AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Hematopoietic Stem CellsBone Marrow CellsHematopoietic Stem Cell TransplantationBone Marrow TransplantationBone MarrowTransplantation, HomologousGraft vs Host DiseaseHematologic NeoplasmsTransplantation, AutologousBone and BonesStem CellsTissue DonorsTransplantation ConditioningImmunocompromised HostCytomegalovirus InfectionsOpportunistic InfectionsWhole-Body IrradiationStem Cell TransplantationLeukemiaHematopoiesisMycosesHistocompatibilityGraft SurvivalTreatment OutcomeTransplantationRetrospective StudiesHematologic DiseasesAspergillosisTime FactorsCell DifferentiationAnemia, AplasticAntigens, CD34CytomegalovirusHistocompatibility TestingHepatic Veno-Occlusive DiseaseMice, Inbred C57BLBone Marrow DiseasesColony-Forming Units AssayBone RemodelingHematopoietic Stem Cell MobilizationTransplantation ChimeraBone Marrow ExaminationFatal OutcomeRecurrenceImmunosuppressive AgentsBone Marrow PurgingBone Marrow NeoplasmsCell LineageFlow CytometryAcute DiseaseAntifungal AgentsLeukemia, Myeloid, AcuteBK VirusCells, CulturedBusulfanAntiviral AgentsPeripheral Blood Stem Cell TransplantationLeukemia, Myelogenous, Chronic, BCR-ABL PositiveBone DensityRadiation ChimeraStem Cell NicheSurvival AnalysisNeutropeniaPrecursor Cell Lymphoblastic Leukemia-LymphomaGraft RejectionSurvival RateKidney TransplantationImmunosuppressionCell SeparationLymphoproliferative DisordersPolymerase Chain ReactionAdult Stem CellsBone ResorptionMyelodysplastic SyndromesAspergillusRisk FactorsMultiple MyelomaCombined Modality TherapyCyclosporineEmbryonic Stem CellsFollow-Up StudiesT-LymphocytesGranulocyte Colony-Stimulating FactorCyclophosphamideStem Cell FactorHLA AntigensFetal BloodProspective StudiesLeukemia, MyeloidLymphocyte DepletionTransplantsTransplantation, IsogeneicNeoplasmsGanciclovirStromal CellsIncidenceMultipotent Stem CellsMesenchymal Stromal CellsMice, KnockoutBone Neoplasms
TransplantationHSCTRecipientsDonorsPatientsClinical1999Autoimmune diseasesAllogeneic stem cell transMultiple myelomaHaploidenticalUmbilical cordTransplantationsOutcomesPatient's bone marrow20212023GVHDMalignanciesOrgansProgenitor cellsPeripheral blood stem cellPediatricPlateletsDiseasesMesenchymalEngraftmentImmune systemAutologous stemGraftPatientProcedureCancerOrganCordMyelomaDonor registryTypes of stemBlood cancersLymphomaOutpatientInfection
Transplantation64
HSCT10
  • Although outcomes after HSCT have improved markedly since transplants were first utilized, infection remains an important source of morbidity. (medscape.com)
  • In contrast, in-vivo TCD is performed using anti-T cell antibodies or, most recently, post-HSCT cyclophosphamide. (wikipedia.org)
  • Fatal hMPV infections have been reported in immunocompromised patients, including a 17-month-old girl who had acute lymphoblastic leukemia ( 3 ) and a 33-year-old woman who had received a hematopoietic stem cell transplant (HSCT) ( 4 ). (cdc.gov)
  • Bone marrow transplants, or hematopoietic stem cell transplantations (HSCT), treat more than 70 different diseases, including some types of leukemia, lymphoma, and sickle cell anaemia. (the-scientist.com)
  • Prior allogeneic hematopoietic stem cell transplant (HSCT) or donor lymphocyte infusion within 6 months prior to enrollment, current acute graft versus host disease grade 2-4 by Glucksberg criteria or severity B-D by by International Bone Marrow Transplant Registry (IBMTR) index or history of severe (grade 3-4) acute graft versus host disease. (moffitt.org)
  • The drug candidate is also under development for bone marrow conditioning before a hematopoietic stem cell transplant (HSCT), in relapsed/refractory elderly AML patients. (pharmaceutical-technology.com)
  • Akari's pipeline includes a Phase 3 clinical trial program investigating nomacopan for severe pediatric hematopoietic stem cell transplant-related thrombotic microangiopathy (HSCT-TMA). (texomashomepage.com)
  • But is there any reason to think that hematopoietic stem cell transplants (HSCT) could 'reset' the immune system in MS? (closerlookatstemcells.org)
  • HSCT) has significantly modified the prognosis of when the pathological process involves BM or when patients with hereditary or acquired hematological, hematopoietic toxicity is the limiting factor in the oncological and immunological diseases and it is the aggressive treatment of the disease. (bvsalud.org)
  • HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)
