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  • cord
  • Based on the origin and source of isolation, SCs may be included in two main groups: (i) embryonic SCs (ESCs)-derived from embryos at different stages of development and (ii) adult SCs (ASCs)-isolated from several postnatal and adult tissue sources, including the umbilical cord, cord blood, bone marrow, adipose tissue, central nervous system, retina, skeletal muscle and other mature tissues [ 7 , 8 ]. (intechopen.com)
  • Major sources of stem cells for transplantation include bone marrow, peripheral blood and cord blood. (hawaii.edu)
  • A method of collecting embryonic-like stem cells from a placenta which has been treated to remove residual cord blood by perfusing the drained placenta with an anticoagulant solution to flush out residual cells, collecting the residual cells and perfusion liquid from the drained placenta, and separating. (google.es)
  • lymphoma
  • For example, high-dose chemotherapy in the setting of stem cell/bone marrow transplantation has become a useful treatment modality in the management of diffuse large cell lymphoma. (medscape.com)
  • A study by Kim et al determined that although the quality of life (QOL) of patients with intestinal diffuse large B-cell lymphoma who underwent surgery and chemotherapy was lower than that of patients who underwent chemotherapy alone, the difference was acceptable. (medscape.com)
  • Unless contraindicated because of significant and preexisting comorbid conditions, the treatment of diffuse large B-cell lymphoma (DLBCL) should include the use of rituximab- and anthracycline-based-multiagent chemotherapy, and the goal should be to achieve a durable complete remission (ie, cure). (medscape.com)
  • [ 73 ] and has activity in diffuse large cell lymphoma. (medscape.com)
  • A phase II pilot study of rituximab in combination with CHOP in patients with previously untreated diffuse large cell lymphoma or high-grade NHL reported an overall response rate of 97% (32 of 33 patients), with a 61% complete remission rate, a 36% partial remission rate, and a 3% progressive disease rate. (medscape.com)
  • In a study of 435 patients with diffuse large cell lymphoma, Villa et al found that the risk of CNS relapse was significantly reduced with the addition of rituximab to the CHOP regimen compared with risk reduction for patients treated with CHOP alone. (medscape.com)
  • Récher et al compared the efficacy of R-CHOP with that of treatment consisting of rituximab added to a regimen of doxorubicin, cyclophosphamide, vindesine, bleomycin, and prednisone (R-ACVBP) and found significant improvement in survival with the R-ACVBP regimen among patients aged 18-59 years with diffuse large B-cell lymphoma and low intermediate risk. (medscape.com)
  • At relapse, evidence suggests that the cell of origin has a better response to rituximab, dexamethasone, high-dose cytarabine, and cisplatin (R-DHAP) than to rituximab, ifosfamide, carboplatin, and etoposide (R-ICE) in patients with germinal center B (GCB)-like diffuse large B-cell lymphoma. (medscape.com)
  • Mantle cell lymphoma (MCL), a subtype of B-cell non-Hodgkin's lymphoma, has a chemoresistant nature, and thus a very poor prognosis with a median survival of less than 3 years. (iseh.org)
  • These mantle cell lymphoma-initiating cells (MCL-ICs) were highly tumorigenic and had self-renewing properties in vivo, unlike the CD45 + 19 + cells which constituted the bulk of the tumor. (iseh.org)
  • That same year, Pecora was the lead author on the study of CD34+CD33− cells as it relates to chemotherapy treatment and bone marrow transplantation for the treatment of non-Hodgkin's lymphoma (NHL). (wikipedia.org)
  • preclinical
  • Included in this global assessment are the derivation, expansion, manipulation, and characterization of human stem cell lines, as well as preclinical efficacy and toxicity testing in appropriate animal models. (nih.gov)
  • Regrettably, serious preclinical concerns remain and differentiation, cell fusion, senescence and signalling crosstalk with growth factors and biomaterials are still challenges for this promising multidisciplinary therapeutic modality. (mdpi.com)
  • lymphoid cells
  • In the medulla, the network of reticular cells is coarser than in the cortex, the lymphoid cells are relatively fewer in number, and there are concentric, nest-like bodies called Hassall's corpuscles. (wikipedia.org)
  • acute
  • Studies comparing bone marrow to PBSC transplantation have shown that PBSCs are associated with a shorter period of neutropenia and red blood cell and platelet transfusion dependence, with an equal probability of acute and chronic GVHD. (hawaii.edu)
  • microenvironment
  • Moreover, biomaterials may enhance the SCs biological activity and their implementation by establishing a specific microenvironment mimicking natural cell niche. (intechopen.com)
  • Finally, using these syngeneic murine ALL models, the HMS is conducting studies on the role the bone marrow microenvironment plays in immunotherapeutic resistance. (cancer.gov)
  • Oncologist
  • Andrew Louis Pecora (born 1957) is an American hematologist and oncologist who has been involved in the research on the use of stem cells and oncolytic viruses to treat diseases, including cancer. (wikipedia.org)
  • Advances
  • The aim of this review is to describe well established characteristics of stem cells and to delineate new advances in the stem cell field, in the context of burn injury and wound healing. (mdpi.com)
  • transplants
  • Because only a small number of cells are collected, successful transplants are typically limited to smaller sized recipients. (hawaii.edu)
  • abnormalities
  • Fanconi anemia (FA) is an inherited bone marrow failure syndrome characterized by pancytopenia, predisposition to malignancy, and physical abnormalities including short stature, microcephaly, developmental delay, café-au-lait skin lesions, and malformations belonging to the VACTERL-H association. (uptodate.com)
