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  • cell replace
  • Moreover, bone marrow cells may also represent an attractive source for cell replacement therapy of type 1 and type 2 diabetes, not least in view of the limited supply of human islets and ethical issues surrounding embryonic stem cell research ( 28 - 31 ). (diabetesjournals.org)
  • However, until this controversy has been resolved, bone marrow cells continue to be promoted as a candidate source for cell replacement therapy for diabetes ( 31 ). (diabetesjournals.org)
  • recipient
  • In this stem cell from bone marrow are injected into a recipient after treating them with growth factor. (medindia.net)
  • The recipient of the first CB transplant was a young boy with Fanconi Anemia who received HLA-matched CB from his sister (Gluckman et al. (stembook.org)
  • Cord blood was originally frozen and transplanted after defrost as totally unseparated cells, which included all nucleated cells and lysates from non-nucleated erythrocytes, without washing to ensure that all HSC/HPC collected were infused into the recipient (Broxmeyer et al. (stembook.org)
  • The recipient is immuno-compromised and therefore cannot destroy or inactivate the transplanted cells. (wikipedia.org)
  • engraftment
  • In this study, the investigators test 2 dose levels of thiotepa (5 mg/kg and 10 mg/kg) added to the backbone of targeted reduced dose IV busulfan, fludarabine and rabbit anti-thymocyte globulin (rATG) to determine the minimum effective dose required for reliable engraftment for subjects undergoing hematopoietic stem cell transplantation for non-malignant disease. (clinicaltrials.gov)
  • Most children with non-malignant disorders present with normocellular or even hypercellular bone marrow, posing a barrier to engraftment and requiring intensive conditioning. (clinicaltrials.gov)
  • cancers
  • In the field of hematopoetic stem cell transplantation, Maloney has played a role in the development of lower-toxicity, non-myeloablative techniques for the treatment of blood cancers. (wikipedia.org)
  • Perfosfamide, or 4-hydroperoxycyclophosphamide (trade name Pergamid) was an experimental drug candidate for blood cancers that was rejected by the FDA in 1993 and never reached the market. (wikipedia.org)
  • On October 27, 2014, it was reported that Case Western Reserve University will conduct a preclinical study of PLX-R18 cells in umbilical cord blood transplants for the treatment of blood cancers and genetic diseases. (wikipedia.org)
  • PMID
  • Journal of Pharmacology and Experimental Therapeutics, 2004 PMID 15231866 SOD2-deficiency anemia: protein oxidation and altered protein expression reveal targets of damage, stress response, and antioxidant responsiveness. (wikipedia.org)
  • Journal of the American Society of Blood and Marrow Transplantation, 2004 PMID 15205666 Rapamycin-resistant proliferation of CD8+ T cells correlates with p27kip1 down-regulation and bcl-xL induction, and is prevented by an inhibitor of phosphoinositide 3-kinase activity. (wikipedia.org)
  • clinical
  • A specialist in chronic myeloid leukaemia, Goldman conducted pioneering research into leukaemia treatment - he was instrumental in the development of bone marrow transplantation as a clinical method, and later in the development of the drug imatinib. (wikipedia.org)
  • In March 1993, the FDA's Oncology Drugs Advisory Committee rejected the application because all the data was from the experimental uses, and no randomized clinical trial had been conducted. (wikipedia.org)
  • Clinical successes since 2006 regained researchers' attention, although as of 2014, it was still largely an experimental technique. (wikipedia.org)
  • mice
  • Recent studies in normal mice have suggested that transplanted bone marrow cells can transdifferentiate into pancreatic β-cells at relatively high efficiency. (diabetesjournals.org)
  • Herein, adopting the same and alternative approaches to deliver and fate map-transplanted bone marrow cells in the pancreas of normal as well as diabetic mice, we further investigated the potential of bone marrow transplantation as an alternative approach for β-cell replacement. (diabetesjournals.org)
