• All patients received high-dose etoposide (60 mg/kg) and allogeneic stem cell transplantation following the TBI. (nature.com)
  • History of prior allogeneic bone marrow progenitor cell or solid organ transplantation. (astrazenecaclinicaltrials.com)
  • Forty infants have subsequently been treated on a protocol incorporating further intensification with an option for high-dose chemotherapy and autologous or allogeneic bone marrow transplantation. (nih.gov)
  • Purpose: Diarrhea associated with acute gastrointestinal (GI) graft- versus-host disease (GVHD) after allogeneic bone marrow transplantation (BMT) can result in severe morbidity and mortality. (elsevierpure.com)
  • A pilot study was conducted to evaluate the efficacy and toxicity of octreotide in the management of diarrhea in patients with GVHD after allogeneic BMT. (elsevierpure.com)
  • Allogeneic stem cell transplantation (SCT) results in a high percentage of complete remissions, but it can be associated with significant treatment-related mortality, which has been primarily attributed to conventional myeloablative transplant regimens. (drugpatentwatch.com)
  • To determine the treatment-related morbidity and mortality of allogeneic stem cell transplantation using a non-myeloablative conditioning regimen in multiple myeloma. (drugpatentwatch.com)
  • A Multicenter, Pivotal Phase 3 Study of Iomab-B Prior to Allogeneic Hematopoietic Cell Transplantation Versus Conventional Care in Older Subjects With Active, Relapsed or Refractory Acute Myeloid Leukemia (SIERRA) Jacksonville, Fla., Rochester, Minn. (mayo.edu)
  • The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)
  • Nevertheless, myelosuppression can be reversed by autologous stem cell transplantation (SCT), even without additional toxicity ( 4 , 5 ). (ijbs.com)
  • In the last decade, the availability of autologous stem cell transplantation and combination therapies consisting of immunomodulatory drugs, proteasome inhibitors, and other chemotherapeutics has improved median 5-y survival from 34.6% in 2004 to 49.6% in 2013 ( 3 , 4 ). (snmjournals.org)
  • To minimize the potential morbidity and mortality from drug-induced respiratory diseases, healthcare providers should be familiar with the possible adverse effects of the medications they prescribe. (medscape.com)
  • GI complications are a prevailing source of morbidity and mortality in solid organ and bone marrow transplant recipients. (elsevierpure.com)
  • The present invention relates generally to improved methods and pharmaceutical compositions for mobilizing hematopoietic stem and progenitor cell from bone marrow into peripheral blood by administration of at least one inhibitor of a GTPase, such as Rac1 and/or Rac2 GTPase. (justia.com)
  • Serious side effects that can happen because of bone marrow suppression include severe infection ( sepsis ), bleeding, and anemia . (bionity.com)
  • however, severe neurological toxicity has been reported rarely following treatment with standard cladribine dosing regimens. (nih.gov)
  • However, melphalan efficacy is variable in the clinical population, especially in relapsed and refractory MM, and is also implicated in various toxicities, including severe mucositis and myelosuppression. (snmjournals.org)
  • Children have been reported to have a low incidence of severe toxicity and significant rates of failure to achieve full engraftment. (johnshopkins.edu)
  • Cyclophosphamide can cause myelosuppression (leukopenia, neutropenia, thrombocytopenia and anemia), bone marrow failure, and severe immunosuppression which may lead to serious and sometimes fatal infections, including sepsis and septic shock. (edrugswiki.com)
  • Its most severe side effect is bone marrow suppression, and it should not be given in conjunction with purine analogs such as allopurinol. (illnesshacker.com)
  • Immunosuppressive drugs also have notable GI side effects, and immunosuppression predisposes patients to infections and malignancies of the liver and GI tract. (elsevierpure.com)
  • Sinusoidal obstruction syndrome (SOS), also known as veno - occlusive disease (VOD), an immunosuppression regimen - related toxicity, has been reported in SOT, but is also more often seen in the HCT population. (elsevierpure.com)
  • Azathioprine is a chemotherapy drug, now rarely used for chemotherapy but more for immunosuppression in organ transplantation and autoimmune diseases such as rheumatoid arthritis or inflammatory bowel disease or Crohn's disease. (illnesshacker.com)
  • Immunosuppression likely occurs because of the ability of the drug to inhibit purine biosynthesis. (illnesshacker.com)