Recipients8
  • In preparation for receipt of the stem cells, recipients undergo myeloablation to eliminate their own myeloid cells. (medscape.com)
  • In addition, adult lung transplant recipients have been able to clear hMPV infection despite high levels of immunosuppression ( 7 ). (cdc.gov)
  • Arvin AM . Varicella-zoster virus: pathogenesis, immunity, and clinical management in hematopoietic cell transplant recipients. (nature.com)
  • Bertram Kasiske, MD, of the Scientific Registry of Transplant Recipients (SRTR) in Minneapolis, led a team that examined the validity of those data. (medindia.net)
  • The researchers analyzed information from the Scientific Registry of Transplant Recipients, which includes data on all donors, wait-listed candidates, and transplant recipients in the United States. (medindia.net)
  • KEYPOINTS: Invasive fungal sinusitis (IFS) rate and risk factors in transplant recipients were explored IFS rate is higher in allogeneic recipients with prior transplants and worse comorbidity scores The at-risk timeframes for IFS development were identified. (wustl.edu)
  • Cytomegalovirus glycoprotein B and N genotypes in pediatric recipients of the hematopoietic stem cell transplant. (cdc.gov)
  • Despite advances in the field, transplant recipients may face several avoidable risks. (who.int)
Donors7
  • Donors for allogeneic transplants may be related or unrelated to the recipient. (medscape.com)
  • Many patients find matched unrelated donors through the National Marrow Donor Program. (mdanderson.org)
  • And while 70 percent of Caucasian patients are successfully matched, only 17 percent of black people in the United States are as lucky, according to The New York Stem Cell Foundation , likely because only 8 percent of donors in US registries are black. (the-scientist.com)
  • Other donor cells can come from unrelated match donors, partially matched or half-matched family members, or in some circumstances, from an umbilical cord blood donor. (reachmd.com)
  • Cord blood does not contain many stem cells, which means that adults needing a transplant will require cord blood stem cells from multiple donors. (medicalnewstoday.com)
  • This site provides information, referrals, and support by trained peer volunteers who are transplant survivors, caregivers, and donors. (myeloma.org)
  • The deduced probable HLA-C*03:187-associated human leukocyte antigen haplotype (A*24:02-B*35:01-C*03:187-DRB1*11:01) revealed in Taiwanese unrelated hematopoietic bone marrow stem cell donors. (cdc.gov)
Patients36
  • Antiretroviral therapy, the most common treatment for patients with HIV, has been shown to restore CD4+ T cell counts. (wikipedia.org)
  • For many patients who don't have a well-matched, healthy donor, a cord blood transplant is a viable option. (mdanderson.org)
  • Clinical characteristics of patients with COVID-19 harboring detectable intracellular SARS-CoV-2 RNA in peripheral blood cells. (google.com)
  • The company also highlighted progress with omidubicel , an advanced cell therapy with positive Phase 3 clinical data, as a potentially life-saving treatment option for patients in need of an allogeneic hematopoietic stem cell (bone marrow) transplant, and GDA-201 , a natural killer (NK) cell immunotherapy in Phase 1/2 development for patients with non-Hodgkin lymphoma (NHL). (biospace.com)
  • In the first quarter of this year, we made significant progress on key initiatives across all functions of our business, starting with omidubicel, a potentially transformative treatment option for patients with hematological malignancies," said Julian Adams, Ph.D., chief executive officer of Gamida Cell. (biospace.com)
  • The company anticipates submitting a Biologics License Application (BLA) to the FDA in the fourth quarter of this year, based on the results of an international, randomized Phase 3 study of omidubicel that was designed to evaluate the safety and efficacy of omidubicel in patients with hematologic malignancies undergoing a bone marrow transplant compared to patients who received a standard umbilical cord blood transplant. (biospace.com)
  • When germ-free cell cultures became a laboratory routine, hopes were high for using this novel technology for treatment of diseases or replacement of cells in patients suffering from injury, inflammation, or cancer or even refreshing cells in the elderly. (hindawi.com)
