AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureInformation ScienceNamed GroupsHealth Care
Bone Marrow CellsBone Marrow TransplantationBone MarrowStem CellsHematopoietic Stem CellsHematopoietic Stem Cell TransplantationStem Cell TransplantationTissue DonorsHematopoietic Stem Cell MobilizationDonor SelectionTransplantation, HomologousGranulocyte Colony-Stimulating FactorTransplantation, AutologousCell DifferentiationMesenchymal Stem Cell TransplantationAdult Stem CellsBone and BonesCells, CulturedMice, Inbred C57BLHematopoiesisColony-Forming Units AssayMesenchymal Stromal CellsRegenerationRadiation ChimeraCell LineageFlow CytometryProto-Oncogene Proteins c-kitCell SeparationGraft SurvivalAntigens, CD34Bone Marrow DiseasesLiver RegenerationMultipotent Stem CellsBone Marrow ExaminationCell SurvivalBone Marrow NeoplasmsTime FactorsEmbryonic Stem CellsRecovery of FunctionCell DivisionNeovascularization, PhysiologicMice, TransgenicBone RemodelingT-LymphocytesGreen Fluorescent ProteinsHistocompatibility TestingOsteogenesisTreatment OutcomeMice, Inbred BALB CWhole-Body IrradiationHepatocytesBone RegenerationMyocardial InfarctionTransplantation ChimeraDisease Models, AnimalMyocardial IschemiaSpleenBone Marrow PurgingCell MovementStem Cell NichePluripotent Stem CellsAntigens, CDRats, Sprague-DawleyBone DensityCell ProliferationMice, Inbred C3HStem Cell FactorLiverBone ResorptionReverse Transcriptase Polymerase Chain ReactionMyocardiumGraft vs Host DiseaseLymphocytesNeural Stem CellsInduced Pluripotent Stem CellsTissue EngineeringBlood DonorsStromal CellsBone NeoplasmsPhenotypeAnemia, AplasticLeukemiaLiving DonorsTransduction, GeneticImmunohistochemistryBone DevelopmentBone DiseasesGranulocytesMultiple MyelomaLeukemia, Myeloid, AcuteMice, KnockoutOsteoblastsTransplantation ConditioningCell Culture TechniquesImmunophenotypingCell CountFetal Stem CellsMegakaryocytesPancytopeniaMyelodysplastic Syndromes
TransplantTRANSPLANTATIONBiopsyProgenitor cellsDamaged or diseased bone marrowMesenchymalAspirationTissuesChemotherapySmall amount of bone marrowPatient's bone marrowImmatureTissueAplasticProcedureEither bone marrowPBSCCure sickle cell diRecipient'sThalassemiaComplicationsAllogeneic stem cellSpongy materialMyelodysplastic syndromeMicroenvironmentFailure syndromesTherapiesAntigenAbnormalCord bloodPatientGeneLeukemicClinical trialsCentersBlood donorsAdult donorsDoctorsPatientsHematopoietic cellDiseasesReceivesUmbilical cordBonesImmune system
Transplant66
  • The more people are willing to donate stem cells the more patients can find a suitable donor and receive a transplant. (oslo-universitetssykehus.no)
  • When a patient needs a transplant, we will search for a donor with the same tissue type as the patient. (oslo-universitetssykehus.no)
  • Stem cells are harvested from the donor at the time of the transplant. (oslo-universitetssykehus.no)
  • The purpose of the transplant is that the new stem cells will establish a new production of blood cells and blood platelets in the patient. (oslo-universitetssykehus.no)
  • Bone marrow , or stem cell transplant may be recommended for younger people. (medlineplus.gov)
  • It is more likely to be recommended for those 50 years and younger, but people over 50 may receive a transplant if they are healthy enough. (medlineplus.gov)
  • A bone marrow transplant with an unrelated donor may be tried if these medicines do not help or if the disease comes back after getting better. (medlineplus.gov)
  • Bone marrow transplant can be very successful in young people. (medlineplus.gov)
  • In some severely affected patients, NEMO deficiency syndrome is treated using a bone marrow or blood stem cell transplant. (wikipedia.org)
  • A stem cell transplant has the best chance to cure CML. (webmd.com)
  • Can I Get a Stem Cell Transplant? (webmd.com)
  • Are you considering a blood stem cell transplant? (nih.gov)
  • This study is investigating a new method for collecting blood stem cells from donors to see if it reduces transplant complications, such as rejection, in patients who have blood diseases. (nih.gov)
  • Have you received a stem cell transplant? (nih.gov)
  • This study aims to monitor the long-term health of patients who have received a donor stem cell transplant from the NIH Clinical Center. (nih.gov)
  • Are you scheduled for a stem cell transplant with cord blood? (nih.gov)
  • Eligibility includes having developed cytopenias (reduced blood cell counts) and not having an HLA-identical matched sibling donor for bone marrow transplant (BMT). (fanconi.org)
  • The objective of the study is to prepare the patient's body before a stem cell transplant by using an antibody-drug instead of radiation/chemotherapy to make transplants safer. (fanconi.org)
  • Close to 5,000 people in the U.S. undergo a bone marrow transplant annually. (medicalxpress.com)
  • Also known as a stem cell transplant, this procedure replaces damaged or diseased bone marrow with healthy cells. (medicalxpress.com)
  • You may be a candidate for a bone marrow transplant (also known as a stem cell transplant) when other therapies prove ineffective. (healthline.com)
  • A bone marrow transplant can sometimes be risky. (healthline.com)
  • Your doctor may suggest maintenance therapy after a bone marrow transplant. (healthline.com)
  • A stem cell transplant using marrow collected from a matched healthy donor, usually a brother or sister. (leukaemia.org.au)
  • A bone marrow transplant is a non-surgical procedure to replace damaged blood-forming cells with healthy, immature donor cells (stem cells). (childrensnational.org)
  • Learn more about our Blood and Marrow Transplant program. (childrensnational.org)
  • Stem cell transplant - also called bone marrow transplant, in this procedure a donor's stem cells are transfused into your blood. (bidmc.org)
