AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Transplantation, HomologousHematopoietic Stem Cell TransplantationBone Marrow TransplantationBone Marrow CellsStem Cell TransplantationBone MarrowGraft vs Host DiseaseTransplantation ConditioningTransplantation, AutologousHematologic NeoplasmsPeripheral Blood Stem Cell TransplantationTransplantation ChimeraHematopoietic Stem CellsBone and BonesTissue DonorsStem CellsLeukemiaWhole-Body IrradiationBusulfanTreatment OutcomeBlood Patch, EpiduralRecurrenceHistocompatibility TestingRemission InductionLeukemia, Myeloid, AcuteGraft vs Leukemia EffectMyeloablative AgonistsImmunosuppressive AgentsCytomegalovirus InfectionsAnemia, AplasticLeukemia, Myelogenous, Chronic, BCR-ABL PositiveGraft vs Tumor EffectLymphocyte TransfusionVidarabineMultiple MyelomaHistocompatibilityRetrospective StudiesMyelodysplastic SyndromesPrecursor Cell Lymphoblastic Leukemia-LymphomaCombined Modality TherapyTime FactorsLymphocyte DepletionHematopoiesisSurvival AnalysisBone Marrow DiseasesAntilymphocyte SerumT-LymphocytesMice, Inbred C57BLDisease-Free SurvivalCell DifferentiationCyclophosphamideSurvival RateAntigens, CD34SiblingsMinor Histocompatibility AntigensCord Blood Stem Cell TransplantationAcute DiseaseImmunosuppressionCytomegalovirusHepatic Veno-Occlusive DiseaseSalvage TherapyBone RemodelingColony-Forming Units AssayImmunocompromised HostHematologic DiseasesBone Marrow ExaminationLeukemia, MyeloidBone Marrow PurgingNeoplasm, ResidualVirus ActivationKidney TransplantationCells, CulturedHLA AntigensFlow CytometryGraft RejectionRadiation ChimeraAntineoplastic Combined Chemotherapy ProtocolsMelphalanChimerismHematopoietic Stem Cell MobilizationBone Marrow NeoplasmsMesenchymal Stem Cell TransplantationOpportunistic InfectionsLiver TransplantationFollow-Up StudiesTransplantation, IsogeneicCyclosporineGranulocyte Colony-Stimulating FactorPrimary MyelofibrosisFatal OutcomePrognosisNuclear FamilyTransplantation ImmunologyCell TransplantationLeukemia, Myeloid, Accelerated PhaseLymphoma, Non-HodgkinGanciclovirBone DensityMycosesLymphoproliferative Disorders
Graft-versus-HSCTDonorHematopoietic cellsMultiple myelomaHaematopoieticPeripheralChemotherapyHematologic malignanciesDonor'sAutologous and allogeneicPlateletsOutcomesTotal body irradiRegimensCancerMesenchymal StemBiopsyPerson'sAdultPediatricRenalHuman leucocyAplasticGVHDProgenitor cellsImmuneCancersRelapseImmunologySeverePlateletDisordersUmbilical cordPatient'sInfectionLeukemiaClinicalAutoimmuneEngraftmentAlloHCTUnderwentMorbidity and mortaLymphomaAdultsIdenticalGraftsAntigenHarvestSickle cell diEBMT
Graft-versus-3
  • A group from Germany and the United States reported that the EASIX is a reliable factor to predict the prognosis of acute graft-versus-host disease after allogeneic stem cell transplantation [ 9 ]. (biomedcentral.com)
  • The investigators then used base editing to inactivate 3 genes encoding CD52 and CD7 receptors and the b chain of the ab T-cell receptor to evade lymphodepleting serotherapy, CAR7 T-cell fratricide, and graft-versus-host disease, respectively. (ajmc.com)
  • Chronic ocular graft-versus-host-disease (oGVHD) is an important complication of allogeneic Hematopoietic Stem Cell Transplantation (HSCT). (uillinois.edu)
HSCT10
  • The purpose of this study is to measure the effect of Hematopoietic Stem Cell Transplantation (HSCT) on symptoms of CSF1R-related Leukoencephalopathy. (mayo.edu)
  • Hematopoietic stem cell transplantation (HSCT) affects serious risks for the patient, including death. (bvsalud.org)
  • HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)
  • Also, drastic changes in daily living habits, qualified and responsible for the implementation of changes in body image, long duration of treatment, HSCT since 2004, agreed to the Brazilian Unified periods of hospitalization and protective isolation, Health System, which meets the needs of the feeling of loss of control, fear of death and lack of patients with an indication for transplantation. (bvsalud.org)
  • This was the first report of a hematopoietic stem cell transplantation (HSCT) conducted in Mexico, only 4 years after the pioneer work by E. Donnall Thomas in Cooperstown, New York, USA (Ruiz-Argüelles et al. (revistadehematologia.org.mx)
  • His research focus is on haematopoietic stem cell transplantation (HSCT) and translational research of normal and malignant stem cells. (edu.au)
  • For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
  • Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
  • There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)
