through regenerative medicine. (mastercellbank.com)
Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)
Prospect of adipose tissue derived mesenchymal stem cells in regenerative medicine. (ui.ac.id)

Researchers at the University of Hong Kong (HKUMed) LKS Faculty of Medicine, and at City University of Hong Kong (CityU) have generated human neural stem cells (hNSCs) that exhibit what they claim is "powerful therapeutic potential" for the treatment of spinal cord injury. (genengnews.com)
A research team from HKUMed has generated human neural stem cells with powerful therapeutic potential for the treatment of spinal cord injury that paves the way for new therapeutic opportunities. (genengnews.com)
The present invention also provides methods of using the differentiated cells of the present invention for therapeutic purposes. (justia.com)
The induction of cardiomyocyte differentiation in stem cells is especially useful in developing therapeutic methods and products for heart disease and abnormal heart conditions. (justia.com)
A number of large biotech companies and scientists are looking toward stem cells as the basis for a therapeutic solution to cure such illnesses as blindness, diabetes and spinal cord injuries. (thefutureofthings.com)
Before delving into the molecular biology and therapeutic potentials of induced pluripotent stem cells, it is crucial to provide foundational definitions and descriptions. (papersowl.com)
The present invention provides stem cells enriched with healthy functional mitochondria, and therapeutic methods utilizing such cells for the alleviation of debilitating conditions, including aging, and age-related diseases as well as the debilitating effects of anti-cancer therapies in subjects in need thereof. (justia.com)
The present invention relates to stem cells enriched with functional mitochondria, and therapeutic methods utilizing such cells to diminish the debilitating effects of various conditions, including aging and age-related diseases as well as the debilitating effects of anti-cancer therapy treatments. (justia.com)
Mesenchymal stem cells: immunology and therapeutic benefits. (ui.ac.id)
2011. http://www.intechopen.com/books/stem-cells-in-clinic-and-research/mesenchymal-stem-cells-immunology-and-therapeutic-benefits . (ui.ac.id)

Osteogenic proliferation and differentiation of canine bone marrow and adipose tissue derived mesenchymal stromal cells and the influence of hypoxia. (sciendo.com)
Furthermore, it is unknown whether endogenous progenitors/stromal cells in the adult human heart could be chemically induced to generate functional atrial or ventricular heart muscle to treat adult heart diseases. (biomedcentral.com)
MSCs are multipotent stromal cells that make and restore skeletal tissue and can differentiate into diverse cell types: bone, cartilage, muscle and fat. (mastercellbank.com)
Presently, kidney organoids contain not only nephrons and ureteric buds but also stromal cells. (j-organoid.org)
Defining essential stem cell characteristics in adipose-derived stromal cells extracted from distinct anatomical sites. (ui.ac.id)

Since neurosphere-forming cells can self-renew and differentiate into neurons and glia, the ability of cells to form neurospheres has generally been taken as evidence that they are stem cells. (elifesciences.org)
The researchers showed that human pluripotent stem cell (hPSC)-derived neural stem cells engineered with reduced expression of a gene called SOX9 differentiate preferentially into spinal motor neurons. (genengnews.com)
When transplanted into a rat model of spinal cord injury (SCI) these neural stem cells generated mature neuronal subtypes, were able to integrate and grow axons that projected over long distances and connected with the recipient's neurons. (genengnews.com)
Stem cell-derived dopamine neurons for brain repair in Parkinson's disease. (mastercellbank.com)
A particular field encouraged by the foundation is stem-cell research, with the great hope that it will result in the ability to get cells to differentiate into neurons and support cells to bridge the gap of a spinal cord injury. (thefutureofthings.com)
ReNcell neural progenitors are immortalized human neural stem cell lines that can differentiate into neurons, astrocytes sand oligodendrocytes. (sigmaaldrich.com)
However, when ectopically transplanted, neurosphere-derived cells from either region are largely unable to generate neurons. (silverchair.com)
With regard specifically to embryonic and adult cerebellar stem cells, we observe that they are able to give rise to neurons that resemble different select classes of cerebellar subclasses when grafted into the perinatal host cerebellum. (silverchair.com)
The idea to use transplants of dopa- ment of protocols that allow generation of fully functional mine-producing cells to substitute for the lost midbrain and safe midbrain dopamine neurons from stem cells. (lu.se)
VM), showed that the recovery of motor functions induced implanted either (1) as a solid piece in the lateral ven- by the grafted fetal dopamine neurons was well cor- tricle6 or a cortical cavity8 adjacent to the denervated related with the extent of graft-derived reinnervation caudate-putamen, or (2) as a crude cell suspension of the host caudate-putamen. (lu.se)

