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  • granulocyte-macrop
  • C. Scheicher, M. Mehlig, R. Zecher and K. Reske, Dendritic cells from mouse bone marrow: in vitro differentiation using low doses of recombinant granulocyte-macrophage colony-stimulating factor. (springer.com)
  • K. Inaba, M. Inaba, N. Romani, H. Aya, M. Deguchi, S. lkehara, S. Muramatsu, and R. M. Steinman, Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. (springer.com)
  • C. Reid, A. Stackpoole, A. Meager, and J. Tikerpae, Interactions of tumor necrosis factor with granulocyte-macrophage colony-stimulating factor and other cytokines in the regulation of dendritic cell growth in vitro from early bipotent CD34* progenitors in human bone marrow. (springer.com)
  • F. Sallusto and A. Lanzavecchia, Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor a. (springer.com)
  • Spleen
  • The dramatic expansion of MDSCs in blood, spleen, and bone marrow has been widely documented in many animal tumor models as well as in patients with various types of cancers [ 9 ]. (thno.org)
  • showed that mice lacking the retinoic acid receptor γ (RARγ) also developed a myeloproliferative condition, with increased numbers of granulocytes in the bone marrow, peripheral blood, and spleen. (sciencemag.org)
  • leukemic
  • Recent studies have shown that leukemic cells suppress the host immune system with tumor progression connected to immune cells dysfunction [ 4 , 5 ]. (mdpi.com)
  • angiogenesis
  • This effect was traced to a pathway of CD11b+Gr1+-mediated angiogenesis that is, at least in part, driven by the secreted protein Bv8, which is up-regulated by the important myeloid growth factor granulocyte colony-stimulating factor (G-CSF). (aacrjournals.org)
  • Targeting
  • Although it is appreciated that physiologic, pathologic, and therapeutic conditions impact hematopoiesis, it remains unclear whether targeting hematopoiesis presents opportunities for limiting bone metastasis. (aacrjournals.org)
  • maturation
  • May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. (abcam.com)
  • recipients
  • These findings demonstrate the development of mature and functionally intact human myeloid subsets in vivo in the NSG recipients. (jimmunol.org)
  • populations
  • In this study, we checked the cardiomyogenic potential of BM cells in vivo , to identify the cell populations in BM that possess the capacity to give rise to CMs and clarify whether cardiomyogenic potential of BM-derived cells require cell fusion with host CMs. (ahajournals.org)
  • Lymphoid
  • The frequency of myeloid-lymphoid-initiating cells (ML-ICs) and SCID-repopulating cells (SRCs) was significantly higher in blood from AC-SCD patients than in blood from patients with steady-state SCD or from normal donors. (jci.org)
  • Cells were analyzed for the expression of lymphoid markers 7 days later. (nih.gov)
  • protein
  • Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. (genecards.org)
  • effector
  • In line with a site-directed delivery of the cytokine, F16-IL2 led to an extensive infiltration of immune effector cells in the bone marrow. (aacrjournals.org)
  • IL-17, the main effector cytokine of Th17 cells, is responsible for inflammatory and autoimmune diseases [ 8 , 9 ]. (mdpi.com)
  • engraftment
  • Although earlier engraftment is seen when cells from GCSF-mobilized blood are transplanted than when bone marrow is transplanted, administration of GCSF to patients with SCD can cause significant morbidity. (jci.org)
  • MDSCs
  • Treatment with T1 targeted doxorubicin liposomes triggered apoptosis of breast cancer cells and PMN-MDSCs. (thno.org)
  • Suppression of PMN-MDSCs, which serve an immunosuppressive function, leads to increased intratumoral infiltration of cytotoxic T cells. (thno.org)