  • are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
Donor32
  • In contrast to the expected mixed chimerism that usually occurs in the absence of conditioning, we found in our patients 100% donor cell engraftment based on fluorescence in situ hybridization (FISH) and microsatellite techniques. (nih.gov)
  • Subset analysis of the engrafted cells using a multiparametric system enabling a combined analysis of morphology, immunophenotyping and FISH showed that both T and B lymphocytes and myeloid cells were of donor origin in two patients, while T lymphocytes and myeloid cells were of donor origin in the third. (nih.gov)
  • Ramos CA " Striking the right balance: optimizing conditioning regimens for unrelated donor bone marrow transplant for severe aplastic anemia. . (bcm.edu)
  • Gurkan E, Patah PA, Saliba RM, Ramos CA, Anderson BS, Champlin R, de Lima M, Lichtiger B " Efficacy of prophylactic transfusions using single donor apheresis platelets versus pooled platelet concentrates in AML/MDS patients receiving allogeneic hematopoietic stem cell transplantation. . (bcm.edu)
  • Where do allogeneic stem cell transplant donor cells come from? (mdanderson.org)
  • With a bone marrow transplant, the donor receives general anesthesia , and the bone marrow is extracted in a 1-2-hour procedure. (mdanderson.org)
  • With a peripheral blood cell transplant, the donor receives growth factor shots to stimulate the bone marrow to push the stem cells into the blood. (mdanderson.org)
  • This allows us to collect more cells in a short period, decrease patient/donor downtime and freeze the cells for future use. (mdanderson.org)
  • For many patients who don't have a well-matched, healthy donor, a cord blood transplant is a viable option. (mdanderson.org)
  • Many patients find matched unrelated donors through the National Marrow Donor Program. (mdanderson.org)
  • If the donor cells aren't a close enough match, the patient's body may recognize the donor cells as foreign and reject them. (mdanderson.org)
  • Or, the cells from the donor may recognize the new body as foreign and attack. (mdanderson.org)
  • For allogeneic transplantation, the patient receives bone marrow or blood stem cells from a tissue-matched (HLA-matched) donor who may or may not be a relative. (ucsfhealth.org)
  • Donor stem cells are used in allogeneic stem cell transplantation. (bonemarrowtransplantations.com)
  • Stem cells from a donor whose tissue is comparable to yours are used in the most popular allogeneic transplant. (bonemarrowtransplantations.com)
  • Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)
  • Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)
  • Donor Killer Cell Immunoglobulin-Like Receptor Genotype Does Not Improve Graft-versus-Leukemia Responses in Chronic Lymphocytic Leukemia after Unrelated Donor Transplant: A Center for International Blood and Marrow Transplant Research Analysis. (anthonynolan.org)
  • All GS-2 iPSC clones displayed a normal karyotype (46XX or 46XY) and were shown to express the same RAB27A gene mutation that was present in the original somatic donor cells. (biomedcentral.com)
  • Overview and choice of donor of hematopoietic stem cell transplantation. (mayoclinic.org)
  • National Marrow Donor Program. (mayoclinic.org)
  • The team transduced healthy volunteer donor T cells using a lentivirus to express a CAR with specificity for CD7, which is expressed in T-cell ALL. (ajmc.com)
  • Finally, patient 3 is a 15-year-old boy who first presented with mixed-phenotype acute leukemia in 2016 and underwent a first allogeneic stem cell transplantation from a matched unrelated donor. (ajmc.com)
  • This is when stem cells that are obtained from the bloodstream or umbilical cord of a donor are used for transplant into a patient. (differencebetween.net)
  • The process is also less painful for the donor since a needle is not being placed into bone. (differencebetween.net)
  • The donor first has to be treated with G-CSF, and then the stem cells can only be harvested a couple of days after the donor since time is needed for the donor's body to form more stem cells and transport these cells into the bloodstream. (differencebetween.net)
  • The procedure in which bone marrow is extracted from a donor does require the use of either a local or a general anesthetic. (differencebetween.net)
  • The advantage is that granulocyte- colony-stimulating factor (G-CSF) does not have to be given to the donor since the procedure involves going to the source of the stem cells, which is the bone marrow. (differencebetween.net)
