Bone marrow hematopoietic stem cell mobilization. Medical search. Frequent questions

G-CSF is also used to increase the number of hematopoietic stem cells in the blood of the donor before collection by leukapheresis for use in hematopoietic stem cell transplantation. (wikipedia.org)
G-CSF may also be given to the receiver in hematopoietic stem cell transplantation, to compensate for conditioning regimens. (wikipedia.org)
HSCs specifically are defined by their ability for self-renewal and to reconstitute the entire hematopoietic system following transplantation. (stemcell.com)
It is used both by hematopoietic researchers and clinical labs to assess the potency of transplantation units of cord blood (CB) and hematopoietic cellular therapy products. (stemcell.com)
Other uses of the CFU assay include studying the effects of stimulatory and inhibitory growth factors, screening novel compounds to predict potential toxicity to the hematopoietic system, and testing the effects of various in vitro manipulations (e.g. cell processing, cryopreservation, gene transduction, and transmission) on cellular products used in hematopoietic cell transplantation. (stemcell.com)
Overview and choice of donor of hematopoietic stem cell transplantation. (mayoclinic.org)
How to perform hematopoietic stem cell transplantation. (mayoclinic.org)
The original transplantation is commonly extracted from the bone marrow manually, a long and potentially painful procedure. (universityofcalifornia.edu)
I have expertise in novel therapies for acute myeloid leukemia, stem cell mobilization and homing, as well as stem cell transplantation. (rochester.edu)
Stem cell transplantation is performed after high-dose chemotherapy (HDC) to restore a cancer patient's blood and immune cell production capacity. (bdbiosciences.com)
30,000 patients with blood-related malignancies receive HDC, which, if the response is satisfactory, could subsequently be followed by hematopoietic stem cell transplantation (HSCT). (bdbiosciences.com)
1 Improvements in transplantation techniques, including the wider use of cell selection, have contributed to a significant reduction in the morbidity and mortality associated with conventional transplantation. (bdbiosciences.com)
This pharmacologically induced egress of HSCs into peripheral blood, called mobilization, is utilized as the preferred strategy for generating HSCs for transplantation. (bdbiosciences.com)
3 Autologous stem cell transplantation almost exclusively uses peripheral blood, while for allogeneic SCT, T-lymphocytes in the peripheral blood could pose some danger. (bdbiosciences.com)
2 The number of viable CD45+/CD34+ cells will determine the quality of specimen for transplantation. (bdbiosciences.com)
An accurate measurement of CD34 is critical for dose requirement protocols in stem cell transplantation. (bdbiosciences.com)
Dimeo FC, Tilmann MH, Bertz H, Kanz L, Mertelsmann R, Keul J: Aerobic exercise in the rehabilitation of cancer patients after high dose chemotherapy and autologous peripheral stem cell transplantation. (karger.com)
Although the WMDA and the European Society for Blood and Marrow Transplantation both argue against the use of biosimilar G-CSF for the mobilization of stem cells in healthy, unrelated hematopoietic stem cell donors, because of a series of issues with product availability, the study's authors were able to retrospectively compare the use of the 2 originator G-CSFs, lenograstim (Granocyte) and filgrastim (Neupogen), with the use of biosimilar filgrastim. (centerforbiosimilars.com)
Under normal conditions the CXCR4 pathway regulates the hematopoietic stem cell niche in the bone marrow (BM)-a property that has led to the approval of the CXCR4 antagonist plerixafor together with G-CSF (AMD3100, Mozobil) for mobilization from the BM and collection of hematopoietic precursors from the blood for transplantation of myeloma and lymphoma patients. (biokine.com)
Mobilization human CD34+ cells for the purpose of donor (allogeneic) transplantation after high-dose chemotherapy is currently performed using a 4-5-day treatment cycle with G-CSF and a 1-2 day apheresis procedure. (biokine.com)
A Phase 3, randomized, double-blind, placebo-controlled, multicenter study, evaluating the safety, tolerability and efficacy of BL-8040 in combination with G-CSF, compared to placebo and G-CSF, for the mobilization of CD34 cells for autologous transplantation in multiple myeloma patients have already initiated. (biokine.com)
Dr. Abdelbaset-Ismail has developed remarkable technical skills in cell transplantation for various animal models, molecular characterization, propagating cells in vitro and in vivo. (livedna.net)
1,2,3 Therefore, it is important to understand that switching mobilization reagents during a study may also change the mobilized cell type and their effect on studies relating to transplantation and stem cell research. (cgt.global)
Peripheral blood stem cell mobilization is very important in hematopoietic stem cell transplantation (as a recent alternative to transplantation of surgically harvested bone marrow ) and is currently performed using drugs such as G-CSF . (wikidoc.org)
Bone Marrow Transplantation , 28 (1), 1-12. (northwestern.edu)
WO 2001/046401 discloses embryonic or stem-like cells produced by cross species nuclear transplantation. (justia.com)
Hematopoietic stem cell transplantation has become a major treatment option for patients with hematopoietic malignancies and immune deficiencies. (cdc.gov)
To the best of our knowledge, only the transmission of malarial parasites has been reported during stem cell transplantation. (cdc.gov)
Because of the patient's risk status, the physicians intended to perform allogeneic stem cell transplantation after induction and consolidation chemotherapy, which was scheduled to end in January 2013, and a conditioning chemotherapy regimen, which was planned to be given in March. (cdc.gov)
Conditioning regimens are treatments used to prepare a patient for stem cell transplantation. (scdstudies.com)
Graft-versus-host disease (GVHD) is a complication that may occur after hematopoietic cell transplantation (HCT) in which donated cells view the recipient's cells as foreign and attack them. (scdstudies.com)
Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
Worldwide, approximately 90,000 first HSCTs-53% autologous and 47% allogeneic-are performed every year, according to the World Wide Network of Blood and Marrow Transplantation. (medscape.com)
Hematopoietic stem cell transplantation is also sometimes used for solid tumors (eg, some germ cell tumors) that respond to chemotherapy. (msdmanuals.com)
Hematopoietic stem cell transplantation may be autologous (using the patient's own cells) or allogeneic (using cells from a donor). (msdmanuals.com)
Peripheral blood has largely replaced bone marrow as a source of stem cells, especially in autologous hematopoietic stem cell transplantation, because stem cell harvest is easier and neutrophil and platelet counts recover faster. (msdmanuals.com)
Umbilical cord hematopoietic stem cell transplantation has been restricted mainly to children because there are too few stem cells in umbilical cord blood for an adult. (msdmanuals.com)
There are no contraindications to autologous hematopoietic stem cell transplantation. (msdmanuals.com)
Allogeneic hematopoietic stem cell transplantation is limited mainly by lack of histocompatible donors. (msdmanuals.com)
The technique for umbilical cord hematopoietic stem cell transplantation is still in its infancy, but it is gaining interest. (msdmanuals.com)
Because cord blood contains immature stem cells, HLA matching appears less crucial than for the other types of hematopoietic stem cell transplantation. (msdmanuals.com)
These outcomes identify potential essential regulators of HSC and present insights in to 8-Gingerol the medically important procedures of HSC mobilization for transplantation and leukemic advancement from cancers stem cells. (abic2004.org)
Elucidating the molecular pathways that keep HSC quiescence will hence enable aimed manipulation of HSC function endogenously and in the framework of hematopoietic cell transplantation. (abic2004.org)
Efficient mobilization of HSPC is a prerequisite for the successful stem cell collection and consecutive transplantation. (conferencedequebec.org)
The CXCL12-3'A allele is associated with a higher mobilization yield of CD34 progenitors to the peripheral blood of healthy donors for allogeneic transplantation. (cdc.gov)
Bone marrow transplantation 2009 Sep 44 (5): 273-8. (cdc.gov)
Donor CTLA-4 genotype influences clinical outcome after T cell-depleted allogeneic hematopoietic stem cell transplantation from HLA-identical sibling donors. (cdc.gov)
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2012 Jan 18 (1): 100-5. (cdc.gov)
Influence of molecular subgroups on outcome of acute myeloid leukemia with normal karyotype in 141 patients undergoing salvage allogeneic stem cell transplantation in primary induction failure or beyond first relapse. (cdc.gov)
Thirty patients (20 males and 10 females), who were candidates for autologous peripheral blood stem cell transplantation, were included in the study. (ogu.edu.tr)
Hematopoietic stem cell transplantation (HSCT) is a standard clinical practice for more than 50 years. (gov.rs)
FYLNETRA is not indicated for the mobilization of peripheral blood progenitor cells for hematopoietic stem cell transplantation. (tarsadia.com)

