Bone marrow mesenchymal stem cell monocyte macrophage precursor cells. Medical search. Frequent questions

The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. (techscience.com)
The bone marrow microenvironment (BMME) is a complex network system primarily comprising stromal cells such as mesenchymal stem cells (MSCs), osteoprogenitor cells, vascular endothelial cells, monocytes, macrophages, and cytokines. (techscience.com)
In addition to their stem/progenitor properties, mesenchymal stromal cells (MSCs) possess broad immunoregulatory properties that are being investigated for potential clinical application in treating immune-based disorders. (pdffox.com)
In this Review, we outline current insights into the ways in which MSCs sense and control inflammation, highlighting the central role of macrophage polarization. (pdffox.com)
Introduction Mesenchymal stromal cells (MSCs) are adult, fibroblast-like multipotent cells characterized by the ability to differentiate into tissues of mesodermal origin, such as adipocytes, chondroblasts, and osteoblasts (Friedenstein et al. (pdffox.com)
1999). First identified and isolated from the bone marrow (BM), MSCs can now be expanded from a variety of other tissues including adipose tissue (AT), umbilical cord blood (UCB), skin, tendon, muscle, and dental pulp (Im et al. (pdffox.com)
In response to this challenge, the International Society for Cellular Therapy formulated minimal criteria for defining MSCs in order to create a broader consensus for more uniform characterization of these cells (Dominici et al. (pdffox.com)
2007). In addition to their stem/progenitor properties, MSCs have also been shown to possess broad immunoregulatory abilities and are capable of influencing both adaptive and innate immune responses. (pdffox.com)
This ability of MSCs to adopt a different phenotype in response to sensing an inflammatory environment is not captured in assays that are commonly used to characterize these cells, but it is crucial for understanding their therapeutic potential in immune-mediated disorders. (pdffox.com)
Bone marrow-derived mesenchymal stem cells (BM-MSCs) are multipotent stromal cells that have a critical role in the maintenance of skeletal tissues such as bone, cartilage, and the fat in bone marrow. (ijbs.com)
In addition to providing microenvironmental support for hematopoietic processes, BM-MSCs can differentiate into various mesodermal lineages including osteoblast/osteocyte, chondrocyte, and adipocyte that are crucial for bone metabolism. (ijbs.com)
While BM-MSCs have high cell-to-cell heterogeneity in gene expression, the cell subtypes that contribute to this heterogeneity in vivo in humans have not been characterized. (ijbs.com)
To investigate the transcriptional diversity of BM-MSCs, we applied single-cell RNA sequencing (scRNA-seq) on freshly isolated CD271 + BM-derived mononuclear cells (BM-MNCs) from two human subjects. (ijbs.com)
We successfully identified LEPR hi CD45 low BM-MSCs within the CD271 + BM-MNC population, and further codified the BM-MSCs into distinct subpopulations corresponding to the osteogenic, chondrogenic, and adipogenic differentiation trajectories, as well as terminal-stage quiescent cells. (ijbs.com)
Among the remaining cells, several different cell types are recognized, including hematopoietic stem cells, mesenchymal stem cells (MSCs), megakaryocytic precursors, and endothelial progenitors. (ebat2018.org)
Mesenchymal stem cells (MSCs), which are activated by secreted, active transforming growth factor beta 1 (TGFβ) to migrate to bone-resorptive sites and differentiate into osteoblasts (see below). (biomedcentral.com)
Pre-osteoblasts, a heterogeneous population of cells, including those transitioning from MSCs to mature osteoblasts, which express the transcription factor runt related transcription factor 2 (RUNX2) , a key player in the osteogenesis process. (biomedcentral.com)
This study is the first systematic in vivo dissection of human BM-MSCs cell subtypes at the single-cell resolution, revealing an insight into the extent of their cellular heterogeneity and roles in maintaining bone homeostasis. (bvsalud.org)
6,7 Mesenchymal stem cells (MSCs) have also been isolated from other sources, such as bone marrow, 8 the placenta, 9 muscle, 10 or blood. (jcadonline.com)
Our group specializes in determining the cellular and molecular mechanisms of beneficial effects of mesenchymal stem cells (MSCs) in diseases that include heart disease, diabetes, and peritonitis. (tamu.edu)
The goal is to develop a cellular therapy for human diseases either (a) with adult stem/progenitor cells (MSCs), or (b) with therapeutic factors that MSCs produce in response to signals from injured tissues. (tamu.edu)
Mesenchymal stem/stromal cells (MSCs) are increasingly used as an intravenously applied cellular therapeutic. (stemcellslab.net)
Later, Arnold Caplan's group described mesenchymal stem/stromal cells (MSCs) as multipotent mesenchymal cell populations which can differentiate into several tissue types, and demonstrated roles for MSCs in the regeneration of bone, cartilage or ligaments in animal and clinical studies [2-4]. (stemcellslab.net)
Pivotal studies by the group of Horwitz in children with osteogenesis imperfecta, an inherited enzyme deficiency of collagen synthesis by mesenchymal cells in bone, opened the field for intravenous use of MSCs. (stemcellslab.net)
This implies homing of transplanted MSCs to sites in bone marrow and/or bone. (stemcellslab.net)
In a second study [6], these authors showed that autologous, enzyme-deficient MSCs transduced with a copy of the intact gene resulted in normal collagen production in bone cavities. (stemcellslab.net)
The tissue source of the MSCs was in most cases not decisive, and cells from various tissue sources were explored. (stemcellslab.net)
and signals from the injected cells were found early after administration of the MSCs at the highest frequencies in the lungs, followed by liver and spleen. (stemcellslab.net)

Nowadays, more and more studies have revealed that cells in the cardiovascular system (such as cardiomyocytes, vascular smooth muscle cells, endothelial cells, et al. (frontiersin.org)
The term mononuclear phagocyte system has replaced the former reticuloendothelial system, which also included less active phagocytic cells such as fibroblasts and endothelial cells. (lookformedical.com)
These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
Macrophages and endothelial cells play interlinked roles in blood vessel formation. (edu.au)
We have discovered unique adult stem cells in mouse tissues termed Endothelial-Macrophage (EndoMac) progenitor cells that give rise to both macrophages and endothelial cells and contribute to blood vessel formation after tissue injury. (edu.au)