  • In the case of a stem cell transplant, granulocyte- colony-stimulating factor has to be given to the donor a few days before the procedure. (differencebetween.net)
  • Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
  • eg, bone, bone marrow, and skin grafts) Genetically identical (syngeneic [between monozygotic twins]) donor tissue (isografts) Genetically. (msdmanuals.com)
  • Hematopoietic stem cell transplantation may be autologous (using the patient's own cells) or allogeneic (using cells from a donor). (msdmanuals.com)
Hematopoietic cells1
  • Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the presence of cells with characteristics similar to bone marrow-derived Langerhans cells juxtaposed against a backdrop of hematopoietic cells, including T-cells, macrophages, and eosinophils. (medscape.com)
Multiple myeloma9
Haematopoietic4
Peripheral6
  • We studied three SCID patients who were transplanted with unmodified mobilized peripheral blood from HLA-identical family sex-mismatched members. (nih.gov)
  • Workup may include a complete blood count (CBC), peripheral smear, iron studies (eg, ferritin and total iron-binding capacity [TIBC]), bone marrow aspiration and biopsy, and other studies as appropriate. (medscape.com)
  • Clinical characteristics of patients with COVID-19 harboring detectable intracellular SARS-CoV-2 RNA in peripheral blood cells. (google.com)
  • The RAB27A protein is responsible for the peripheral distribution of melanosomes in melanocytes and exocytosis of cytotoxic granules in the cytosol of cytotoxic T cells (CTL) and natural killer (NK) cells. (biomedcentral.com)
  • 1989). Hematopoietic stem cells could be harvested easier from peripheral blood after mobilization with G-CSF (Sheridan et al. (revistadehematologia.org.mx)
  • Peripheral blood has largely replaced bone marrow as a source of stem cells, especially in autologous hematopoietic stem cell transplantation, because stem cell harvest is easier and neutrophil and platelet counts recover faster. (msdmanuals.com)
Chemotherapy12
  • T-prolymphocytic leukemia (T-PLL) is an aggressive mature T-cell neoplasm that responds poorly to conventional chemotherapy and has a dismal outcome. (haematologica.org)
  • Conventional chemotherapy drugs kill cancer cells by working on the "machinery" inside of cells and causing the cells to die. (northside.com)
  • We extract blood cells, treat the cancer with high-dose chemotherapy , then place the cells back into the patient. (mdanderson.org)
  • Once the cancer is less active and the patient has been pre-treated with chemotherapy (known as conditioning), he or she receives the donor's healthy stem cells. (mdanderson.org)
  • The transplant of blood stem cells or bone marrow will be infused one to three days after the last chemotherapy or radiation dose. (ucsfhealth.org)
  • Growing evidence demonstrates that various cancer treatment modalities, including chemotherapy, radiation therapy, targeted therapy, immunotherapy, hormone therapy, stem cell or bone marrow transplant, and surgery [ 3 - 5 ] , cause premature senescence, as reviewed elsewhere [ 6 - 8 ] . (oaepublish.com)
  • The stem cells are then frozen and given back to you after receiving significant doses of chemotherapy and radiation as part of your myeloablative therapy. (bonemarrowtransplantations.com)
  • Most children with T-cell acute lymphoblastic leukemia (ALL) can be treated with standard chemotherapy regimens, but patients with induction failure or elevated minimal residual disease after consolidation generally receive allogeneic stem-cell transplantation. (ajmc.com)
  • Despite reinduction therapy and 2 blocks of high-intensity chemotherapy, he had refractory disease that manifested as persistent cytopenia with more than 80% blasts in bone marrow, all of which were expressing CD7. (ajmc.com)
  • Myeloablative megatherapy with autologous stem-cell rescue versus oral maintenance chemotherapy as consolidation treatment in patients with high-risk neuroblastoma: a randomised controlled trial. (findmedarticle.com)
  • In April 1960, Dr. Álvaro Gómez-Leal, presented during the first meeting of the Agrupación Mexicana para el Estudio de la Hematología, A.C., data on a transplant of allogeneic stem cells in a patient with acute leukemia done in Monterrey, Mexico: the patient received high-dose chemotherapy followed by stem cells from the bone marrow of his brother, improving and obtaining remission for months but relapsing and subsequently died. (revistadehematologia.org.mx)