Hematopoietic System G-CSF is also a potent inducer of hematopoietic stem cell (HSC) mobilization from the bone marrow into the bloodstream, although it has been shown that it does not directly affect the hematopoietic progenitors that are mobilized. (wikipedia.org)
Endothelial progenitors should be devoid of hematopoietic markers and able to form vessels both in vitro and in vivo . (hindawi.com)
In our study, we worked on cells derived from the CD34 + hematopoietic stem and progenitor cells, enriched with CD133 + population, and used culture media promoting growth of hematopoietic progenitors. (hindawi.com)
Considerably, while differentiation of HSC to multipotent progenitors (MPP) is normally associated with elevated proliferation and lack of self-renewal activity [4]C[6], change and mobilization of HSC induces proliferation without lack of self-renewal potential, demonstrating a proliferative condition will not preclude maintenance of long-term self-renewal highly. (abic2004.org)
Following the action of cytokines and growth factors, such as vascular endothelial growth factor (VEGF) and stromal cell-derived factor-1 (SDF-1), progenitors of bone marrow (BM) origin circulate in peripheral blood (PB) and might contribute to the formation Hycamtin novel inhibtior of blood vessels in damaged/ischemic tissue (7, 10, 46). (mingsheng88.org)
Although low degrees of ROS are necessary for correct function of adult differentiation and cells of progenitors, the circumstances of serious oxidative stress, as an important mechanism root the pathogenesis of CVDs, can lead to PAC harm lowering their antioxidative and proangiogenic features (24, 26, 54). (mingsheng88.org)
Red cell development is initially regulated by stem cell factor (SCF), which commits hematopoietic stem cells to develop into erythroid progenitors. (medscape.com)

White blood cells The G-CSF-receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates proliferation and differentiation into mature granulocytes. (wikipedia.org)
The colony-forming unit (CFU) assay is a clonal, in vitro culture assay that measures the growth and frequency of functionally viable HSPCs by assessing the proliferation and differentiation of individual progenitor cells, resulting in the formation of discrete colonies in a semi-solid methylcellulose medium (such as MethoCult™ ) when supplemented with appropriate cytokines. (stemcell.com)
Cell markers, or surface antigens, are molecules located on a cell's membrane used to identify specific cell types, their lineage, and their stage in the differentiation process according to the presence or absence of the expression of defined markers. (stemcell.com)
Granulocyte colony-stimulating factor (G-CSF) is a member of the CSF family of glycoproteins that regulate hematopoietic cell proliferation, differentiation, and function. (stemcell.com)
There is a growing body of evidence that multipotent mesenchymal stromal cells' (MSCs') remarkable therapeutic potential is attributed not only to their differentiation and regenerative capacity, but also to the paracrine effect, underlying their immunomodulatory properties. (biomedcentral.com)
Thioredoxin-1 regulates self-renewal and differentiation of murine hematopoietic stem cells through p53 tumor suppressor. (dukecancerinstitute.org)
Flt-3 Ligand, also known as FL, is an alpha-helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages. (rndsystems.com)
Flt-3 Ligand induces the expansion of monocytes and immature dendritic cells as well as early B cell lineage differentiation. (rndsystems.com)
It synergizes with IL-3, GM-CSF, and SCF to promote the mobilization and myeloid differentiation of hematopoietic stem cells. (rndsystems.com)
It acts on precursor cells in the bone marrow to initiate their proliferation and differentiation into mature granulocytes, on hematopoietic stem cells to induce their mobilization in the blood stream, and on neurons to promote neurogenesis and block apoptosis. (myassays.com)
For instance, during stem cell differentiation, which is necessary for normal bloodstream cell creation, HSC leave quiescence to create older multi- and oligopotent progenitor cells, with concurrent lack of self-renewal potential and gain in proliferative activity [3]. (abic2004.org)
Introduction Functions of somatic stem cells are strictly governed by an appropriate balance between self-renewal and differentiation. (conferencedequebec.org)
In colony-forming unit assays, the hematopoietic stem cell plasticity remained similar after 14 days of bioreactor co-culture, whereas monolayer co-cultures showed increasing signs of HPC differentiation and loss of stemness. (fairdomhub.org)
To determine therapeutic potential of hematopoietic stem cell (HSC), we need to understand better correlation between the metabolic/energy status of the cells and stages of stem cell differentiation during hematopoiesis. (gov.rs)