  • p>A blood and bone marrow transplant takes unhealthy stem cells out of the bone marrow and replaces them with healthy stem cells, with the intent to treat childhood cancers and nonmalignant blood and bone marrow diseases. (nemours.org)
  • After her first cycle of chemotherapy, her counts would not come back up and the leukemia was still there so we started planning a bone marrow/stem cell transplant. (lls.org)
  • The Love Hope Strength bone marrow registry did two drives for Madi, and as soon as she was 100 days post-transplant, we started volunteering and working to add more people to "the list. (lls.org)
  • A blood and marrow stem cell transplant replaces faulty stem cells with healthy ones from another person (a donor). (pediatriconcall.com)
  • A stem cell transplant is the only treatment that can cure thalassemia. (pediatriconcall.com)
  • A bone marrow transplant may be autologous (using a patient's own stem cells that were collected from the marrow and saved before treatment), allogeneic (using stem cells donated by someone who is not an identical twin), or syngeneic (using stem cells donated by an identical twin). (cancer101.org)
  • It may be performed using cells from the patient's own body (autologous transplant) or cells from a donor (allogeneic transplant). (mayo.edu)
  • For the first time, researchers have found that having a healthy balance of microorganisms in the body before a bone marrow transplant is associated with higher survival rates after the transplant. (mskcc.org)
  • In this condition, a donor's immune cells attack the vital organs of a transplant recipient. (mskcc.org)
  • In a bone marrow transplant, the recipient's unhealthy blood stem cells are replaced with a donor's healthy ones, which go on to make a variety of immune cells. (medium.com)
  • Treatment for multiple myeloma with symptoms may depend on the age and overall health of the person, which determines whether they are eligible for a stem cell transplant. (medicalnewstoday.com)
  • A new story I wrote for Stanford Medicine magazine explains how an unusual stem cell transplant technique used at Lucile Packard Children's Hospital Stanford saved the lives of the boys, who are now 2 and 1. (stanford.edu)
  • An ideal transplant sce-nario is to use stem cells donated by a healthy sibling with a 10-for-10 antigen match. (stanford.edu)
  • The processing method allowed Ronnie and Levi to receive a stem cell transplant from their father, who does not have the autoimmune disease. (stanford.edu)
  • Tampa, FL (Oct. 3, 2022) - As part of its commitment to world-class, innovative cancer care for the Tampa Bay region and beyond, Tampa General Hospital (TGH) Cancer Institute has established an adult Bone Marrow Transplant (BMT) and Cell Therapies unit that focuses on treating patients with aggressive blood cancers such as leukemias, lymphomas, multiple myeloma as well as other cancers. (tgh.org)
  • Bone marrow transplant (BMT), also known as stem cell therapy (SCT), is a proven treatment for patients with cancers of the blood for which the standard treatments have not been effective or those who have a high risk of relapsing after traditional therapies. (tgh.org)
  • Bone marrow transplant and now cell therapies can significantly increase the chance of recovery from blood cancers and, hopefully soon, of patients with solid malignancies," said Dr. Abraham Schwarzberg, chief of oncology and senior vice president of network development at Tampa General. (tgh.org)
  • In addition to physicians who are hematology oncologists with specific training in bone marrow transplant and immunotherapy, the team includes highly trained nurse practitioners, nurse navigators, nurses, social workers, counselors, spiritual services, physical and occupational therapy, dietary services, and pharmacy. (tgh.org)
  • Tampa General's cancer physicians offer a highly coordinated range of multidisciplinary specialties such as hematologic malignancies, thoracic, breast, colorectal, gynecologic oncology, and now bone marrow transplant and cell therapies. (tgh.org)
  • There is only one approved treatment that can cure sickle cell disease: a bone marrow transplant in which a healthy donor offers stem cells that create red blood cells in the sick patient. (wkbn.com)
  • Though they're doing something novel in the space of fixing the problem in the cell, you're still giving a transplant because you need to get those cells back in the body," said Titilope Fasipe, co-director of the Texas Children's Hospital sickle cell program. (wkbn.com)
  • Building off experience in hematopoietic stem cell transplant and exploiting advances in genetic engineering, genome editing, immunology, immunotherapy, stem cell biology, understanding disease mechanisms and cell therapy manufacturing, considerable progress has been made with hundreds of clinical trials underway. (bdbiosciences.com)
  • What is a Bone Marrow Transplant? (icla.org)
  • A bone marrow or cord blood transplant is used to treat more than 70 diseases, including leukemia, lymphoma, and sickle cell disease. (icla.org)
  • A bone marrow transplant takes a donor's healthy blood-forming cells and puts them into the patient's bloodstream, where they begin to grow and make healthy red blood cells, white blood cells, and platelets. (icla.org)
  • On the day of the transplant, the patient receives the donated cells. (icla.org)
  • When a person needs a bone marrow transplant, doctors must retrieve and harvest stem cells from that individual or a donor. (popsci.com)
  • If the strategy proves effective and equally quick-acting in humans, it could have significant implications for stem cell donation and transplant, he says. (popsci.com)
  • A marrow transplant may be someone's only hope for a cure. (bethematch.org)
  • Learn how marrow donation works, the steps of a patient transplant, steps of donation, and factors that can impact the likelihood of finding a match. (bethematch.org)
  • You could be a possible match for a patient in need of a bone marrow transplant. (bethematch.org)