  • Hematopoietic stem cell transplantation is also sometimes used for solid tumors (eg, some germ cell tumors) that respond to chemotherapy. (msdmanuals.com)
Hematologic malignancies2
  • In the last two decades allogeneic hematopoietic cell transplantation (HCT) has been used with increasing frequencies in hematologic malignancies with curative intent. (haematologica.org)
  • ClinicaTrials.gov identifier NCT01597778) was a multicenter phase III randomized trial comparing the clinical outcomes and quality of life (QoL) of patients with hematologic malignancies undergoing double umbilical cord blood transplantation (dUCBT) or HLA-haploidentical bone marrow transplantation (haplo-BMT) after reduced-intensity conditioning. (bvsalud.org)
Donor's2
Autologous and allogeneic1
  • Stem cell transplants fall into two categories: autologous and allogeneic. (mdanderson.org)
Platelets8
  • Evans syndrome is an autoimmune disease in which an individual's immune system attacks their own red blood cells and platelets, the syndrome can include immune neutropenia. (wikipedia.org)
  • Autoantibodies targeted at different antigenic determinants on red cells and platelets are assumed to cause isolated episodes of hemolytic anemia and thrombocytopenia, respectively. (wikipedia.org)
  • It takes approximately two to three weeks for your marrow to start producing white blood cells, red blood cells and platelets. (ucsfhealth.org)
  • The pathognomonic characteristic of HPS is the activation of well-differentiated macrophages, phagocyting erythrocytes, leukocytes and platelets in bone marrow, lymph nodes, spleen, liver and other organs, which can infiltrate almost anybody district and may account for many of its systemic features [ 3 ]. (biomedcentral.com)
  • Other MDS symptoms are associated with low counts of other types of blood cells, such as white blood cells (WBCs) and platelets. (healthline.com)
  • It also makes it harder for the bone marrow to make healthy blood cells and platelets. (medlineplus.gov)
  • There are several broad categories of blood cells, including red blood cells (RBCs), white blood cells (WBCs), and platelets. (healthline.com)
  • Further benefits are that the platelets and neutrophil cells (one of the white blood cells) are more easily able to recover if this method is used compared with the bone marrow procedure. (differencebetween.net)
Outcomes5
  • Prevalence of decisional regret among patients who underwent allogeneic hematopoietic stem cell transplantation and associations with quality of life and clinical outcomes. (cdc.gov)
  • Earlier work from MSK physician-scientists Eric Pamer, MD, and Marcel van den Brink, MD, PhD , has shown that out-of-balance intestinal microbes can contribute to serious side effects that can affect outcomes after stem cell transplants. (mskcc.org)
  • Mayo Clinic scientists are actively studying ways to improve bone marrow transplant outcomes. (mayoclinic.org)
  • Higher doses of infused nucleated cells (NCs) are associated with improved clinical outcomes in bone marrow transplantation (BMT) recipients. (bvsalud.org)
  • Minimizing harvest volume and cell processing could lead to increased infused dose and thus improved outcomes. (bvsalud.org)
Total body irradi2
  • Since approximately 30% of leukemia patients relapse after allogeneic BMT using total body irradiation (TBI)-based preparative regimens, treatment intensity may be suboptimal. (nature.com)
  • Treatment of metastatic renal cell carcinoma with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning with fludarabine/total body irradiation is feasible and may induce tumor regression or stabilization in some patients. (aacrjournals.org)
Regimens1
  • More specifically, the development of minimal intensity or so called "nonmyeloablative" conditioning regimens paved the way towards the application of allogeneic HCT in older patients and all of those who probably would not tolerate classical intensity conditioning. (haematologica.org)
Cancer31
  • Methods Center for International Blood and Marrow Transplant Research data from 184 adults who completed the Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) before undergoing alloHCT and at day 100 were used. (cdc.gov)
  • National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines also recommend the use of serum free light chain assay and plasma cell fluorescence in situ hybridization (FISH) on bone marrow: del 13, del 17p13, t(4;14), t(11;14), t(14;16), t(14;20), 1q21 amplification, 1p deletion as part of the initial diagnostic workup. (medscape.com)