These adult stem cells are considered multipotent, having the ability to differentiate into different cell types, albeit with a more limited repertoire than embryonic stem cells. (thefutureofthings.com)
To delve further into the specifics, embryonic and adult stem cells fall into potency categories reflecting their ability to differentiate: totipotent, pluripotent, multipotent, and unipotent. (papersowl.com)
Multipotent stem cells are capable of forming many, but not all, cell types of the body. (papersowl.com)
Using these definitions, embryonic stem cells can be classified as totipotent or pluripotent at different developmental stages and locations, whereas adult stem cells can be categorized as pluripotent, multipotent, or unipotent (Figure 1). (papersowl.com)

By employing microRNA expression profiling and functional knockdown studies on human embryonic stem cell-derived cardiomyocytes, the authors identified miR-363 as an upstream negative regulator of left ventricular specification transcription factor HAND1 . (biomedcentral.com)
Herein, we introduce a cardiac-mimetic cell-culture system that resembles the microenvironment in the heart and provides interactions with cardiomyocytes and electrical cues to the cultured fibroblasts for direct cardiac reprogramming. (thno.org)
In the heart, cardiomyocytes interact with neighboring cells through direct cell-cell interactions, various secreted cytokines, and electric signals (Figure 1 A) [ 24 ]. (thno.org)
Evaluation of the cardiotoxicity of mitragynine and its analogues using human induced pluripotent stem cell-derived cardiomyocytes. (1library.org)
Efficient and scalable purification of cardiomyocytes from human embryonic and induced pluripotent stem cells by VCAM1 surface expression. (1library.org)

Equine mesenchymal stem cells from bonemarrow, adipose tissue and umbilical cord:immunophenotypic characterization anddifferentiation potential. (sciendo.com)
Mesenchymal stem cells: clinical applications and biological characterization. (ui.ac.id)

It is essential to have sensitive and reproducible methods of either quantifying or isolating these stem cells and progenitors to understand their intrinsic properties and how extrinsic signals regulate their development. (karger.com)
However, stem cells are difficult to distinguish from multipotential progenitors, which may look and act like them. (karger.com)
Here we define a 4-color flow cytometry panel using CD133, LeX, CD140a, NG2 to define a neural stem cell (NSC) as well as 4 classes of multipotential progenitors and 3 classes of bipotential progenitors, several of which have not been described previously. (karger.com)

In 2004, Yamanaka began working at Kyoto University as a professor, where he studied factors that help an organism fend off retroviruses, which are single-stranded RNA viruses that can incorporate their genetic material into the DNA of a host cell. (asu.edu)
However, the crowning achievement arose in 2006 when researchers at Kyoto University discovered the necessary means to reprogram differentiated adult cells to possess embryonic stem cell-like functionality, as if reversing time itself. (papersowl.com)

Stem Cell Research - Journal - Elsevier Stem Cell Research is dedicated to publishing high-quality manuscripts focusing on the biology and applications of stem cell research. (firebaseapp.com)
Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. (lu.se)
Rather, the issues that so beguiled pioneering developmental biologists have now become crucial to the understanding of such disparate fields as cancer biology, cloning and stem cell totipotency. (silverchair.com)

Mathematical modeling of Hematopoietic Stem Cell and Leukaemic Stem Cell culture systems. (imperial.ac.uk)

Special focus of SCR is on mechanisms of pluripotency and description of newly generated pluripotent stem cell lines. (firebaseapp.com)

After examination, Takahashi and Yamanaka concluded that the cells were similar to embryonic stem cells and duplicated themselves in similar periods of as embryonic stem cells. (asu.edu)