  • Donor lymphocyte infusion (DLI) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been widely used in preventing post-transplant relapse. (bvsalud.org)
  • Their recent research aims to help more patients find a cure through expanded bone marrow transplant treatment and gene therapy. (medlineplus.gov)
  • In a more traditional bone marrow transplant, a patient is first treated with chemotherapy. (medlineplus.gov)
  • Then, he or she receives a bone marrow transplant from a healthy donor. (medlineplus.gov)
  • To provide insights into their pathogenic potential in vivo, we assessed the frequency of PARV4/5 viremia in healthy patients, transplant patients, and those with suspected viral disease. (cdc.gov)
  • Is a matched unrelated donor search needed for all allogeneic transplant candidates? (cdc.gov)
  • Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)
  • For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
TRANSPLANTATION47
Biopsy5
  • A bone marrow biopsy shows fewer-than-normal blood cells and an increased amount of fat. (medlineplus.gov)
  • Bone marrow aspiration or biopsy. (uhhospitals.org)
  • biopsy - either a bone marrow biopsy to examine blood cells, or a surgical or CT-guided biopsy to obtain lymph node tissue samples. (bidmc.org)
  • After your test results come in, your doctor may want to do a bone marrow biopsy. (webmd.com)
  • Single-cell PCR performed on the DNA extracted from isolated BM erythroid and myeloid progenitors in the formalin-fixed, paraffin-embedded BM tissue biopsy specimens, collected 2 days before death and at autopsy, were PARV4/5 negative. (cdc.gov)
Progenitor cells6
  • Annamarija Raic, Lisa Rodling, Hubert Kalbacher, Cornelia Lee-Thedieck: Biomimetic macroporous PEG hydrogels as 3D scaffolds for the multiplication of human hematopoietic stem and progenitor cells. (disabled-world.com)
  • The etiology of bone marrow failure (BMF) includes defective stem/progenitor cells and/or stroma/accessory cells/growth factors, as well as deficient nonspecific nutrients or, as in the case of acquired aplastic anemia, immune-mediated abnormalities. (medscape.com)
  • MegaCult™-C Collagen and Medium with Lipids kit includes medium and collagen solution for colony-forming unit (CFU) assays of human or mouse megakaryocyte progenitor cells (CFU-Mk). (stemcell.com)
  • This process relies on the formation of a blastema, a pool of progenitor cells that is formed in response to amputation. (lu.se)
  • This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
  • Early fate decisions in hematopoietic stem and progenitor cells. (lu.se)
Damaged or diseased bone marrow1
Mesenchymal9
  • Bone marrow mesenchymal stem cells from healthy donors and sporadic amyotrophic lateral sclerosis patients. (unito.it)
  • We analyzed expanded mesenchymal stem cells (MSCs) isolated from sporadic ALS patients and compared them with MSCs isolated from healthy donors. (unito.it)
  • Mesenchymal stem cells (MSCs) possess great therapeutic potential. (hindawi.com)
  • The differentiation of mesenchymal stem cells (MSCs) into multiple cell lineages can be exploited as an attractive strategy for cell-based therapy and regenerative medicine [ 1 ]. (hindawi.com)
  • The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. (techscience.com)
  • The bone marrow microenvironment (BMME) is a complex network system primarily comprising stromal cells such as mesenchymal stem cells (MSCs), osteoprogenitor cells, vascular endothelial cells, monocytes, macrophages, and cytokines. (techscience.com)
  • Prochymal is a preparation of mesenchymal stem cells obtained from the bone marrow of healthy donors and specially formulated for intravenous infusion. (wtnnews.com)
  • Inspired from developmental processes, human mesenchymal cell lines can be programmed to form cartilage, bone and bone marrow tissues in vitro and in vivo. (lu.se)
  • These dental stem cells are considered mesenchymal stem cells (MSCs) and possess different levels of capacities to become specific tissue forming cells. (bvsalud.org)
Aspiration1
  • Bone marrow aspiration is performed after hematopoietic recovery, or day 28 at the latest. (cancercentrum.se)
Tissues18
  • Hodgkin lymphoma cells can also spread (metastasize) to other organs and tissues. (uhhospitals.org)
  • However, MSCs need to be expanded in vitro in order to obtain sufficient cells for clinical trials since they are extremely rare in various tissues. (hindawi.com)
  • Red blood cells use haemoglobin to carry oxygen to your tissues and organs. (bupa.co.uk)
  • The removal of cells or tissues for examination by a pathologist. (cancer101.org)
  • These complex sugars play crucial roles in maintaining healthy tissues and organs. (cbinsights.com)
  • Center for Regenerative Biotherapeutics protocols have been developed to generate adult stem cell-derived bonelike, nerve-like and heart-like tissues. (mayo.edu)
  • Transplanting organs, tissues or cells from one person to another. (mayo.edu)
  • Transplanting tissues or cells from one area of a person's own body to another. (mayo.edu)
  • Using specific types of stem cells to repair damaged tissues and treat disease. (mayo.edu)
  • Brothers Ronnie and Levi Dogan were born with IPEX syndrome , a life-threatening genetic disease that causes patients' immune systems to attack their own healthy tissues. (stanford.edu)
  • Tissues and organs from living donors are preferable because they are usually healthier. (msdmanuals.com)
  • Stem cells (from bone marrow, umbilical cord blood, or blood from a vein) and kidneys are the tissues most often donated by living donors. (msdmanuals.com)
  • In the United States, being paid to donate an organ is illegal, but reimbursement for cells and tissues is allowed. (msdmanuals.com)
  • PARV4/5 were also found in bone marrow (BM) and lymphoid tissues from 17 of 24 HIV-positive cadavers from Scotland ( 4 ) and in BM aspirates from 16 of 35 Italian patients with AIDS ( 5 ). (cdc.gov)