  • On the other hand, the infiltration of organs by a monoclonal population of aberrant cells, the possibility of lethal evolution, and the cancer-based modalities of successful treatment are all consistent with a neoplastic process. (medscape.com)
  • Such transplants represented the first definitive proof of the human immune system's capacity to cure cancer. (northside.com)
  • Northside Hospital Cancer Institute's Immunotherapy Program is part of our nationally recognized treatment center for blood and marrow transplants. (northside.com)
  • However, with cancer, the immune system has trouble eliminating these cancer cells because of the way cancer cells are able to hide and trick the immune system in order to survive. (northside.com)
  • Stopping or slowing the growth of cancer cells. (northside.com)
  • Boosting the immune system's ability to get rid of cancer cells. (northside.com)
  • An immune checkpoint inhibitor is a drug - often made of antibodies - that unleashes an immune system attack on cancer cells. (northside.com)
  • Cytokines are man-made versions of the natural proteins interferon and interleukin found in the body that activate the immune system to help it attack cancer cells. (northside.com)
  • Bispecific monoclonal antibodies are biologic agents (proteins) given by IV that attach to both immune cells and cancer cells and bring them together in proximity to strengthen the immune system's ability to fight cancer. (northside.com)
  • With immunotherapy, instead of directly targeting cancer cells themselves, we indirectly boost one's immune system to fight the cancer. (northside.com)
  • Northside Hospital Cancer Institute is among select centers in the country offering chimeric antigen receptor (CAR) T-cell therapy, one of the most promising cell-based cancer immunotherapies available. (northside.com)
  • Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
  • A randomized clinical trial at Memorial Sloan Kettering Cancer Center (MSK) has shown that fecal microbiota transplants (FMTs) can reestablish the health-promoting bacteria that are often damaged by intense antibiotic treatment in people who have stem cell or bone marrow transplants for blood cancer. (mskcc.org)
  • He continues as transplant physician in Royal Melbourne Hospital/Peter MacCallum Cancer Centre within the precinct of Victorian Comprehensive Cancer Centre. (epworth.org.au)
  • The transplanted cells kill any remaining cancer cells and restore the patient's immune system. (mdanderson.org)
  • Advances in the treatment of cancer and improvements in supportive care over the past 10 years have improved the results and tolerability of blood and marrow transplants (BMT). (ucsfhealth.org)
  • This radiation therapy is intended to destroy remaining cancer cells and further suppress the immune system. (ucsfhealth.org)
  • The success of the operation, namely unrelated allogeneic allo umbilical cord stem cell transplantation (allo UCBSCT), is good news to other blood cancer patients, said professor Yu Rongxi who participated in the operation. (china.org.cn)
  • http://www.cancer.gov/about-cancer/treatment/types/stem-cell-transplant/stem-cell-fact-sheet. (mayoclinic.org)
  • As the cancer cells grow in the bone marrow, you may have bone pain, most often in the ribs or back. (medlineplus.gov)
  • The cancer cells can weaken bones. (medlineplus.gov)
  • If your provider suspects this type of cancer, a bone marrow biopsy will be performed. (medlineplus.gov)
  • Matrix metalloproteinase-12 expression correlates with local recurrence and metastatic disease in non-small cell lung cancer patients. (findmedarticle.com)
  • Leukemia is a cancer of the blood cells. (healthline.com)
  • Leukemia can also cause symptoms in organs that have been infiltrated or affected by the cancer cells. (healthline.com)
  • In acute leukemia, cancer cells multiply quickly. (healthline.com)
  • Professor Ma heads the Blood, Stem Cell and Cancer Research Programme at St Vincent's Centre for Applied Medical Research, Sydney. (edu.au)
  • The procedure can also be used to replace bone marrow which has been somewhat depleted because of some types of cancer treatments. (differencebetween.net)
  • It can also be used to help patients whose own bone marrow has been destroyed because of cancer treatments. (differencebetween.net)
Mesenchymal Stem2
Biopsy1
  • Additional tests used to eliminate the possibility of other conditions include a computed tomography (CT) scan and a biopsy of bone marrow. (wikipedia.org)
Person's2
Adult7
Pediatric2