A) The biological activity of Human Recombinant G-CSF, ACF was tested by its ability to promote the proliferation of mouse NFS-60 cells. (stemcell.com)
Cell proliferation was measured using a fluorometric assay method. (stemcell.com)
The EC50 is defined as the effective concentration of the cytokine at which cell proliferation is at 50% of maximum. (stemcell.com)
Such extended long-term culture-initiating cells (ELTC-IC) are of the CD34(+)CD38(-) phenotype, are quiescent, and are difficult to recruit into proliferation, implicating ELTC-IC as the most primitive human progenitor cells detectable in vitro. (ox.ac.uk)
Here, CD34(+)CD38(-) BM ELTC-IC (12-week) were efficiently recruited into proliferation and expanded in vitro in response to early acting cytokines, but conditions for expansion of ELTC-IC activity were distinct from those of traditional (5-week) LTC-IC and murine long-term repopulating cells. (ox.ac.uk)
A group of related diseases characterized by an unbalanced or disproportionate proliferation of immunoglobulin-producing cells, usually from a single clone. (lookformedical.com)
Additional processes in which mitochondria are involved include heat production, storage of calcium ions, calcium signaling, programmed cell death (apoptosis) and cellular proliferation. (justia.com)
Precise legislation of HSC proliferation and cell destiny decisions is essential to keep ongoing creation of mature bloodstream cells throughout adult lifestyle as well as for speedy, regenerative 8-Gingerol replies to hematologic damage. (abic2004.org)
Others encode soluble mediators, made by niche cells that respond to switch on HSC proliferation extrinsically. (abic2004.org)
However the tightly governed equilibrium between HSC quiescence and proliferation is actually very important to long-term maintenance of stem cell function, some physiologic features of HSC need short-term perturbation of the balance. (abic2004.org)
Stem cell function is normally perturbed during leukemogenesis, where oncogenic change derails the standard condition of HSC to market proliferation, metastasis to extramedullary sites, as well as the creation of unusual blast cells. (abic2004.org)
Both StemPro and HPL medium proved to be suitable for clinical application and allowed sufficient cell proliferation. (fairdomhub.org)
Polycythemia vera, also known as polycythemia rubra vera, is a myeloproliferative disorder characterized by clonal proliferation of myeloid cells. (medscape.com)

Distinct requirements for optimal growth and In vitro expansion of human CD34(+)CD38(-) bone marrow long-term culture-initiating cells (LTC-IC), extended LTC-IC, and murine in vivo long-term reconstituting stem cells. (ox.ac.uk)
Butcher: A molecular map of murine lymph node blood vascular endothelium at single cell resolution Nat Commun 2020 Jul 30;11:3798. (edu.pl)
Long-term hematopoietic stem cell damage in a murine model of the hematopoietic syndrome of the acute radiation syndrome. (iu.edu)
Establishing a murine model of the hematopoietic syndrome of the acute radiation syndrome. (iu.edu)

We used G-CSF-mobilized CD34 + HSPCs, FACS-sorted from healthy donor peripheral blood mononuclear cells (PBMCs). (hindawi.com)
National Marrow Donor Program. (mayoclinic.org)
Recently, biosimilars of G-CSF have been introduced into stem cell mobilization protocols, but there has been limited experience with biosimilar G-CSF in this area, and the World Marrow Donor Association (WMDA) recommends the use of originator G-CSFs for mobilization in healthy unrelated hematopoietic stem cell donors. (centerforbiosimilars.com)
The study's primary endpoints were the efficiency of CD34+ cell mobilization to circulation and the results of the first apheresis (the collection process by which donor blood is collected via catheter and directed into a cell separator machine where white cells and stem cells are separated from other blood components and collected for use). (centerforbiosimilars.com)
These mobilization agents increase circulating leukocytes and stimulate the bone marrow to produce a large number of hematopoietic stem cells, which are mobilized into the bloodstream, allowing for large quantities of stem cells and peripheral blood mononuclear cells (PBMCs) to be collected from a single donor. (cgt.global)
Collection volumes for a full non-mobilized fresh Leukopak range from 300-500 ml and cell enumeration is typically >10 billion cells with cell yields as high as 28 billion, subject to donor variability. (ispecimen.com)
Nuclear transfer efficiency is enhanced by introduction of compatible cytoplasm or mitochondrial DNA (same species or similar to donor cell or nucleus). (justia.com)
Here, we report transmission of dengue virus to a peripheral blood stem cell recipient by a donor who had recently traveled to an area to which the virus is endemic. (cdc.gov)
The 24-year-old woman, who was registered as a volunteer donor in the German Bone Marrow Donor Registry, was selected. (cdc.gov)
A second apheresis or a bone marrow collection was considered, but neither was performed because the clinical condition of the donor worsened. (cdc.gov)
Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
Three days after donation of peripheral blood stem cells to a recipient with acute myeloblastic leukemia, dengue virus was detected in the donor, who had recently traveled to Sri Lanka. (cdc.gov)
eg, bone, bone marrow, and skin grafts) Genetically identical (syngeneic [between monozygotic twins]) donor tissue (isografts) Genetically. (msdmanuals.com)

