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Hematopoietic Stem Cell TransplantationHematopoietic Stem CellsBone MarrowBone Marrow CellsBone Marrow TransplantationTransplantation, HomologousStem CellsStem Cell TransplantationGraft vs Host DiseaseTransplantation, AutologousMyeloid CellsHematologic NeoplasmsTransplantationTransplantation ConditioningBone and BonesStem Cell NicheCell DifferentiationHematopoiesisHistocompatibility TestingImmunocompromised HostTissue DonorsHepatic Veno-Occlusive DiseaseMice, Inbred C57BLPeripheral Blood Stem Cell TransplantationAntigens, CD34LeukemiaPancytopeniaCell LineageTreatment OutcomeTransplantation ChimeraAdult Stem CellsImmunosuppressive AgentsColony-Forming Units AssayFlow CytometryAnemia, AplasticCells, CulturedFetal BloodStromal CellsEmbryonic Stem CellsRetrospective StudiesCell ProliferationBone RemodelingBone Marrow DiseasesHLA AntigensCytomegalovirus InfectionsAntifungal AgentsGraft SurvivalBone Marrow ExaminationCell CountBone Marrow NeoplasmsBone Marrow PurgingPluripotent Stem CellsWhole-Body IrradiationTime FactorsMesenchymal Stem Cell TransplantationOpportunistic InfectionsFollow-Up StudiesHematopoietic Stem Cell MobilizationBone DensityHistocompatibilityMesenchymal Stromal CellsMultiple MyelomaSignal TransductionMycosesKidney TransplantationStem Cell FactorMultipotent Stem CellsAspergillosisBone ResorptionGene Expression RegulationNeural Stem CellsLeukemia, Myeloid, AcuteInduced Pluripotent Stem CellsRecurrenceRoseolovirus InfectionsBusulfanTransplantsCytomegalovirusHematologic DiseasesCell SeparationGranulocyte Colony-Stimulating FactorLeukemia, MyeloidCell DivisionGraft RejectionCombined Modality TherapyGranulocytesCell SurvivalBone NeoplasmsLeukemia, Myelogenous, Chronic, BCR-ABL PositiveAcute DiseasePrecursor Cell Lymphoblastic Leukemia-LymphomaFatal OutcomeT-LymphocytesMyelodysplastic SyndromesImmunosuppressionSurvival AnalysisBone DevelopmentBone DiseasesCord Blood Stem Cell TransplantationRadiation Chimera
TransplantationProgenitor cellsVivoHematologyPost-transplantHomeostasisAcuteDonorDifferentiationPeripheral bloodClinical applicationRecipientTherapyCytomegalovirusReconstitutionPatientsBLOODBasisSpecificAcute myeloidHSCTHSCsPlateletAllogeneicLineageSolid tumorsHemoglobinopathiesBlastsInhibitionSomaticMurinePathwaysRecipientsDisorderUndergoTumor cellsDepletionEngraftmentSourceTreatmentCasesIncreaseMultipleTypeComplete
Transplantation19
Progenitor cells3
  • In this study, we observed that the expression of pseudouridine (Ψ) synthase 10 is increased in aged hematopoietic stem and progenitor cells (HSPC) and enforced protein of Ψ synthase 10 (PUS10) recapitulates the phenotype of aged HSC, which is not achieved by its Ψ synthase activity. (haematologica.org)
  • Melinda is highly proficient in the use of in vitro and in vivo assays for normal and malignant hematopoietic stem and progenitor cells, determination of self-renewal, expansion and lineage specific differentiation capabilities, and the use of induced pluripotent stem cells for the investigation of hematopoietic disorders and leukemic progression and the testing of targeted therapeutics. (edu.au)
  • The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
Vivo1
  • We previously established a direct single-cell analysis to simultaneously identify and quantify in vivo CMV-CTL clones after allo-HCT 9 , 10 . (nature.com)
Hematology1
  • 2021 , '3101 - MIR-10A AS A THERAPEUTIC TARGET AND PREDICTIVE BIOMARKER FOR MDM2 INHIBITION IN ACUTE MYELOID LEUKEMIA' , Experimental Hematology , 100 , pp. (edu.au)
Post-transplant4
  • Allogeneic HCT has been widely used, while autologous HCT, which is still useful, is less prevalent because of concerns around post-transplant relapse, as well as the recently extended application of allogeneic HCT. (apbmt.org)
  • Each participating center is required to register all consecutive HCTs, report core information for registered HCTs as of post-transplant day 100, and report follow-up information annually. (apbmt.org)