Biological functional annotations of the transcriptomes suggest that osteoblast precursors induce angiogenesis coupled with osteogenesis, and chondrocyte precursors have the potential to differentiate into myocytes. (ijbs.com)
Hematopoietic stem cells (HSCs) were first identified in 1961, and their ability to migrate and differentiate into multiple cell types was documented [ 2 ]. (biomedcentral.com)
A progenitor cell is a biological cell that, like an SC, has a tendency to differentiate into a specific type of cell but is already more specific than an SC and is pushed to differentiate into its 'target' cell. (biomedcentral.com)
They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (lookformedical.com)
Bone marrow contains cells that can travel to multiple organ sites and differentiate into specific tissue cells. (endonews.com)
Intradermal adipocyte progenitor cells are activated toward the end of the telogen phase to proliferate and differentiate into mature adipocytes. (jcadonline.com)
As needed, the stem cells differentiate to become a particular kind of cell-a white blood cell, red blood cell, or platelet. (medscape.com)
T lymphocytes originate via lymphoid stem cells that migrate to the thymus and differentiate under the influence of the thymic hormones thymopoietin and thymosin. (medscape.com)

A more tissue-centric view of these processes, claiming that the tissues define phenotype and function of resident and infiltrating immune cells to meet tissues needs during homeostasis and disease, seems provocative [ 4 , 5 ]. (hindawi.com)
For example, organs like the lung and the liver are exposed to pathogen components from the air or from the gut barrier, respectively, which explains the predominance of a macrophage phenotype that has a higher capacity for phagocytic clearance of pathogen components. (hindawi.com)
Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. (thermofisher.com)
Recent studies by F rid and co-workers [ 9 - 11 ] in the chronically hypoxic neonatal calf and in rats have shown that a proportion of the adventitial cells of pulmonary hypertensive animals are of a blood-derived fibrocyte phenotype. (ersjournals.com)
Specifically, a subpopulation of cells with a phenotype of CD34+/CD45? (ebat2018.org)
Mostly homogeneous monocyte-derived DCs (MoDCs) were obtained with similar phenotype and phagocytic characteristics to that of blood DCs. (bvsalud.org)

The MMT cells were a major source of collagen-producing fibroblasts in the fibrosing kidney, accounting for more than 60% of α-SMA+ myofibroblasts. (oncotarget.com)
In conclusion, we have demonstrated that bone marrow-derived fibroblasts originate from the monocyte/macrophage population via a process of MMT. (oncotarget.com)
The principal cell type responsible for increased deposition of fibrillar collagen during active tissue fibrosis are myofibroblasts - a subset of activated fibroblasts characterized by expression of alpha-smooth muscle actin (α-SMA) [ 2 , 3 ]. (oncotarget.com)

[ 5 ] Osteoblasts synthesize bone matrix, which is composed predominantly of type I collagen and is found at the bone-forming surface. (medscape.com)
Osteoblasts arise from multipotent mesenchymal stem cells. (medscape.com)
Osteoblasts are responsible for synthesizing bone matrix and thereby creating an environment that supports the growth, maturation, and function of osteoclasts. (medscape.com)
Osteoblasts mature from BMSCs to osteoprogenitor cells, to osteoblast precursors, and ultimately to osteoblasts. (researchpad.co)
Our findings demonstrate for the first time that molecular changes in osteoblasts influence the susceptibility to swelling by altering evasion of innate immune cells from your bone Lesopitron dihydrochloride marrow space. (informationalwebs.com)
This bone turnover comprises the temporal and spatial coordination of two processes performed in bone remodeling units at discrete sites throughout the skeleton: removal of old and damaged bone by osteoclasts, called resorption, which can last 4-6 weeks, followed by new bone formation by osteoblasts, which produce collagen and mineralized bone matrix in a process lasting 4-5 months [ 3 ]. (biomedcentral.com)
Osteoblasts, polarized cuboidal cells specialized for the active secretion of ECM. (biomedcentral.com)
They are derived from terminally differentiated osteoblasts surrounded by unmineralized matrix (osteoid) during bone formation. (biomedcentral.com)
Once the osteoid mineralizes, the osteocytes are trapped there and form an extensive network with each other, with osteoblasts, and with the lining cells on the bone surface (explained below). (biomedcentral.com)
Engraftment of donor-type MSC-derived osteoblasts was shown using bone specimens and microsatellite DNA marker analysis. (stemcellslab.net)

The strong demonstration of a significant bone marrow contribution to vascular remodelling is not uniform across disease models. (ersjournals.com)
Adipose tissue is a loose connective tissue composed of cells supported by an intracellular matrix as well as by vascular, lymphatic, and neural networks. (jcadonline.com)
however, a variety of other cell types are found as well, collectively labeled as stromal vascular fraction (SVF). (jcadonline.com)
He has unique expertise across all three disciplines of basic, translational and clinical research, and leads bench-to-bedside projects spanning topics of developmental, macrophage biology, vascular stem cells, inflammatory regulation of atherosclerosis, pharmacological modification of atherosclerosis and coronary plaque imaging. (edu.au)
Our group undertakes basic, translational, and clinical research on vascular and immune stem cells, macrophage and vascular biology, inflammatory regulators of atherosclerosis, pharmacological modulation of atherosclerosis, biomarkers of coronary artery disease and coronary plaque imaging. (edu.au)
He has delineated the function of these molecules in diverse set of biological processes including: 1) gut and kidney formation, 2) vascular permeability, 3) mucosal inflammatory disease, 4) stem cell homing and migration, and 5) epithelial tumor progression. (ubc.ca)
Both types of bone marrow are highly vascular, being enriched with numerous blood vessels and capillaries. (medscape.com)

Osteopetrosis is a clinical syndrome characterized by the failure of osteoclasts to resorb bone. (medscape.com)
To understand the etiology of osteopetrosis, it is very essential to understand the bone-remodeling cycle and the cell biology of osteoclasts. (medscape.com)
In contrast, osteoclasts are derived from the monocyte/macrophage lineage. (medscape.com)
Osteoclasts can tightly attach to the bone matrix by integrin receptors to form a sealing zone, within which is a sequestered, acidified compartment. (medscape.com)
BMMs, that act as osteoclast precursors, were cultured with M-CSF (50 ng/ml) and RANKL (100 ng/ml) for 4 days to generate osteoclasts. (biomedcentral.com)
Osteoclasts are specialized as the only bone-resorbing cell type and increased numbers are implicated in the development of bone loss-accompanied diseases such as osteoporosis, periodontitis, rheumatoid arthritis, osteosarcoma, and bone cancer metastases [ 2 - 4 ]. (biomedcentral.com)

