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  • clonal
  • Patients are removed from study for failure to achieve a complete response by week 16, unacceptable nonhematologic toxicity, the identification of a clonal karyotype in marrow, or the onset of leukemia. (clinicaltrials.gov)
  • MSCs
  • Objective- Vascular smooth muscle cells (VSMCs) and circulating mesenchymal progenitor cells (MSCs) with a VSMC phenotype contribute to neointima formation and lumen loss after angioplasty and during allograft arteriosclerosis. (ahajournals.org)
  • 11 Based on our previous findings on VSMC differentiation of human bone marrow MSCs, 12 we investigated activation and inhibition of the PI3K/Akt/mTOR/p70S6K pathway in the phenotypic modulation and expression of VSMC markers in MSCs. (ahajournals.org)
  • Human MSCs were isolated by plastic adherence from aspirated iliac crest marrow from consenting normal adult donors and cultured as described previously. (ahajournals.org)
  • The present study was conducted to test the hypothesis that MSCs mobilize bone marrow progenitor cells and improve function by stimulating myocyte proliferation in collateral-dependent hibernating myocardium. (ahajournals.org)
  • Human MSCs can expand rapidly in culture, but the rate of expansion and the yields of multipotential progenitors are inversely related to the plating density and incubation time of each passage. (wiley.com)
  • The results indicate that, when preparing cultures of human MSCs, it is necessary to compromise between conditions that provide the highest overall yields and those that provide the highest content of early progenitor cells. (wiley.com)
  • autologous bone
  • D. Enea, S. Cecconi, S. Calcagno, A. Busilacchi, S. Manzotti, and A. Gigante, "One-step cartilage repair in the knee: collagen-covered microfracture and autologous bone marrow concentrate. (hindawi.com)
  • The safety of the administration of autologous bone marrow-derived EPC in patients with advanced cirrhosis will be evaluated by anamnesis, physical examination, hematological and biochemical variables and imaging examination. (clinicaltrials.gov)
  • BMPCs
  • Bone marrow progenitor cells (BMPCs), known to express CD105, are important in local trophic and immunomodulatory activity and central to musculoskeletal healing/regeneration. (hindawi.com)
  • We have developed a safe and effective method for rapid isolation of CD105 + BMPCs from bone marrow aspirate. (hindawi.com)
  • This method enables us to obtain large numbers of BMPCs for both research and clinical use from a relatively small sample of bone marrow aspirate. (hindawi.com)
  • peripheral
  • Although BM and peripheral blood are both still considered a source of stem/progenitor cells for this purpose [ 8 , 9 ], peripheral blood is used in 71% of allogeneic transplantations [ 6 ]. (hindawi.com)
  • Moreover, peripheral blood mononuclear cells (PBMNCs) from the BMP-2-implanted mouse were then shown to include osteoblast progenitor cells (OPCs) in culture. (osti.gov)
  • The bone marrow (BM) 1 is a site of intense cellular traffic from the hematopoietic compartment to the peripheral blood and vice versa. (rupress.org)
  • Myocardial
  • Bone marrow - derived progenitor cells (BMC) may contribute as an endogenous repair mechanism to the recovery of left ventricular function after acute myocardial infarction (AMI). (ahajournals.org)
  • The REPAIR-AMI trial has demonstrated that intracoronary infusion of bone marrow-derived progenitor cells (BMC) is associated with a larger recovery of left ventricular contractile function after acute myocardial infarction (AMI) compared to placebo. (ahajournals.org)
  • Using a double-blind, placebo controlled multicenter trial design, we randomized 204 patients with successfully reperfused acute myocardial infarction to receive intracoronary infusion of bone marrow - derived progenitor cells (BMC, n = 101) or placebo medium (n= 103) into the reperfused infarct artery. (ahajournals.org)
  • In sham-normal animals, icMSCs increased myocardial bone marrow progenitor cells with no effect on myocyte proliferation or regional function. (ahajournals.org)
  • modulates
  • As a secondary aim, diabetic patients will be divided in those with and without diabetic autonomic neuropathy (DAN) to understand if DAN modulates bone marrow responsiveness to G-CSF. (clinicaltrials.gov)
  • adult
  • To address this possibility in an experimental model of PD, bone marrow-derived neuroprogenitor-like cells were generated from bone marrow procured from healthy human adult volunteers and their potential to elicit recovery of damaged DA axons was studied in a partial lesion rat model of PD. (luriechildrens.org)
  • Iliac
  • Iliac bone marrow samples were collected from individuals aged 18-65 years during the first steps of pelvic surgery, under IRB approval with informed consent. (hindawi.com)
  • stem cell
  • 4 ), which indicate that a single marrow stem cell can generate both hematopoietic and nonhematopoietic lineages. (pnas.org)
  • further, recent evidence shows that many examples of so-called stem cell developmental plasticity may represent fusions of hematopoietic stem cells with committed progenitors of nonhematopoietic tissues, generating cell hybrids that possess both donor and host genetic information ( 5 - 8 ). (pnas.org)