  • Shwachman-Diamond syndrome (SDS) is a rare autosomal recessive disorder characterized by exocrine pancreatic insufficiency, bone marrow dysfunction, and skeletal abnormalities. (medscape.com)
  • regeneration
  • Biologic therapies derived from such cells-through tissue regeneration and repair as well as through the targeted delivery of genetic material-are expected to be effective in the treatment of a wide range of medical conditions. (nih.gov)
  • In addition, the combination of stem cells with biocompatible materials that may constitute a scaffold for the seeded cells may lead to enforcement of biological activity of stem cells and as such accelerate the process of regeneration or restoration of impaired tissue [ 3 , 4 ]. (intechopen.com)
  • adult stem
  • This vast, heterogeneous family of cells are now both naturally (embryonic and adult stem cells) or artificially obtained (induced pluripotent stem cells or iPSCs) and their fates have become increasingly controllable, thanks to ongoing research in this passionate new field. (mdpi.com)
  • I'll discuss about adult stem cells. (celltrials.info)
  • impairs
  • In addition, administration of immunosuppressive drugs to prevent GVHD after HSC transplantation impairs T cell function and increases the risk of opportunistic infection and tumor relapse. (biomedcentral.com)
  • therapies
  • The rapid evolution of cell and gene therapies is giving rise to numerous controversies that need to be carefully addressed. (springer.com)
  • chemotherapy
  • In this study, Ran et al showed that the frequency of ALDH bright cells at diagnosis predicted the failure to achieve complete remission at the end of the first cycle of chemotherapy, and was the strongest prognostic marker affecting overall survival in the multivariate model. (iseh.org)
  • Cancer cells may either exhibit a significant primary resistance to chemotherapeutic drugs (intrinsic resistance), or acquire characteristics of MDR during chemotherapy (acquired resistance). (mdpi.com)
  • The term chemotherapy has come to connote non-specific usage of intracellular poisons to inhibit mitosis, or cell division. (wikipedia.org)
  • To a large extent, chemotherapy can be thought of as a way to damage or stress cells, which may then lead to cell death if apoptosis is initiated. (wikipedia.org)
  • Many of the side effects of chemotherapy can be traced to damage to normal cells that divide rapidly and are thus sensitive to anti-mitotic drugs: cells in the bone marrow, digestive tract and hair follicles. (wikipedia.org)
  • This results in the most common side-effects of chemotherapy: myelosuppression (decreased production of blood cells, hence also immunosuppression), mucositis (inflammation of the lining of the digestive tract), and alopecia (hair loss). (wikipedia.org)
  • Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity). (wikipedia.org)
  • These micrometastases can be treated with adjuvant chemotherapy and can reduce relapse rates caused by these disseminated cells. (wikipedia.org)
  • Pecora et al discovered that patients who had received more than two cycles of chemotherapy and were shown to have "chemotherapy-resistant NHL mobilized a significantly lower percentage of CD34+CD33− cells than did chemotherapy-sensitive NHL patients. (wikipedia.org)
  • They also found the reverse that those who had received less significant levels of chemotherapy treatment had higher levels of CD34+CD33− cells. (wikipedia.org)
  • Fanconi
  • Shwachman-Diamond syndrome is the second most common cause of inherited pancreatic insufficiency after cystic fibrosis and the third most common inherited bone marrow failure syndrome after Fanconi anemia and Blackfan-Diamond anemia. (medscape.com)
  • refractory
  • Dr. Fry will be leading the first-in-human clinical trial using this CAR in children and young adults with relapsed and refractory pre-B cell ALL. (cancer.gov)
  • organs
  • Some are of the view that it is reasonable to expect within the next five years that human stem cells will be used in transplantation settings to replace dead or dying cells within organs such as the failing heart or that genetically modified human stem cells will be created for delivery of therapeutic genes. (nih.gov)
  • Prof Alexander's specific expertise and interests include virus-mediated gene transfer with a focus on target organs including the liver and bone marrow, both of which have immense promise as target organs for the treatment of genetic disease in children. (edu.au)
  • Long-term in vivo imaging of multiple organs at the single cell level. (duke.edu)
  • gene
  • The SBDS gene may not be required for neutrophil maturation but may act to maintain survival of granulocyte precursor cells. (medscape.com)
  • The cortex is the location of the earliest events in thymocyte development, where T-cell receptor gene rearrangement and positive selection takes place. (wikipedia.org)
  • Thymocytes that reach the medulla have already successfully undergone T-cell receptor gene rearrangement and positive selection, and have been exposed to a limited degree of negative selection. (wikipedia.org)
  • therapeutic
  • The capabilities to self-renew and differentiate that are inherent to human stem cells point simultaneously to their perceived therapeutic potential and to the challenge of assessing their safety. (nih.gov)
  • I'd like to look at 3 parts of this problem - quantity, purity and function of stem cells in therapeutic cell product. (celltrials.info)
  • Even if the percentage of well defined stem cells in heterogeneous cell mix is relatively high (aka enriched stem cells), we still have some accessory cells (let's call them contaminants), which could possess therapeutic value. (celltrials.info)
  • The stem cell enrichment is definitely increasing a probability of their contribution into therapeutic effect (aka potency), because of depletion accessory cell-contaminants. (celltrials.info)
  • Finally, the mechanism of therapeutic action by stem cells should be proven and based on evidence. (celltrials.info)