  • Existing immunosuppressive drugs for organ transplantation may achieve sufficient immunosuppression to prevent organ rejection or limit autoreactivity, but they are typically not successful in achieving long-term survival of the graft or preventing progression of fibrosis and chronic rejection [ 3 ]. (biomedcentral.com)
  • Patients may also develop progressive marrow failure or transform to acute myelogenous leukemia. (wikipedia.org)
  • Before starting patients on any medication, educate them about the potential adverse effects of the drug. (medscape.com)
  • Patients who develop drug toxicity should be advised to avoid the drug in the future. (medscape.com)
  • How the Busulfan testing improved the management of Bone Marrow Transplant Patients? (labroots.com)
  • Therapeutic drug monitoring (TDM) of Busulfan is essential for management of Bone Marrow Transplant (BMT) patients, by optimizing dose, supporting compliance, and minimizing toxicity. (labroots.com)
  • Of the 15 responding patients, 6 had post-clofarabine bone marrow transplantation. (bionity.com)
  • Atovaquone is an FDA-approved antiparasitic and antifungal therapeutic that is currently used as a prophylactic agent to prevent Pneumocystis carinii pneumonia (PCP) infections in acute myeloid leukemia (AML) patients after receiving hematopoietic stem cell transplantation (HSCT). (bvsalud.org)
  • The high variability in atovaquone bioavailability prompts the need for therapeutic drug monitoring, especially in pediatric patients. (bvsalud.org)
  • It is widely used with cyclophosphamide for conditioning patients undergoing bone marrow transplantation for myeloid leukemia. (bvsalud.org)
  • Patients preparing for bone marrow or stem-cell transplantation have a particularly high risk because of the high doses needed. (myamericannurse.com)
  • Patients receiving external beam radiation therapy on large areas of bone marrow, such as the sternum, pelvis, and long bones, have a high risk of neutropenia, as do patients receiving both chemotherapy and radiation therapy. (myamericannurse.com)
  • Patients with a tumor affecting the bone marrow usually have myelosuppression and neutropenia. (myamericannurse.com)
  • Cancer patients older than age 70 who receive myelosuppressive chemotherapy are at increased risk for neutropenia and fatal infection, likely because of a decline in bone marrow reserves. (myamericannurse.com)
  • Current recommendations say these drugs should be given to patients whose risk for febrile neutropenia is 20% or higher. (myamericannurse.com)
  • One study with 10 patients concluded that tumescent anesthesia with a lidocaine dose of 55 mg/kg is safe for liposuction.1 We have personally performed tumescent liposuction on more than 400 patients using lidocaine doses in the range of 50-60 mg/kg without evidence of lidocaine toxicity. (liposuction.com)
  • Serious neurological toxicity (including irreversible paraparesis and quadraparesis) has been reported in patients who received LEUSTATIN Injection by continuous infusion at high doses (4 to 9 times the recommended dose for Hairy Cell Leukemia). (nih.gov)
  • Combination therapies involving melphalan, a small-molecule DNA alkylating agent, are commonly prescribed to patients with relapsed or refractory MM, necessitating the stratification of responding patients to minimize toxicities and improve quality of life. (snmjournals.org)
  • Thus, stratification of melphalan-responsive patients in the MM patient population is critical for reducing therapy-induced toxicities. (snmjournals.org)
  • Cutaneous manifestations in patients with Wiskott-Aldrich syndrome submitted to haematopoietic stem cell transplantation. (medscape.com)
  • More than a hundred leukaemia patients in Hong Kong have been treated, the majority being cured by this novel drug. (hku.hk)
  • The use of oral arsenic has replaced bone marrow transplantation as the standard treatment for these patients. (hku.hk)
  • HKU is investigating the feasibility of making oral arsenic available on a compassionate basis to patients in developing countries, who face immense difficulties with drug costs, and the provision of in-patient hospital facilities and laboratory tests. (hku.hk)
  • Solid organ transplantation (SOT) and hematopoietic cell transplantation (HCT) have dramatically improved the survival and quality of life in patients with a variety of malignancies and chronic end - organ disease. (elsevierpure.com)
  • Patients received either peripheral- blood stem cells (n = 13) or bone marrow (n = 8). (elsevierpure.com)
  • For patients diagnosed with lymphoma, a vital research enterprise allows Kellogg patients access to the latest drugs and treatment options, as well as a wide array of clinical trials . (northshore.org)