Additionally, miR-690 knockdown in M2 macrophages with a miR-690 inhibitor partially counteracted the effect of M2D-Exos on BMSC differentiation and the upregulation of IRS-1 and TAZ expression. (researchpad.co)
Bone marrow mesenchymal stem cells (BMSCs) are stromal stem cells that are derived from bone marrow and possess multiplex differentiation potential ( 3 ). (researchpad.co)
As early as 2002, Champaign found that macrophages could promote the osteogenic differentiation of BMSCs ( 11 ). (researchpad.co)
A recent study suggested that human bone marrow mesenchymal stem cells showed stronger proliferation and osteogenic differentiation when cocultured with inactive human monocytes ( 12 ). (researchpad.co)
In addition, whether M2 macrophages can regulate the balance of osteogenic and adipogenic differentiation of BMSCs needs to be further explored. (researchpad.co)
This makes their identification and differentiation from resident mesenchymal cells extremely difficult in the absence of further specific markers. (ersjournals.com)
It maintains normal hematopoietic function by interacting with hematopoietic stem cells (HSCs) to control their proliferation and differentiation ( Morrison and Scadden, 2014 ). (techscience.com)
Several investigations [ 5 - 7 ] have been carried out with isolated embryonic, fetal, and adult SCs in a well-defined culture microenvironment to define the sequential steps and intracellular pathways that are involved in their differentiation into the specific cell lineages. (biomedcentral.com)
In this study, we examined the potential of SF extract (SFE) to inhibit receptor activator of NF-κB ligand (RANKL) -induced osteoclast differentiation in cultured mouse-derived bone marrow macrophages (BMMs). (biomedcentral.com)
Pharmaceutical inhibition of osteoclast differentiation is a current therapeutic approach for the treatment of bone loss-related diseases. (biomedcentral.com)
At the cellular level, the mesenchymal stem cell pool in the bone marrow niche shows a biased differentiation into adipogenesis at the cost of osteogenesis. (biomedcentral.com)
This differentiation shift leads to decreased bone formation, contributing to the etiology of osteoporosis. (biomedcentral.com)
Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)

Signaling through CD19 induces tyrosine phosphorylation, calcium flux and proliferation of B cells. (thermofisher.com)
The receptor for CD19 is an important functional regulator of normal and malignant B cell proliferation, and is expressed in all B cell precursor leukemias. (thermofisher.com)
Recombinant rat M-CSF induces the proliferation of M-NFS-60 cells in a dose dependent manner. (biolegend.com)
M-CSF is constitutively present at biologically active concentrations in human serum, and binds CD14 + monocytes, and promotes the survival and proliferation of peripheral blood monocytes. (biolegend.com)
ED 50 = 2.5 - 12.5 ng/mL, corresponding to a specific activity of 0.8 - 4.0 x 10 5 units/mg, as determined by induction of N-MSF-60 mouse myelogenous leukemia lymphoblast cell proliferation. (biolegend.com)
X-VIVO Serum-free Hematopoietic Cell Media provide nutritionally complete and balanced environments for a variety of cells including lymphokine activated killer (LAK) cells, peripheral blood lymphocytes (PBL), and tumor infiltrating lymphocytes (TIL).These media do not contain any exogenous growth factors, artificial stimulators of cellular proliferation, or undefined supplements. (lonza.com)
It also supports the proliferation of purified CD3+ cells isolated from peripheral blood and human tumors, and can be used to support the growth of human monocytes, macrophage cells and cell lines, PBL, granulocytes, and natural killer (NK) cells as well as the expansion of HUT-78 and related human lymphocytic cell lines. (lonza.com)

Most tissues harbor resident mononuclear phagocytes, that is, dendritic cells and macrophages. (hindawi.com)
An immune-centric view assumes that a particular priming of phagocytes then causes a particular type of pathology in target tissues, conceptually similar to antigen-specific T-cell priming. (hindawi.com)
Mononuclear phagocytes are a group of phenotypic distinct members, often referred to as either macrophages or dendritic cells (DC), that derive from myeloid precursors and that contribute to the functions of peripheral tissues [ 1 ]. (hindawi.com)
All solid organs and most other tissues harbor a network of DC or macrophages (Table 1 ). (hindawi.com)
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. (lookformedical.com)
Endometriosis is non-malignant but shares some similar features with cancer, such as the occurrence of local and distant foci, the ability to resist cell death, and the ability to invade other tissues, causing damage to the organs. (endonews.com)
hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
Because of the difficulty in obtaining these cells directly from tissues, different sources of DCs are frequently used for in vitro experimentation and many of their biological and functional characteristics were studied using these systems. (bvsalud.org)
Previous comparative studies of mouse and human tissues were limited by the use of bulk-cell material. (bvsalud.org)
It has been found that some of the SVF cell types possess regenerative and anti-inflammatory potentials in damaged tissues due to their ability to secrete growth factors and anti-inflammatory molecules. (jcadonline.com)
In adult tissues, these cell types are thought to originate independently of each other. (edu.au)
We have found analogous cells in human tissues. (edu.au)
Built upon scDiffCom, scAgeCom is an atlas of age-related cell-cell communication changes covering 23 mouse tissues from 58 single-cell RNA sequencing datasets from Tabula Muris Senis and the Calico murine aging cell atlas. (nature.com)
Tachykinins are small neuropeptides from 10-12 amino acids long synthesized in various nuclei of the central nervous system such as the substania gelatinosa of the dorsal spinal cord and certain nuclei of the limbic lobes as well as in a number of non-neuronal tissues like stromal cells of the BM [3]. (brainimmune.com)
When the oxygen content of body tissues is low, if there is loss of blood or anemia, or if the number of red blood cells decreases, the kidneys produce and release erythropoietin, a hormone that stimulates the bone marrow to produce more red blood cells. (medscape.com)
2011). Stem cell frequency appears to be significantly higher in adipose tissue than in other tissues such as bone marrow (Bieback et al. (neurogelenmarche-usa.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