The recent publication in Stem Cell Research and Therapy by Wagh and colleagues reports a novel regulatory role for miR-363 in cardiomyocyte specification. (biomedcentral.com)
This commentary discusses the findings from Wagh and colleagues published in this issue of Stem Cell Research and Therapy demonstrating a critical role for miR-363 in post-transcriptional regulation of CM differentiation via the hand and neural crest derivative expressed HAND1 transcription factor [ 1 ]. (biomedcentral.com)
Further exploring the role of miRNAs in cardiac cells during development and disease may therefore hold great promise for cardiac therapy applications. (biomedcentral.com)
This observation has led to the 'cancer stem cell' (CSCs) hypothesis, stating that a subpopulation of cancer cells survive therapy and lead to tumor relapse. (mdpi.com)
This approach alters the grafts' response in the injury environment and confers enhanced neuronal differentiation capacity, survival, and integration, as well as reduced glial scar formation to provide a more effective stem cell therapy for severe traumatic SCI. (genengnews.com)
Peripheral blood stem cell transplantations (PBSCT) are now the most common cell therapy procedure. (mastercellbank.com)
A new cell therapy, donor lymphocyte infusion, emerged in the 1990s to ensure that the donor stem cells remain engrafted whereby lymphocytes from the blood of a donor are given to a patient who has already received a hematopoietic stem cells from the same donor. (mastercellbank.com)
Mesenchymal stem cells (MSCs) the most significant stem cells for cell therapy were first isolated and characterized in 1974 and have been used in the clinic since 2004. (mastercellbank.com)
The cell therapy industry is rapidly expanding. (mastercellbank.com)
Avant-garde approaches to stem-cell therapy may be the first stepping-stones to a bright new future of stem-cell medicine and are emerging in leading laboratories worldwide. (thefutureofthings.com)
Cell Therapy for Parkinsons Disease: What Next? (lu.se)

A germ cell is any cell that gives rise to the gametes of an organism that reproduces sexually. (wikipedia.org)
Cell lines are a cluster of cells that continuously multiply on their own outside of the organism from which they originated. (asu.edu)
As scientific understanding of stem cells, gene editing, and organism development improved, Garry felt that her career path was clear. (the-scientist.com)
However, advances in stem cell research in the 2000s revolutionized the field, opening up new possibilities and new applications for multispecies organism research. (the-scientist.com)
At the top of the list comes the zygote-a fertilized egg, which of course has the ability to divide and differentiate into all cell types in the body and create a new organism. (thefutureofthings.com)
The first three divisions of the zygote give birth to eight totipotent cells, each of which also has the ability to become an entire organism. (thefutureofthings.com)
On the other hand, a chimera is defined as an organism in which cells from two or more different organisms have contributed. (frontiersin.org)
Internal signals producing apoptosis depend on interactions of several proteins and may serve to protect the organism from cancer by killing cells that have pre-cancerous changes. (agemed.org)

In mammals, functional analysis of the individual RAD51 paralogues in cell lines has shown similar but non-redundant contributions in DNA repair processes such as HR efficiency, RAD51 nuclear focus formation, sensitization to mitomycin C (MMC) and protection of perturbed replications forks [ 11 ]. (nature.com)
The researchers reported on their developments in Advanced Science , in a paper titled, " Transplanting Human Neural Stem Cells with ≈50% Reduction of SOX9 Gene Dosage Promotes Tissue Repair and Functional Recovery from Severe Spinal Cord Injury ," in which they concluded, "Our findings represent a new paradigm in generating genetically modified hNSCs for the treatment of SCI. (genengnews.com)
Stem cells are undifferentiated cells which can give rise to a succession of mature functional cells. (justia.com)
Functional recovery of spinal cord injury following application of intralesional bone marrow mononuclear cells embedded in polymer scaffold? (ui.ac.id)
These organoids include a polarized epithelial layer that surrounds a functional lumen and contains cell types of the intestinal epithelium present in proportions and relative spatial arrangement that mimic what is observed in vivo. (stemcell.com)

