• Moreover, Mitofilin is revealed to be indispensable for mitochondrial homeostasis and osteogenesis of BMMSCs, and that insufficiency of Mitofilin leads to BMMSC senescence and bone loss. (thno.org)
  • Leptin acts on various brain regions including the hypothalamus, ventral tegmental area, and hindbrain ( 2 , , , , , , , - 10 ) and regulates energy homeostasis by triggering decreased food consumption and increased energy expenditure. (diabetesjournals.org)
  • Among these micronutrients are vitamins that are required in small amounts for optimum metabolism, homeostasis, and a healthy lifestyle, acting as coenzymes in several biochemical reactions. (biomedcentral.com)
  • Matsuoka K, Park KA, Ito M, Ikeda K, Takeshita S. Osteoclast-derived complement component 3a stimulates osteoblast differentiation. (dntb.gov.ua)
  • Furthermore, intraperitoneal administration of GSK4112, a Rev-erb agonist, protects RANKL-induced bone loss via inhibition of osteoclast differentiation in vivo . (molcells.org)
  • Bone mass, bone formation rates and osteogenic differentiation of BMMSCs were primarily evaluated. (thno.org)
  • Chronic intermittent application of RESV enhances bone formation and counteracts accelerated bone loss, with RESV improving osteogenic differentiation of senescent BMMSCs. (thno.org)
  • MeCP2 interacts with HP1 and modulates its heterochromatin association during myogenic differentiation. (mdc-berlin.de)
  • At the cellular level, the mesenchymal stem cell pool in the bone marrow niche shows a biased differentiation into adipogenesis at the cost of osteogenesis. (biomedcentral.com)
  • This differentiation shift leads to decreased bone formation, contributing to the etiology of osteoporosis. (biomedcentral.com)
  • Decreased bone quality and increased risk of fractures are associated with changes in bone microarchitecture and local humoral environment. (dntb.gov.ua)
  • Given the importance of developing new approaches to the diagnosis and correction of metabolic disorders in diabetic patients, the study of the influence of bone hormones on hormonal and metabolic parameters and bone status, including the risk of fractures, remains relevant in modern diabetology. (dntb.gov.ua)
  • Bone loss causes thinning of bones thereby increasing the risk of fractures [ 19 ]. (biomedcentral.com)
  • Aging is a high risk factor for the development of osteoporosis, a multifactorial age-related progressive disease characterized by reduced bone mass and increased risk of fractures. (biomedcentral.com)
  • As a consequence, bone aging is the main risk factor for primary osteoporosis, characterized by a reduction in bone mineral density, predisposing the elderly population to an increased risk of fractures. (biomedcentral.com)
  • The circadian clock regulates various physiological processes, including bone metabolism. (molcells.org)
  • In addition to the incorporation of frequently used bioactive macromolecules and nanomolecules, burgeoning research has found that multiple physiological cues, including mechanics, electricity, and magnetism, represent fresh prospects for bone regeneration by influencing bone-related cell behaviors and cell maturation events [ 12 ]. (biomedcentral.com)
  • Of the amino acids, it's the most abundant source of sulfur, and is required for a wide range of physiological processes, including the healthy function of your immune system, nervous system, 1 , 2 metabolism and digestion. (naturalhealth24-7.com)
  • The fat-soluble vitamins include vitamins (A, D, E, and K). Fat-soluble vitamins were found to have an indisputable role in an array of physiological processes such as immune regulation, vision, bone and mental health. (biomedcentral.com)
  • these hormones modulate a variety of physiological processes, including but not limited to normal growth and development (Larsen et al. (nationalacademies.org)
  • The result of these passive and active processes is that each kind of ion has a characteristic concentration in each compartment, according to the metabolic energy state of the organism. (raypeat.com)
  • Furthermore, in rescuing osteogenic decline under BMMSC senescence, RESV restores cellular metabolism through mitochondrial functional recovery via facilitating mitochondrial autonomous gene transcription. (thno.org)
  • Reishi mushrooms include a diverse array of bioactive compounds that, collectively, may boost cellular metabolism and restore the efficiency that the immune system tends to lose over time. (vitanetonline.com)
  • Osteoporosis, a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility, occurs frequently, particularly in older women. (springer.com)
  • In conclusion, CLA increases bone mass in both cancellous and cortical bones, and the effects of CLA on bone is not further improved by EX in pure cortical bone of young male mice. (biomedcentral.com)