  • Fertile male and female patients must be willing to use a contraceptive method before, during, and for at least 12 months after the last T cell infusion. (moffitt.org)
  • This informational program was created in conjunction with the NCCN Guidelines for Patients®: Squamous Cell Skin Cancer . (nccn.org)
  • For years now, bone marrow transplants have been used to treat patients with leukemia and other blood disorders. (closerlookatstemcells.org)
  • Previously, he had been exploring ways to manipulate the immune system in leukemia patients to be able to give them highly mismatched donor stem cell transplants, and one of his colleagues wondered if the approach might also work for autoimmune diseases. (closerlookatstemcells.org)
  • For example, in their phase II trial with 24 patients who failed conventional therapy, Drs. Atkins and Freeman found that a very high dose of chemotherapy followed by purified autologous hematopoietic stem cell transplants appeared to have the most impact on preventing ongoing inflammatory activity and progression in these patients. (closerlookatstemcells.org)
  • Dr. Atkins highlights a few priorities for better understanding how to use hematopoietic stem cells transplants for MS. The first is finding the minimal dose of chemotherapy that will effectively destroy the immune system without being too toxic, and the second is to understand which patients could benefit most from this therapy and whether it would be better to start the therapy earlier during the treatment pathway. (closerlookatstemcells.org)
  • To assess the morphologic bone marrow response in MDS/MPN patients treated on each Arm of the study. (mycancergenome.org)
  • But unfortunately, only about 20% of patients with sickle cell disease in the United States have a matched donor. (reachmd.com)
  • Well, the reality is that most patients who are transplanted are younger, typically under age 16 years. (reachmd.com)
  • February 11, 2021 - Apamistamab conditioning treatment with targeted radioimmunotherapy to the bone marrow resulted in high rates of successful allogeneic hematopoietic stem cell transplants in patients with active, relapsed, or refractory acute myeloid leukemia. (onclive.com)
  • Apamistamab (Iomab-B) conditioning treatment with targeted radioimmunotherapy to the bone marrow resulted in high rates of successful allogeneic hematopoietic stem cell transplants in patients with active, relapsed, or refractory acute myeloid leukemia (AML), according to interim results from the phase 3 SIERRA trial, which were presented virtually at the 2021 Transplant and Cellular Therapies Meetings. (onclive.com)
  • In these patients with relapsed or refractory AML, we observed high rates of allogeneic stem cell transplant with curative intent [in] 88% of patients on the Iomab-B arm, 18% of patients who were randomized to the conventional care arm achieved complete remission and received standard of care allo-transplant, and an overall rate of 79% of allo-transplant in all enrolled patients," Boglarka Gyurkocza, MD, said in a virtual presentation. (onclive.com)
  • Investigators sought to prove with this study that targeted radiation to the marrow with apamistamab, a radioactive iodine ( 131 I)-labeled anti-CD45 antibody, could enable the successful engraftment of patients despite active disease in the marrow. (onclive.com)
  • Patients are eligible for enrollment if they have marrow blast count ≥ 5% or the presence of peripheral blasts, age ≥ 55 years, a Karnofsky score ≥ 70, and related/unrelated donor matching at human leukocyte antigen (HLA)-A, HLA-B, HLA-C, and DRB-1. (onclive.com)
  • Under immunosuppression conditions, all infectious foci can be activated and, for this reason, all active infections in hematopoietic stem cell pre-transplant patients must be eradicated prior to transplant so as to prevent or reduce the risk of systemic complications in these patients. (bvsalud.org)
  • BMT InfoNet provides emotional support and information about bone marrow and peripheral blood stem cell transplants to patients and their loved ones. (myeloma.org)
  • This site provides information for patients and their families ranges from data about transplant outcomes to best practices in follow-up care for patients post-transplant. (myeloma.org)
  • This site provides information about bone marrow or cord blood transplant process for patients, their families, and health care providers. (myeloma.org)
