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  • support
  • Their origin is still speculative, but since their counterparts in the bone marrow are essential for osteoclastogenesis, support lymphocyte development and maturation, and protect T cells and B cells from programmed cell death, the BMPR-positive cells may be essential elements in the pathogenesis of RA and other inflammatory forms of chronic synovitis. (ox.ac.uk)
  • An alternative is to use recombinant human bone morphogenetic protein 2 (rhBMP-2), which is able to support bone regeneration in the oral environment. (quintpub.com)
  • rhBMP
  • The expression of bone morphogenetic proteins (BMP) in primary osseous tumors (n=15) with a potential of osteogenesis and/or chondrogenesis was re-evaluated by using a recently characterized monoclonal antibody raised by using rhBMP-2 as an immunogen in a streptavidin-biotin complex immunoperoxidase method. (nii.ac.jp)
  • Although rhBMP-2 and rhBMP-7 are used in the treatment of a variety of bone-related conditions including spinal fusions and nonunions, the risks of this off-label treatment are not understood. (wikipedia.org)
  • rhBMP-2 helps grow bone better than any other rhBMP so it is much more widely used clinically. (wikipedia.org)
  • There is "little debate or controversy" about the effectiveness of rhBMP-2 to grow bone to achieve spinal fusions, and Medtronic generates $700 million in annual sales from their product. (wikipedia.org)
  • Bone morphogenetic protein (rhBMP) should not be routinely used in any type of anterior cervical spine fusion, such as with anterior cervical discectomy and fusion. (wikipedia.org)
  • regeneration
  • There hasn't been a gold standard for how orthopaedic spine surgeons promote new bone growth in patients, but now Northwestern University scientists have designed a bioactive nanomaterial that is so good at stimulating bone regeneration it could become the method surgeons prefer. (news-medical.net)
  • human
  • Bone morphogenetic proteins in human bone. (mendeley.com)
  • BMP compositions including the human factor and bovine factor thereof, the process of isolating BMP compositions and factors, and the use of such factors and compositions to induce bone formation in animals. (google.ca)
  • Human BMP-2 proteins are produced by culturing a cell transformed with a cDNA substantially as shown in Table II or Table III and recovering from the culture medium a protein containing the 97 amino acid sequence #299 to #396 of Table II or amino acid #311 to #408 of Table III, respectively. (google.com)
  • In human embryonic development, Cerberus and the protein coded by GREM3 inhibit NODAL in the Wnt signaling pathway during the formation of the germ layers. (wikipedia.org)
  • encodes
  • A team headed by Professor Albert Rizvanov, director of the Gene and Cell Technologies Open Lab, created a gene therapy drug that encodes growth factors for the stimulation of blood vessel and bone formation. (news-medical.net)
  • The BMP1 locus encodes a protein that is capable of inducing formation of cartilage in vivo. (wikipedia.org)
  • Cerberus (Cer) is a gene that encodes a cytokine (a secreted signaling protein) important for induction and formation of the heart and head in vertebrates. (wikipedia.org)
  • autograft
  • Stryker Biotech) for a humanitarian device exemption as an alternative to autograft in long bone nonunions. (wikipedia.org)
  • molecular
  • Work with BMP material isolated from rabbit dentin matrix protein fraction, using polyacrylamide gel electrophoresis (PAGE) has been assigned a molecular weight of about 23,000. (google.ca)
  • growth
  • Researchers compared the effects of three bone growth factors to bone morphogenetic protein 2 (BMP2) -- the most commonly used agent for repair of large bone defects, which is not without risks at the doses required--and showed significant bone-healing effects including the formation of new blood vessels at low doses relative to BMP2. (news-medical.net)
  • 10. A composition of claim 9 further comprising a matrix for supporting said composition and providing a surface for bone and/or cartilage growth. (google.com)
  • An additional review by Agrawal and Sinha of BMP-2 and its common delivery systems in early 2016 showed how "problems like ectopic growth, lesser protein delivery, [and] inactivation of the protein" reveal a further need "to modify the available carrier systems as well as explore other biomaterials with desired properties. (wikipedia.org)
  • Bone morphogenetic proteins are known for their ability to induce the growth of bone and cartilage. (wikipedia.org)
  • Bmp5
  • In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity. (wikipedia.org)
  • It has close sequence homology to BMP7 and BMP5 and is believed to play a role in bone and cartilage development. (wikipedia.org)
  • abnormal
  • Scientists at Children's Hospital of Philadelphia report that a drug candidate that blocks abnormal protein signals may lead to the first pharmacologic treatment for hereditary multiple exostoses (HME), a rare pediatric genetic disease. (news-medical.net)
  • novel
  • It is a novel protein that, unlike most other BMP's, is likely to be involved in the trabeculation of the heart. (wikipedia.org)