Submissions to Stem Cell Research, may cover all aspects of stem cells, including embryonic stem cells, tissue-specific stem cells, cancerstem cells, developmental studies, genomics and translational research. (firebaseapp.com)
Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stem Cells from Sheep: Culture Characteristics. (sciendo.com)
During this process, leukocytes lose lineage-associated markers home and undergo homocytic aggregation, upregulate expression of stem cell antigens, and subsequently redifferentiate to give rise original tissue or, transdifferentiate into a different tissue altogether. (eurekaselect.com)
The robustness and efficacy of the retrodifferentiation process in generating unprecedented quantities of stem cells belonging to the three germ layers will enable organ and tissue reconstruction ex vivo, using bio-printing and various scaffold materials. (eurekaselect.com)
Stem cells have attracted much interest in tissue engineering as a cell source due to their ability to proliferate in an undifferentiated state for prolonged time and capability of differentiating to different cell types after induction. (wjgnet.com)
Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. (wjgnet.com)
An immunologically identical cardiac tissue can be produced by direct reprogramming from the patients' tissue without the potential risk of tumorigenesis that occurs with induced pluripotent stem cells [ 2 ] and the ethical issue using embryonic stem cells. (thno.org)
These adult stem cells are highly specialized and can only produce the tissue in which they reside. (pas.va)
In addition, there has been remarkable progress in developing approaches to stimulate these tissue-resident stem cells in situ in the tissue. (pas.va)
Biostór / Master Cell Bank is a leading EU-licensed Tissue Establishment (TE) storing life-saving cell therapies, GMP Cell Banks and Clinical Trial samples since 2007. (mastercellbank.com)
Serving global markets, it provides cell and tissue biostorage and cold chain logistics solutions to many leading medical and biotechnology research organisations world-wide. (mastercellbank.com)
Bone marrow was the original and most common source of MSCs and they are also found in Wharton's Jelly, Cord Blood, Adipose Tissue, Molar Teeth, Amniotic Fluid and Peripheral Blood. (mastercellbank.com)
In both processes, rapid proliferation gives rise to new tissue, cell fate has to be specified within that tissue, and distinct positional identities have to be established to generate a properly patterned structure. (frontiersin.org)
An organoid is a 3D organization of cells that can recapitulate some of the structure and function of native tissue. (mdpi.com)
Adipose tissue derived mesenchymal stem cells (AT-MSCs) are relatively easy in isolation procedure compared to bone marrow-derived. (ui.ac.id)
This experimental study used cryopreserved adipose tissue derived MSCs stored in Stem Cell Medical Technology Integrated Service Unit Cipto Mangunkusumo Hospital. (ui.ac.id)
Side-by-side comparison of the biological characteristics of human umbilical cord and adipose tissue-derived mesenchymal stem cells. (ui.ac.id)
Cell Tissue Res. (ui.ac.id)
Cell Tissue Transplant Ther. (ui.ac.id)
Since the introduction of the mouse small intestinal organoid model in 2009, 1 there has been an avalanche of developments in this field, including development of culture conditions for human organoids derived from primary colonic tissue, 2 as well as from human pluripotent stem cells (hPSCs). (stemcell.com)

Section II is applicable to stem cells derived from human embryos. (firebaseapp.com)
This is because, as Robertson has indicated, human embryos consist of one of the most potent sources of stem cells, and the extraction of stem cells from the embryos requires the destruction of the embryos. (firebaseapp.com)
These studies led to our discovery of a novel type of pluripotent epiblast stem cell (EpiSC) from the late epiblast layer of mouse and rat embryos. (qscience.com)
Yamanaka worked to find new ways to acquire embryonic stem cells to avoid the social and ethical controversies surrounding the use of human embryos in stem cell research during the late twentieth and early twenty-first centuries. (asu.edu)
However, these models may behave differently from human embryos when the cells start to differentiate. (scitechdaily.com)
Efficient generation of embryonic stem cells from single blastomeres of cryopreserved mouse embryos in the presence of signalling modulators. (axonmedchem.com)

Recent studies have demonstrated that it is possible to give rise to primordial germ cells from ESCs. (wikipedia.org)
Takahashi and Yamanaka's 2006 and 2007 experiments showed that scientists can prompt adult body cells to dedifferentiate, or lose specialized characteristics, and behave similarly to embryonic stem cells (ESCs). (asu.edu)

WO 2016/135723 to the present inventors discloses mammalian bone marrow cells enriched with mitochondria for treatment of mitochondrial diseases. (justia.com)

One sentence summary Murine hematopoietic stem cells display transcriptional heterogeneity that is quantitatively altered with age and leads to the age-dependent myeloid bias evident after inflammatory challenge. (biorxiv.org)
In addition, the authors also review future strategies in DN treatment such as transcriptional reprogramming of mature adult kidney cells into uncommitted induced pluripotent stem cells for renal repair and therapeutics. (emjreviews.com)
Genetic background drives transcriptional variation in human induced pluripotent stem cells. (1library.org)
In terminally differentiated cell fate is coupled to appropriate regulation of the alternative cells, transcriptional networks must be stable and irreversible, pathways. (lu.se)

Pharmacological modulation of cell fate decisions and developmental gene regulatory networks holds promise for the treatment of heart failure. (biomedcentral.com)
The ICM continues to differentiate into three germ layers-ectoderm, mesoderm and endoderm, each of which follows a specific developmental destiny that takes them along an ever-specifying path at which end the daughter cells will make up the different organs of the human body. (thefutureofthings.com)