  • A 28-year-old brain-dead man had his kidneys, lungs, and liver successfully transplanted into four critically ill patients at multiple hospitals in India. (medindia.net)
  • We retrospectively analyzed data for 118 patients who had undergone allogeneic hematopoietic SCT and had received MTX for GVHD prophylaxis. (elsevierpure.com)
  • Systemic folinic acid administration and mouthwash appear to be useful for reducing the incidence of severe oral mucositis in patients who have received allogeneic hematopoietic SCT using MTX as GVHD prophylaxis. (elsevierpure.com)
  • Of the NHL patients, 59 (44%) had diffuse large B-cell lymphoma (DLBCL). (smw.ch)
  • 0103 Genotype in Survival of Patients After Allogeneic Hematopoietic Stem Cell Transplant. (cdc.gov)
  • Cytomegalovirus Glycoprotein Polymorphisms and Increasing Viral Load in Non-Transplant Patients with Hematological Malignancies Undergoing Chemotherapy: A Prospective Observational Study. (cdc.gov)
  • In this context, patients experience the first psychological conflicts before this transplant. (bvsalud.org)
  • To describe the psychological suffering developed by patients transplanted with hematopoietic stem cells from a referral service in the state of Rio Grande do Norte. (bvsalud.org)
  • Arguments supporting the reactive nature of LCH include the occurrence of spontaneous remissions, the extensive elaboration of multiple cytokines by dendritic cells and T-cells (the so-called cytokine storm) in LCH lesions, and the good survival rate in patients without organ dysfunction. (medscape.com)
  • The drug of choice for prevention of CMV disease in solid-organ transplant patients is valganciclovir. (medscape.com)
  • Specialty care area for the care of patients who undergo bone marrow (stem cell) transplant for the treatment of various disorders. (cdc.gov)
Clinical12
  • We also continue to expand our clinical pipeline with plans to submit an IND for our GDA-201 natural killer cell therapy, initiate a multi-center Phase 1/2 clinical study in NHL and continue to advance our R&D activities to pursue the development of genetically modified NAM-enabled NK cells in solid tumors. (biospace.com)
  • Additionally, the study met key secondary endpoints related to the speed of platelet engraftment, decrease in infections and reduction in hospitalizations, all significant clinical measures in bone marrow transplant. (biospace.com)
  • We have a series of clinical trials available to evaluate several different strategies to prevent GVHD, such as T cell depletion and the use of novel immunosuppressive agents. (harvard.edu)
  • But research progressed and different trials explore the clinical potential of human MSCs isolated from bone marrow but also from other tissues including adipose tissue. (hindawi.com)
  • This same approach is now being tested in clinical trials for people with multiple sclerosis (MS) and other autoimmune diseases in the hope that providing brand new blood cells will reset the immune system to a healthy state. (closerlookatstemcells.org)
  • Since then, people with certain forms of MS have received autologous hematopoietic stem cell transplants in clinical trials worldwide, and many lessons have been learned along the way. (closerlookatstemcells.org)
  • This is the next step for Drs. Atkins and Freeman who are organizing a phase III randomized clinical trial to compare the hematopoietic stem cell transplant approach in people with MS who have highly active disease, and who have failed one or two conventional drugs, against individuals with MS who are treated with the best available, approved drug therapy. (closerlookatstemcells.org)
  • A resource for scientists and clinicians that highlights the latest basic, clinical and translational research in bone and mineral metabolism. (myeloma.org)
  • This site provides information about stem cell transplants provided by the American Society of Clinical Oncology (ASCO). (myeloma.org)
  • A second apheresis or a bone marrow collection was considered, but neither was performed because the clinical condition of the donor worsened. (cdc.gov)
  • On one end, the clinical spectrum includes an acute, fulminant, disseminated disease called Letterer-Siwe disease, and, on the other end, solitary or few, indolent and chronic lesions of bone or other organs called eosinophilic granulomas . (medscape.com)
  • The intermediate clinical form called Hand-Schüller-Christian disease is characterized by multifocal, chronic involvement and classically presents as the triad of diabetes insipidus, proptosis, and lytic bone lesions. (medscape.com)