Applications Tested: This HIB19 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. (thermofisher.com)
The CD19 molecule is expressed on 100% of the peripheral B cells as defined by expression of kappa or lambda light chains. (thermofisher.com)
The fibrocyte is one of many populations of bone marrow-derived cells that can be detected in the peripheral blood and is considered to represent a mesenchymal progenitor cell [ 1 ]. (ersjournals.com)
To investigate the in vivo trafficking of HPDSCs, peripheral blood and organs including lung, spleen, bone marrow, GI, and skin were isolated from your recipient RDEB mice on different days Fraxinellone after HPDSC administration. (ebat2018.org)
Oligodendrocytes (OLs) and Schwann cells are the myelinating glia of the CNS and the peripheral nervous system (PNS), respectively. (biologists.com)
Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
Following this approach, porcine DCs were directly isolated from peripheral blood or differentiated in vitro by culturing bone marrow (BM) progenitor cells or blood monocytes treated with growth factors. (bvsalud.org)
All experiments performed on red cell lysed murine peripheral blood in the presence of murine SeroBlock ( BUF041A ). (bio-rad-antibodies.com)
X-VIVO 20 - optimized to support the generation of lymphokine activated killer (LAK) cells from monocyte depleted peripheral blood lymphocytes (PBL) at high density and has also been used as a growth medium for PBL and tumor infiltrating lymphocytes (TIL). (lonza.com)

CD19 appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. (thermofisher.com)
Macroglia - astrocytes and the oligodendrocyte lineage - arise from neuroepithelial progenitor cells (NPCs) in the embryonic neural tube and forebrain ( Rowitch and Kriegstein, 2010 ). (biologists.com)
However, BMDCs MHC-II++ population expressed a higher amount of surface markers and transcribed genes associated with Macs-lineage exhibiting a higher phagocytic capacity than all the other cells. (bvsalud.org)
However, lineage tracing studies with hepatic stellate cells (counterparts of PSCs in the liver) have confirmed a mesenchymal origin for these cells (9). (pancreapedia.org)
In the present study, cell lineage tracing studies by adoptive transfer of GFP+ or dye-labelled macrophages identified that monocyte/macrophages from bone marrow can give rise to myofibroblasts via the process of macrophage-myofibroblast transition (MMT) in a mouse model of unilateral ureteric obstruction. (oncotarget.com)

We further discuss how injuries alter tissue environments and how this primes mononuclear phagocytes to enforce this particular environment, for example, to support host defense and pathogen clearance, to support the resolution of inflammation, to support epithelial and mesenchymal healing, and to support the resolution of fibrosis to the smallest possible scar. (hindawi.com)
During the last decades, research has focused on the cell-type-specific properties of these cells in culture, which then led to an immunocentric view of their role in disease like if they were primed like T cells to infiltrate target organs to cause tissue damage and drive progressive scaring [ 2 , 3 ]. (hindawi.com)
In this paper we apply the tissue-centric perspective to discuss the role of resident and infiltrating macrophages and dendritic cells in different organs. (hindawi.com)
Furthermore, we discuss how published data supports the view that changing tissue environments induce the well-known different phenotypes of mononuclear phagocytes, a process that not only enforces each of the different environments but also explains the contribution of these cells to the different tissue pathologies. (hindawi.com)
This slightly different perspective may somewhat shape our understanding of macrophage heterogeneity and tissue pathology but certainly also raise new questions for future research. (hindawi.com)
Due to their considerable plasticity and heterogeneity, the tissue-based DC and macrophage populations have been defined as mononuclear phagocytes [ 1 , 6 , 7 ]. (hindawi.com)
M2 macrophages, positive expression of CD206, contribute to tissue repair and anti-inflammatory functions. (researchpad.co)
Similarly, CD34+ cells can be identified in human scar tissue, suggesting that these cells may contribute to tissue remodelling and repair [ 5 ]. (ersjournals.com)
All stem cells are undifferentiated cells that exhibit unlimited self-renewal and can generate multiple cell lineages or more restricted progenitor populations that can contribute to tissue homeostasis by replenishing the cells or to tissue regeneration after injury. (biomedcentral.com)
In humans, bone is a highly active tissue which undergoes continuous self-regeneration throughout adulthood to maintain structural integrity in a process called bone remodeling. (biomedcentral.com)
Bone is a very dynamic and heterogeneous tissue formed by two components which are in close relationship with each other during the bone remodeling process: extracellular matrix (ECM) and bone cells. (biomedcentral.com)
Studies have shown that cell-to-cell mitochondrial transfer plays an essential role in regulating cardiovascular system development and maintaining normal tissue homeostasis under physiological conditions. (frontiersin.org)
It inhibits bone resorption and soft tissue calcification. (lookformedical.com)
Macrophages change their role depending on signals from their environment, and can therefore have a variety of tissue-specific functions. (endonews.com)
Recent data suggest that tissue-resident macrophages are derived from embryonic precursors and being maintained by longevity/self-renewal. (endonews.com)
Increasingly, it is believed that tissue-resident and monocyte-derived macrophages have distinct roles. (endonews.com)
For example, tissue-resident macrophages have tissue-specific homeostatic functions e.g. (endonews.com)
These cells can affect epithelial and stromal cell regeneration both in eutopic endometrial tissue and endometriosis. (endonews.com)
Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
We have found hyperglycemia to dampen the vasculogenic capacity of mouse EndoMac progenitor cells after tissue injury. (edu.au)
C-X-C chemokine receptor 2 (CXCR2) is a chemotactic receptor that is critical in neutrophil mobilization from bone marrow to blood and tissue sites. (frontiersin.org)
and d) IL-1β neutralization reduced CXCR2 expression on bone marrow and blood neutrophils and their subsequent accrual to colonic tissue. (frontiersin.org)
In sum, our data indicate that IL-1β is a key molecular mediator that communicates between gastro-intestinal tract (i.e. site of CDI) and bone marrow (i.e. primary neutrophil reservoir) and regulates the intensity of CDI-induced tissue neutrophilia by modulating CXCR2 expression. (frontiersin.org)
Bone marrow is the soft, spongy, gelatinous tissue found in the hollow spaces in the interior of bones. (medscape.com)
Bone marrow consists of stem cells, which are large, "primitive," undifferentiated cells supported by fibrous tissue called stroma. (medscape.com)
There are 2 main types of stem cells and, therefore, the bone marrow consists of 2 types of cellular tissue. (medscape.com)
Bone marrow can be 1 of 2 types, red or yellow, depending on whether it consists of mainly hematopoietic (and therefore, red-colored) tissue or fatty (and therefore a yellow-colored) tissue. (medscape.com)
1. Activation of adipose tissue and related mesenchymal stem cells: promotion of anti-inflammatory properties through SOX2 transcription factor and HuR RNA-binding protein modulation. (neurogelenmarche-usa.org)
1999). Recent studies have shown that the potentiality of tissue regeneration can be enhanced using adipose derived stem cells (hADSCs) (see Gimble et al. (neurogelenmarche-usa.org)
We have recently reported that mechanical manipulation of human adipose tissue without modification of tissue composition, structure and histology, that was totally comparable to that of the original source (see Experimental procedure for details), increased significantly the number of stromal cells bearing the expression of beta-tubulin III. (neurogelenmarche-usa.org)
We have suspected that mechanical forces may be of key relevance in adult tissue plasticity as it occurs during embryogenesis, tissue remodeling and mitotic and motile behavior of cells (Vogel et al, 2006). (neurogelenmarche-usa.org)
Myofibroblasts are a main cell-type of collagen-producing cells during tissue fibrosis, but their origins remains controversial. (oncotarget.com)