Neurosphere formation is commonly used as a surrogate for neural stem cell (NSC) function but the relationship between neurosphere-initiating cells (NICs) and NSCs remains unclear. (elifesciences.org)

Specification of primordial germ cells in the laboratory mouse is initiated by high levels of bone morphogenetic protein (BMP) signaling, which activates expression of the transcription factors Blimp-1/Prdm1 and Prdm14. (wikipedia.org)
In our most recent work we have focused on the role of bone morphogenetic protein (BMP)-4 in the cell fate decision between endoderm and mesoderm, demonstrating the similarity of BMP-induced hESC and EpiSC differentiation to mesoderm induction during mouse gastrulation. (qscience.com)
The intestinal niche has been well-characterized, and shown to consist of spatial gradients of high WNT and Epithelial Growth Factor (EGF), while Bone Morphogenetic Protein (BMP) signals are inhibited. (stemcell.com)

Pre-GEPCOT cells could not form neurospheres but expressed the stem cell markers Slc1a3-CreER T , GFAP-CreER T2 , Sox2 CreERT2 , and Gli1 CreERT2 and were long-lived in vivo. (elifesciences.org)

Intra-articular injection of expanded autologous bone marrow mesenchymal cells in moderate and severe knee osteoarthritis is safe: a phase I/II study. (sciendo.com)
Use of a chronic model of articular cartilage and meniscal injury for the assessment of long-term effects after autologous mesenchymal stromal cell treatment in Steep. (sciendo.com)
Its clinical introduction in 1986 replaced bone marrow (BM) as a stem cell source to almost 100% in the and to autologous approximately 75% in the allogeneic transplant setting. (mastercellbank.com)

Accordingly, Rad51b-c.92delT variant reduced replication fork progression of patient-derived lymphoblastoid cell lines and pluripotent reprogramming efficiency of primary mouse embryonic fibroblasts. (nature.com)
Negligible immunogenicity of induced pluripotent stem cells derived from human skin fibroblasts. (1library.org)
2008). Historically, this concept is highlighted by the experi- factors are key intrinsic regulators of these fate decisions and mental phenomenon of lineage reprogramming, for example, that fate choice involves modulating networks of transcription by the conversion of fibroblasts to muscles cells following trans- factors. (lu.se)

Mammalian eggs are somewhat symmetrical and after the first divisions of the fertilized egg, the produced cells are all totipotent. (wikipedia.org)
The zygote and the cells within the initial zygotic divisions are considered totipotent (Kara et al. (papersowl.com)

Embryonic stem cells have the ability to differentiate into more cell types than adult stem cells. (sigmaaldrich.com)
Oligopotent stem cells, though not often widely discussed, have the ability to differentiate into a few cells (Kara et al. (papersowl.com)

This general definition includes a wide variety of cells with varying degrees of differentiation potential. (thefutureofthings.com)
Since suboptimal media may change the differentiation potential of stem cells, it is vital to select the correct stem cell-validated media and reagents at the start of your research process. (sigmaaldrich.com)

After splitting into two populations, the germ cells continue migrating laterally and in parallel until they reach the gonads. (wikipedia.org)
The intestinal epithelium incorporates several distinct cell populations, including the rapidly dividing intestinal stem cells (ISCs) that facilitate the typical four-to-five day turnover cycle of the adult intestinal epithelium. (stemcell.com)

Immunoselected STRO-3+ mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis. (sciendo.com)
Cryopreserved allogeneic mesenchymal stem cells enhance wound repair in full thickness skin wound model and cattle clinical teat injuries. (sciendo.com)
Taken together, these studies should significantly accelerate the progression from basic stem cell research to clinical applications. (qscience.com)
The hematopoietic retrodifferentiated stem cells have been shown to engraft an animal host in two proofs of principle clinical studies, demonstrating long-term engraftment and safety in acquired aplastic anaemia, while transient amelioration of beta thalassemia major was also observed. (eurekaselect.com)
The ease by which various stem cell types can be generated from human peripheral blood has allowed the design of various kits to guarantee the specificity, sterility and efficacy of stem cells production for various clinical and research applications. (eurekaselect.com)
The clinical application cells began in 1956 with the first successful bone marrow transplant, performed between twins, with bone marrow taken from the healthy identical twin, and given to the other, who had leukaemia. (mastercellbank.com)
Human iPSC derived cardiovascular and neuronal cells are being used in preclinical studies and will find use in clinical application as cell therapies. (mastercellbank.com)
Hardly a day goes by without hearing of some new cell involved in a new disease treatment: Numerous cellular immunotherapies are currently in clinical development, using natural killer cells, dendritic cells (DCs), macrophages, polyclonal or antigen-specific T cells and lymphokine-activated killer cells. (mastercellbank.com)
The biological properties and clinical potential of stem cells elicit that are generated must not be unduly sensitive to small fluctu- continued scientific, commercial, and public interest. (lu.se)
Safety of mesenchymal stem cells for clinical application. (ui.ac.id)