19992
  • The investigators looked specifically at mortality rates by age for candidates registered on the lung transplant waiting list between January 1, 1999, and December 31, 2011. (medindia.net)
  • In Europe, hundreds of thousands of tissue transplants are performed each year, and in 1999 an estimated 750 000 people in the United States of America received human tissue, twice as many as in 1990. (who.int)
Autoimmune diseases2
  • Those who have had/or are planning to have an organ transplant or a hematopoietic cell transplant (also known as stem cell or bone marrow transplant), and those with autoimmune diseases are at increased risk for squamous cell skin cancer. (nccn.org)
  • A vaccine that stimulates CD8 T regulatory cells helps to prevent self-destructive immune reactions in autoimmune diseases and organ transplant rejection. (medindia.net)
Allogeneic stem cell trans2
  • An allogeneic stem cell transplant is similar, but we take cells from someone other than the patient. (mdanderson.org)
  • Where do allogeneic stem cell transplant donor cells come from? (mdanderson.org)
Multiple myeloma2
Haploidentical2
  • The child, a girl who was born in January 2002, received an allogeneic haploidentical stem cell transplant from her father in May 2002 after her diagnosis of SCID. (cdc.gov)
  • That's something that we call a haploidentical transplant. (reachmd.com)
Umbilical cord2
  • The stem cell source may be bone marrow, peripheral blood, or umbilical cord blood. (medscape.com)
  • Adebiyi also plans to establish another Nigerian source for stem cell transplants-an umbilical cord blood bank. (the-scientist.com)
Transplantations2
  • When it comes to hematopoietic stem cell transplantations, these are the important cells. (lu.se)
  • Globally, it is estimated that 120 000 corneal transplantations and 18 000 transplantations of allogeneic haematopoietic progenitor cells took place in the year 2000. (who.int)
Outcomes1
Patient's bone marrow1
  • The cells are remarkable in that they can find their way into the recipient's bone marrow, where they begin to divide and repopulate the patient's bone marrow as his or her own. (reachmd.com)
20213
  • The bone marrow market is expected to gain market growth in the forecast period of 2021 to 2028. (powershow.com)
  • BOSTON--( BUSINESS WIRE )-- Gamida Cell Ltd. (Nasdaq: GMDA), an advanced cell therapy company committed to cures for blood cancers and serious blood diseases, today reported financial results for the quarter ended March 31, 2021. (biospace.com)
  • Transplant Cell Ther 2021. (harvard.edu)
20231
  • The most recent Patient Webinar: Squamous Cell Skin Cancer occurred in September 2023. (nccn.org)
GVHD5
  • If your child received bone marrow from someone else, look for signs of graft-versus-host disease ( GVHD ). (medlineplus.gov)
  • In GVHD, the donated stem cells view the recipient cells as foreign and attack recipient cells. (medscape.com)
  • TCD can reduce the risk of graft-versus-host disease (GVHD), which is a common issue in transplants. (wikipedia.org)
  • Although TCD is beneficial to prevent GVHD there are some problems it can cause a delay in recovery of the immune system of the transplanted individual and a decreased Graft-versus-tumor effect. (wikipedia.org)
  • Early on it was apparent that TCD was good for preventing GVHD, but also led to increased graft rejection, this problem can be solved by transplanting more hematopoietic stem cells. (wikipedia.org)
Malignancies1
  • The purpose of the study is to find out if an investigational drug called PRGN-3007 UltraCAR-T cells (PRGN-3007 T cells) can help people with ROR1-positive hematologic chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), acute lymphoblastic leukemia (ALL), diffuse large B-cell lymphoma (DLBCL) and solid tumor triple negative breast cancer (TNBC) malignancies. (moffitt.org)
Organs8
  • These fatty materials are stored naturally in the body's cells, organs, and tissues. (nih.gov)
  • These stem cells come from developed organs and tissues in the body. (healthline.com)
  • Their cells stop dividing too early, resulting in failure of their organs and disease. (childrenshospital.org)
  • In the SIERRA trial, patient-specific dosimetry was used to generate an individualized therapeutic dose to target marrow and spare non-hematopoietic organs. (onclive.com)