  • It has also improved symptoms in patients with rheumatoid arthritis, and the Food and Drug Administration has approved it for treating patients with this disease. (drugpatentwatch.com)
  • For the prevention of fungal infections in immunocompromised patients considered at risk as a consequence of neutropenia following cytotoxic chemotherapy or radiotherapy, including bone marrow transplant patients. (medeasy.health)
  • Prophylaxis in patients undergoing bone marrow transplantation: 400 mg once daily. (medeasy.health)
  • Conditions associated with bone marrow failure such as aplastic anemia with hypocellular marrow, typical bone marrow findings of MDS are a hypercellular marrow for a persons age, dysplasia in 1 to 3 lineages manifested by pseudo Pelger-Huet nuclei, hypogranular neutrophils, micro megakaryocytes, and/or ringed sideroblasts, glass Siri glass, and increased myeloblasts in a subset of patients. (standardofcare.com)
  • In patients with unexplained anemia, thrombocytopenia, or neutropenia without dysplasia in the bone marrow but with abnormal chromosome activity in 5, 7 or 13 the diagnosis is consistent with MDS and occurs in less than 10% of patients with MDS. (standardofcare.com)
  • Neupogen is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with established cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes) and for the reduction in the duration of neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation considered to be at increased risk of prolonged severe neutropenia. (medicines.org.uk)
  • Lung transplantation is a life-saving surgical replacement of diseased lungs in patients with end-stage respiratory malfunctions. (biomedcentral.com)
  • Lung transplantation is a life-saving surgical procedure for patients with end-stage lung diseases. (biomedcentral.com)
  • A new clinical intervention trial aims to improve outcomes for patients with the bone marrow cancer multiple myeloma (MM). (leeds.ac.uk)
  • Research shows that patients who receive intensive therapy including stem cell transplantation have the best outcomes, with younger and fitter patients generally living more than six years after diagnosis. (leeds.ac.uk)
  • Gordon Cook, Professor of Haematology and Myeloma Studies and Clinical Director (Haematology) at Leeds Institute of Clinical Trials Research, said: This is the only trial globally looking to test if a clinical score can identify vulnerable patients at risk of treatment-related toxicity and modifying how we deliver therapy up-front rather than in response to developing side effects, which is the standard of care. (leeds.ac.uk)
  • In order to assess the incidence and analyze reasons which cause prolongation of hospital stay in patients engrafted after peripheral blood stem cell transplantation (PBSCT), we performed this retrospective analysis. (nature.com)
  • 0.05) while GIT toxicity was the most common reason for discharge delays in patients conditioned with melfalan 200 mg/m 2 (8.2% vs 14.7%, NS). (nature.com)
  • We conclude that in spite of rapid engraftment, non-hematological toxicities and infections remain important limitations for further reduction of the length of patient hospitalization in a significant number of patients after PBSCT. (nature.com)
  • Depending on the degree of bone marrow damage (i.e., suppression), patients who undergo cytoreductive therapy must also receive therapy to reconstitute bone marrow function (hematopoiesis). (justia.com)
  • In such procedures, patients undergo successive treatments with cell mobilization agents to cause mobilization of hematopoietic progenitor cells from the bone marrow to the peripheral circulation for harvesting. (justia.com)
  • In 30-50% of patients, the lymphoblasts infiltrate bone marrow, causing ineffective hematopoiesis. (medscape.com)
  • Gastrointestinal toxicities were the most frequent (97.1%) and all patients received antineoplastic/chemotherapeutic and antiemetic treatment. (bvsalud.org)
  • Treatment for this condition remains difficult and largely ineffective, because the growth of cells in the wound is inhibited ( 2 ) and chemotherapy usually leads to myelosuppression, the latter of which further compromises the migration of multipotent cells from the bone marrow ( 3 ). (ijbs.com)
  • Urotoxicity and myelosuppression is known as the most prevailing dose-limiting toxicity associated with CP. (researchwap.com)
  • The result of the present study revealed that aqueous leaf extract of V. amygdalina has the potential to prevent urotoxicity and myelosuppression induced by CP and thus can be used as therapeutic adjuvant in the management of CP and other oxazaphosphorine toxicities. (researchwap.com)
  • An immunosuppressive antimetabolite pro-drug. (illnesshacker.com)