Wunen proteins are chemorepellents that lead the germ cells away from the endoderm and into the mesoderm. (wikipedia.org)
In response to ligation of monomorphic regions of MHC class II antigens with monoclonal antibody CR3/43, human leukocytes retrodifferentiate into a variety of heterogeneous stem cell types belonging to the mesoderm, ectoderm or endoderm lineage, depending on culture media and conditions. (eurekaselect.com)

Here, we show that young and aged LT-HSCs respond differently to inflammatory stress, such that aged LT-HSCs produce a cell-intrinsic, myeloid-biased expression program. (biorxiv.org)
Aged LT-HSCs demonstrate a cell-intrinsic myeloid bias during inflammatory challenge. (biorxiv.org)
Here, we aimed to highlight the intrinsic antiviral resistance in different stem cells against viral infection. (shengsci.com)

Altogether our FACS (fluorescence-activated cell sorter) analyses reveal that the neonatal subventricular zone is far more heterogeneous than previously suspected and our studies provide new insights into the signals and mechanisms that regulate their self-renewal and proliferation. (karger.com)
Additional processes in which mitochondria are involved include heat production, storage of calcium ions, calcium signaling, programmed cell death (apoptosis) and cellular proliferation. (justia.com)

Germ cells produce gametes and are the only cells that can undergo meiosis as well as mitosis. (wikipedia.org)
Our research focuses on understanding how pluripotent mammalian stem cells maintain their undifferentiated state and undergo differentiation in culture - this reflecting my enduring interest in the emergence of diversity during mouse gastrulation. (qscience.com)
A stem cell commences as an undifferentiated cell that can either undergo self-renewal, whereby it generates daughter cells that remain as stem cells, or mature into a specific cell type via differentiation (Can/Hematol 2008). (papersowl.com)
Cancer A clonal growth (cells all descended from one ancestral cell) that undergo continuing mitotic divisions and are not inhibited in their growth when they come in contact with neighboring cells (contact inhibition). (agemed.org)

We prospectively identified, and isolated by flow cytometry, adult mouse lateral ventricle subventricular zone (SVZ) NICs as Glast mid EGFR high PlexinB2 high CD24 −/low O4/PSA-NCAM −/low Ter119/CD45 − (GEPCOT) cells. (elifesciences.org)
When cells from the subventricular zone are cultured in a way that allows the cells to freely float around (rather than growing on a surface), a few percent form spherical colonies called neurospheres. (elifesciences.org)
have used a technique called flow cytometry to identify and isolate neural stem cells and neurosphere-forming cells directly from the subventricular zone. (elifesciences.org)

MicroRNAs (miRNAs) are small noncoding RNAs (~22 nucleotides in length) that regulate gene expression post-transcriptionally by imperfect binding to the 3′ untranslated region of target mRNAs in a wide variety of cell types. (biomedcentral.com)
Top PDF Morphologic and gene expression criteria for identifying human induced pluripotent stem cells. (1library.org)
Persistent donor cell gene expression among human induced pluripotent stem cells contributes to differences with human embryonic stem cells. (1library.org)

Stem cell therapies, once a dream, are now becoming a reality. (pas.va)

More detailed structure-function analysis revealed a distinct subclass of GATA4/NKX2-5 inhibitory compounds with an acetyl lysine-like domain that contributed to ventricular cells (%Myl2-eGFP+). (biomedcentral.com)