  • Opportunities for improvement include bringing the lung donor yield in the 0-11 age group closer to the yield in adolescents, relaxing geographic allocation boundaries to ensure that pediatric lungs are offered first to children, and reserving deceased donor lobar transplant for circumstances where suitably sized donor organs are not available," they wrote. (medindia.net)
  • On the other hand, the infiltration of organs by a monoclonal population of aberrant cells, the possibility of lethal evolution, and the cancer-based modalities of successful treatment are all consistent with a neoplastic process. (medscape.com)
  • Of the 70 000 or so solid organs transplanted annually, 50 000 are kidney replacements, more than one-third of the latter operations are done in low- or medium-income countries. (who.int)
  • The supply of cadaveric organs is limited by an inadequately informed and educated public, inefficient or non-existent organizations for procuring transplant material, and cultural and religious barriers in some countries. (who.int)
Progenitor cells4
  • However, transplanting other than hematopoietic stem and progenitor cells is still limited to a few applications, and it mainly applies to mesenchymal stromal cells (MSCs) isolated from bone marrow. (hindawi.com)
  • At the same time, by asymmetric cell division or after specific activation, stem cells must be able to generate more mature progenitor cells or differentiated effector cells (Figure 1 ). (hindawi.com)
  • They display differentiation capacities and therefore qualify as multipotent progenitor cells (Figure 1 ). (hindawi.com)
  • [ 18 ] Arylsulfatase A deficiency leads to defective glial and neuronal differentiation from neural progenitor cells. (medscape.com)
Peripheral blood stem cell1
  • Here, we report transmission of dengue virus to a peripheral blood stem cell recipient by a donor who had recently traveled to an area to which the virus is endemic. (cdc.gov)
Pediatric2
  • Establishment of the First Comprehensive Adult and Pediatric Hematopoietic Stem Cell Transplant Unit in the United Arab Emirates: Rising to the Challenge. (nih.gov)
  • In an accompanying editorial, Stuart Sweet, MD, PhD, of Washington University in St. Louis, and Mark Barr, MD, of the University of Southern California in Los Angeles, noted that there are several other factors that should be considered as officials and the transplant community consider whether changes to pediatric lung allocation are warranted. (medindia.net)
Platelets2
Diseases9
  • The bone marrow transplant is the last alternative generally recommended by the physicians in the cases of fatal bone marrow diseases and bone or skin cancer. (powershow.com)
  • The growing amount of bone marrow diseases will help in escalating the growth of the bone marrow market. (powershow.com)
  • Lipid storage diseases (also known as lipidoses) are a group of inherited metabolic disorders in which harmful amounts of fatty materials (lipids) accumulate in various cells and tissues in the body. (nih.gov)
  • Since stem cells have the ability to turn into various other types of cells, scientists believe that they can be useful for treating and understanding diseases. (healthline.com)
  • Diseases treatable by transplants. (mayoclinic.org)
  • PLX-RAD will be used for treatment of bone marrow deficiency, genetic diseases, and treatment of acute radiation syndrome. (israel21c.org)
  • These diseases can often cause bone marrow failure and lung disease. (childrenshospital.org)
  • In dyskeratosis congenita and other telomere diseases, the protective caps on people's chromosomes shorten too quickly, causing cells and tissues to age prematurely. (childrenshospital.org)
  • Understanding the mechanism by which KSHV increases the infected cell population is crucial for curing KSHV-associated diseases. (bvsalud.org)
Mesenchymal1
Engraftment1
  • A key milestone in a patient's recovery, neutrophil engraftment is a measure of how quickly the stem cells a patient receives in a bone marrow transplant are established and begin to make healthy new cells. (biospace.com)
Immune system8
  • T-cell depletion (TCD) is the process of T cell removal or reduction, which alters the immune system and its responses. (wikipedia.org)
  • This problem is partially answered by more selective depletion, such as depletion of CD3+ or αβT-cell and CD19 B cell, which preserves other important cells of the immune system. (wikipedia.org)
