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  • MSCs
  • In this review, I discuss the known, emerging and postulated mechanisms of action underlying effects that transplanted MSCs may exert to promote motor neuron survival and/or to encourage regeneration in ALS. (degruyter.com)
  • MSCs are purified from the marrow, cultured and packaged, with up to 10,000 doses derived from a single donor. (wikipedia.org)
  • tumor
  • The treatment can be different than adults, and may include surgical tumor removal, stem cell transplants, chemotherapy, and/or radiation therapy. (mountainside-medical.com)
  • They have shown that stem cell self-renewal is regulated by networks of proto-oncogenes and tumor suppressors and that the balance between proto-oncogenic and tumor suppressor signals changes with age. (wikipedia.org)
  • Rarely, the first sign of leukemia may be the development of a solid leukemic mass or tumor outside of the bone marrow, called a chloroma. (wikipedia.org)
  • Other conditions treated with stem cell transplants include sickle-cell disease, myelodysplastic syndrome, neuroblastoma, lymphoma, Ewing's sarcoma, desmoplastic small round cell tumor, chronic granulomatous disease and Hodgkin's disease. (wikipedia.org)
  • organ
  • Besides in the future becoming an important alternative to organ transplants, ES are also being used in field of toxicology and as cellular screens to uncover new chemical entities (NCEs) that can be developed as small molecule drugs. (wikipedia.org)
  • adults
  • At Mayo Clinic, doctors who specialize in blood diseases (hematologists) form a multidisciplinary team with other experts to provide personalized, whole-person care to adults and children undergoing bone marrow transplants. (mayoclinic.org)
  • Mayo Clinic doctors have extensive experience performing bone marrow transplants for adults and children with a variety of cancerous and noncancerous diseases. (mayoclinic.org)
  • tissues
  • Transplantable organs and tissues may both refer to organs and tissues that are relatively often or routinely transplanted (here "main organs and tissues"), as well as relatively seldom transplanted organs and tissues and ones on the experimental stage. (wikipedia.org)
  • disorders
  • The main indications for transplant were lymphoproliferative disorders (54.5 percent) and leukemias (33.8 percent), and the majority took place in either Europe (48 percent) or the Americas (36 percent). (wikipedia.org)