  • Existing immunosuppressive drugs are also associated with low specificity leading to toxicity and increased risk of infections and malignancies. (biomedcentral.com)
  • Etiologic diagnosis of hepatitis is even more problematic in organ transplant recipients because a wide range of possible drug toxicities induced by immunosuppressive therapies must be considered ( 4 ). (cdc.gov)
  • These studies suggest that, in young children, BSA-based dosing of BU (40 mg/m 2 ) provides drug exposures (AUCs) closer to adult values with acceptable toxicities and may improve therapeutic effects. (umn.edu)
  • Therapeutic drug monitoring (TDM) of busulfan plasma concentration guides the dosage adjustment to optimally achieve complete bone marrow ablation while minimizing the dosage-dependent toxicity. (bvsalud.org)
  • Moreover, common targeted therapeutic drug formulations have weak stability in malignant tumor leukemia, and their application effects are limited. (frontiersin.org)
  • Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)
  • More than 600 drugs are known to cause pulmonary toxicity, and illicit drugs are well-known to result in pulmonary toxicities. (medscape.com)
  • A list of drugs that are reported to cause pulmonary toxicity is available on the continually updated Website PNEUMOTOX online . (medscape.com)
  • Drug-induced pulmonary toxicity is a diagnosis of exclusion. (medscape.com)
  • The diagnosis of drug-mediated pulmonary toxicity is usually established based on clinical findings. (medscape.com)
  • Radiologic patterns observed in drug-induced pulmonary toxicity are highly variable and depend on the type of adverse reaction the patient is experiencing. (medscape.com)
  • Most drug-induced pulmonary toxicities involve the parenchyma, thus, interstitial infiltrates may be demonstrated on radiographs. (medscape.com)
  • If the drug-induced pulmonary toxicity causes airway obstruction, then the FEV 1 /FVC ratio and FEV 1 will be reduced. (medscape.com)
  • In general, bronchoscopy with transbronchial biopsy is not helpful in establishing the diagnosis of drug-induced pulmonary toxicity. (medscape.com)
  • There were three cases of grade 4 pulmonary toxicity and three cases of grade 4 hepatic toxicity among the 14.4 Gy cohort, and one case each of grade 4 pulmonary and hepatic toxicities among the 15.3 Gy cohort. (nature.com)
  • Lung shielding is facilitated to reduce the risk of pulmonary toxicity. (biomedcentral.com)
  • Lung transplantation is the only intervention that prolongs survival in idiopathic pulmonary fibrosis (IPF). (ersjournals.com)
  • Idiopathic pulmonary fibrosis (IPF) is progressive and fatal, and lung transplantation is the only therapy that has been shown to prolong survival [ 1 ], [ 2 ]. (ersjournals.com)
  • Toxicities that required dose reduction occurred in 40% of the dogs. (vin.com)
  • Agreement to use contraception during the study and for 30 days after the last dose of study drugs if sexually active and able to bear or beget children. (astrazenecaclinicaltrials.com)
  • Any immunotherapy within 4 weeks of first dose of study drug. (astrazenecaclinicaltrials.com)
  • For subjects with recent chemotherapy or experimental therapy the first dose of study drug must occur after 5 times the half-life of the agent(s). (astrazenecaclinicaltrials.com)
  • The incidence of neutropenia varies, depending on the specific drugs, the dose intensity, the number of myelosuppressive drugs, and the administration schedule. (myamericannurse.com)
  • The higher the dose of myelosuppressive drugs, the higher the risk of neutropenia. (myamericannurse.com)
  • Only three of 11 children treated by high-dose chemotherapy and transplantation remain alive in remission. (nih.gov)
  • These results show the susceptibility of infants to the toxicity of intensive chemotherapy and do not support the use of short term high-dose chemotherapy alone in the management of infant leukaemia. (nih.gov)
  • After harvesting, the patient is given high dose chemotherapy or radiotherapy and the bone marrow function is reconstituted by infusion of the cells harvested earlier. (justia.com)
  • The use of high-dosage chemotherapy or radiotherapy for bone marrow ablation requires subsequent incorporation of hematopoietic stem cells into the patient, in which case prior harvesting of such cells is required. (justia.com)
  • Multiple myeloma (MM) is a cancer of terminally differentiated plasma B cells that originates in the hematopoietic bone marrow and accounts for 15%-20% of all hematologic malignancies ( 1 , 2 ). (snmjournals.org)
  • Studies have shown that the busulfan plasma concentration correlates better with clinical efficacy and toxicity than the patient's administered dosage. (bvsalud.org)