  • Although current treatment modalities offer high levels of success for many conditions, an ideal form of therapy might consist of regenerative approaches in which diseased or necrotic pulp tissues are removed and replaced with healthy pulp tissue to revitalize teeth. (bvsalud.org)
  • All tissues originate from stem cells. (bvsalud.org)
  • A stem cell is commonly defined as a cell that has the ability to continuously divide and produce progeny cells that differentiate (develop) into various other types of cells or tissues. (bvsalud.org)
  • Postnatal stem cells have been sourced from umbilical cord blood, umbilical cord, bone marrow, peripheral blood, body fat, and almost all body tissues, including the pulp tissue of teeth 8 . (bvsalud.org)
Chemotherapy11
  • First, you get high doses of chemotherapy drugs to kill blood-forming stem cells in your bone marrow. (webmd.com)
  • Chemotherapy is a powerful treatment used to kill cancer cells. (healthline.com)
  • Additionally, a steroid such as prednisone may be prescribed to off-set some chemotherapy side effects while also suppressing inflammation and cancer cell growth. (healthline.com)
  • Commonly used for solitary plasmacytomas, radiation therapy may also be considered in cases of bone damage or a non-response to chemotherapy. (healthline.com)
  • Chemotherapy for cancer treatment can affect your bone marrow. (bupa.co.uk)
  • Chemotherapy interferes with cancer cells' ability to grow. (bidmc.org)
  • Doctors extract stem cells from your blood or bone marrow, place them in frozen storage, and re-infuse them back into your body following high-dose chemotherapy to eliminate blood cancers. (bidmc.org)
  • After the patient receives high-dose chemotherapy, the collected stem cells are thawed and given back to the cancer patient through an intravenous infusion (IV) to produce blood cells and to re-establish a healthier immune system. (tgh.org)
  • Before a patient can receive new bone marrow, they must first undergo chemotherapy to kill off the faulty cells. (wkbn.com)
  • Right now, GCSFs don't work for some patients who might benefit from autologous stem cell transplants-a procedure where doctors harvest a person's own stem cells and use them to replace their unhealthy bone marrow, that's used in conditions like Hodgkin's lymphoma-because they often don't work in people who have had chemotherapy in the past. (popsci.com)
  • Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
Small amount of bone marrow2
Patient's bone marrow2
Immature3
Tissue21
  • As a volunteer donor you will first be tissue typed. (oslo-universitetssykehus.no)
  • After you have been tissue typed, your data will be entered into the database of The Norwegian Bone Marrow Donor Registry. (oslo-universitetssykehus.no)
  • If a sister or a brother has the same tissue type as the patient, she or he will be the best donor. (oslo-universitetssykehus.no)
  • If the patient does not have a sibling or other close relatives with the same tissue type, one will need to search for an unrelated donor with the same tissue type as the patient. (oslo-universitetssykehus.no)
  • Bone marrow is the spongy tissue present inside the centre of bones. (newscientist.com)
  • They have their own bone tissue and now an additional one that can be used if needed. (newscientist.com)
  • Bone marrow is the soft, tissue in the center of bones that is responsible for producing blood cells and platelets. (medlineplus.gov)
  • Or solid bone marrow tissue may be removed with a needle. (uhhospitals.org)
  • Bone marrow is a soft tissue inside your bone that creates blood-forming cells. (healthline.com)
  • MSCs can easily be obtained from various human tissue sources such as the bone marrow, cord blood, placenta, and adipose [ 2 - 5 ]. (hindawi.com)
  • Neurosurgery researchers have used a new, leading-edge stem cell therapy to promote the growth of bone tissue following the removal of cervical discs -- the cushions between the bones in the neck -- to relieve chronic, debilitating pain. (sciencedaily.com)
  • It used bone marrow-derived adult stem cells to promote the growth of the bone tissue essential for spinal fusion following surgery, as part of a nationwide, multicenter clinical trial of the therapy. (sciencedaily.com)
  • Current methods of promoting spinal fusion include implanting bone tissue from the patient's hip or a cadaver to encourage bone regrowth as well as implanting bone growth-inducing proteins. (sciencedaily.com)
  • The pathologist may study the tissue under a microscope or perform other tests on the cells or tissue. (cancer101.org)
  • The process of removing all the cells from a donor organ, such as a heart or lung, leaving behind just a tissue scaffold. (mayo.edu)
  • The cells of this cancer have features of plasma cells as well as lymphoid tissue. (webmd.com)
  • And the best match possible is a sibling who happens to have the same tissue type that they do, but only about less than 20 percent of sickle cell patients will have a sibling with an appropriate match," said Alexis Thompson, chief of the Division of Hematology at Children's Hospital of Philadelphia. (wkbn.com)
  • Victoria Gray, the first sickle cell patient to undergo exa-cel, told the FDA's advisory committee on cellular, tissue, and gene therapies that the treatment freed her from constant hospital visits due to SCD-related pain events. (wkbn.com)
  • He anticipates launching a clinical trial soon to study the safety of injecting stem cells into disc tissue to repair degenerated discs. (weeksmd.com)
  • The key elements of tissue engineering are stem cells, morphogen, and a scaffold of extracellular matrix. (bvsalud.org)
  • Subsequent regenerative dental procedures include the development of guided tissue or bone regeneration (GTR, GBR) procedures and distraction osteogenesis 2 the application of platelet rich plasma (PRP) for bone augmentation 17 . (bvsalud.org)