Animals with human cells could provide donor organs or help us understand neuropsychiatric disorders. (the-scientist.com)
However, though BC is emerging as a potential organ transplant option, challenges regarding organ size scalability, immune system incompatibilities, long-term maintenance, potential evolutionary distance, or unveiled mechanisms between donor and host cells remain. (frontiersin.org)
Nuclear transfer efficiency is enhanced by introduction of compatible cytoplasm or mitochondrial DNA (same species or similar to donor cell or nucleus). (justia.com)
the donor.4,11 In the case of nerve cells obtained from either delivery of dopamine released from cells the developing central nervous system (CNS), the opti- implanted into the ventricle, adjacent to the stria- mal age was shown to be at, or close to, the cell-cycle tum,6,7 or restoration of synaptic dopamine release exit. (lu.se)

These changed cells are then called embryonic germ cells. (wikipedia.org)

ALS (Lou Gehrig's Disease) Goal: Test that safety of delivering embryonic stem cells to the spinal cord. (firebaseapp.com)
In rodents, and even in some preliminary trials in humans, human embryonic stem cells have been shown to bridge gaps in spinal cord injuries , allowing restoration of motor functions. (thefutureofthings.com)

2017). MMP-2 and MMP-14 Silencing Inhibits VEGFR2 Cleavage and Induces the Differentiation of Porcine Adipose-Derived Mesenchymal Stem Cells to Endothelial Cells. (sciendo.com)
Bovine fetal mesenchymal stem cells exert antiproliferative efect against mastitis causing pathogen Staphylococcus aureus. (sciendo.com)
Information about mesenchyme, specifically mesenchymal stem cell procotols. (sigmaaldrich.com)
Step-by-step cell culture protocols for mesenchymal stem cell (MSC) isolation, expansion and differentiation. (sigmaaldrich.com)
Isolation and cultivation of mesenchymal stem cells from iliac crest bone marrow for further cartilage defect management. (ui.ac.id)

Takahashi and Yamanaka also experimented with human cell cultures in 2007. (asu.edu)

To make gastruloids in the lab, defined numbers of human embryonic stem cells were placed in small wells, where they formed tight aggregates. (scitechdaily.com)
Since the first publication on generating kidney-like cell aggregates from pluripotent stem cells, various modifications have been made to develop more complex and detailed kidney structures. (j-organoid.org)

Aug 23, 2017 · To start a research paper on stem cells, students have to know the basics about them first and narrow down the general topic from there. (firebaseapp.com)

However, more mutation rate data will need to be collected across several taxa, particularly data collected both before and after the specification of primordial germ cells before this hypothesis on the evolution of germ plasm can be backed by strong evidence. (wikipedia.org)

Stem Cell Research Paper - Educational Writing Topics Ideas And Thesis Statement For Stem Cell Research Paper Stem cell research is considered to the biggest breakthrough in the history of medical science while highly controversial as well. (firebaseapp.com)
If you are assigned to write ethical issues in stem cell research paper, then you have to have a thorough knowledge about the study. (firebaseapp.com)
The potential of stem cell research is unlimited, including offering the chance to improve mental health. (firebaseapp.com)
Stem cell laws and policy in the United States - Wikipedia National Academies Guidelines for Human Embryonic Stem Cell Research. (firebaseapp.com)
Applicants proposing research, may use stem cell lines that are posted on the NIH registry, or may submit an assurance of compliance with section II of the guidelines. (firebaseapp.com)
FREE Stem Cell Research Essay - ExampleEssays Stem cell research. (firebaseapp.com)
Stem Cell Research: A Look at the Ethical Debate of Federal Funding Stem cell research has been becoming a larger national issue of public concern in the last few years. (firebaseapp.com)
Conduct initial research and determine what stem cells are, their different kinds, and their existing as well as future uses. (firebaseapp.com)
8 Important Pros and Cons of Embryonic Stem Cell Research List of Cons of Embryonic Stem Cell Research. (firebaseapp.com)
Stem cell research has been done in mice but not in people with Alzheimer's disease. (firebaseapp.com)
Stem cell research is a broad field, dealing with embryonic and adult stem cells (e.g. mesenchymal and neural stem cells) or induced pluripotent cells. (firebaseapp.com)
The issue of stem cell research has always been closely connected with the issue of abortion. (firebaseapp.com)
Stem Cell Research Paper Sample - Writing-Expert.com Stem Cell Research Paper Sample. (firebaseapp.com)
1 Wellcome Trust Centre for Stem Cell Research, Tennis Court Road, Cambridge CB2 1QR, UK. (biologists.com)
Today, Garry and her husband Dan, a transplant cardiologist, are pioneers in the field of interspecies chimera research, the study of organisms containing cells from two different species. (the-scientist.com)
Stem cells are at the forefront of medical research and incite some of the most controversial ethical and religious debates worldwide. (thefutureofthings.com)
While regarded by many top scientists as the Holy Grail of medicine, others consider embryonic stem-cell research sacrilegious. (thefutureofthings.com)
Recent advances in the field of stem-cell research are giving hope to millions. (thefutureofthings.com)
Recent advances in the realm of stem cell research are due to the advent of CRISPR genome editing technology and more advanced 3D cell culture techniques. (sigmaaldrich.com)
Innovations in Training: Toward Mitigating "Eternal post-docdum" in Stem Cell Research. (shengsci.com)
Stem Cells in Clinic and Research. (ui.ac.id)
At International Society for Stem Cell Research-the big stem cell meeting-Yamanaka revealed one more factor. (medscape.com)