  • For these reasons, if the patient's own blood stem cells could be corrected by inserting a normal human Artemis gene into their DNA and these cells put back into the patient's bone marrow to grow and restore normal T and B lymphocyte function, many if not all of the problems associated with BMT would be eliminated. (ca.gov)
  • For a typical bone marrow transplant this is done by pre-treating the patient (recipient) with high doses of chemotherapy that destroy the patient's own stem cells and allow the donor stem cells to stay and grow in the bone marrow. (ca.gov)
  • These therapies decrease a patient's white blood cell counts, suppress bone marrow hematopoietic activity, and increase the patient's risk of infection and/or hemorrhage. (justia.com)
  • Current treatments to manage the problems that result from prolonged bone marrow suppression include the reinfusion of a patient's own previously harvested hematopoietic stem and progenitor cells. (justia.com)
  • We are also studying ways that we can open up "space" in the bone marrow to permit large numbers of donor stem cells to live and grow. (ca.gov)
  • In early experiments we have demonstrated that a drug called anti-ckit (ACK2) that attacks bone marrow stem cells in severely immunodeficient mice, also works in Artemis-deficient mice and following transplantation of highly purified normal mouse stem cells, the ACK2-treated mice begin to generate both donor T and B lymphocytes that are absent in Artemis deficiency as early as 4 weeks post transplant. (ca.gov)
  • Therefore, we plan in the coming year to evaluate three other possible agents that are currently available for use in humans and that may also be effective in opening "space" in the marrow and allow the viral vector-treated bone marrow stem cells to grow and mature. (ca.gov)
  • In order to eliminate the interference from the transplanted cells themselves, fetal stem cells were used for transplantation because the proliferation and differentiation potentials of fetal stem cells are superior to the adult ones ( 8 ). (ijbs.com)
  • It causes malignant proliferation of hematopoietic stem cells in the bone marrow, resulting in the production of cancerous cells that lack normal physiological functions. (frontiersin.org)
  • Therefore, hematopoietic stem cells mobilized into a subject's peripheral blood by the method of the invention is useful as a source of donor cells in bone marrow transplantation for the treatment of a variety of disorders, including cancer, anemia, autoimmunity and immunodeficiency. (justia.com)
  • Stem cells represent a very small percentage of bone marrow cells, and are normally quiescent. (justia.com)
  • The success of treatment crucially depends on the mobilization of the bone marrow stem cells, the subsequent return of which permits the patient to achieve reconstitution of a functioning hematopoietic system. (justia.com)
  • The selective toxicity of 2-chloro-2΄-deoxy-β-D-adenosine towards certain normal and malignant lymphocyte and monocyte populations is based on the relative activities of deoxycytidine kinase and deoxynucleotidase. (nih.gov)
  • Its selective toxicity to anaerobic microbes involves 1. (orionlifes.com)
  • To optimize BU dosage in young BMT recipients, we developed a dosage regimen based on body surface area (BSA) and determined BU pharmacokinetics and BU-associated toxicities. (umn.edu)
  • Other uses of the CFU assay include studying the effects of stimulatory and inhibitory growth factors, screening novel compounds to predict potential toxicity to the hematopoietic system, and testing the effects of various in vitro manipulations (e.g. cell processing, cryopreservation, gene transduction, and transmission) on cellular products used in hematopoietic cell transplantation. (stemcell.com)
  • Stem cell transplantation is a promising strategy for delayed wound healing caused by chemotherapy. (ijbs.com)
  • Stem cell transplantation is sometimes a course of lymphoma treatment. (northshore.org)
  • The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
  • When the bone marrow hematopoietic cells are mostly clonally derived cells, the disease is clinically manifested as cytopenia and morphologic dysplasia. (standardofcare.com)
  • This evolving approach includes a variety of new drugs that target specific mutations in malignant cells interfering with the bloodstream's pathways. (northshore.org)
  • It is used both by hematopoietic researchers and clinical labs to assess the potency of transplantation units of cord blood (CB) and hematopoietic cellular therapy products. (stemcell.com)
  • Drug screening is an important diagnostic tool in patient management and is an indispensable part of clinical toxicology laboratory services. (bvsalud.org)