  • Four-year data after pediatric renal transplantation: a randomized trial of tacrolimus vs. cyclosporin microemulsion. (findmedarticle.com)
  • Primary focal segmental glomerulosclerosis--long-term outcome after pediatric renal transplantation. (findmedarticle.com)
Renal2
  • This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)
  • Clones from three patients with a partial response or stable disease recognized antigens expressed on renal cell carcinoma tumor cells. (aacrjournals.org)
Human leucocy1
Aplastic1
  • Antithymocyte gobulin, derived from rabbits or horses against human thymocytes, has predominantly been used for the treatment of severe aplastic anemia but also within conditioning for allogeneic HCT in selected protocols, mainly for non-malignant indications. (haematologica.org)
GVHD2
  • His main research interests are in leukaemic stem cells, CLL, GVHD and autoimmune blood disorders such as immune thrombocytopenia. (epworth.org.au)
  • We performed a randomized trial comparing Tac/MTX (full-MTX) with Tac/mini-MTX/MMF (mini-MTX/MMF) for GVHD prevention after allogeneic hematopoietic cell transplantation (HCT). (bvsalud.org)
Progenitor cells2
  • In vitro differentiation of GS-2 iPSCs into hematopoietic stem and progenitor cells was done using Op9 feeder layers and specified media. (biomedcentral.com)
  • This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
Immune9
  • Cell-based immunotherapies, including CAR T-cell therapy, refer to a treatment option where immune cells are taken directly from a patient and genetically modified to be more effective tumor-fighting immune cells. (northside.com)
  • The increased understanding of immune tolerance and allogeneic antileukemic immune reactivity has led several investigators to develop optimized conditioning protocols and new strategies to manipulate the effector cells either within the graft or in vivo . (haematologica.org)
  • As stated above, the fine tuning of the allogeneic immune response by T-cell depletion or pharmacological means represents the second important pillar in the development of optimized transplantation protocols. (haematologica.org)
  • Cord blood, the blood left in the placenta after a baby is born, has been proved to be as effective as bone marrow in saving children who suffer from leukemia or people whose immune system has been damaged. (china.org.cn)
  • Genetic HPS is heterogeneous and arises from defects in the critical regulatory pathways responsible for the natural termination of immune responses that lead to the failure of the homeostatic removal of cells that are superfluous or dangerous to the host. (biomedcentral.com)
  • Griscelli syndrome type 2 (GS-2) is a rare, autosomal recessive immune deficiency syndrome caused by a mutation in the RAB27A gene, which results in the absence of a protein involved in vesicle trafficking and consequent loss of function of in particular cytotoxic T and NK cells. (biomedcentral.com)
  • Immune Reconstitution After Autologous Hematopoietic Stem Cell Transplantation in Crohn's Disease: Current Status and Future Directions. (wizaxe-prod.com)
  • 1957). This pioneering work laid the foundation for the exploration of hematopoietic stem cells and their role in treating diseases of the blood and immune system. (revistadehematologia.org.mx)
  • One concern about the procedure is that immune cells in cord blood do not have experience with the viruses responsible for latent infections, leading to a higher percentage of naive T cells and thus increased vulnerability to reactivation of cytomegalovirus or Epstein-Barr virus infection. (msdmanuals.com)
Cancers4
  • Blood cancers multiply uncontrollably, hindering the growth of these cells. (mdanderson.org)
  • Myelodysplastic syndromes (MDS) are a group of blood cancers in which your bone marrow doesn't make enough healthy blood cells. (healthline.com)
  • For these patients, cellular immunotherapy could help achieve deep leukemic clearance, although chimeric antigen receptor (CAR) T-cell strategies against T-cell cancers have been difficult. (ajmc.com)
  • Leukemia can refer to all cancers affecting the white blood cells. (healthline.com)
Relapse2
Immunology2
  • The aim of the academic journal is to provide a platform for researchers, scientists, physicians, and other health professionals to find latest research information in the areas of stem cell research, transplantations such as stem cell transplantation, transplantation immunology, kidney transplantation and its treatment. (slideshare.net)