  • Understanding of the mechanisms that integrate energy metabolism in the entire organism has significantly improved with the application of contemporary biochemical tools for quantifying the fuel substrate metabolism with cutting-edge mouse genetic procedures. (mdpi.com)
  • But there are ways of looking at the organism, focusing on energy metabolism, that dont involve the ad hoc theory of calcium pumps, and that make it easy to keep things in context. (raypeat.com)
  • High leptin levels are interpreted by the brain that energy reserves are high, whereas low leptin levels indicate that energy reserves are low, in the process adapting the organism to starvation through a variety of metabolic, endocrine, neurobiochemical, and behavioral changes. (cloudfront.net)
  • Patients with type 2 diabetes mellitus usually have normal or even slightly elevated bone mineral density compared to age-appropriate controls. (dntb.gov.ua)
  • A significant increase in DNA synthesis was observed at the wavelengths of 632.8, 635 and 830 nm, depending on the energy density level. (warminglight.com)
  • After 8 weeks of oral dosing in mice, treatment with the combination did not alter prednisolone-induced reduction in osteocalcin and mid-femur bone density, which are markers of steroid-induced osteoporosis. (biomedcentral.com)
  • accordingly, a decrease in bone mineral density occurs. (biomedcentral.com)
  • In this study, a porous piezoelectric hydrogel bone scaffold was fabricated by incorporating polydopamine (PDA)-modified ceramic hydroxyapatite (PDA-hydroxyapatite, PHA) and PDA-modified barium titanate (PDA-BaTiO 3 , PBT) nanoparticles into a chitosan/gelatin (Cs/Gel) matrix. (biomedcentral.com)
  • In vitro research confirmed the apple peels modulate the inflammation response. (realrawfood.com)
  • Effects of laser acupuncture on longitudinal bone growth in adolescent rats. (warminglight.com)
  • BMP-2 induces chondrocyte proliferation, endochondral bone formation, longitudinal bone growth, and bone and cartilage repair (6, 7). (novusbio.com)
  • The primary goal of this study is to elucidate how the basic properties of MSC derived EVs can be exploited for function-specific activity in regenerative medicine. (frontiersin.org)
  • We invent biomaterials and engineering tools to elucidate and modulate biology, and also use biology to inform materials and engineering design. (stanford.edu)
  • Lecka-Czernik B. Diabetes, bone and glucose-lowering agents: basic biology. (dntb.gov.ua)
  • Biotin-dependent enzymes are involved in glucose metabolism, fatty acid synthesis, nervous system function, and skin and hair nutrition. (geneticprotocol.store)
  • Extra biotin can be beneficial for supporting healthy glucose metabolism, for individuals who have had bariatric surgery, or those with compromised absorption or higher demand for this B vitamin. (geneticprotocol.store)
  • Agreement and Reliability of Fasted and Oral Glucose Tolerance Test-Derived Indices of Insulin Sensitivity and Beta Cell Function in Boys. (exeter.ac.uk)
  • In obesity , a decreased sensitivity to leptin occurs (similar to insulin resistance in type 2 diabetes ), resulting in an inability to detect satiety despite high energy stores and high levels of leptin. (cloudfront.net)
  • The co-existence of impaired bone health (osteopenia/osteoporosis), reduced muscle mass and strength (sarcopenia), and increased adiposity (obesity) in middle-aged and older people has been identified in recent studies, leading to a proposal for the existence of "osteosarcopenic obesity" as a distinct entity. (springer.com)
  • Increased body fat can be present either as an overt overweight/obesity or fat redistributed into visceral organs and/or fat infiltrated into bone and muscle, which occurs especially with age and some chronic diseases [ 3 , 4 ]. (springer.com)
  • Highly bioavailable forms of minerals essential for bone health plus synergistic nutrients are included to maximize mineral absorption using the least number of pills. (geneticprotocol.store)
  • 1) To help teenagers and young adult women optimize peak bone mass and reduce bone loss later in life. (geneticprotocol.store)
  • The human skeleton is especially affected by the passage of time: bone loss begins as early as the third decade of life, immediately after peak bone mass. (biomedcentral.com)
  • Abarrategi A, Mian SA, Passaro D, Rouault-Pierre K, Grey W, Bonnet D. Modeling the human bone marrow niche in mice: From host bone marrow engraftment to bioengineering approaches. (dntb.gov.ua)
  • Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1. (dntb.gov.ua)
  • Cai X, Xing J, Long C, Peng Q, Humphrey M. DOK3 modulates bone remodeling by negatively regulating osteoclastogenesis and positively regulating osteoblastogenesis. (dntb.gov.ua)
