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  • growth
  • Invasion and metastasis are two important hallmarks of malignant tumors associated with complex genetic and epigenetic alterations that allow tumors to disseminate throughout lymphatics or blood vessels, giving rise to the colonization and growth of metastatic cells in distant organs [ 4 - 6 ]. (pubmedcentralcanada.ca)
  • osteoporosis
  • The function of endogenous BMP-6 will be explained by using BMP-6 knock-out ( Bmp-6 -/- ) mice that spontaneously develop osteoporosis ( preliminary data ). (weebly.com)
  • Crosstalk with antiresorptive and anabolic signalling pathways involved in bone remodelling will be tested by estradiol (E2), parathyroid hormone (PTH) and BMP-6 treatment of ovariectomized (OVX) Bmp-6 -/- and wild type (WT) mice and potential requirement of endogenous BMP-6 for treatment of osteoporosis will be disclosed. (weebly.com)
  • The results will disclose the BMP-6 anabolic effect on bone with a potential for treating osteoporosis. (weebly.com)
  • Since the fractures are frequent features of osteoporosis, the effect of BMP-6 on fracture healing will be studied in OVX Bmp-6 -/- and WT femoral fracture model. (weebly.com)
  • The project will develop a strategy for treating osteoporosis and related fractures based on BMP-6 biology. (weebly.com)
  • The results of this project will serve as a basis to find commercial partners for clinical multi-centre studies to evaluate the effect of BMP-6 therapy in patients with osteoporosis. (weebly.com)
  • tissues
  • To assess the expression of cytokines and genes invloved in osteoclastogenesis on the bone tissues, we set up the system of in situ hybridization using decalcified bone specimen. (nii.ac.jp)
  • Cells
  • In 5/6-nephrectomy, the cells failed to protect renal function, but proteinuria was reduced after administering untreated eEOCs. (physiology.org)
  • In 5/6-nephrectomized animals, percentages of anti-smooth muscle actin+/CD31+ cells increased, indicating endothelial-mesenchymal transition (EnMT). (physiology.org)
  • Cell effects in 5/6-nephrectomy are heterogenous, but untreated cells act antiproteinurically and antifibrotically without any impact on EnMT. (physiology.org)
  • early endothelial outgrowth cells (eEOCs), a major subpopulation of so-called endothelial progenitor cells (EPCs) ( 1 , 6 , 19 , 33 ), have been shown to protect mice reliably from acute ischemic kidney injury (AKI) ( 19 , 20 , 23 ). (physiology.org)
  • phenotypes
  • Different cellular developmental histories, 5 microenvironmental cues, and factor-dependent polarization 6 vastly increase the complexity of macrophage phenotypes in vivo. (bloodjournal.org)
  • role
  • The role of endogenous BMP-6 in humans will be investigated by measuring BMP-6 in blood of healthy and osteoporotic women by matrix-assisted laser desorption ionization time-of-flight protein profiling. (weebly.com)
  • mice
  • Male C57/Bl6N mice were either subjected to unilateral renal artery clamping postuninephrectomy or to 5/6-nephrectomy. (physiology.org)
  • therapy
  • The aim of the curent study was to analyze effects of BMP-5 treatment in an eEOC-based therapy of murine AKI and 5/6-nephrectomy. (physiology.org)
  • activities
  • Impaired immunoregulatory activities of MSCs are found in both SS patients and animal models [ 6 ]. (hindawi.com)
  • cell
  • Heparan sulfate proteoglycans: structure, protein interactions and cell signaling. (semanticscholar.org)
  • This review will focus on the structural characteristics of the heparan sulfate proteoglycans related to protein interactions leading to cell signaling. (semanticscholar.org)
  • further
  • It is recommended to reconstitute the lyophilized BMP-6 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. (prospecbio.com)
  • test
  • The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (cloud-clone.us)
  • effects
  • Since, PTH is the only approved bone anabolic drug, but with serious side-effects, there is a great need for new bone forming agents like BMP-6. (weebly.com)
  • Region
  • Most of the individuals with this syndrome carry a terminal deletion of the short arm of chromosome 6 (6p) with a breakpoint within the 6p25.3p23 region. (springer.com)
  • Upon
  • Lyophilized BMP-6 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BMP-6 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). (prospecbio.com)