  • In contrast to previous studies, transplanted bone marrow cells expressing green fluorescence protein (GFP) under the control of the mouse insulin promoter failed to express GFP in the pancreas of normal as well as diabetic mice. (diabetesjournals.org)
  • Although bone marrow cells expressing GFP under the ubiquitously expressed β-actin promoter efficiently engrafted the pancreas of normal and hyperglycemic mice, virtually all expressed CD45 and Mac-1/Gr-1, demonstrating that they adopt a hematopoietic rather than β-cell fate, a finding further substantiated by the complete absence of GFP + cells expressing insulin and the β-cell transcription factors pancreatic duodenal homeobox factor-1 and homeodomain protein. (diabetesjournals.org)
  • 25 ) suggested that as much as 1.7-3% of the insulin-expressing cells in the islets of transplanted mice were derived from reconstituting bone marrow cells. (diabetesjournals.org)
  • Here, we have adopted different experimental strategies to follow the fate of transplanted bone marrow cells in the pancreas of normal as well as hyperglycemic mice. (diabetesjournals.org)
  • Washington, Sep 18 (ANI): Scripps Research Institute scientists have offered new hope for parents whose children suffer from the rare genetic disorder 'cystinosis' by showing through an experiment on mice that stem cell transplantation can successfully correct the defect. (thaindian.com)
  • In the new study, the researchers found that transplanted bone marrow stem cells carrying the normal lysosomal cystine transporter gene abundantly engrafted into every tissue of the experimental mice. (thaindian.com)
  • Scripps Research Institute scientists have offered new hope for parents whose children suffer from the rare genetic disorder 'cystinosis' by showing through an experiment on mice that stem cell transplantation can successfully correct the defect. (medindia.net)
  • procedure
  • Optimization of the bone marrow transplantation procedure using stem cells that are genetically modified to systemically secrete potent protein payloads of Par-4/SAC killer activity may offer a new approach to treat not only primary tumors but also metastatic tumors of diverse origin. (bio-medicine.org)
  • acute
  • In 1989 Nova Pharmaceutical took over development of the compound and in 1992, it submitted a new drug application to the FDA for using perfosamide to purge malignant cells in transplants for the treatment of acute myeloid leukemia. (wikipedia.org)
  • PLX-R18 were initially developed with Prof Raphael Gorodetsky at Hadassah Hospital for the treatment of acute radiation syndrome and enhancement of bone marrow regeneration. (wikipedia.org)
  • occurs
  • Whereas most other reports ( 13 , 26 , 27 ) of bone marrow plasticity have indicated that transdifferentiation occurs at a very low rate, the studies of Ianus et al. (diabetesjournals.org)
  • If these findings can be confirmed, bone marrow cells might clearly play a role in the adaptive increase in β-cell mass that occurs physiologically during, for example, obesity and pregnancy. (diabetesjournals.org)
  • efficacy
  • Thus, means to enhance numbers and/or potency of collected cells and their engrafting capability through ex-vivo and/or in-vivo maneuvers would likely enhance the efficacy and applicability of CB transplantation. (stembook.org)
  • treatment
  • A blood stem cell transplant is a treatment option for someone with a severe form of the disease. (clinicaltrials.gov)
  • For people with severe forms of SCD, one treatment option is a bone marrow transplant, which may correct the abnormal blood cell production problem. (clinicaltrials.gov)
  • Currently, liver transplantation is the only effective treatment for end-stage liver disease. (readbyqxmd.com)
  • and the region's only pediatric Experimental Therapeutics Program investigating promising new drugs for cancer treatment. (wikipedia.org)
  • In May 2012, Pluristem reported that its experimental PLacental eXpanded cells were injected into the muscles of a 7-year-old Romanian girl undergoing treatment for bone marrow aplasia disease at the Hadassah Medical Center in Jerusalem. (wikipedia.org)
  • In September 2012 Pluristem reported saving the life of a third bone marrow disease patient using its PLacental eXpanded cell treatment, again at Jerusalem's Hadassah Medical Center and again under the terms of compassionate use. (wikipedia.org)
  • cells
