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  • donor
  • When certain stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. (clinicaltrials.gov)
  • Cancer
  • Finally, it provides the rationale for a "two-pronged" approach, directly targeting cancer cells themselves while also targeting the bone microenvironment to make it inhospitable to malignant cells and, ultimately, eradicating cancer stem-like cells. (haematologica.org)
  • myeloproliferative neoplasm (MPN) A cancer in which the bone marrow makes too many red blood cells, white blood cells, or platelets. (nccn.org)
  • flow cytometry
  • 5% morphologic blasts) and additionally the requirements that marrow Minimal Residual Disease (MRD) - detected by 10-color flow cytometry or conventional cytogenetic evaluation - be absent and that the above blood counts be obtained. (clinicaltrials.gov)
  • Stem
  • Interest in the leukemic stem-like cell (LSC) niche in the bone marrow (BM) developed due to the major advances made in the understanding of the normal hematopoietic stem/progenitor cell (HSPC) niche over the last 15 years. (haematologica.org)
  • overlap
  • Despite an increasing knowledge on the molecular and cellular features of CMML, the clinical management of these overlap MDS/MPN syndromes remains poorly codified," Prof Fenaux and coauthors write. (ehaweb.org)
  • niche
  • A large number of studies have extensively addressed the composition of the bone marrow niche in mouse models, as well as the cellular and molecular communication modalities at play under both normal and pathogenic situations. (nih.gov)
  • primary
  • Primary myelofibrosis, the gradual replacement of bone marrow tissue by fibrous scar-like tissue, disrupting normal blood cell production. (aamds.org)