Aplastic5
Procedure5
  • This procedure transplants a donor's healthy blood-forming cells into your body. (healthline.com)
  • The stem cell procedure at UC Davis took place early in August. (sciencedaily.com)
  • The leading-edge stem cell procedure is part of a prospective, randomized, single-blinded controlled study to evaluate the safety and preliminary efficacy of an investigational therapy: modified bone marrow-derived stem cells combined with the use of a delivery device as an alternative to promote and maintain spinal fusion. (sciencedaily.com)
  • But only a small number of people who have severe thalassemias are able to find a good donor match and have a risky procedure. (pediatriconcall.com)
  • A procedure in which a patient receives healthy blood-forming cells (stem cells) to replace their own stem cells that have been destroyed by disease or by the radiation or high doses of anticancer drugs that are given as part of the procedure. (cancer101.org)
Either bone marrow2
PBSC2
  • Bone marrow or PBSC cells are donated by an adult donor between 18 and 40 years of age. (icla.org)
  • After bone marrow or PBSC donation, most donors are back to their normal routine in a few days. (bethematch.org)
Cure sickle cell di1
  • If we could cure sickle cell disease in a safe and effective way, such as a pill that can reverse the disease, that would be a home run. (medlineplus.gov)
Recipient's3
  • The authors confirm chronic graft-versus-host disease (GVHD), a serious complication that occurs when donor cells attack the recipient's cells, as a potential source of sexual dysfunction and say they are the first to demonstrate an association between total body irradiation and sexual dysfunction in men. (science20.com)
  • Leukemic transformation of healthy donor HSCs in recipient's bone marrow microenvironment provides a useful in vivo model for investigating the mechanisms involved in leukemogenesis. (bvsalud.org)
  • Whole-genome sequencing indicates that donor-derived cells harboring clonal hematopoiesis of indeterminate potential (CHIP)-associated genetic alterations expand and eventually transform to full-blown AML via acquisition of additional somatic mutations within the recipient's bone marrow microenvironment. (bvsalud.org)
Thalassemia1
  • 3 Today, serologic and molecular techniques, along with laboratory information systems and electronic health records, contribute to precise blood product management and personalized transfusion therapies, particularly benefiting complex patients with sickle cell disease, thalassemia, and other diseases requiring chronic transfusion support. (cap.org)
Complications6
  • One of the most serious complications of blood stem cell or bone marrow transplants (BMTs) , which are used to treat many types of blood cancer, is graft-versus-host disease (GVHD). (mskcc.org)
  • Blood and bone marrow transplants have been done for decades and have always had risks of complications, like virtually any treatment for serious diseases, but a new study has found an additional one for the list: sexual health. (science20.com)
  • The disease causes red blood cells to become sickle or c-shaped, clumping together and clogging blood vessels, causing pain and other complications. (wkbn.com)
  • Millions worldwide suffer complications from sickle cell disease and nearly 300,000 infants with sickle cell disease are born each year. (childrenshospital.org)
  • A variety of symptoms and complications of sickle cell disease occur. (childrenshospital.org)
  • All complications of sickle cell disease may occur but tend to be a milder degree. (childrenshospital.org)
Allogeneic stem cell2
  • While both treatments help your bone marrow to develop new blood cells, studies show allogeneic stem cell transplantations work by causing the donor cells to attack unhealthy cells. (clevelandclinic.org)
  • The expanded analysis now includes 8,767 stool samples from 1,362 people who have had allogeneic stem cell or bone marrow transplants at four centers around the world. (mskcc.org)
Spongy material2
Myelodysplastic syndrome1
  • Bone marrow loss and a high proclivity to leukemic progression are the characteristics of myelodysplastic syndrome (MDS). (techscience.com)
Microenvironment3
  • The microenvironment, consisting of lymphocytes, macrophages, fibroblasts, endothelial elements, and stroma in which hematopoietic cells reside, creates a regulatory niche that determines the local area network. (medscape.com)
  • The bone marrow stromal cell (BMSC) population, which makes up a large part of the hematopoietic microenvironment, encompasses a variety of adherent cell types. (techscience.com)
  • The fourth generation of CAR-T design attempts to deliver cytokines to modulate the tumor microenvironment either by activating host effector T cells or hampering host suppressors and reinforcing memory T cells. (bdbiosciences.com)
Failure syndromes1
  • Inherited bone marrow failure syndromes (IBMFS) are usually the result of intrinsic stem cell/progenitor defects. (medscape.com)
Therapies15
  • Patient must not be on other experimental therapies at the time and not have active cancers or concerns for high-risk bone marrow disease. (fanconi.org)
  • Systemic treatments, such as targeted therapies may be selected if cancer cells are present in multiple areas of your body. (healthline.com)
  • When used in combination with other therapies, these drugs may help treat myeloid cells, according to in-vivo studies . (healthline.com)
  • Along with a technique called TALENs, invented several years ago, and a slightly older predecessor based on molecules called zinc finger nucleases, CRISPR could make gene therapies more broadly applicable, providing remedies for simple genetic disorders like sickle-cell anemia and eventually even leading to cures for more complex diseases involving multiple genes. (technologyreview.com)