  • The LLLT was effective to stimulate osteoblastogenesis but failed to increase bone formation. (warminglight.com)
  • MSCs derived from bone marrow (BMMSCs) and the bone-specific, senescence-accelerated, osteoblastogenesis/osteogenesis-defective mice (the SAMP6 strain) were used as experimental models. (thno.org)
  • When cells are stressed or dying, they take up calcium, which tends to excite the cells at the same time that it inhibits their energy production, intensifying their stress. (raypeat.com)
  • Osteocalcin promotes pancreatic β-cell proliferation and insulin secretion, and also affects the insulin sensitivity of peripheral tissues. (dntb.gov.ua)
  • Low-level laser therapy associated to a resistance training protocol on bone tissue in diabetic rats. (warminglight.com)
  • Human mesenchymal stem cells (HMSCs) are multipotent somatic stem cells that can be isolated from a variety of tissues such as the bone marrow, adipose tissue, and dental pulp. (frontiersin.org)
  • The piezoelectric Cs/Gel/PHA/PBT hydrogels developed here with favorable immunomodulation, angiogenesis, and osteogenesis functions may be used as a substitute in periosteum injuries, thereby offering the novel strategy of applying piezoelectric stimulation in bone tissue engineering for the enhancement of combat effectiveness in grassroots troops. (biomedcentral.com)
  • The use of bone tissue engineering scaffold material, which can provide a microenvironment for bone regeneration, is an effective alternative strategy to support bone regeneration [ 6 ]. (biomedcentral.com)
  • CSF sampling was performed by Actinomycin D irreversible inhibition incising the skin and soft tissue over the occipital bone, carrying the dissection down to the atlanto-occipital ligament which was exposed and incised, entering the cisterna magna. (insulin-receptor.info)
  • The amount of circulating leptin correlates with the amount of energy reserves, mainly triglycerides stored in adipose tissue. (cloudfront.net)
  • The primary function of the hormone leptin is the regulation of adipose tissue mass through central hypothalamus mediated effects on hunger , food energy use, physical exercise and energy balance . (cloudfront.net)
  • She was awarded with a postdoc fellow from the Ministry of Science at the Technical University of Catalonia in Biomaterials for bone tissue regeneration and since 2010 has been professor at this university. (ibecbarcelona.eu)
  • In humans, bone is a highly active tissue which undergoes continuous self-regeneration throughout adulthood to maintain structural integrity in a process called bone remodeling. (biomedcentral.com)
  • Bone is a very dynamic and heterogeneous tissue formed by two components which are in close relationship with each other during the bone remodeling process: extracellular matrix (ECM) and bone cells. (biomedcentral.com)
  • Mechanisms of diabetes mellitus-induced bone fragility. (dntb.gov.ua)
  • In the present work, a model of partial IGF-I deficiency was used in order to provide insight into the mechanisms of the beneficial actions of IGF-I replacement therapy in bone. (biomedcentral.com)
  • Nevertheless, the mechanisms of the beneficial actions of IGF-I replacement therapy on bone are not entirely known yet. (biomedcentral.com)
  • Additionally, activated GR can affect transcription through mechanisms independent of DNA binding that modulate the activity of other transcription factors, including nuclear factor-κB, activator protein-1, and STAT (signal transducer and activator of transcription) [ 4 ]. (biomedcentral.com)
  • Recommended for: Vitamin D deficiency, immune system support and good bone health. (geneticprotocol.store)
  • The active form of vitamin D plays important roles in the intestinal absorption of calcium and phosphate and thus in healthy bones. (pressbooks.pub)
  • Derived ultimately from cholesterol, vitamin D can be made in a reaction catalyzed by ultraviolet light. (pressbooks.pub)
  • MOST ACTIVE FORM: NatureWise Vitamin D3 in organic olive oil helps to support the health of teeth and bones, provide immune support, and promote proper muscle function. (onedaymd.com)
  • The aim of this study was to investigate possible genetic interactions between these two genes to determine whether combined reduction in these inhibitory activities results in synergistic, epistatic, or additive effects on energy balance control. (diabetesjournals.org)
  • Several unexpected findings in genetically altered mice have prompted research into the direction of intermediate metabolism of skeletal cells. (mdpi.com)
  • An imbalance in osteoblast/osteoclast activity may be due to oxidative stress and the accumulation of glycosylation end products, which contributes to chronic inflammation and bone resorbtion in patients with diabetes. (dntb.gov.ua)