  • Acute and chronic toxicities were primarily related to GVHD, infection and relapse rather than to TBI. (nature.com)
  • The two-dimensional nano drug carrier has high safety and effectiveness in drug delivery, and its targeted treatment effect on acute T lymphoblastic leukemia cells is obvious. (frontiersin.org)
  • After transplantation, wounds closed as early as 8 days and were positive for α-smooth muscle actin (α-SMA), implicating the enhanced re-epithelialization and wound contraction. (ijbs.com)
  • This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (bvsalud.org)
  • The bone marrow microenvironment and inflammatory signaling can also determine the rate of development and progression of MDS. (standardofcare.com)
  • Immunotolerance is a major immunological phase, which facilitates reparative microenvironment during transplantation, and plays a vital role to suppress alloimmune responses. (biomedcentral.com)
  • Peripheral blood stem cell and bone marrow transplantation for solid tumors and lymphomas: hematologic recovery and costs. (nature.com)
  • Improved methods and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as Rac1 and Rac2 alone or in combination. (justia.com)
  • 20% lymphoblasts in marrow), a diagnosis of lymphoblastic lymphoma is made. (medscape.com)
  • Conversely, a diagnosis of ALL generally requires at least 20% lymphoblasts in marrow. (medscape.com)
  • Bronchoalveolar lavage (BAL) can contribute to the expected clinicopathologic pattern of a given drug-induced lung disease such as identifying eosinophils in a drug-induced eosinophilic pneumonia. (medscape.com)
  • Because of this, children with SCID-A are also more sensitive to typical chemotherapeutic drugs used for bone marrow stem cell transplant (BMT). (ca.gov)
  • These targeted therapies have been shown to significantly improve response rates without increasing toxicity. (northshore.org)
  • Because no additional reduction in the volume of diarrhea occurred after 7 days of therapy, continuation of the drug beyond this time is not cost effective. (elsevierpure.com)
  • He observed that this highly aggressive bone cancer was remarkably sensitive to radiation therapy. (sarcomahelp.org)
  • Experimental analysis was also conducted on the characterization ability, drug release, and targeted therapy of nanomedicine. (frontiersin.org)
  • Its drug release characteristics perform well in photothermal therapy, indicating that black phosphorus nano drugs can improve the biological safety and applicability of drugs in new tumor targeted therapy. (frontiersin.org)
  • Targeted therapy uses targeted drugs to maintain a high concentration of the drug in the tumor area, improving the killing efficiency of cancer cells while avoiding damage to other normal cells. (frontiersin.org)
  • Four recipients (50%) required dialysis for tubular injury and calcineurin inhibitor toxicity. (ersjournals.com)
  • HSCs specifically are defined by their ability for self-renewal and to reconstitute the entire hematopoietic system following transplantation. (stemcell.com)
  • This condition can be suspected if the patient has been exposed to a likely causative drug, develops new signs and symptoms, and has a remittence of these symptoms once the drug is withheld. (medscape.com)
  • Aetna considers laboratory testing medically necessary for heavy metal poisoning (e.g., arsenic, cadmium, copper, gold, iron, mercury) for members with specific signs and symptoms of heavy metal toxicity and/or a history of likely exposure to heavy metals. (aetna.com)
  • Aetna considers laboratory testing for manganese medically necessary for persons with specific signs and symptoms of manganese toxicity (dyscoordination, loss of balance, confusion) who have a history of likely exposure to high levels of manganese (e.g., occupational exposures to manganese aerosols or dust in the welding or steel industries, exposure to high levels of manganese in contaminated drinking water, suspected manganese toxicity in persons on chronic total parenteral nutrition). (aetna.com)
  • Participants with a locally advanced or metastatic pathologically confirmed cancer who are candidates for treatment with atezolizumab, either alone or in combination with other FDA-approved drug(s) as part of guideline-endorsed regimens. (who.int)
  • With ACK2 pre-treatment we expect that these cells will grow in the bone marrow of Artemis-deficient mice and restore normal immune function. (ca.gov)
  • This study will investigate the safety and effectiveness of the drug Leflunomide to treat uveitis-an inflammation of the eye caused by an immune system abnormality. (drugpatentwatch.com)