Administration of anti-inflammatory M2 macrophages suppresses progression of angiotensin II-induced aortic aneurysm in mice. (nagoya-u.ac.jp)

The orderly progress of bone reconstruction is a complex process that involves many factors, including enzymes, hormones, and cytokines ( 2 ). (researchpad.co)
M1 macrophages, positive expression of CD86, can produce tumor necrosis factor-α (TNF-α), induced nitrogen monoxide synthase (iNOS), Interleukin-12 (IL-12), and other proinflammatory cytokines to induce immune response. (researchpad.co)
It also induces the synthesis of inflammatory cytokines such as IL-1-β, TNF-α, and INF-γ in monocytes. (biolegend.com)
Macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-κB ligand (RANKL) are two cytokines secreted mainly by osteoclast. (biomedcentral.com)
3%). The organic phase is mainly formed by collagen type I fibers, which provide elasticity and flexibility to bone, but also non-collagenous proteins as well, such as cytokines, growth factors, and proteoglycans. (biomedcentral.com)
Aberrantly expressed cytokines in the bone marrow (BM) niche are increasingly recognized as critical mediators of survival and expansion of leukemic stem cells. (haematologica.org)
Out of the 313 unique human cytokines evaluated, 11 were found to expand cell numbers ≥2-fold in a 7-day culture. (haematologica.org)
Cytokines are essential for the function and maintenance of cells, and altered cytokine levels influence not only leukemic cells, but also the normal HSC within the BM. (haematologica.org)

The crosstalk between bone cells and surrounding cells as well as the relationship between the bone and bone microenvironment has been gradually recognized and regarded as a relatively important factor in bone metabolism ( 9 ). (researchpad.co)
The bone marrow stromal cell (BMSC) population, which makes up a large part of the hematopoietic microenvironment, encompasses a variety of adherent cell types. (techscience.com)
Aggressive B-cell malignancies, such as mantle cell lymphoma (MCL), are microenvironment-dependent tumors and a better understanding of the dialogs occurring in lymphoma-protective ecosystems will provide new perspectives to increase treatment efficiency. (haematologica.org)
Finally, we demonstrated the efficacy of selective NIK/alternative-NFkB inhibition to counteract microenvironment-dependent induction of IL32β and BAFF-dependent survival of MCL cells. (haematologica.org)
Within the bone marrow, the tachykinins have been shown to have critical effects on the microenvironment, including metastasis and dormancy of cancer cells during clinical remission. (brainimmune.com)
His laboratory has followed two primary interests: 1) the transcription factor networks that regulate fate determination in various cells that make blood, and 2) the cell surface proteins expressed by hematopoietic stem cells that and allow them to communicate with their microenvironment. (ubc.ca)
The stroma is not directly involved in the primary function of hematopoiesis, but it provides the microenvironment and colony-stimulating factors needed to facilitate hematopoiesis by the parenchymal cells. (medscape.com)
γδ T cells recruited into the tumor microenvironment can act as effector cells to mediate cancer immune surveillance. (explorationpub.com)
Therefore, an in-depth understanding of γδ T cells that play conflicting roles in the tumor microenvironment is necessary. (explorationpub.com)

In both cell sources, greater than 80% of the cells are lymphocytes, monocytes, or granulocytes. (ebat2018.org)
Activated γδ T cells exhibit strong cytotoxic activity and cytokine secretion functions and are effective antitumor lymphocytes with simple and direct recognition modes and rapid responses. (explorationpub.com)

In the after-math of the bombings of Hiroshima and Nagasaki in 1945, researchers discovered that bone marrow (BM) transplanted into irradiated mice produced hematopoiesis [ 1 ]. (biomedcentral.com)
Hematopoiesis is the development of immune and other blood cells from a small population of stem cells known as hematopoietic stem cells (HSCs). (brainimmune.com)
this includes regulation of bone marrow processes like hematopoiesis. (brainimmune.com)
In this chapter we attempt to uncover the different roles of tachykinins in human disease and homeostatic conditions, in particular hematopoiesis within the bone marrow cavity. (brainimmune.com)
In the 1970s, Friedenstein and colleagues [1] first reported that locally applied culture-expanded populations of bone marrow stroma-derived fibroblastic cells remained at their injection sites under the kidney capsule, where an ectopic hematopoiesis was initiated. (stemcellslab.net)