  • It is shown that the level of osteocalcin in the blood serum is significantly reduced compared to healthy controls, both in patients with type 1 diabetes mellitus and, especially, in type 2 diabetes mellitus. (dntb.gov.ua)
  • IOF Bone and Diabetes Working Group. (dntb.gov.ua)
  • The overexpression of Rev-erbα in osteoblast precursors attenuated the expression of osteoblast marker genes including Runx2, alkaline phosphatase (ALP), bone sialoprotein (BSP), and osteocalcin (OC). (molcells.org)
  • but a combination of CLA and EX, however, did not show any further increase in bone mass. (biomedcentral.com)
  • Throughout young adulthood more bone is formed than is resorbed, resulting in an increase in bone mass. (biomedcentral.com)
  • Zhou R, Guo Q, Xiao Y, Guo Q, Huang Y, Li C, Luo X. Endocrine role of bone in the regulation of energy metabolism. (dntb.gov.ua)
  • The calcium ion is essential to any physiologic phenomena, including preservation of the integrity of cellular membranes, neuromuscular activity, regulation of endocrine and exocrine secretory activities, blood coagulation, activation of the complement system, and bone metabolism. (abdominalkey.com)
  • Fibrin Sealant Derived from Human Plasma as a Scaffold for Bone Grafts Associated with Photobiomodulation Therapy. (warminglight.com)
  • Her research group is particularly interested in developing biomaterials and cell-based therapeutics to improve regeneration of various musculoskeletal tissues including bone, cartilage, tendon, blood vessels etc. (stanford.edu)
  • Several aspects of MSC function have been attributed to the paracrine effects of MSC derived extracellular vesicles (EVs). (frontiersin.org)
  • Renewing interest in the study of intermediate metabolism and cellular bioenergetics is brought on by the global increase in the prevalence of metabolic illnesses. (mdpi.com)
  • Recent studies have demonstrated the importance of bone as an endocrine organ that produces biologically active substances, which regulate both local bone metabolism and metabolic functions throughout the body. (dntb.gov.ua)
  • Bone is one of the major target tissues for Insulin-like Growth Factor I (IGF-I). Low doses of IGF-I were able to improve liver-associated osteopenia. (biomedcentral.com)
  • Results revealed that TPS3A intervention could effectively delay the atherosclerotic plaque progression, modulate dyslipidemia, and reduce the transformation of vascular smooth muscle cells (VSMCs) from contractile phenotype to synthetic phenotype by activating the expression of contractile marker alpha-smooth muscle actin (α-SMA) and inhibiting the expression of synthetic marker osteopontin (OPN) in high-fat diet-induced ApoE-/- mice. (bvsalud.org)
  • In this paper, we report the beneficial effects of CLA and EX on bone, in four different groups of Balb-C young, male mice. (biomedcentral.com)
  • In the process of bone remodeling (formation/destruction), the active cells secrete specific biomarkers that help detect osteometabolic dysfunction. (dntb.gov.ua)
  • The level of osteocalcin in the serum is used as a specific marker of bone formation. (dntb.gov.ua)
  • The InGaAsP laser at the low dosage induced a favorable effect on bone formation in the orthopedically expanded midpalatal suture of rats. (warminglight.com)
  • The in vivo evaluations showed that these piezoelectric hydrogels with versatile capabilities significantly facilitated new bone formation in a rat large-sized cranial injury model. (biomedcentral.com)
  • Formation of mineralized ECM results in the hard but lightweight material that forms bone. (biomedcentral.com)
  • They are derived from terminally differentiated osteoblasts surrounded by unmineralized matrix (osteoid) during bone formation. (biomedcentral.com)
  • It plays a dominant role in embryonic dorsal-ventral patterning, organogenesis, limb bud formation, and bone formation and regeneration (1, 2). (novusbio.com)
  • As one of the major signals of energy status, leptin levels influence appetite , satiety , and motivated behaviors oriented towards the maintenance of energy reserves (e.g., feeding, foraging behaviors). (cloudfront.net)
  • Molecular impacts of photobiomodulation on bone regeneration: A systematic review. (warminglight.com)
  • In the last decade, more evidence has suggested that males also lose almost the same amount of bone as women [ 20 ]. (biomedcentral.com)
  • Furthermore, another factor that is well established to have a beneficial effect on bone is exercise (EX). (biomedcentral.com)
  • Association of Bioglass/Collagen/Magnesium composites and low level irradiation: effects on bone healing in a model of tibial defect in rats. (warminglight.com)
  • However, weight loss is generally associated with negative effects on bone mass, but CLA is reported to have beneficial effects on bone. (biomedcentral.com)