Chemotherapy can cause myelosuppression and unacceptably low levels of white blood cells (leukopenia), making patients susceptible to infections and sepsis. (wikipedia.org)
Her innovative research has already led to several discoveries, such as a novel strategy to protect normal Haematopoietic Stem Cells from chemotherapy or radiation damage. (edu.au)
3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
For many hematopoietic malignancies, collection and infusion of CD34+ hematopoietic stem/progenitor cells following chemotherapy is critical. (bdbiosciences.com)
Stem cell mobilization is a process used to stimulate the production of hematopoietic stem cells in bone marrow in patients who have received chemotherapy, as well as in unrelated hematopoietic stem cell donors. (centerforbiosimilars.com)
Compared with traditional surgery and chemotherapy, siRNA has fewer side effects and less damage to normal cells. (bvsalud.org)
The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)
FYLNETRA™ is used to treat neutropenia (low neutrophils which are a type of white blood cells that fight infection) which is commonly experienced by patients undergoing chemotherapy. (tarsadia.com)

CD34 + cells after six days in culture were stimulated with atorvastatin (AT), acetylsalicylic acid (ASA), sulforaphane (SR), resveratrol (RV), or metformin (Met) for 48 h. (hindawi.com)
EPCs are enriched in the population coexpressing CD34, CD133, and KDR with a low or absent expression of pan-hematopoietic marker CD45 [ 1 ]. (hindawi.com)
CD34 is a transmembrane phosphoglycoprotein that was first identified on HSPCs, but its expression is also present on other cell types, such as vascular tissue. (stemcell.com)
CD34 is the most commonly used cell surface marker to identify human HSPCs as it is expressed on HSCs, in addition to both multipotent and more differentiated progenitor cells of individual blood cell lineages. (stemcell.com)
CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
4 CD34 expression is historically related to hematopoietic cells and it is considered as the marker of HSCs. (bdbiosciences.com)
6 Fluorochrome-conjugated monoclonal antibodies directed against CD34 molecule can be used to identify CD34+ cells by flow cytometry. (bdbiosciences.com)
Apheresis for collection of CD34 cells will be performed on day 5. (biokine.com)
An additional 3 apheresis sessions may be conducted if needed in order to reach the goal of ≥ 6×106 mobilized CD34 cells/kg. (biokine.com)
In a small human clinical trial to evaluate the safety and efficacy of fucoidan ingestion (brown seaweed extract), 3g daily of 75% w/w oral fucoidan for 12 days increased the proportion of CD34+CXCR4+ from 45 to 90% and the serum SDF-1 levels, which could be useful in CD34+ cells homing/mobilization via SDF-1/CXCR4 axis. (wikidoc.org)
We evaluated hematopoietic stem cells according to CD34 expression and aldehyde dehydrogenase (ALDH) activity in peripheral blood and apheresis product samples from patients after mobilization with granulocyte-colony-stimulating factor (G-CSF) alone or G-CSF after high-dose cyclophosphamide (4 g/m(2) once daily, intravenously on day 1). (ogu.edu.tr)
We also investigated the relationship between the number of SSClo CD45(dim) CD34(hi) cells, SSClo ALDH(br) cells and engraftment. (ogu.edu.tr)
Numbers of SSClo CD45(dim) CD34(hi) cells and SSClo ALDH(br) cells were highly correlated in both peripheral blood and apheresis products (P (ogu.edu.tr)
We could not find a relationship between the transplanted SSClo CD45(dim) CD34(hi) cell dose or SSClo ALDH(br) cell dose and platelet or neutrophil recovery. (ogu.edu.tr)
The optimal thresholds for SSClo CD45(dim) CD34(hi) cells were 5.40 x 106/kg for neutrophil recovery and 7.22 x 106/kg for platelet recovery. (ogu.edu.tr)
According to our data, numbers of SSClo ALDH(br) cells are in very good agreement with numbers of SSClo CD45(dim) CD34(hi) cells and can be a predictor of stem cell mobilization. (ogu.edu.tr)

Trends in the approaches to, and results of, progenitor cell mobilization are suggested by this survey. (northwestern.edu)

It is a key cytokine involved in the production of neutrophils and the stimulation of granulocyte colony formation from hematopoietic progenitor cells (Metcalf & Nicola). (stemcell.com)
Effects of hematopoietic stem cell adhesion on marrow stromal cell cytokine p. (rochester.edu)
The possible underlying mechanisms are proposed to come mainly from bone marrow, including stimulated erythropoiesis with hyperplasia of the hematopoietic bone marrow, improvement of the hematopoietic microenvironment induced by exercise training, and hormone- and cytokine-accelerated erythropoiesis. (karger.com)
Interferon-ß therapy was associated with lower proportions of FcRÎ³(-) CD56dim NK cells in HCMV(+) and increased PLZF(-) CD56bright NK cells in HCMV(-) patients, pointing out to an influence of the cytokine on the expression of adaptive NK cell-associated markers. (bvsalud.org)
Also known as CSF3 (colony-stimulating factor 3), G-CSF is a hematopoietic cytokine. (myassays.com)
While cytokine-based mobilization appears less toxic, it is more likely to result in disease reactivation. (northwestern.edu)

HSCs make up a very small population of the hematopoietic system, however, these cells are invaluable as they have the potential to give rise to all mature blood and immune cell types and sustain life-long blood production. (stemcell.com)
Although hematopoietic stem cells (HSCs) are useful in a variety of treatments, HSC donation is a difficult procedure. (universityofcalifornia.edu)
2 HSCs are primarily found in bone marrow niches, but a small fraction of HSCs can also be found in the peripheral blood. (bdbiosciences.com)
Flow cytometric enumeration of CD34+ HSCs and progenitor cells is an established method for the evaluation of bone marrow and stem cell grafts. (bdbiosciences.com)
To stimulate egress of hematopoietic stem cells (HSCs) from the bone marrow into peripheral blood, healthy consented donors are mobilized using granulocyte colony-stimulating factor (G-CSF, filgrastim/Neupogen) administered via subcutaneous injection on a daily basis. (ispecimen.com)
We have tested the feasibility of using the granulocyte colony-stimulating factor (G-CSF), which is known to mobilize hematopoietic stem cells (HSCs) from the bone marrow into the peripheral blood, as a therapeutic agent for AD. (silverchair.com)