Although the aetiology of these disorders remains unknown, in this review we analyse the pathogenic mechanisms by cell of interest (fibroblast, fibrocyte, myofibroblast, endothelial and alveolar epithelial cells and immune competent cells). (ersjournals.com)
They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules. (lookformedical.com)
In this scholarly study, we present proof that MAGI proteins, structural the different parts of AJC whose function continued to be unclear, regulate apical constriction of epithelial cells through the Par polarity proteins. (aboutsciencenow.info)
We reveal that MAGIs must uniformly spread Partitioning faulty-3 (Par-3) at AJC of cells through the entire epithelial monolayer. (aboutsciencenow.info)
By coupling the adhesion equipment towards the polarity proteins to modify mobile contractility, we suggest that MAGIs play important and central tasks in maintaining stable state intercellular pressure through the entire epithelial cell sheet. (aboutsciencenow.info)
Therefore, we exposed the MAGIs are crucial regulators of Par polarity proteins that are central towards the rules of pressure distribution in epithelial cells homeostasis. (aboutsciencenow.info)
Results Lack of ZO proteins highly perturbs Par-3 localization and alters apical morphology We previously demonstrated that depletion of ZO proteins in the mouse mammary epithelial cell range, EpH4, delays the forming of the contractile belt-like AJ18, recommending that ZO proteins are necessary for epithelial polarization. (aboutsciencenow.info)

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by an acquired 9;22-chromosomal translocation in a hematopoietic stem cell (HSC) resulting in the expression of the BCR-ABL1 fusion protein. (haematologica.org)
There his work focused on transcriptional control of hematopoietic stem cell maturation and cell fate. (ubc.ca)
In addition, he identified a number of novel hematopoietic stem cell surface proteins and began analyzing their function. (ubc.ca)

In 1999, Baron clearly and concisely reviewed the cell biology of the bone remodeling. (medscape.com)
from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed. (lookformedical.com)
Here we show that transfer learning-the branch of machine learning that concerns passing information from one domain to another-can be used to efficiently map bone marrow biology between species, using data obtained from single-cell RNA sequencing. (bvsalud.org)
An improved understanding of PSC biology and of the interactions of PSCs with other pancreatic cells provides a strong platform for the development of novel therapeutic approaches for notoriously hard to treat diseases of the pancreas such as chronic pancreatitis and pancreatic cancer. (pancreapedia.org)

A classification that sufficiently covers their phenotypic heterogeneity and plasticity during homeostasis and disease does not yet exist because cell culture-based phenotypes often do not match those found in vivo . (hindawi.com)
Thus, organ- and disease phase-specific microenvironments determine macrophage and dendritic cell heterogeneity in a temporal and spatial manner, which assures their support to maintain and regain homeostasis in whatever condition. (hindawi.com)
These cells provide several important physiological functions during homeostasis (Figure 1 ). (hindawi.com)
Mitochondria not only serve as power plants in cells but also act as crucial regulators in many biological processes, including reactive oxygen species (ROS) signaling, redox balance, calcium homeostasis, protein quality control, and programmed cell death ( 3 , 4 ). (frontiersin.org)
Studies have shown that cells can eliminate defective mitochondria by delivering them to recipient cells (such as macrophages) to maintain homeostasis. (frontiersin.org)
form adjustments in cells maintenance and morphogenesis of cells integrity in homeostasis. (aboutsciencenow.info)

Progenitor cell (stem cell) lines in the bone marrow produce new blood cells and stromal cells. (medscape.com)
In health, PSCs are known to not only play a role in regulating normal extracellular matrix turnover but are also thought to have progenitor cell functions as well as a role in innate immunity. (pancreapedia.org)

However, those authors did confirm the presence of inflammatory cells accumulating in the adventitia of monocrotaline-treated/pneumonectomised rats. (ersjournals.com)
A pro-inflammatory environment is thought to provide a selective advantage for the leukemic stem cells (LSC). (haematologica.org)

Recent studies have indicated that exosomes are vital messengers for cell-cell communication in various biological processes. (researchpad.co)
In this experiment, we found that exosomes derived from M2 macrophages (M2D-Exos) could inhibit adipogenesis and promote osteogenesis of BMSCs. (researchpad.co)
Taken together, the results of our study indicate that exosomes isolated from M2 macrophages could facilitate osteogenesis and reduce adipogenesis through the miR-690/IRS-1/TAZ axis and might be a therapeutic tool for bone loss diseases. (researchpad.co)
Recent studies have found that exosomes play a vital role in bone diseases ( 15 , 16 ). (researchpad.co)
In this study, exosomes from bone marrow plasma were successfully extracted and identified. (techscience.com)
Extracellular vesicles (EVs), including exosomes, are membranous particles released by cells into the extracellular space. (mdpi.com)

Microglia, the resident immune cells in the CNS, have been studied extensively with regard to their roles in inflammation and disease, but less is known about their functions in the developing and adult brain ( Casano and Peri, 2015 ). (biologists.com)
The complement system is part of the body's immune system, and plays integral roles in the recognition and clearance of pathogens, apoptotic and necrotic cells. (endonews.com)
As the Bone Marrow (BM) develops and becomes functional, it becomes the main site of blood and immune cell formation. (brainimmune.com)
This review further emphasizes the diversified cross-talk between γδ T cells and other immune cells. (explorationpub.com)
It is hoped that the host immune status can be accurately predicted and gradually advance γδ T cell precise individualized medicine. (explorationpub.com)

To identify regulators of primitive chronic myeloid leukemia (CML) cells, we performed a high-content cytokine screen using primary CD34 + CD38 low chronic phase CML cells. (haematologica.org)
This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
The common stem cell produces 2 other stem cells, the myeloid stem cell and the lymphoid stem cell. (medscape.com)

Also, M-CSF induces VEGF in monocytes in human tumors. (biolegend.com)
Special advances are achieved in HER-positive tumors using targeted therapy with drugs which suppress the tumor cell growth factors (trastuzumab, herceptin). (cttjournal.com)

Follicular dendritic cells also express CD19. (thermofisher.com)
Dendritic cells (DCs) are the most potent antigen presenting cells (APCs). (bvsalud.org)

M-CSF was first characterized as a glycoprotein that induces monocyte and macrophage colony formation from precursors in murine bone marrow cultures. (biolegend.com)
All experiments performed on red cell lysed murine splenocytes gated on mononuclear cells. (bio-rad-antibodies.com)

Cells propagated in vitro in special media conducive to their growth. (lookformedical.com)
In vitro studies in Smad3 null bone marrow macrophages also showed that Smad3 was required for TGF-β1-induced MMT and collagen production. (oncotarget.com)

Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. (lookformedical.com)