  • Most conventional gene therapies crudely place new genetic material at a random location in the cell and can only add a gene. (technologyreview.com)
  • Other biological therapies attack specific cancer cells, which may help keep them from growing or kill them. (cancer101.org)
  • Discover which therapies are expected to grab the major mucopolysaccharidosis market share @ Mucopolysaccharidosis Market Report Mucopolysaccharidosis Overview Mucopolysaccharidosis (MPS) refers to a group of inherited metabolic disorders characterized by the accumulation of glycosaminoglycans (GAGs) within cells throughout the body. (cbinsights.com)
  • However, we are just beginning to realize the power of an emerging field known as cell therapies. (tgh.org)
  • In our BMT and Cell Therapies unit, we aim to provide these therapies as well as make groundbreaking contributions to the field through innovative research. (tgh.org)
  • After several months of careful planning and designing, the TGH Cancer Institute BMT and Cell Therapies Unit opened in Spring 2022. (tgh.org)
  • The TGH Cancer Institute's BMT and Cell Therapies Unit reflects the Institute's philosophy of bringing together a range of multidisciplinary specialties that strongly emphasizes compassionate and personalized care focusing on the whole patient. (tgh.org)
  • Engineered chimeric antigen receptor (CAR) T cell therapies (CAR-T) are now commercially available to treat certain leukemias and lymphomas. (bdbiosciences.com)
  • Investigational cell therapies are addressing a wide range of hematological malignancies. (bdbiosciences.com)
  • Literature review: This review summarizes current knowledge, barriers, and challenges in the clinical use of adult stem cells, scaffolds, and growth factors for the development and evaluation of regenerative endodontic therapies. (bvsalud.org)
  • This explains why researchers are now focusing attention on developing stem cell therapies using postnatal stem cells donated by the patients themselves or their close relatives. (bvsalud.org)
Antigen3
  • A protein made by plasma cells (type of white blood cell) in response to an antigen (a substance that causes the body to make an immune response against that substance). (cancer101.org)
  • Others make it easier for white blood cells to destroy the antigen. (cancer101.org)
  • The technique has also shown preliminarily promising outcomes in B cell acute lymphoblastic leukemia (B-ALL), B cell non-Hodgkin's lymphoma (B-NHL), chronic lymphocytic leukemia (CLL), Hodgkin's lymphoma and multiple myeloma in clinical trials targeting CD19, CD20, CD22, CD30 and B-cell maturation antigen (BCMA), with many more under investigation. (bdbiosciences.com)
Abnormal11
  • When you have this cancer, it makes a lot of abnormal white blood cells that don't fight infections well. (webmd.com)
  • It carries a new gene called bcr-abl, which sets off a process that creates abnormal white blood cells. (webmd.com)
  • Only a small number of abnormal white blood cells are in your blood and bone marrow, so your body is still able to fight infections. (webmd.com)
  • When you're in this stage, the number of your abnormal blood cells has increased. (webmd.com)
  • The number of abnormal blood cells in your bone marrow and blood is now high. (webmd.com)
  • They kill off CML blood cells by blocking the protein made by the abnormal gene bcr-abl. (webmd.com)
  • Hodgkin lymphoma causes abnormal growth of the cells in the lymphatic system. (uhhospitals.org)
  • Through this process, the cells that produced the abnormal cells are replaced with healthy cells that produce normal blood cells. (bidmc.org)
  • In someone who has SCD, the hemoglobin is abnormal, which causes the red blood cells to become hard and sticky and look like a C-shaped farm tool called a "sickle. (cdc.gov)
  • People who have this form of SCD inherit two genes, one from each parent, that code for hemoglobin "S." Hemoglobin S is an abnormal form of hemoglobin that causes the red cells to become rigid, and sickle shaped. (cdc.gov)
  • These abnormal cells can't protect the body from germs. (kidshealth.org)
Cord blood2
Patient20
  • These results suggest that extensive in vitro expansion of patient MSCs does not involve any functional modification of the cells, including chromosomal alterations or cellular senescence. (unito.it)
  • Imagine being able to donate healthy stem cells to a patient and thus saving the life of a patient. (oslo-universitetssykehus.no)
  • As a volunteer in The Bone Marrow Donor Registry you may be asked to donate stem cells to a patient. (oslo-universitetssykehus.no)
  • Afterwards, the patient receives healthy stem cells from the donor through an intravenous infusion, just like a regular blood transfusion. (oslo-universitetssykehus.no)
  • Patient must be willing to attend a single clinic visit lasting about 7 hours, consume one alcoholic drink, and provide saliva, mouth cells, and urine samples. (fanconi.org)
  • The affected cells of the patient are replaced by healthy hematopoietic stem cells of an eligible donor. (disabled-world.com)
  • But such donors must be precisely matched with the patient, and even then, immune rejection-a potentially deadly problem-is a serious risk. (technologyreview.com)
  • After harvesting blood cell precursors called hematopoietic stem cells from the bone marrow of a sickle-cell patient, scientists would use CRISPR to correct the defective gene. (technologyreview.com)
  • Then the gene--corrected stem cells would be returned to the patient, producing healthy red blood cells to replace the sickle cells. (technologyreview.com)
  • She had always been very healthy and had never been in the hospital as a patient before. (lls.org)
  • The healthy stem cells may come from the bone marrow of the patient or a donor. (cancer101.org)
  • Stem cell transplants remove blood-forming stem cells from a healthy donor, and then inject them into a patient, where they take hold and grow in the bone marrow. (stanford.edu)