GFP + CD133 + cells had upregulated Wnt, FGF and BMP pathways and expressed neural crest markers. (biologists.com)
In GFP - CD133 + cells,the hedgehog, IGF, Notch and integrin pathways were prominent. (biologists.com)
However, the molecular pathways that lead to specification and terminal differentiation of specific cell types, such as myocytes, from embryonic stem cells during development are not entirely clear. (justia.com)

In 2006, Kazutoshi Takahashi and Shinya Yamanaka reprogrammed mice fibroblast cells, which can produce only other fibroblast cells, to become pluripotent stem cells, which have the capacity to produce many different types of cells. (asu.edu)
We have thus demonstrated a previously unrecognised heterogeneity in dermal papilla cells and shown that Sox2-positive cells specify particular hair follicle types. (biologists.com)
The term stem cells dates back to the late 1800s at which time it referred to the fertilized egg, a pluripotent cell able to give rise to all of the complex cell types that comprise our body. (pas.va)
Placing the cells under conditions which induce specific cell types has been one form of an attempt to regulate the differentiation outcome. (justia.com)
In any case, the respective cell types may then be selectively cultured to enrich their percentage population to eventually obtain a single cell type and culture. (justia.com)
Therefore there remains a need for providing effective methods of inducing differentiation of stem cells into specific cell types, such as myocytes or endothelial cells. (justia.com)
Stem cells have the unique ability to self-renew or to differentiate into various cell types in response to appropriate signals. (sigmaaldrich.com)
Specific stem cell types possess unique potencies, or abilities to self-renew. (papersowl.com)
Hematopoietic stem cells, which can produce several different types of blood cells, are prime examples of multipotency. (papersowl.com)
The human kidney contains approximately one million nephrons, each composed of at least 20 different cell types. (j-organoid.org)
Thereafter, they give rise not only to ectodermal cell types, but also to mesodermal cell types. (shengsci.com)
Diagram of the small intestinal epithelium highlighting the identity and spatial arrangement of key epithelial cell types. (stemcell.com)
The adult intestinal epithelium is primarily composed of six cell types that are arranged in a crypt-villus structure (Figure 1). (stemcell.com)
As these cells move upward out of the crypt, they move along signaling gradients that trigger them to differentiate, giving rise to the mature cell types that populate the villus domain. (stemcell.com)

Anatomy62

Organisms16

Diseases10

Chemicals and Drugs51

Analytical, Diagnostic and Therapeutic Techniques and Equipment55

Phenomena and Processes60

Disciplines and Occupations7

Technology, Industry, Agriculture3

Information Science3

Somatic19

Produced induced pluri1

Vitro16

Transplantation9

IPSCs6

Genes12

Embryo14

Regeneration12

Tissues17

Progenitor13

Regenerative8

Therapeutic10

Stromal cells5

Neurons10

Multipotent4

Cardiomyocytes5

Characterization2

Progenitors3

Kyoto University2

Biology3

Hematopoietic stem1

Pluripotency1

Similar to embryonic stem1

Therapy11

Organism8

Functional5

Tissue20

Embryos6

ESCs2

Marrow cells1

Transcriptional4

Developmental2

Neural stem1

Morphogenetic protein3

Vivo1

Autologous3

Fibroblasts3

Totipotent2

Ability to differentiate2

Differentiation Potential2

Populations2

Clinical10

Mesoderm2

Intrinsic3

Proliferation2

Undergo4

Subventricular zone3

Gene expression3

Therapies1

Distinct1

Donor4

Embryonic germ1

Spinal cord2

Mesenchymal stem5

Cultures1

Aggregates2

20171

Evidence1

Research22

Pathways3

Types14