Myeloid angiogenic cells (MAC) derive from hematopoietic stem/progenitor cells (HSPCs) that are mobilized from the bone marrow. (hindawi.com)
Our study is aimed at investigating whether precursors of myeloid angiogenic cells (PACs) treated with known pharmaceuticals would produce media with better proangiogenic activity in vitro and if such media can be used to stimulate blood vessel growth in vivo . (hindawi.com)
Such myeloid angiogenic cells (MAC) [ 1 ] of bone marrow origin were known as endothelial progenitor cells (EPCs). (hindawi.com)
Cells previously known as endothelial progenitor cells are considered now to be rather myeloid angiogenic cells than endothelial precursors [ 4 ]. (hindawi.com)
Therefore, the cells we used should be considered as hematopoietic precursors of myeloid angiogenic cells and are referred as PACs. (hindawi.com)
The G-CSF receptor is expressed on a variety of hematopoietic cells, including myeloid-committed progenitor cells, neutrophils, granulocytes, and monocytes. (stemcell.com)

Conditioned media from such cells were then used to stimulate human aortic endothelial cells (HAoECs) to enhance tube-like structure formation in a Matrigel assay. (hindawi.com)
Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)

NOD-SCID-Gamma (NSG) mice) and measuring the presence of human blood cells in the blood or bone marrow (BM) after extended periods of engraftment, e.g., 20 weeks or longer. (stemcell.com)
Additional markers can be used to distinguish HSPC subsets within the CD34+ population and isolate HSPCs with different engraftment abilities and capacities to expand or generate mature blood cells in culture. (stemcell.com)
He has also much experience in context of homing, mobilization, and engraftment of hematopoietic stem cells and cancer research. (livedna.net)
The mechanism of action of these mobilization agents, and the combination of them, have been shown to change the expression profile, cell composition, and engraftment potential of the mobilized cells. (cgt.global)

Human Mobilized Peripheral Blood Primary Cells are collected from healthy IRB consented donors that are injected with Granulocyte-Colony Stimulating Factor (G-CSF aka Neupogen ® ), Plerixafor (aka Mozobil ® ), or a combination of Plerixafor and G-CSF. (cgt.global)
We offer G-CSF, Plerixafor, and G-CSF plus Plerixafor options to mobilize the cells from the bone marrow. (cgt.global)
CGT Global offers PBMCs and CD34+ stem cells mobilized with G-CSF, Plerixafor, and G-CSF plus plerixafor. (cgt.global)
For example, plerixafor (AMD3100)25,26 has been proven highly effective for the mobilization of CD34+ cells for autologous transplantations, especially in poor mobilizing patients27C35. (conferencedequebec.org)

Human peripheral blood mononuclear cells-derived macrophages were then treated with umbilical cord-derived MSCs' conditioned media and their effect on macrophages polarization was assessed. (biomedcentral.com)
The microcavities of the 3(D)-KITChip were inoculated with human bone marrow MSCs together with umbilical cord blood HPCs. (fairdomhub.org)

Mesenchymal stromal cells (MSCs) from human bone marrow serve as a resource for cell-based therapies in regenerative medicine. (fairdomhub.org)

Well-illustrated and clinically focused, it details the basic science and clinical practice of hematology and hematopoietic cellular therapy-covering virtually all aspects of hematology in one definitive resource. (elsevierhealth.com)
This promising field may open new avenues to modulate inflammatory responses and to preserve blood cell homeostasis in the clinical setting. (haematologica.org)
To further explore this issue, additional adaptive NK cell markers, i.e., downregulation of FcÎµRIÎ³ chain (FcRÎ³) and PLZF transcription factor, as well as antibody-dependent NK cell activation were assessed in controls and MS patients considering HCMV serology and clinical features. (bvsalud.org)
Conditions characterized by the presence of M protein (Monoclonal protein) in serum or urine without clinical manifestations of plasma cell dyscrasia. (lookformedical.com)
Each of those cell sources has specific advantages and disadvantages, and each has found particular clinical applications. (medscape.com)
This review describes current considerations in the use of hydroxyurea for the management of sickle cell disease in the context of clinical severity. (cdc.gov)

The biology and therapeutic application of mesenchymal cells. (edu.au)

G-CSF is produced by endothelium, macrophages, and a number of other immune cells. (wikipedia.org)
MSCs are reported to contribute both to the inflammation initiation and to its resolution via complex cross talk with immune cells, most importantly macrophages [ 1 ]. (biomedcentral.com)
Nonetheless, when cells rely on anaerobic glycolysis, like cancer cells and certain innate immune cells upon activation, other metabolic pathways sustain succinate levels, including glutamine-dependent anerplerosis to α-ketoglutarate, and eventually citrate by reductive carboxylation. (haematologica.org)
In myocardial infarction or ischemia, G-CSF promotes T cells' immune tolerance and tissue recovery. (myassays.com)
Neutrophils are the first immune cells that infiltrate the damaged tissue as early as 24 h after injury. (springer.com)
One concern about the procedure is that immune cells in cord blood do not have experience with the viruses responsible for latent infections, leading to a higher percentage of naive T cells and thus increased vulnerability to reactivation of cytomegalovirus or Epstein-Barr virus infection. (msdmanuals.com)

Primary polycythemias are due to factors intrinsic to red cell precursors caused by acquired or inherited mutations. (medscape.com)

Evidence suggests that the CXC-chemokine receptor-4 (CXCR4) pathway plays a major role in cancer cell homing and metastasis and in shaping the tumor microenvironment (TME), and thus represents a potential target for cancer therapy. (biokine.com)
This balance is in turn regulated by interactions between MK2-IN-1 hydrochloride stem cells and their microenvironment-the so-called niche. (conferencedequebec.org)
These data support the notion that the 3D microenvironment created within the microcavity array preserves vital stem cell functions of HPCs more efficiently than conventional co-culture systems. (fairdomhub.org)