  • and umbilical cord blood (PUCB), capable of 2017), associated with the results of the procedure restoring spinal cord function and immunology of and require a process of hospitalization and patients with indication for transplantation, with the prolonged hospital recovery. (bvsalud.org)
Severe3
Platelet1
  • The goal is to support you with red blood cell and platelet transfusion until you are producing cells again. (ucsfhealth.org)
Disorders6
  • The sideroblastic anemias (SAs) are a group of inherited and acquired bone marrow disorders characterized by pathological iron accumulation in the mitochondria of red blood cell precursors (nucleated erythroblasts). (medscape.com)
  • RSs can be detected in the bone marrow in a variety of clonal hematological and non-clonal disorders. (medscape.com)
  • Sideroblasts are not pathognomonic of any one disease but rather are a bone marrow manifestation of several diverse disorders. (medscape.com)
  • The working group of the Histiocyte Society divided histocytic disorders into three groups: (1) dendritic cell histiocytosis, (2) macrophage-related disorders, and (3) malignant histiocytosis. (medscape.com)
  • 1992). Since then, hematopoietic stem cells, with their unique ability to differentiate into various blood cell types, have proven to be a revolutionary tool in the treatment of numerous hematological disorders. (revistadehematologia.org.mx)
  • Pemphigus vulgaris (PV) is a life-threate- disorders and to shed a light on the role of ning blistering skin disease in which pa- mast cells in autoimmune diseases [ 7 ]. (who.int)
Umbilical cord1
Patient's4
  • An autologous stem cell transplant uses the patient's own cells for treatment. (mdanderson.org)
  • The patient has low blood counts until the replaced cells replenish the patient's body with healthy cells. (mdanderson.org)
  • Patients who undergo bone marrow transplantation are generally immunosuppressed with a dose of cyclophosphamide which is usually calculated based on the patient's weight. (slideshare.net)
  • On day 27, the patient's bone marrow was hypocellular and in morphologic remission with undetectable minimal residual disease and she was discharged 52 days after stem-cell transplantation. (ajmc.com)
Infection5
  • In the less common instance that white blood cells are attacked, symptoms may include increased proneness to infection, fevers, and/or mouth sores. (wikipedia.org)
  • CMV infection characteristically is associated with "owl's-eye" cells, which are large cells with basophilic intranuclear inclusions and a surrounding clear zone. (medscape.com)
  • Unfortunately, the same antibiotics that are essential for healing the body after the transplant also significantly disrupt the diversity of intestinal microbiota, leading to the loss of many beneficial microbes and an increased risk of intestinal infection. (mskcc.org)
  • Epstein-Barr virus (EBV) infection has been prominently associated with HPS, with clonal proliferation and the hyperactivation of EBV-infected T cells. (biomedcentral.com)
  • Plasma cells help your body fight infection by producing proteins called antibodies . (medlineplus.gov)
Leukemia9
  • The killing of leukemia cells is proportional to the radiation absorbed dose. (nature.com)
  • 1 T-PLL cells commonly demonstrate rearrangements involving T-cell leukemia/lymphoma 1 (TCL1) family genes TCL1A, MTCP1 (mature T-cell proliferation), or TCL1B as molecular hallmarks. (haematologica.org)
  • [ 1 ] First described in 1848, MM is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance ( MGUS ) to plasma cell leukemia. (medscape.com)
  • The use of base editing to generate universal, off-the-shelf CAR T cells is a promising approach for relapsed leukemia, with potential implications for the future of gene therapy. (ajmc.com)
  • New research in clustered regularly interspaced short palindromic repeats (CRISPR) technology suggests that base-edited T cells could be useful in patients with relapsed leukemia and could help anticipate the risks of immunotherapy -related complications. (ajmc.com)
  • These edited cells were investigated in 3 children with relapsed leukemia. (ajmc.com)
  • Leukemia is also classified according to the type of cell that's affected. (healthline.com)
  • Leukemia involving myeloid cells is called myeloid or myelogenous leukemia. (healthline.com)
  • Hairy cell leukemia is a very rare subtype of CLL. (healthline.com)
Clinical4
  • On one end, the clinical spectrum includes an acute, fulminant, disseminated disease called Letterer-Siwe disease, and, on the other end, solitary or few, indolent and chronic lesions of bone or other organs called eosinophilic granulomas . (medscape.com)