Osteocytes, which are the most abundant cells in bone, composing 90-95% of all bone cells in an adult. (biomedcentral.com)
In an adult, roughly half of the bone marrow is still red. (medscape.com)

It is composed of over 50 proteins with soluble activation precursor components, regulators and cell surface receptors. (endonews.com)
Focusing on novel positive regulators of primitive CML cells, the myostatin antagonist myostatin propeptide gave the largest increase in cell expansion and was chosen for further studies. (haematologica.org)

26,27 Dermal adipocytes are organized in small clusters under the reticular dermis and interact with the hair follicular cells regulating the hair cycle. (jcadonline.com)

This review will focus on the most recent/relevant molecular findings driving this functional impairment of mesenchymal stem cells in the aging process. (biomedcentral.com)
In pathological conditions, damaged cells transfer dysfunctional mitochondria toward recipient cells to ask for help and take up exogenous functional mitochondria to alleviate injury. (frontiersin.org)
They demonstrated that transferring functional mitochondria of bone marrow-derived stem cells to defective parenchymal cells increases the aerobic respiration capacity of recipient mitochondria ( 7 ). (frontiersin.org)
γδ T cells express unique T cell receptor (TCR) γ and TCR δ chains, with structural and functional heterogeneity. (explorationpub.com)
At present, the phenotypic heterogeneity and functional variation of human γδ T cells are increasing. (explorationpub.com)

At around embryonic day (E) 9 in mice, NPCs transform into radial glia, which are the primary progenitor cells for both neurons and macroglia during embryogenesis. (biologists.com)
MAGI ortholog localizes apically to cadherin-based adhesions and its own loss qualified prospects to actin disorganization and decreases the entire robustness of cell adhesions in the embryonic epidermis14,15. (aboutsciencenow.info)

We then discuss emerging roles for each glial cell type (astrocytes, oligodendrocytes, Schwann cells and microglia) in regulating the development and plasticity of the nervous system. (biologists.com)
Astrocytes, the most abundant cell type in the vertebrate central nervous system (CNS), have perhaps the most diverse roles among glia. (biologists.com)

Specialized phagocytic cells of the MONONUCLEAR PHAGOCYTE SYSTEM found on the luminal surface of the hepatic sinusoids. (lookformedical.com)
and foreign particles by phagocytic cells (PHAGOCYTES). (lookformedical.com)
Mononuclear cells with pronounced phagocytic ability that are distributed extensively in lymphoid and other organs. (lookformedical.com)

The prognosis of some patients with infantile osteopetrosis can markedly change after bone marrow transplantation (BMT). (medscape.com)
We also discussed the advantage and challenges of mitochondrial transfer strategies, including cell-based mitochondrial transplantation, extracellular vesicle-based mitochondrial transplantation, and naked mitochondrial transplantation, for the treatment of cardiovascular disorders. (frontiersin.org)
In these studies, however, transplanted cells were followed, if at all, at the site of transplantation, and biodistribution was not an issue. (stemcellslab.net)
This concept started from the observation that bone marrow transplantation can provide stromal cells able to synthesize intact collagen type I, replacing deficient patient cell function and ameliorating disease symptoms [5]. (stemcellslab.net)

Depletion of bone marrow-derived monocytes prevented the adventitial remodelling. (ersjournals.com)
After reddish blood cell depletion using Hetastarch and volume reduction, the cells were cryopreserved in a solution containing 5% human albumin and 10% dimethyl sulfoxide with a controlled rate freezer prior to final storage in the gas phase of a liquid nitrogen tank. (ebat2018.org)

According to current challenges, there is a need to explore innovative immunotherapies, maximize the tumor-killing efficacy of γδ T cells, and attenuate or eliminate tumor immunosuppression. (explorationpub.com)

Yet, the maturation and activations of these cells occurs throughout the body, either in secondary lymphoid organs or the blood itself. (brainimmune.com)

In a rat monocrotaline model combined with unilateral pneumonectomy using green fluorescent protein-expressing chimeric bone marrow transplanted rats, S ahara et al . (ersjournals.com)
The MMT process occurred predominantly within M2-type macrophages and was regulated by TGF-β/Smad3 signalling as deletion of Smad3 in the bone marrow compartment of GFP+ chimeric mice prevented the M2 macrophage transition into the MMT cells and progressive renal fibrosis. (oncotarget.com)

2 ] in 1994 and is defined by the expression of a variety of cell surface antigens, including the stem cell marker CD34, the pan-leukocyte marker CD45, and monocyte markers CD14 and CD11. (ersjournals.com)

New insights into the complex cellular contributions and interactions will be provided, comparing the role of cell subsets in the pathogenesis of IPF and systemic sclerosis. (ersjournals.com)
The glomerulopathic light chains interact with mesangial cells where purported receptors regulate the downstream cellular mechanisms that will be activated and result in glomerular alterations. (heraldopenaccess.us)

In addition, M-CSF enhances monocyte functions such asphagocytic activity, microbial killing, and tumor cell cytotoxicity. (biolegend.com)
It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. (lookformedical.com)

check the tag ADOLESCENCE HN - 2008 BX - Nutrition in Adolescence FX - Adolescent Nutrition Physiology MH - Peritoneal Stomata UI - D054048 MN - A01.047.025.600.700 MN - A10.810 MS - Natural openings in the subdiaphragmatic lymphatic plexus in the PERITONEUM, delimited by adjacent mesothelial cells. (bvsalud.org)

First, γδ T cells exposed to complicated cytokine networks are potentially affected by multiple inhibitory mechanisms. (explorationpub.com)
The development of isolation and culture methods for PSCs in 1998 helped to unravel the mechanisms involved in the process of pancreatic fibrogenesis (5, 11) and also helped researchers to investigate the functions of these cells both in health and disease. (pancreapedia.org)
While bone marrow-derived myofibroblasts in renal fibrosis has been reported, the cell origin and mechanisms regulating their transition into myofibroblasts remain undefined. (oncotarget.com)

The defect in bone turnover characteristically results in skeletal fragility despite increased bone mass, and it may also cause hematopoietic insufficiency, disturbed tooth eruption, nerve entrapment syndromes, and growth impairment. (medscape.com)
Several unexpected findings in genetically altered mice have prompted research into the direction of intermediate metabolism of skeletal cells. (mdpi.com)

