Myelodysplastic SyndromesMyeloproliferative DisordersBone MarrowJanus Kinase 2Primary MyelofibrosisMyelodysplastic-Myeloproliferative DiseasesPolycythemia VeraThrombocythemia, EssentialBone Marrow CellsAnemia, RefractoryBone Marrow NeoplasmsLeukemia, Myelomonocytic, ChronicBone Marrow TransplantationReceptors, ThrombopoietinAnemia, Refractory, with Excess of BlastsLeukemia, Myeloid, AcuteThrombocytosisBone and BonesSyndromeBone Marrow DiseasesLeukemia, MyeloidHematopoietic Stem CellsLeukemia, Myeloid, Chronic, Atypical, BCR-ABL NegativeAnemia, SideroblasticLeukemia, Myelomonocytic, JuvenileMutationBone Marrow ExaminationChromosomes, Human, Pair 5LeukemiaHematologic NeoplasmsSplenomegalyLeukemia, Myelogenous, Chronic, BCR-ABL PositiveProto-Oncogene Proteins c-cblHematopoiesisPrognosisKaryotypingAzacitidineBlast CrisisAnemia, AplasticPhiladelphia ChromosomeChromosome AberrationsBone RemodelingMegakaryocytesPreleukemiaMyeloid Progenitor CellsHematologyPancytopeniaTreatment OutcomeTransplantation, HomologousMonosomyJanus KinasesHematopoietic Stem Cell TransplantationDNA Mutational AnalysisThalidomideAntigens, CD34Megakaryocyte Progenitor CellsColony-Forming Units AssaySTAT5 Transcription FactorAcute DiseaseChromosomes, Human, Pair 7Mice, Inbred C57BLDisease ProgressionCell Transformation, NeoplasticBone DensityMegakaryocyte-Erythroid Progenitor CellsGranulocytesMyelopoiesisCytogenetic AnalysisFlow CytometryMutation, MissenseNeoplasms, Second PrimaryClonal EvolutionCell DifferentiationCell ProliferationFusion Proteins, bcr-ablChromosome DeletionBlood Cell CountGranulocyte Precursor CellsAntineoplastic AgentsBone ResorptionWhole-Body IrradiationErythropoietinCytogeneticsHematologic DiseasesGranulocyte Colony-Stimulating FactorBone NeoplasmsGene Knock-In TechniquesImmunophenotypingAmino Acid SubstitutionPhenotypeProtein Kinase InhibitorsBone Marrow PurgingPoint MutationTransplantation, AutologousProto-Oncogene ProteinsSurvival AnalysisTranslocation, GeneticDown SyndromeNeoplasmsErythroid Precursor Cells