Abnormal immunoglobulins synthesized by atypical cells of the MONONUCLEAR PHAGOCYTE SYSTEM. (lookformedical.com)
iSpecimen also offers diseased mononuclear cells through its continually growing network of partners. (ispecimen.com)
Mononuclear cells are collected and concentrated from peripheral blood of healthy consented donors according to IRB approved protocols using an automated leukapheresis system. (ispecimen.com)
Main goal of this work is to investigate metabolic status of peripheral blood mononuclear cells (PBMC) in patients with solid tumors (neuroblastoma, Ewing sarcoma) and lymphoma (Hodgkin and nonHodgkin). (gov.rs)

Positive data from the dose-escalation stage of the study, which was recently presented at the 2014 ASH (American Society of Hematology) Conference, has shown substantial mobilization of AML cancer cells from the bone marrow to the peripheral blood and robust apoptosis of these cells, as well as an excellent safety and tolerability profile. (technologynetworks.com)
Dr. Abdelbaset-Ismail is one of the founding members of International Perinatal Stem Cells Society, and he has received the very prestigious 2015 Abstract Achievement Award from the American Society of Hematology. (livedna.net)

Krzysztof Szade (PhD) together with Andy Reinisch from the Medical University of Graz were awarded the Mozart grant for their joint project Identifying the hematopoietic and leukemic stem cell niches. (edu.pl)

A recent study, by Roiya Farhan and colleagues, published in the September 2017 Annals of Hematology, found that, comparing biosimilar G-CSF (Zarzio) with originator filgrastim and lenograstim in unrelated stem cell donors showed that there was no mobilization failure in any of the 313 donors. (centerforbiosimilars.com)
Preclinical data (presented at the European Hematology Association Conference in June 2014) show that by inhibiting the CXCR4 receptor, BL-8040 enhances the effect of FLT3 inhibition in killing FLT3-mutated leukemic cells. (technologynetworks.com)

It has been also shown that CXCR4 signalling regulates the expression of CD20 on B cells. (wikidoc.org)
Pyk2 regulates megakaryocyte-induced increases in osteoblast number and bone formation. (iu.edu)

Launch Hematopoietic stem cells (HSC) are uncommon, multipotent, self-renewing precursor cells with the capacity of generating every single specialized cell from the bloodstream system. (abic2004.org)

Granulocyte colony-stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream. (wikipedia.org)
G-CSF stimulates the production of granulocytes, a type of white blood cell. (wikipedia.org)

Drugs that block the CXCR4 receptor appear to be capable of "mobilizing" hematopoietic stem cells into the bloodstream as peripheral blood stem cells . (wikidoc.org)

The standard way to conduct mobilization in hematopoietic stem cell donors relies on using 2 original granulocyte-colony stimulating factors (G-CSFs), filgrastim (Neupogen) and lenograstim (Granocyte). (centerforbiosimilars.com)
The authors conclude that biosimilar G-CSF is as effective in the mobilization of hematopoietic stem cells in unrelated donors as originator G-CSF. (centerforbiosimilars.com)
Target doses of CD34+ cells were reached with 1 apheresis in 87% of donors mobilized with lenograstim and in 93% of donors mobilized with the originator and biosimilar filgrastim ( P = 0.005). (centerforbiosimilars.com)
Experiments were performed on PBMC samples of patients that were: a) subjected to mobilization of stem cells from bone marrow, b) not subjected to mobilization, and c) healthy donors (control group). (gov.rs)

Quantitating the CD34+ cell population can also be useful during mobilization as well as for determining the optimal timing of apheresis sessions to make sure that enough CD34+ cells have been harvested. (bdbiosciences.com)
When corrected for patient weight and apheresis volume, progenitor cell yields tended to vary by underlying disease, prior medication history and mobilization regimen. (northwestern.edu)
Before apheresis, the donor's blood count showed mild thrombocytopenia after G-CSF mobilization. (cdc.gov)

He has also gained salient experience in various experimental setups using hematopoietic stem cells, bone marrow, cord blood-derived and adipose tissue-derived MSCs, very small embryonic-like stem cells, leukemic cells, and germline-derived cells. (livedna.net)
Bioactive phospholipids enhance migration and adhesion of human leukemic cells by inhibiting Heme oxygenase 1 (HO-1) and inducible nitric oxygenase synthase (iNOS) in a p38 MAPK-dependent manner. (livedna.net)
Activation of the complement cascade enhances motility of leukemic cells by downregulating expression of HO-1. (livedna.net)

However, the features initially ascribed to endothelial progenitor cells, i.e ., phenotype, expression of endothelial markers, and ability to form tube-like structures on Matrigel, can be mimicked by blood monocytes [ 3 ]. (hindawi.com)
The enriched cell fraction consisting of pan T, NK, B cells, hematopoietic stem cells (CD34+), monocytes, dendritic, and other white blood cell types is collected and shipped in a sterile blood bag. (ispecimen.com)

In addition to mobilizing HSPC, the interference with the CXCR4-SDF1 axis has also been proposed as a possible strategy to mobilize malignant stem cells from their protective niche, hence making tumor stem cells even more susceptible to irradiation or chemo- therapy. (conferencedequebec.org)

Blood-forming stem cell transplants. (mayoclinic.org)
In recent years, peripheral HSPC have largely replaced bone marrow-derived cells for autologous transplants, and they have become the major source of stem cells also for allogeneic transplantations16C21. (conferencedequebec.org)

G-CSF is a growth factor for neutrophils (a common type of white blood cells), and may act by increasing the activity of neutrophil-derived proteases such as neutrophil elastase in the bone marrow leading to proteolytic degradation of SDF-1. (wikidoc.org)
[14] Another explanation of this observation is provided by a study that shows the ability of CXCL12 (and CCL2 ) producing tumors to entrain neutrophils that inhibit seeding of tumor cells in the lung. (wikidoc.org)

It is a very efficient inducer of hematopoietic stem cell mobilization in animal and human studies. (wikidoc.org)