  • Thus, transplanted bone marrow cells demonstrated little, if any, capacity to adopt a β-cell fate. (diabetesjournals.org)
  • However, these data are controversial, as other studies ( 9 - 14 ) have failed to document such transdifferentiation, although in some cases bone marrow-derived hematopoietic cells have been demonstrated to contribute at very low frequencies to other cell lineages through cell fusion ( 12 , 15 - 19 ). (diabetesjournals.org)
  • In parallel with this work, other studies ( 20 - 24 ) have extended the concept of developmental plasticity of transplanted bone marrow cells. (diabetesjournals.org)
  • One of the most surprising and compelling claims of cell plasticity following bone marrow transplantation suggests that transplanted bone marrow cells can give rise to fully competent insulin-producing pancreatic β-cells ( 25 ). (diabetesjournals.org)
  • Although some subsequent studies ( 32 , 33 ) have obtained results compatible with the generation of insulin-expressing pancreatic cells from transplanted bone marrow cells, the reported efficiency has been several orders of magnitude lower than initially reported, and other studies have failed to detect any transdifferentiation into β-cells at all ( 34 ). (diabetesjournals.org)
  • Even when insulin-expressing cells were obtained following bone marrow transplantation, these did not express any of the transcription factors characterizing the mature β-cell ( 35 ). (diabetesjournals.org)
  • Thus, the capacity of transplanted bone marrow cells to contribute to β-cell regeneration remains controversial. (diabetesjournals.org)
  • Bone marrow a spongy tissue inside bones contains stem cells that pr. (bio-medicine.org)
  • Aug. 23, 2011) Bone marrow transplantation with genetically modified cells may prolong the period of cancer-free survival, suggests a study led by Dr. Vivek Rangnekar, associate director of translational research for the Markey Cancer Center at the University of Kentucky. (bio-medicine.org)
  • Bone marrow, a spongy tissue inside bones, contains stem cells that produce blood cells, including leukocytes, erythrocytes and platelets. (bio-medicine.org)
  • 1989 ), and subsequent CB transplants (Broxmeyer and Smith, 2009 ) were made possible by the biological laboratory studies that suggested CB as a potential source of transplantable hematopoietic stem (HSC) and progenitor (HPC) cells (Broxmeyer et al. (stembook.org)
  • Although such attempts produced no positive benefit, further research found in the mid twentieth century that human cells could be used to help prevent the human body rejecting transplanted organs, leading in time to successful bone marrow transplantation. (wikipedia.org)
  • These agents, however, cannot discriminate between the leukaemia or neoplastic cells, and the hematopoietic stem cells within the bone marrow. (wikipedia.org)
  • citation needed] Possible mechanisms of recovery include: Generation of heart muscle cells Stimulation of growth of new blood vessels to repopulate damaged heart tissue Secretion of growth factors Assistance via some other mechanism It may be possible to have adult bone-marrow cells differentiate into heart muscle cells. (wikipedia.org)
  • The US FDA has also cleared Pluristem to commence patient enrollment in a Phase I trial of its PLX-R18 cells to treat insufficient hematopoietic recovery following bone marrow transplant. (wikipedia.org)
  • centers
  • From 1980-1997, Gale was Chairman of the Scientific Advisory Committee of the Center for International Blood and Marrow Transplant Research (CIBMTR), an organization of more than 400 transplant centers in over 60 countries worldwide working together to analyze and advance knowledge about blood cell and bone marrow transplants. (wikipedia.org)
  • Haematology
  • Since 2005 Gale has been a Visiting Professor of Haematoloy in the Department of Medicine, Division of Experimental Medicine, Section of Haematology, Imperial College, London assigned to Hammersmith Hospital. (wikipedia.org)
  • Disorder
  • After meeting the children who suffer from this disease, like an 18-year-old who has already had three kidney transplants, and the families who are desperately searching for help, our team is committed to moving toward a cure for cystinosis, a lysosomal storage disorder. (thaindian.com)