  • The intermediate clinical form called Hand-Schüller-Christian disease is characterized by multifocal, chronic involvement and classically presents as the triad of diabetes insipidus, proptosis, and lytic bone lesions. (medscape.com)
  • These data suggest that with appropriate pre-transplant clinical evaluation, high-dose cyclophosphamide and irradiation in the BMT preparative phase does not result in frequent, clinically relevant short-term cardiac toxicity [31]. (slideshare.net)
  • Autologous Hematopoetic Stem Cell Transplantation for Refractory Crohn Disease: A Randomized Clinical Trial. (wizaxe-prod.com)
Autoimmune4
  • Autoimmune hemolytic anemia is a condition in which the red blood cells that normally carry oxygen are destroyed by an autoimmune process. (wikipedia.org)
  • It has been observed that there is a risk of developing other autoimmune problems and hypogammaglobulinemia, in one cohort 58% of children with Evans syndrome had CD4-/CD8- T cells which is a strong predictor for having autoimmune lymphoproliferative syndrome. (wikipedia.org)
  • European Society for Blood and Marrow Transplantation (EBMT) Autoimmune Diseases Working Party (ADWP). (wizaxe-prod.com)
  • A Review on Behalf of the EBMT Autoimmune Diseases Working Party and the Autologous Stem Cell Transplantation In Refractory CD-Low Intensity Therapy Evaluation Study Investigators. (wizaxe-prod.com)
Engraftment4
  • Full hematopoietic engraftment was reported in one case after bone marrow transplantation without conditioning for a SCID patient. (nih.gov)
  • Kamble RT, Guo S, Ramos CA, Carrum G " Acute gout at engraftment following hematopoietic transplantation. . (bcm.edu)
  • Engraftment is the term used to describe when your new marrow begins to function and produce blood cells. (ucsfhealth.org)
  • While awaiting engraftment, no mature cells leave the marrow and enter the blood stream. (ucsfhealth.org)
AlloHCT2
Underwent1
  • He underwent lymphodepletion and received 1x106 BE-CAR7 T cells per kilogram. (ajmc.com)
Morbidity and morta2
  • 1980). As with many countries embarking on this procedure, there were challenges related to transplant-related morbidity and mortality. (revistadehematologia.org.mx)
  • Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)
Lymphoma1
  • However, it has not been validated as a prognostic marker for diffuse large B-cell lymphoma (DLBCL) to date. (biomedcentral.com)
Adults4
  • [ 5 ] Heme and globin chains (alpha and beta) in adults are manufactured in separate cell compartments-mitochondria and cytoplasm, respectively-and then combined in cytoplasm in an amazingly accurate manner. (medscape.com)
  • Bone marrow is the soft, spongy tissue found inside most bones in children and in the front chest bone (sternum) and the pelvis bones in adults. (medlineplus.gov)
  • T-cell cytokine levels are age-dependent in healthy children and adults. (findmedarticle.com)
  • A potential future source of stem cells is induced pluripotent stem cells (certain cells taken from adults and reprogrammed to act like stem cells). (msdmanuals.com)
Identical2
  • Identical twin allogeneic transplants are called syngeneic transplants. (ucsfhealth.org)
  • In the mid-20th century, Dr. E. Donnall Thomas achieved a landmark breakthrough by successfully performing the first bone marrow transplant between identical twins in 1956 (Thomas et al. (revistadehematologia.org.mx)
Grafts1
Antigen4
  • Viral-antigen detection is one of the new tests, but the results are generally less sensitive and less specific than those of conventional cell cultures. (medscape.com)
  • In the transplant population, antigen assays or PCR is used (sometimes in conjunction with cytopathology) for diagnosis and treatment determinations. (medscape.com)
  • The work of Jean Dausset, whose discovery of the human leukocyte antigen (HLA) system revolutionized our understanding of tissue compatibility for transplantation (Dausset J, 1958). (revistadehematologia.org.mx)
  • 205. Prior chimeric antigen receptor therapy or other genetically modified T cell therapy 206. (who.int)
Harvest3
  • We conducted this retrospective study to investigate the quality of bone marrow (BM) harvest and factors that influence infused NC doses at our institution. (bvsalud.org)
  • Additionally, the harvest volume and cell processing method were significantly correlated with the infused dose. (bvsalud.org)
  • Harvest volume and cell process play significant roles in determining the final infused dose. (bvsalud.org)
Sickle cell di2
EBMT1