Over the course of her career, Dr Winkler has produced 49 peer-reviewed articles, including a recent landmark study in Nature Medicine 2012, describing a key component of the bone marrow vascular niche (E-selectin) in regulating Haematopoietic Stem Cell self-renewal and chemo-sensitivity and last year her research was recognized to be among 'Ten of the Best Research Projects'in Australia by the National Health & Medical Research Council. (edu.au)
The legislation of HSC quiescence in the bone tissue marrow (BM) specific niche market is normally of particular importance [1], [2]. (abic2004.org)
Jointly, these data claim that specific control of cell department is essential for suitable stem cell behavior which the proliferative activity of HSC is generally Rabbit polyclonal to NGFR limited by both HSC intrinsic elements and extrinsic elements stated in the HSC specific niche market. (abic2004.org)
In the case of hematopoietic stem and progenitor cells, the dormancy of the most primitive HSPC is maintained by the bone marrow niche by means of several key molecular interactions between receptor-ligand pairs1C3. (conferencedequebec.org)
G-CSF, the standard and most widely used agent for this purpose over the past 25 years, mobilizes stem cells from the marrow niche by secretion of neutrophil-associated extracellular proteases which subsequently releases HSPC from their niche22,23. (conferencedequebec.org)
Several research indicated that seductive get in touch with between CXCR4 portrayed on tumor cells and SDF1 in the specific niche market might represent an integral system for metastatic spread and tumor level of resistance37,38. (conferencedequebec.org)
We establish a three-dimensional (3D) co-culture system based on a custom-made chip, the 3(D)-KITChip, as an in vitro model system of the human hematopoietic stem cell niche. (fairdomhub.org)

Concluding, high concentrations of atorvastatin stabilize tubes and enhance the paracrine angiogenic activity of human PAC cells in vitro . (hindawi.com)
There is evidence that 2D or 3D culturing conditions have an impact on the cells' secretome, and here we aimed to compare the secretion of cytokines and growth factors in human MSCs from different sources cultured in 2D and 3D conditions and assess their effect on human macrophages polarization in vitro. (biomedcentral.com)
The distinct requirements for expansion of ELTC-IC activity when compared with traditional LTC-IC suggest that the ELTC-IC could prove more reliable as a predictor for true human stem cell activity after in vitro stem cell manipulation. (ox.ac.uk)
For these studies, he has acquired experience in in vitro angiogenesis models and their imaging in 3D models of either hydrogels or scaffold-free cell-sheet culture. (sfbmec.fr)

Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
Launch The breakthrough of endothelial progenitor cells, broadly thought as proangiogenic cells (PACs), described a new path in the treatment of cardiovascular disorders (CVDs), since they were recognized as responsible for postnatal vasculogenesis in physiological and regenerative neovascularization after, for example, hind limb ischemia (HLI) (5, 6). (mingsheng88.org)

Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. (lookformedical.com)
Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells. (lookformedical.com)
These cell biology projects have also led to applications in a tissue engineering context. (sfbmec.fr)
The aim of this study was to comparatively assess the efficiency of xeno-free human platelet lysate (HPL)-based cell expansion with two commercially available media-StemPro MSC SFM CTS (for human ex vivo tissue and cell culture processing applications) and MSCGM (non-GMP-compliant, for research only)-in an academic setting as the first optimization step toward GMP-compliant manufacturing. (fairdomhub.org)

BD Biosciences offers flow cytometers and assays for the enumeration of CD34+ cells. (bdbiosciences.com)
Luminex Assays are validated for use with cell culture supernatants, plasma and serum. (bio-techne.com)

Twenty-one unprimed bone marrow harvests and 174 peripheral blood stem cell mobilizations were performed on 187 patients. (northwestern.edu)

Researchers at the University of California, Davis have developed a self-assembling, fibrous photosensitizer that targets mitochondria in tumor cells for destruction via photodynamic therapy with enhanced localization and potency. (universityofcalifornia.edu)
A cell line derived from cultured tumor cells. (lookformedical.com)

We examined whether CPM is expressed by hematopoietic and stromal cells and could degrade stromal cell-derived factor (SDF)-1a, a potent chemoattractant for hematopoietic stem/progenitor cells (HSPC). (razikurd.ir)
For example, it has been suggested that homophilic, N-cadherin-mediated adhesion between HSPC and mesenchymal stem cells (MSC) supports long-term maintenance of the primitive HSPC pool4C6. (conferencedequebec.org)
Another key molecular axis is the interaction between MK2-IN-1 hydrochloride stromal cell-derived factor 1 (SDF1 or CXCL12) and its receptor CXCR4, expressed on the cell surface of HSPC. (conferencedequebec.org)

abstract = "We reviewed data from 24 transplant centers in Asia, Australia, Europe, and North America to determine the outcomes of stem cell collection including methods used, cell yields, effects on disease activity, and complications in patients with autoimmune diseases. (northwestern.edu)

http://www.cancer.gov/about-cancer/treatment/types/stem-cell-transplant/stem-cell-fact-sheet. (mayoclinic.org)
Associate Professor Ingrid Winkler is a Senior Research Fellow and head of the Stem Cells and Cancer group at Mater Research, Brisbane, Australia. (edu.au)
New ways to sensitise cancer cells to standard cancer therapy. (edu.au)
Later on, Dr. Abdelbaset-Ismail then has joined the Stem Cell Institute at James Graham Brown Cancer, University of Louisville, as a Visiting Scholar from September 2013 to March 2014, where he has been then employed as a Postdoctoral Associate beginning May 2014. (livedna.net)
Pituitary sex hormones enhance the pro metastatic potential of human lung cancer cells by downregulating the intracellular expression of heme oxygenase 1. (livedna.net)
Expression of this receptor in cancer cells has been linked to metastasis to tissues containing a high concentration of CXCL12, such as lungs, liver and bone marrow. (wikidoc.org)
[12] [13] However, in breast cancer where SDF1/CXCL12 is also expressed by the cancer cells themselves along with CXCR4, CXCL12 expression is positively correlated with disease free (metastasis free) survival. (wikidoc.org)
In addition to basic science investigations in such areas as tumor cell invasion, oncogenes, immunotherapy and genetic inheritance, our scientists and physicians participate in national cancer trials. (upstate.edu)
T lymphocytes for adoptive cell therapy against hematological cancer. (upstate.edu)
Gene therapy has attracted much attention because of its unique mechanism of action, non-toxicity, and good tolerance, which can kill cancer cells without damaging healthy tissues. (bvsalud.org)
The present invention provides stem cells enriched with healthy functional mitochondria, and therapeutic methods utilizing such cells for the alleviation of debilitating conditions, including aging, and age-related diseases as well as the debilitating effects of anti-cancer therapies in subjects in need thereof. (justia.com)
The present invention relates to stem cells enriched with functional mitochondria, and therapeutic methods utilizing such cells to diminish the debilitating effects of various conditions, including aging and age-related diseases as well as the debilitating effects of anti-cancer therapy treatments. (justia.com)
Alemtuzumab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. (scdstudies.com)

