• Perfosfamide was used experimentally by oncologists in the 1980s for use in bone marrow transplant procedures for treatment of blood cancers. (wikipedia.org)
  • Bone Marrow Transplant. (covalab.com)
  • If confirmed, this would be the first time HIV has been eliminated without a bone marrow or stem cell transplant like the ones that have cured two other men, nicknamed the Berlin and London patients for where they were treated. (wxyz.com)
  • A bone marrow transplant was her only treatment option. (dartmouth.edu)
  • In allogeneic stem cell (stem cells from a donor) transplant, there is another benefit in addition to replenishing the HSCs in the bone marrow after chemotherapy or radiotherapy. (parkwaycancercentre.com)
  • It generally requires a bone marrow transplant after a cancer diagnosis. (lgbtqnation.com)
  • It is officially one year since my bone-marrow transplant (BMT)! (blogspot.com)
  • 255 In 1989 Nova Pharmaceutical took over development of the compound and in 1992, it submitted a new drug application to the FDA for using perfosamide to purge malignant cells in transplants for the treatment of acute myeloid leukemia. (wikipedia.org)
  • The cause was a return of the cancer that originally prompted the unusual bone marrow and cell transplants Brown received in 2007 and 2008, which for years seemed to have eliminated both his leukemia and HIV, the virus that causes AIDS. (wxyz.com)
  • bone marrow transplants (using a patient's own marrow after it's been purged of cancer cells), but because Kenyon had acute lymphoblastic leukemia, her own marrow would not work. (dartmouth.edu)
  • Frequently, stem cells are taken from the pelvic bone, filtered, and stored under special conditions for future transplants. (parkwaycancercentre.com)
  • Interestingly, thiscell transplants (PBSCTs) from donors given granulocyte-colony- immature peripheral phenotype was similar to bone marrow transplantsstimulating-factor (G-CSF) has decreased relapse rates and improved before G-CSF. (fliphtml5.com)
  • Our hypothesis about a splenic stem cell contributionor maintained survival compared to bone marrow transplants, to PBSCT also derives from the observation that G-CSF mobilizationsalthough graft versus host disease (GVHD) still occurs [1]. (fliphtml5.com)
  • It was added to the tissue after it had been taken from the donor but before the tissue was administered to the patient to "purge" lymphocytes in order to prevent Graft Versus Host Disease, which results from donor lymphocytes attacking normal host cells and tissues, and to "purge" a patient's own (autologous) collected hematopoietic stem cells of any malignant cells it may still contain at the time of harvesting. (wikipedia.org)
  • A second challenge is funding: many of these approaches involve using the patient's own bone marrow cells. (translationalethics.com)
  • In the present study, we examined immune function after BMT in a series of patients who had received HLA compatible sibling marrow grafts purged of T cells with anti-CD6 monoclonal antibody and complement. (ashpublications.org)
  • eg, bone, bone marrow, and skin grafts) Genetically identical (syngeneic [between monozygotic twins]) donor tissue (isografts) Genetically. (msdmanuals.com)
  • Granulocyte chemicals facilitate many functions, including purging pathogens. (ishinobu.com)
  • Helps destroy and purge pathogens from the body, helping the immune system to win the war on invaders. (medicalmedium.com)
  • The presence of a cytopenia caused by clonal bone marrow involvement establishes the diagnosis of CLL regardless of the peripheral B-lymphocyte count. (medscape.com)
  • The 30 patients who had no marrow metastases at the time of PSC harvesting had an actuarial event-free survival of 47%, while those 26 patients with marrow metastases had a significantly different actuarial event-free survival of 27% (P = .02). (shengsci.com)
  • CBV and PSCT for patients with relapsed Hodgkin's diseases who have marrow hypocellularity in traditional harvest sites or histopathologic evidence of BM metastases can result in long-term event-free survival. (shengsci.com)
  • The recurrence, which presented with multiple metastases in the bone marrow, occurred 2 years after PBSCT (Figure 1 A). At this time, VAM and HVA had increased to 273.5 and 87.7 μg/mg Cr, respectively. (biomedcentral.com)
  • We conclude that despite the recovery of normal numbers of T lymphocytes early after engraftment of CD6-depleted marrow, these T cells exhibit several physiologic and functional abnormalities that persist for varying intervals post-BMT. (ashpublications.org)
  • Results Using the 5TGM1-Kalw/RijHSD immunocompetent in vivo model we have demonstrated that reovirus reduces both MM tumor burden and myeloma-induced bone disease. (bmj.com)
  • A validated real-time quantitative PCR approach shows a correlation between tumor burden and successful ex vivo purging in follicular lymphoma patients. (unito.it)
  • The European Calcified Tissue Society (ECTS) is the premier bone research society in Europe. (meduniwien.ac.at)
  • The recommended dose is 250 mcg/m2/day administered IV over a 2-hour period beginning two to four hours after bone marrow infusion, and not less than 24 hours after the last dose of chemotherapy or radiotherapy. (wikidoc.org)
  • Chemotherapy or radiotherapy used to treat these cancers will destroy the HSCs in the bone marrow and abolish the body's ability to regenerate blood cells. (parkwaycancercentre.com)
  • Diagnosis: Refractory or relapsed neuroblastoma with original diagnosis based on tumor histopathology or elevated urine catecholamines with typical tumor cells in the bone marrow. (ucsf.edu)
  • The subject was a 2-year-old female with a diagnosis of stage 4 neuroblastoma with unfavorable histology according to the international neuroblastoma pathology classification, non-amplification of MYCN, and primary localization to the left adrenal gland with metastasis to the thoracic vertebrae, pelvis, and bone marrow. (biomedcentral.com)
  • I renounce _________________ and all associated genetic or cellular anchoring, data packets, ungodly DNA strands, bone marrow, blood, markers, mesh, and all the powers of darkness associated with this, and serve them a bill of divorce. (bridemovement.com)
  • Further, clinically insignifi cant colonization or con- tronically purged of the names of patients with positive HIV tamination can be diffi cult to distinguish from true disease, serologic test results, patients with HIV viral load, and pa- tients who had had genotyping studies performed. (cdc.gov)
  • The findingssupport the hypothesis that G-CSF mobilizes two distinct stem cell populations, one from the bone marrow andthe other from the spleen. (fliphtml5.com)
  • She said, "Your marrow looks fabulous and you are 100% donor. (blogspot.com)
  • However, to date, the role for reovirus-induced immunotherapy against MM, and the impact of the bone marrow (BM) niche, have not been reported. (bmj.com)
  • Across three different murine models of human prostate and breast cancer, KBU2046 inhibits metastasis, decreases bone destruction, and prolongs survival at nanomolar blood concentrations after oral administration. (nature.com)
  • Efficacy of KBU2046 is demonstrated across several different in vitro models and across multiple murine models of human cancer metastasis, which includes decreased metastasis, decreased bone destruction, and prolonged survival. (nature.com)
  • A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. (curehunter.com)
  • An effective immunomagnetic method for bone marrow purging in T cell malignancies. (covalab.com)
  • 123 I-MIBG accumulation decreased after treatment in the parietal bone and humerus (black arrows), but it was still detected in the thoracic vertebrae and femur (white arrows). (biomedcentral.com)
  • A Brazilian man who was infected with the AIDS virus has shown no sign of it for more than a year since he stopped HIV medicines after an intense drug therapy aimed at purging hidden, dormant virus from his body, doctors are reporting. (wxyz.com)
  • Furthermore, It can penetrate up to 11.8 inches into the body reaching the bone marrow. (yummy.doctor)