  • However, over time, an individual's immune system can no longer continue to replace CD4+ T cells. (wikipedia.org)
  • The transplanted cells kill any remaining cancer cells and restore the patient's immune system. (mdanderson.org)
  • This will help prevent the immune system from rejecting an organ transplant. (healthline.com)
  • Scientists first tested the approach in animals with an MS-like disease and showed that radiation or chemotherapy followed by a bone marrow stem cell transplant could help to control the immune system. (closerlookatstemcells.org)
  • Primary HLH can only be cured by replacing the immune system by receiving a hematopoietic (blood or bone marrow) stem cell transplant. (candlelighters.org.uk)
  • Cord blood stem cells may support the immune system during cancer treatments. (medicalnewstoday.com)
Autologous stem2
  • An autologous stem cell transplant uses the patient's own cells for treatment. (mdanderson.org)
  • Varicella zoster virus infection associated with high-dose chemotherapy and autologous stem-cell rescue. (nature.com)
Graft8
  • However, T-cell depletion is associated with higher rates of graft rejection and increased vulnerability to viral and fungal infections while the T-cell population is diminished. (medscape.com)
  • Ex vivo techniques enable a more accurate count of the T cells in a graft and also has the option to 'addback' a set number of T cells if necessary. (wikipedia.org)
  • Another method is addition of cells back into the graft, after a comprehensive TCD method, examples are re-introduction of natural killer cells (NK), γδ T-cells and T regulatory cells (Tregs). (wikipedia.org)
  • These veto cells can also exert graft vs tumor effect. (wikipedia.org)
  • Four years after the transplant, she was still lymphopenic (800 × 10 9 /L, mostly T cells) and had chronic graft-versus-host disease, which had been treated with steroids (prednisone 2.5 mg twice a day for many months). (cdc.gov)
  • Donor Killer Cell Immunoglobulin-Like Receptor Genotype Does Not Improve Graft-versus-Leukemia Responses in Chronic Lymphocytic Leukemia after Unrelated Donor Transplant: A Center for International Blood and Marrow Transplant Research Analysis. (anthonynolan.org)
  • Unfortunately, two weeks after his stem cell transplant, Hughie developed a severe graft versus host reaction to his transplant. (candlelighters.org.uk)
  • However, since there are transplant-related risks such as graft versus host disease and life-threatening infection, as well as organ toxicity, one could likely not be transplanted if their sickle cell disease was not under really good control or if they had minimal disease manifestations. (reachmd.com)
Patient13
  • We extract blood cells, treat the cancer with high-dose chemotherapy , then place the cells back into the patient. (mdanderson.org)
  • The patient has low blood counts until the replaced cells replenish the patient's body with healthy cells. (mdanderson.org)
  • Once the cancer is less active and the patient has been pre-treated with chemotherapy (known as conditioning), he or she receives the donor's healthy stem cells. (mdanderson.org)
  • This allows us to collect more cells in a short period, decrease patient/donor downtime and freeze the cells for future use. (mdanderson.org)
  • Patient has undergone prior solid organ and/or non-autologous hematopoietic stem cell or bone marrow transplant. (mayo.edu)
  • We are progressing well with our manufacturing readiness activities in response to the clear feedback from the FDA regarding registration of our commercial manufacturing facilities and are actively building our launch readiness capabilities, including market access and support services, to ensure a positive patient experience at transplant at the time of potential FDA approval. (biospace.com)
  • Free patient webinar for those experiencing squamous cell skin cancer, their caregivers, and their families. (nccn.org)
  • Experts discussed squamous cell skin cancer and its various treatments, side effects from treatments, how to prevent future skin cancers and available patient and caregiver resources. (nccn.org)
  • The blood cells are harvested from the donor and stored, and then the sickle cell disease patient is given high doses of chemotherapy to get rid of all the remaining blood cells in the bone marrow in order for them to be able to receive the healthy donated cells. (reachmd.com)