Recent evidence obtained in mouse models shows its essential role regulating blood cell function through various mechanisms that include pseudohypoxia responses by hypoxia-inducible factor-1α activation, post-translational modifications like succinylation, and communication mediated by succinate receptor 1. (haematologica.org)
Here, we further discuss current suggestions of the possible contribution of succinate to blood stem cell function and blood formation. (haematologica.org)
Further study will be required in the future to better understand succinate biology in blood cells. (haematologica.org)
A rare, aggressive variant of MULTIPLE MYELOMA characterized by the circulation of excessive PLASMA CELLS in the peripheral blood. (lookformedical.com)
Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. (lookformedical.com)
The work presents a molecular map of blood vessels in the lymph nodes and defines the subpopulations of endothelial cells involved in leukocyte recruitment. (edu.pl)
The development of the inflammatory process is regulated by specialized endothelial cells that control the recruitment of leukocytes from the blood into the lymphoid tissues. (edu.pl)
In contrast, the diversity of blood endothelial cells (BECs) and their origin during inflammatory angiogenesis were not fully characterized so far. (edu.pl)
The study uses scRNA-seq to define and characterize different subsets of blood endothelial cells in the mouse lymph node. (edu.pl)
A stem cell transplant is a procedure in which a person receives blood stem cells, which make any type of blood cell. (scdstudies.com)
It helps make room in the patient's bone marrow for new blood stem cells to grow, and helps prevent the patient's body from rejecting the transplanted cells. (scdstudies.com)
hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
Many recently discovered genes that perturb HSC quiescence disrupt stem cell maintenance and homeostatic blood cell production also. (abic2004.org)
increased white blood cell count (leukocytosis) and inflammation of your blood vessels (cutaneous vasculitis) have been reported. (tarsadia.com)
Monitor platelet counts and white blood cell count. (tarsadia.com)
Polycythemia is characterized by an increase in the red blood cell (RBC) compartment in the peripheral blood and is measured by an increase in the RBC count, the hemoglobin content, and the hematocrit level above reference ranges adjusted for age, sex, race, and altitude. (medscape.com)

Multipotent mesenchymal stromal cells (MSCs) are an extensively researched yet still understudied tool for treating a wide range of pathological conditions, one particular area of research interest being their immunomodulatory properties. (biomedcentral.com)
Thus, bone marrow is the first established and still one of the most commonly used sources of MSCs [ 7 ]. (biomedcentral.com)
however, relatively low cell yield and high invasiveness of the harvesting procedure [ 9 ] have urged the quest for alternative MSCs sources. (biomedcentral.com)
MSCs exhibited the typical fibroblastoid morphology, with distinct differences in cell size depending on the medium. (fairdomhub.org)
In previous studies human mesenchymal stromal cells (MSCs) maintained the "stemness" of human hematopoietic progenitor cells (HPCs) through direct cell-cell contact in two-dimensional co-culture … systems. (fairdomhub.org)

Then, we used atorvastatin-stimulated cells or conditioned media from them in the Matrigel plug in vivo angiogenic assay. (hindawi.com)
angiogenic signaling of endothelial PACs and cells. (mingsheng88.org)
Technology This ongoing function recognizes a novel, direct function of nuclear aspect E2-related aspect 2 (Nrf2) in angiogenic properties of both bone-marrow-derived proangiogenic progenitor cells and adult endothelial cells. (mingsheng88.org)
Moreover, by showing that lack of Nrf2 did not impair revascularization after hind limb ischemia, despite decreased mobilization and angiogenic potential of proangiogenic cells (26)] has created great anticipations of PAC software. (mingsheng88.org)

Bone marrow film at 400X magnification demonstrating dominance of erythropoiesis. (medscape.com)
Erythropoiesis initially occurs in fetal hepatocytes, subsequently occurring in the bone marrow of children and adults. (medscape.com)

The course and physiological effects of the interaction of leukocytes with vascular wall cells have been studied for years and relatively well understood. (edu.pl)

It cooperates with IL-2, -6, -7, and -15 to induce NK cell development and with IL-3, -7, and -11 to induce terminal B cell maturation. (rndsystems.com)

Anatomy16

Organisms6

Diseases8

Chemicals and Drugs13

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes12

Health Care2

Transplantation52

Progenitors7

Differentiation14

Proliferation13

Murine4

Donor14

Chemotherapy8

CD3416

Progenitor cell mobilization1

Cytokine6

HSCs6

Myeloid6

Stimulate2

Engraftment4

Plerixafor4

Umbilical2

Human bone marrow1

Clinical6

Mesenchymal cells1

Immune6

Precursors1

Microenvironment3

Mononuclear4

American Society of2

Niches1

Hematology2

Regulates2

Precursor1

Granulocytes2

Bloodstream1

Donors4

Apheresis3

Leukemic3

Monocytes2

Malignant1

Transplants2

Neutrophils2

Inducer1

Niche7

Vitro4

Endothelial progenitor cells3

Tissue4

Assays2

Peripheral blood stem cell1

Tumor cells2

HSPC3

Abstract1

Cancer13

Blood16

MSCs5

Angiogenic4

Erythropoiesis2

Vascular1

Induce1