  • Thus, a reasonable hypothesis is that the hematopoietic marrow harbors a stem cell with osteogenic potential. (pnas.org)
  • 3. The neural progenitor cells of claim 1 , wherein the medium further comprises an additional compound selected from the group consisting of interleukin-3 (IL-3), stem cell factor-1 (SCF-1), sonic hedgehog (Shh), fms-like tyrosine kinase-3 (Flt3) ligand, leukemia inhibitory factor (LIF), and combinations thereof. (google.com)
  • Nearly every cell in an animal's body, from neural to blood to bone, owes its existence to a stem cell. (google.com)
  • These findings, for the first time, document activation of the stem cell niche within the bone marrow following AMI, which may have important implications for the optimal timing of cell therapy using BMC in patients with AMI. (ahajournals.org)
  • Acute lymphocytic leukemia - progenitor but not only stem cell disease. (hematopoiesis.info)
  • morphogenetic protein
  • Here, we examined how these cells contribute to osteogenesis in a bone morphogenetic protein (BMP)-induced model of ectopic bone formation. (osti.gov)
  • Purpose: This study investigated the role of the bone marrow derived CD34+ cell in a milieu of osteoprogenitor cells, bone marrow plasma cell adhesion molecules, recombinant human bone morphogenetic protein (rhBMP), and a matrix of crushed cancellous allogeneic bone in the clinical regeneration of functionally useful bone in craniomandibular reconstructions. (quintpub.com)
  • infusion
  • Intracoronary infusion of bone marrow-derived progenitor cells is associated with enhanced efficacy in patients with the most severe depression of left ventricular function as well as when performed at ≥ 5 days after AMI reperfusion therapy. (ahajournals.org)
  • subsets
  • In order to determine a possible relationship between the two granule subsets, immunoelectron-microscopic techniques were used to determine the presence and precise intragranular distribution of major basic protein (MBP), eosinophil cationic protein (ECP), eosinophil peroxidase (EPO), and arylsulfatase B of eosinophil granules, as well as the Charcot-Leyden crystal (CLC) protein, in eosinophil progenitors of the bone marrow. (lu.se)
  • Genetically
  • Genetically modified, marrow-derived myogenic progenitors could potentially be used to target therapeutic genes to muscle tissue, providing an alternative strategy for treatment of muscular dystrophies. (sciencemag.org)
  • Following collection of bone marrow, mesenchymal stem cells (MSC) were isolated and then genetically modified to create SB623 cells by transient transfection with the intracellular domain of the Notch1 gene (NICD), a modification that upregulates expression of certain neuroprogenitor markers. (luriechildrens.org)
  • therefore
  • It is therefore important to note that a bone fracture, like any other musculoskeletal injury, should be considered a systemic event, resulting in a systemic response [ 25 ]. (hindawi.com)
  • neural
  • A method is described for generating a clinically significant volume of neural progenitor cells from whole bone marrow. (google.com)
  • Further methods of the present invention are directed to utilizing the neural progenitor cells cultured in this fashion in the treatment of various neuropathological conditions, and in targeting delivery of cells transfected with a particular gene to diseased or damaged tissue. (google.com)
  • 2. The neural progenitor cells of claim 1 , wherein the medium further comprises a supplement selected from the group consisting of B27, N2, and combinations thereof. (google.com)
  • Embodiments of the present invention are directed to a method for generating a clinically substantial volume of neural progenitor cells from mammalian whole bone marrow. (google.com)
  • Further embodiments of the present invention are directed to the treatment of neurological disorders using neural progenitor cells cultured in this fashion. (google.com)
  • recombinant
  • A collagen-hydroxyapatite scaffold allows for binding and co-delivery of recombinant bone morphogenetic proteins and bisphosphonates," Acta Biomaterialia , vol. 10, no. 5, pp. 2250-2258, 2014. (hindawi.com)
  • potent
  • One interpretation of these observations is that cells other than those in the adherent population, where mesenchymal stem cells are thought to reside ( 3 ), are potent transplantable progenitors of osteoblasts, consistent with laboratory studies showing that nonadherent cells can give rise to bone ( 12 , 13 , 16 ). (pnas.org)
  • defect
  • Group A received an in situ tissue-engineered graft containing 54 38 CD34+ cells/mL along with 54 38 CD44+, CD90+, and CD105+ cells/mL together with rhBMP-2 in an absorbable collagen sponge (1 mg/cm of defect) and crushed cancellous allogeneic bone. (quintpub.com)
  • diseases
  • Its isolation and characterization may suggest novel treatments for genetic bone diseases and bone injuries. (pnas.org)
  • clinically
  • The results were analyzed clinically, radiographic bone density was measured in Hounsfield units (HU), and specimens were analyzed histomorphometrically. (quintpub.com)