  • We will not have to face all the problems of compatibility between the donor and patient. (stanford.edu)
  • This therapy involves taking stem cells from the bone marrow or peripheral blood from a cancer patient or from a donor. (tgh.org)
  • Gene therapy really becomes a really important option because the patient is their own donor," said Thompson. (wkbn.com)
  • Patient PBMCs are collected by leukapheresis followed by enrichment approaches to isolate T cells while removing other cells such as B cells, monocytes, neutrophils, dendritic cells and contaminating tumor cells. (bdbiosciences.com)
  • Quality control testing is essential to ensure the CAR-T cell product meets established specifications for manufacturing release and patient infusion. (bdbiosciences.com)
  • Harvested cells are then administered to the patient. (bdbiosciences.com)
  • Doctors will choose the best source of cells for a patient. (icla.org)
  • Now we can take the patient's own bone marrow, use an engineered virus that carries genes to the bone marrow, and give repaired bone marrow stem cells back to the patient so that healthy bone marrow cells can grow,' Dr. Tisdale says. (medlineplus.gov)
Gene12
  • A disease caused by a single mutation, in a single gene, that involves only a single cell type. (technologyreview.com)
  • For example, it might be possible someday to insert a normal hemoglobin gene into stem cells in the bone marrow. (pediatriconcall.com)
  • People who have sickle cell trait (SCT) inherit a hemoglobin "S" gene from one parent and a normal gene (one that codes for hemoglobin "A") from the other parent. (cdc.gov)
  • The reason, researchers found, was that Crohn had a mutation in a gene called CCR5 , which effectively blocks HIV from entering immune cells. (medium.com)
  • The main, huge difference is that with gene therapy we correct the patient's cells,' Bacchetta said. (stanford.edu)
  • The Hill ) - A breakthrough treatment for sickle cell patients could soon become the first gene-editing treatment to be approved by the Food and Drug Administration (FDA). (wkbn.com)
  • People with sickle cell trait have one copy of the HbS gene and one copy of the normal hemoglobin A gene ( HbA ). (childrenshospital.org)
  • People with sickle cell trait may pass on the HbS gene to their children. (childrenshospital.org)
  • The type of sickle cell disease depends on the specific gene variant that your child has inherited. (childrenshospital.org)
  • To address these limitations, Dr. Rodgers, Dr. Tisdale, and their research teams are studying how to repair bone marrow through gene therapy. (medlineplus.gov)
  • At present, about 5% of the world's population are carriers of a potentially pathological haemoglobin gene (i.e. healthy people who have inherited only one mutant gene from one parent). (who.int)
  • Globally, the percentage of carriers of thalassaemia is greater than that of carriers of sickle-cell anaemia, but because of the higher frequency of the sickle-cell gene in certain regions, the number of affected births is higher than with thalassaemia. (who.int)
Leukemic3
  • Acute myeloid leukemia (AML) is a disease with diverse genetic features of the leukemic cells and with variable outcome. (cancercentrum.se)
  • In all patients that might become considered for intensive treatment, the AML diagnosis should be based on morphologic and immunophenotypic features of bone marrow aspirates as well as on genetic characteristics of the leukemic blasts. (cancercentrum.se)
  • Storage of bone marrow or blood leukemic cells in biobanks is strongly recommended. (cancercentrum.se)
Clinical trials2
  • Clinical trials can be vexing, just ask anyone associated with Osiris Therapeutics, a leading stem cell therapeutic company. (wtnnews.com)
  • T cell-targeted immunomodulators such as monoclonal antibodies against PD-1 or CTLA4 may be used in combination with CAR-T cells in clinical trials. (bdbiosciences.com)
Centers2
  • Resilient blood centers implemented operational changes and intensified donor recruitment efforts to stabilize the situation. (cap.org)
  • 9 Blood centers are actively urging healthy donors to contribute, bearing in mind that only 3% of eligible Americans donate blood. (cap.org)
Blood donors3
Adult donors1
  • The product, administered through tiny holes bored into the skull and placed near the site of the damage, came from the bone marrow of two healthy adult donors. (news-medical.net)
Doctors3
  • Doctors use these to rule out other causes of symptoms, or look for a mass of leukemia cells in the chest that can affect breathing or blood circulation. (kidshealth.org)
  • Doctors carefully look at the cancer cells and figure out the type and subtype of the leukemia. (kidshealth.org)
  • Doctors request donors in the 18-35 age group nearly 75% of the time. (bethematch.org)
Patients28
  • No morphological differences were observed in the MSCs isolated from donors or patients. (unito.it)
  • The cellular expansion potential of MSCs from donors and patients was slightly different. (unito.it)
  • After three passages, the MSCs isolated from donors reached a cumulative population doubling higher than from patients but the difference was not statistically significant. (unito.it)
  • No significant differences between donors or patients were observed in the immunophenotype analysis. (unito.it)
  • Hence, there is a good chance that MSCs might be used as a cell-based therapy for ALS patients. (unito.it)
  • Dr. Cohen has developed a program called Common Sense Parenting, and educates patients and families on how to raise healthy children-stress free. (barnesandnoble.com)
  • Patients receiving the control were 3.5 times more likely to experience degenerative bone changes associated with OA as compared to those receiving Chondrogen. (salesandmarketingnetwork.com)
