Loading...
  • grafts
  • We previously reported early results of a clinical trial using ex vivo induction of alloanergy in donor T cells within bone marrow (BM) grafts via CTLA4-Ig-mediated CSB. (bloodjournal.org)
  • immunotherapy
  • As one of Hadassah University's senior scientists, Prof. Or continues to conduct research on various clinical topics, including the prevention of liver complications following bone marrow transplantation and immunotherapy using donor derived lymphocytes (immune cells) for the eradication of malignant diseases that would otherwise prove fatal. (isracast.com)
  • disorders
  • 1 Congenital disorders account for approximately one third of cases of bone marrow failure in childhood and include many different genetic diseases, such as Fanconi anemia, dyskeratosis congenita (DC), 2 Diamond-Blackfan anemia (DBA) 3 and others. (haematologica.org)
  • Beta thalassemias (β thalassemias) are a group of inherited blood disorders. (wikipedia.org)
  • Thalassemias are inherited blood disorders characterized by abnormal hemoglobin production. (wikipedia.org)
  • cells
  • The donated tissue repopulated the marrow and restored production of the blood cells. (uchospitals.edu)
  • There are many different types of blood cell, but they all develop from stem cells. (cancerindex.org)
  • CD34) progenitors and total cells than bone marrow. (knowcancer.com)
  • Blood samples will also be collected to see if infection fighting cells are working. (knowcancer.com)
  • Intracoronary transplantation of peripheral blood- or bone marrow-derived cells, as tested in several recent trials, is associated with moderate increases in left ventricular (LV) ejection fraction (EF) and a small reduction of LV end-systolic volumes. (onlinejacc.org)
  • In the following discussion, the effects of intracoronary transplantation of bone marrow- and blood-derived stem cells in AMI on functional and morphometric LV parameters are put into the context of established therapy, such as reperfusion therapy and adjunctive pharmacotherapy. (onlinejacc.org)
  • In 2 trials (n = 126), peripheral blood cells were used for intracoronary infusion and in 8 investigations bone marrow-derived cells were used. (onlinejacc.org)
  • This allows the bone marrow to recover, proliferate and continue producing healthy blood cells. (wikipedia.org)
  • This further causes clumping of HbS molecules into rigid fibers, causing "sickling" of the entire red blood cells in the homozygous (HbS/HbS) condition. (wikipedia.org)
  • Myelokathexis is a congenital disorder of the white blood cells that causes severe, chronic leukopenia (a reduction of circulating white blood cells) and neutropenia (a reduction of neutrophil granulocytes). (wikipedia.org)
  • In a developing embryo, stem cells can differentiate into all the specialized cells-ectoderm, endoderm and mesoderm (see induced pluripotent stem cells)-but also maintain the normal turnover of regenerative organs, such as blood, skin, or intestinal tissues. (wikipedia.org)
  • Blood, which requires extraction through apheresis, wherein blood is drawn from the donor (similar to a blood donation), and passed through a machine that extracts the stem cells and returns other portions of the blood to the donor. (wikipedia.org)
  • Adult stem cells are frequently used in various medical therapies (e.g., bone marrow transplantation). (wikipedia.org)
  • For example, the defining test for bone marrow or hematopoietic stem cells (HSCs) is the ability to transplant the cells and save an individual without HSCs. (wikipedia.org)
  • This demonstrates that the cells can produce new blood cells over a long term. (wikipedia.org)
  • These long chains of sugar carbohydrates occur within the cells that help build bone, cartilage, tendons, corneas, skin and connective tissue. (wikipedia.org)
  • Over time, these glycosaminoglycans collect in the cells, blood and connective tissues. (wikipedia.org)
  • Reductions in HbA available overall to fill the red blood cells in turn leads to microcytic anemia. (wikipedia.org)
  • Often there is mild to severe anemia (low red blood cells). (wikipedia.org)
  • Enlarged spleen: The spleen aids in fighting infection and filters unwanted material, such as old or damaged blood cells. (wikipedia.org)
  • Thalassemia is often accompanied by the destruction of a large number of red blood cells and the task of removing these cells causes the spleen to enlarge. (wikipedia.org)
  • Splenomegaly can make anemia worse, and it can reduce the life of transfused red blood cells. (wikipedia.org)
  • In April 2007, an international team of researchers announced in the journal Nature Biotechnology an inexpensive and efficient way to convert types A, B, and AB blood into type O. This is done by using glycosidase enzymes from specific bacteria to strip the blood group antigens from red blood cells. (wikipedia.org)
  • The resulting red blood cells do not usually express A or B antigen at the same level that would be expected on common group A1 or B red blood cells, which can help solve the problem of an apparently genetically impossible blood group. (wikipedia.org)
  • spleen
  • In the late 1940s, University of Chicago researcher Dr. Leon Jacobson discovered that he could save a mouse, whose bone marrow and spleen had been destroyed with radiation, by transplanting healthy spleen tissue from another mouse. (uchospitals.edu)
  • Physical symptoms generally include coarse or rough facial features (including a flat nasal bridge, thick lips, and enlarged mouth and tongue), short stature with disproportionately short trunk (dwarfism), dysplasia (abnormal bone size and/or shape) and other skeletal irregularities, thickened skin, enlarged organs such as liver (hepatomegaly) or spleen (splenomegaly), hernias, and excessive body hair growth. (wikipedia.org)
  • Increased gastrointestinal iron absorption is seen in all grades of beta thalassemia and increased red blood cell destruction by the spleen due to ineffective erythropoiesis further releases additional iron into the bloodstream. (wikipedia.org)
  • There may also be bone problems, an enlarged spleen, yellowish skin, dark urine, and among children slow growth. (wikipedia.org)