In addition, they act as antigen presenting cells and promote angiogenesis [ 8 ]. (ersjournals.com)
This chapter provides an overview of the key role of hEPC in promoting angiogenesis and their potential use for cell therapy. (intechopen.com)

In summary, we identify myostatin propeptide as a novel positive regulator of primitive CML cells and corresponding normal hematopoietic cells. (haematologica.org)

They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. (lookformedical.com)

[ 8 ] Acidification promotes solubilization of the bone mineral in the sealing zone, and various proteases, notably cathepsin K, catalyze degradation of the matrix proteins. (medscape.com)
i) Precipitated proteins in A10 cell lysates with m7GTP\agarose beads were identified by Western blot analysis. (informationalwebs.com)
ii) A10 cell lysates were incubated with GTP\agarose beads, and none of the proteins tested were precipitated with the beads. (informationalwebs.com)
Moreover, in HEK 293T cells, forced expression of Flag\FMRP results in an increased association of endogenous \catenin with the eIF4E pre\initiation complex without affecting \catenin expression, while again, no proteins interacted with the GTP\agarose control beads (Fig?4D\i and ii, respectively). (informationalwebs.com)
They filter bacteria and small foreign proteins out of the blood, and dispose of worn out red blood cells. (lookformedical.com)
Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: domain composition, intracellular localization, and function in male germ cells in mice. (shengsci.com)
There he worked with Dr. Max D. Cooper (Howard Hughes Medical Institute, National Academy of Sciences) and his research focused on cell surface proteins expressed by preB cells that regulate B cell maturation and homing. (ubc.ca)
In this regard, his lab has identified a novel family of hematopoietic cell surface proteins, called the CD34 family, and shown that these are essential for a number of developmentally important processes. (ubc.ca)
Approximately 85% of the monoclonal proteins in patients with plasma cell dyscrasia are associated with renal disease. (heraldopenaccess.us)
Only mature blood cells contain the membrane proteins required to attach to and pass the blood vessel endothelium. (medscape.com)
Right here, we propose a molecular system where AJC scaffolding proteins control apical cell contractility by differentially recruiting MAGI-1 and MAGI-3 to apical AZD-3965 junctions. (aboutsciencenow.info)
Open up in another windowpane Fig. 1 Lack of ZO proteins dysregulates ROCK-dependent contractility to improve apical morphology.a Consultant immunofluorescence pictures of ZO-1 and WT, dKO cells stained for activated -catenin -2. (aboutsciencenow.info)

Recently, intercellular communication between bone cells and surrounding cells has been gradually recognized, and macrophages on the surface of bone have been proven to regulate bone metabolism. (researchpad.co)
Adipose cells organized in small clusters under the reticular dermis closely interact with hair follicular cells and regulate the hair cycle. (jcadonline.com)

2 1 There is growing evidence to suggest that primitive CML cells affect the bone marrow (BM) niche, contributing to deregulated cytokine levels. (haematologica.org)

Once the balance of bone metabolism is disrupted, a variety of bone disorders will develop. (researchpad.co)
We employ cutting-edge technologies such as single cell RNA sequencing, multi-coloured flow cytometry and mitochondrial metabolism assays for basic research and optical coherence tomography (OCT) for translational research. (edu.au)

Thus, regulating the balance between osteogenesis and adipogenesis may be a potential treatment strategy for bone loss diseases. (researchpad.co)
This paper reviews recent advances and potential sources of stem cells for cell therapy in retinal diseases. (biomedcentral.com)

Colony Forming Cell (CFU) Assay CD34+ cells were selected from HPDSCs with a human CD34 positive selection kit and isolated using automated cell separator RoboSep (StemCell Technologies, Inc., Vancouver, Canada). (ebat2018.org)
Experimental and human studies with intravitreal bone marrow-derived stem cells have begun. (biomedcentral.com)
The human skeleton is especially affected by the passage of time: bone loss begins as early as the third decade of life, immediately after peak bone mass. (biomedcentral.com)
These cells have a relatively short-lifespan, estimated at 3 months in human bones [ 5 ]. (biomedcentral.com)
Next, we used a peptide array method that involved human dental pulp stem cells (hDPSCs) to evaluate the mineralization-inducing ability of each peptide. (nagoya-u.ac.jp)
We use animal models, cell culture systems and human clinical specimens for research. (edu.au)
This project aims to isolate, characterise, and investigate the properties of human EndoMac progenitor cells, for therapeutic manipulation. (edu.au)
Preliminary biological studies were conducted to evaluate adhesion (6 h) of human mesenchymal stem cells (hMSC) to the patterns in terms of cell number and morphology. (ibecbarcelona.eu)
In this review, we use the Heilig nomenclature to describe human γδ T cells [ 1 ]. (explorationpub.com)
Over the two decades since these cells were first isolated and cultured from rodent and human pancreas, research in this area has progressed at a rapid rate. (pancreapedia.org)

Anatomy60

Organisms19

Diseases14

Chemicals and Drugs65

Analytical, Diagnostic and Therapeutic Techniques and Equipment47

Phenomena and Processes52

Disciplines and Occupations3

Technology, Industry, Agriculture6

Information Science3

MSCs28

Endothelial cells5

Differentiate8

Phenotype6

Fibroblasts3

Osteoblasts10

Vascular7

Osteoclasts6

Differentiation13

Proliferation7

Tissues17

Peripheral9

Lineage5

Tissue32

Anti-inflammatory1

Cytokines8

Microenvironment9

Lymphocytes2

Hematopoiesis5

Epithelial7

Hematopoietic stem3

Biology4

Homeostasis6

Progenitor cell2

Inflammatory2

Exosomes6

Immune5

Myeloid3

Tumors2

Dendritic cells2

Murine2

Vitro2

Glycoprotein1

Adult2

Regulators2

Adipocytes1

Functional5

Embryonic2

Roles2

Phagocytic3

Transplantation4

Depletion2

Efficacy1

Organs1

Chimeric2

CD141

Cellular2

Tumor cell2

Mesothelial cells1

Mechanisms3

Skeletal2

Angiogenesis2

Normal hematopoietic1

Induce1

Proteins12

Regulate2

Niche1

Metabolism2

Diseases2

Human10