  • The cells from the donor which are healthy are then infused into the sickle cell patient through a simple IV. (reachmd.com)
  • This essentially cures the patient of sickle cell disease. (reachmd.com)
  • And it's really best to consult a transplant expert to evaluate which is best for a particular patient. (reachmd.com)
  • Aim: Present a case report of dental care provided to a non-Hodgkin lymphoma patient with an urgent need for hematopoietic stem cell transplant. (bvsalud.org)
Procedure3
Cancer5
  • One example is antigen-specific CD4+ T cell tolerance, which serves as the primary mechanism restricting immunotherapeutic responses to the endogenous self antigen guanylyl cyclase c (GUCY2C) in colorectal cancer. (wikipedia.org)
  • However, in some cases, selective CD4+ T cell tolerance provides a unique therapeutic opportunity to maximize self antigen-targeted immune and antitumor responses without inducing autoimmunity by incorporating self antigen-independent CD4+ T cell epitopes into cancer vaccines. (wikipedia.org)
  • Doctors have been performing stem cell transplants, also known as bone marrow transplants, for decades using hematopoietic stem cells in order to treat certain types of cancer. (healthline.com)
  • http://www.cancer.gov/about-cancer/treatment/types/stem-cell-transplant/stem-cell-fact-sheet. (mayoclinic.org)
  • Methods Center for International Blood and Marrow Transplant Research data from 184 adults who completed the Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) before undergoing alloHCT and at day 100 were used. (cdc.gov)
Organ3
  • These cells can only serve a specific purpose in a particular organ. (healthline.com)
  • This means they can potentially produce new cells for any organ or tissue. (healthline.com)
  • So the goal is to transplant someone with sickle cell disease before they become too sick, particularly before they develop significant organ damage, such as kidney disease, liver disease, or heart disease, that might even preclude their ability to safely undergo the rigors of a transplant. (reachmd.com)
Cord15
Myeloma3
  • Myeloma cells destroy bone , which releases calcium, a condition called hypercalcemia. (webmd.com)
  • Myeloma cells produce excess abnormal proteins, called paraproteins, in the bone marrow that can cause your blood to become so thick that it flows sluggishly in your body, a condition called hyperviscosity. (webmd.com)
  • Abnormal proteins from myeloma cells can also damage the kidneys. (webmd.com)
Donor registry1
  • The 24-year-old woman, who was registered as a volunteer donor in the German Bone Marrow Donor Registry, was selected. (cdc.gov)
Types of stem3
Blood cancers2
  • Blood cancers multiply uncontrollably, hindering the growth of these cells. (mdanderson.org)
  • These cells have been successfully used to treat children with blood cancers, such as leukemia, and certain genetic blood disorders. (healthline.com)
Lymphoma1
  • GDA-201 in Marginal Zone B-cell Lymphoma Drug Details: GDA-201 is under development for the treatment. (globaldata.com)
Outpatient1
  • Lack of caregivers limits use of outpatient hematopoietic stem cell transplant program. (uchicago.edu)
Infection8
  • During this time, the risk for infection, bleeding, and skin problems are higher than before the transplant. (medlineplus.gov)
  • CMV infection characteristically is associated with "owl's-eye" cells, which are large cells with basophilic intranuclear inclusions and a surrounding clear zone. (medscape.com)
  • The main requirement for a donor is to not have sickle cell disease or infection, such as HIV or hepatitis C. But what's important to know is that it's perfectly fine for the donor to have sickle cell trait. (reachmd.com)
  • Nearly all KSHV-positive cells displayed co-infection with EBV. (bvsalud.org)
  • The macrophages derived from vIL-6(+) KSHV infection showed a distinct transcriptional profile of elevated IFN-pathway activation with immune suppression and were compromised in T-cell stimulation function compared to those from vIL-6(-) KSHV infection or uninfected control. (bvsalud.org)
  • Five days before the scheduled transplant day, or day minus 5, the recipient tested positive for Klebsiella pneumoniae infection of the central venous catheter. (cdc.gov)
  • infection with axillary temperature, bone pain, and headache. (cdc.gov)
  • After being informed about possible infection of the donor, the transplant physicians administered immunoglobulin to the recipient intravenously. (cdc.gov)