  • This is an exciting clinical trial to test the ability of the bone-forming stem cells from healthy donors to help patients with spinal disease," said Jan Nolta, director of the UC Davis Institute for Regenerative Cures. (sciencedaily.com)
  • For the past 50 years, bone marrow-derived stem cells have been used to rebuild patients' blood-forming systems. (sciencedaily.com)
  • This new technology may help patients grow new bone, and it avoids harvesting a bone graft from the patient's own hip or using bone from a deceased donor. (sciencedaily.com)
  • This trial is one of the first randomized, sham-controlled studies to test the efficacy of administering adult-derived stem cells in patients disabled with a chronic stroke," said Sean I. Savitz, M.D., professor and the Frank M. Yatsu Chair in Neurology at McGovern Medical School and director of the UTHealth Institute for Stroke and Cerebrovascular Disease. (news-medical.net)
  • In the double-blind, sham-surgery controlled study, patients randomized to the study intervention will receive a stem cell product made by SanBio and patients must have chronic motor deficits from an ischemic stroke to be eligible for the study. (news-medical.net)
  • Through this line, patients will receive healthy blood. (pediatriconcall.com)
  • So, patients may need repeated transfusions to maintain a healthy supply of red blood cells. (pediatriconcall.com)
  • But it's not practical to give all HIV patients bone marrow transplants. (medium.com)
  • But traditional stem cell transplants are so risky that they've usually been offered only to patients who would otherwise die. (stanford.edu)
  • But patients from ethnic minority populations are less likely than white patients to match to a reg-istered donor, and none were a fit for Ronnie or Levi, who are black. (stanford.edu)
  • As a re-sult, patients can be safely transplanted us-ing stem cells from a donor with only 5 of 10 matching HLA antigens -- such as a parent. (stanford.edu)
  • Antibody-based hematopoietic stem cell transplants may transform the treatment of patients with blood and immune diseases including cancers. (stanford.edu)
  • After examining the data with the FDA, it was concluded that that there was a potential "systematic design flaw" in the trial that "might be related to the fact that patients responding to the initial stem cell therapy were eligible to participate in a second, longer-term trial evaluating Prochymal as a maintenance therapy. (wtnnews.com)
  • The drugs also can't be used in patients with sickle cell disease. (popsci.com)
  • Research shows cells from younger, healthy donors lead to more successful stem cell transplants for patients. (bethematch.org)
  • At Be The Match our goal is to find a cure for patients and protect the safety of both patients and donors. (bethematch.org)
  • While it's not a cure, hydroxyurea helps red blood cells better carry oxygen in patients with moderate to severe SCD. (medlineplus.gov)
  • Patients with thalassaemia need regular transfusions of red blood cells (once or twice monthly) in order to maintain a mean haemoglobin concentration of about 9.0-10.5 g/dl. (who.int)
  • In practice, however, a compatible donor can be found for less than 30% of patients, and the success rate of the intervention depends on their age and the quality of clinical management they have received throughout their lives. (who.int)
  • In patients with Niemann-Pick disease type A, the infantile form, sphingomyelinase activity is 0.7% of that of healthy individuals, whereas in patients with adult-onset neuronopathic or nonneuronopathic disease, the activity is 0-19% of that of healthy individuals. (medscape.com)
  • In both healthy individuals and patients with Niemann-Pick disease types A and B, fibroblasts synthesize sphingomyelinase polypeptides with the same molecular mass of 110 kd, in the same amount. (medscape.com)
Hematopoietic cell1
Diseases7
  • Cell replacement therapy has been suggested as a promising therapeutic approach for multiple neurodegenerative diseases, including motor neuron disease. (unito.it)
  • Bone marrow transplants are sometimes needed to treat immune diseases that attack these stem cells, or in certain types of anaemia, in which the body can't make enough blood cells or clotting factors. (newscientist.com)
  • The finding may lead to new treatments for osteoporosis and other diseases that occur when the body doesn't make enough bone. (wustl.edu)
  • Hematopoietic stem cells can be used for the treatment of blood diseases, such as leukemia. (disabled-world.com)
  • While he has ambitions to eventually work on a variety of diseases, Bao says it makes sense to start with sickle-cell anemia. (technologyreview.com)
  • Solid tumors, autoimmune diseases, graft versus host disease (GvHD), genetic diseases and neurodegenerative diseases are investigated using many types of autologous and allogeneic cells with rapidly evolving cell engineering and editing approaches. (bdbiosciences.com)
  • Many people don't realize the severity of this disease,' says John Tisdale, M.D., senior investigator at NIH's National Heart, Lung, and Blood Institute, who leads NIH sickle cell disease research along with Griffin Rodgers, M.D., director of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). (medlineplus.gov)
Receives1
Umbilical cord1
  • Cells collected from the umbilical cord, occur only after a full-term delivery where both mother and baby are healthy and safe. (icla.org)
Bones7
Immune system4
  • Older people and those who do not have a matched sibling donor are given medicine to suppress the immune system. (medlineplus.gov)
  • The aim is to replace the faulty immune system with an immune system from a healthy donor. (wikipedia.org)
  • Immunotherapy consists of drugs that modulate your immune system to fight cancer cells, and is considered the future of multiple myeloma cancer treatment. (healthline.com)
  • A lack of white blood cells can also weaken your immune system. (webmd.com)