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  • bony
  • The skin temperature around the bone may increase, a bony swelling may be evident, and movement may be restricted in adjacent joints. (wikipedia.org)
  • fracture
  • Sometimes a sudden fracture is the first symptom, because affected bone is not as strong as normal bone and may fracture abnormally with minor trauma. (wikipedia.org)
  • Plain film often seen as a lobulated, eccentric radiolucent lesion long axis parallel to long axis of long bone no periosteal reaction (unless a complicating fracture present) geographic bone destruction: almost 100% well defined sclerotic margin: 86% there can be presence of septations (pseudotrabeculation): 57% 2 there can be presence of matrix calcification in a small proportion of cases: 12.5%1 MRI MR features are often not particularly specific. (wikipedia.org)
  • abnormal
  • Bone scintigraphy (bone scan) demonstrates abnormal radiotracer accumulation at the affected site, substantiating clinical suspicion, but this finding is not specific for osteoblastoma. (wikipedia.org)
  • There may be signs of specific causes of anemia, e.g., koilonychia (in iron deficiency), jaundice (when anemia results from abnormal break down of red blood cells - in hemolytic anemia), bone deformities (found in thalassemia major) or leg ulcers (seen in sickle-cell disease). (wikipedia.org)
  • occur
  • Osteosarcomas tend to occur at the sites of bone growth, presumably because proliferation makes osteoblastic cells in this region prone to acquire mutations that could lead to transformation of cells (the RB gene and p53 gene are commonly involved). (wikipedia.org)
  • scan
  • Signal characteristics include T1 - low signal T1 C+ (Gd) - the majority (~70%) tend to show peripheral nodular enhancement ~ 30% diffuse contrast enhancement and this can be either homogeneous or heterogeneous 19 T2 - high signal Bone scan A scintigraphic "doughnut sign" has been described in this tumour type 11. (wikipedia.org)
  • soft
  • Physical findings include localized tenderness and a decreased range of motion in the involved bone and nearby joint, muscle atrophy, a palpable mass, soft tissue swelling, and joint effusion in the affected area. (wikipedia.org)
  • adult
  • Adult patients have worsening myalgias, bone pains and fatigue which are followed by recurrent fractures. (wikipedia.org)
  • tissue
  • No treatment is needed in asymptomatic patients and spontaneous remission with replacement by bone tissue is to be expected. (wikipedia.org)
  • long
  • It usually presents in the vertebral column or long bones. (wikipedia.org)
  • Most chondromyxoid fibromas are located in the metaphyseal region of long bones (60%), and may extend to the epiphyseal line and even rarely abut the articular surface 3,12. (wikipedia.org)
  • skin
  • Rothmund-Thomson syndrome (i.e. autosomal recessive association of congenital bone defects, hair and skin dysplasias, hypogonadism, and cataracts) is associated with increased risk of this disease. (wikipedia.org)
  • cases
  • In cases involving the temporal bone, tinnitus, dizziness, and hearing loss have been reported. (wikipedia.org)
  • cancer
  • Large doses of Sr-90 emission from nuclear reactor, nicknamed bone seeker increases the risk of bone cancer and leukemia in animals, and is presumed to do so in people. (wikipedia.org)
  • marrow plasma cells
  • this disorder is a form of plasma cell dyscrasia in which no myeloma protein is detected in serum or urine (at least as determined by conventional laboratory methods) of individuals who have clear evidence of an increase in clonal bone marrow plasma cells and/or evidence of clonal plasma cell-mediated tissue injury (e.g. plasmacytoma tumors). (wikipedia.org)
  • mouse CD79a Ser191, Ser197, Thr203), and play a role in limiting formation of bone marrow plasma cells secreting IgG2a and IgG2b. (wikipedia.org)
  • skeletal
  • Rapidly, Dahlin became a skilled general surgical pathologist in the mold of Dockerty, but began to develop special expertise in neoplasms of the skeletal system. (wikipedia.org)
  • Limb patterning and skeletal development may also go awry when GCP3 mutations inhibit regulations of responses to bone morphogenetic proteins, another type of growth factor. (wikipedia.org)
  • It is divided into two types, homologous (in which the sarcomatous component is made of tissues found in the uterus such as endometrial, fibrous and/or smooth muscle tissues) and a heterologous type (made up of tissues not found in the uterus, such as cartilage, skeletal muscle and/or bone). (wikipedia.org)
  • Spread
  • In those in whom the disease has spread to the bones, pain medications, bisphosphonates and targeted therapy, among others, may be useful. (wikipedia.org)
  • Inflammation from the middle ear can spread to the canalis facialis of the temporal bone - through this canal travels the facial nerve together with the steatoacoustisus nerve. (wikipedia.org)
  • multiple
  • At the other end of this spectrum, detection of the myeloid protein indicates the presence of a hematological malignancy, i.e. multiple myeloma, Waldenström's macroglobulinemia, or other B cell-associated neoplasm, that derives stepwise from its MGUS precursors. (wikipedia.org)
  • connective tissue
  • Histologically, osteoblastomas are similar to osteoid osteomas, producing both osteoid and primitive woven bone amidst fibrovascular connective tissue, the difference being that osteoblastoma can grow larger than 2.0 cm in diameter while osteoid osteomas cannot. (wikipedia.org)
  • Lesion
  • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. (icd10data.com)
  • Plain film often seen as a lobulated, eccentric radiolucent lesion long axis parallel to long axis of long bone no periosteal reaction (unless a complicating fracture present) geographic bone destruction: almost 100% well defined sclerotic margin: 86% there can be presence of septations (pseudotrabeculation): 57% 2 there can be presence of matrix calcification in a small proportion of cases: 12.5%1 MRI MR features are often not particularly specific. (wikipedia.org)
  • Osteosarcomas
  • Osteosarcomas tend to occur at the sites of bone growth, presumably because proliferation makes osteoblastic cells in this region prone to acquire mutations that could lead to transformation of cells (the RB gene and p53 gene are commonly involved). (wikipedia.org)
  • heterogeneous
  • Signal characteristics include T1 - low signal T1 C+ (Gd) - the majority (~70%) tend to show peripheral nodular enhancement ~ 30% diffuse contrast enhancement and this can be either homogeneous or heterogeneous 19 T2 - high signal Bone scan A scintigraphic "doughnut sign" has been described in this tumour type 11. (wikipedia.org)
  • causes
  • Hemorrhage from local bone osteolysis by osteoclastic activity causes a local release of bradykinin, prostaglandins, histamine and substance P that can irritate the endosteal nerves as well as local nerves. (clinicaltrials.gov)
  • There may be signs of specific causes of anemia, e.g., koilonychia (in iron deficiency), jaundice (when anemia results from abnormal break down of red blood cells - in hemolytic anemia), bone deformities (found in thalassemia major) or leg ulcers (seen in sickle-cell disease). (wikipedia.org)
  • Growth
  • They originate from the growth plate, and are located in adjacent parts of the metaphysis and diaphysis of long bones, most often of the legs. (wikipedia.org)
  • Adult
  • Adult patients have worsening myalgias, bone pains and fatigue which are followed by recurrent fractures. (wikipedia.org)
  • Clinical
  • Clinical trials of HIFU in bone metastases have indicated that the method is safe and gives an effective reduction of patient pain. (clinicaltrials.gov)
  • Bone scintigraphy (bone scan) demonstrates abnormal radiotracer accumulation at the affected site, substantiating clinical suspicion, but this finding is not specific for osteoblastoma. (wikipedia.org)