  • The post-transplant course was uneventful. (frontiersin.org)
  • At 4 years of age and 29 months post-transplant, the patient demonstrated normal T-lymphocyte and natural killer cell numbers. (frontiersin.org)
Homeostasis2
  • No significant alteration of hematopoietic homeostasis and HSC function is observed in young Pus10-/- mice, while aged Pus10-/- mice exhibit mild alteration of hematopoietic homeostasis and HSC function. (haematologica.org)
  • External insults (eg, infections, radiation, drugs) may disrupt stem cell homeostasis in marrow environment, leading to altered growth. (medscape.com)
Acute1
Donor3
Differentiation2
  • Aged hematopoietic stem cells (HSC) exhibit compromised reconstitution capacity and differentiation-bias towards myeloid lineage, however, the molecular mechanism behind it remains not fully understood. (haematologica.org)
  • 1 , 2 During aging, the function of HSC declines, featured as compromised reconstitution capacity and differentiation skewing towards myeloid line-age. (haematologica.org)
Peripheral blood1
  • The number of related HCTs has remained stable, while the use of peripheral blood stem cells (PBSCs) has now largely replaced that of bone marrow (BM). (apbmt.org)
Clinical application1
  • A better and deeper understanding of immune reconstitution following allo-HCT is required for further clinical application of these adoptive T-cell therapies. (nature.com)
Recipient1
  • Single-cell RNA-sequence analyses demonstrate the homogenous distribution of the gene expression profile in individual cytomegalovirus-specific cytotoxic T-cells within each recipient. (nature.com)
Therapy1
  • high-risk patients included male subjects, recipients of stem cells from female donors, patients younger than 10 years, those with nonidentical donors, and those who received radiation therapy in the transplant preparative regimen. (medscape.com)
Cytomegalovirus3
Reconstitution1
  • However, cellular immune reconstitution of CMV-specific cytotoxic T-cells (CMV-CTL) is generally considered to be necessary for the long-term control of CMV reactivation after allo-HCT. (nature.com)
Patients2
  • The 5-year probability of overall survival (OS) after allogeneic HCT was estimated to be 56% (95% confidence interval[CI], 55%- 57%) for patients receiving a transplant while in CR, and 22% (95% CI, 21%-23%) for those who were experiencing active disease. (apbmt.org)
  • The clinical presentation of patients with aplastic anemia includes signs and symptoms related to the decrease in bone marrow production of hematopoietic cells. (medscape.com)
BLOOD1
Basis1
  • The theoretical basis for marrow failure includes primary defects in or damage to the stem cell or the marrow microenvironment. (medscape.com)
Specific1
  • An individual T-cell has a specific complementarity-determining region 3 (CDR3) of T cell receptor (TCR)-α and -β, which is a result of the recombination of somatic TCR V-(D)-J genes and junction diversity. (nature.com)
Acute myeloid7
HSCT1
  • Approximately 50% of the transplants in case of acute myeloid leukaemia and ALL account for allogeneic HSCT. (zenonco.io)
HSCs4
  • HMGN1 amplification is associated with increased accessibility, expression, and histone H3K27 acetylation of loci important for hematopoietic stem cells (HSCs) and leukemia, such as HoxA cluster genes. (nature.com)
  • Hematopoiesis is a highly regulated process requiring both self-renewal and differentiation of hematopoietic stem cells (HSCs) to maintain diverse mature blood components. (nature.com)
  • We focussen ons vooral op het begrijpen van de oorsprong van HSCs tijdens de embryonale ontwikkeling, de mechanismen die betrokken zijn bij het genereren en expanderen van HSCs, de samenstelling en functie van de verschillende HSC niches tijdens maturatie, en de cellulaire en moleculaire kenmerken van HSCs en hun voorlopers. (hubrecht.eu)
  • Haematopoietic stem cells (HSCs) are adult stem cells that represent almost 0.05 to 0.5% of the cellular density of the normal bone marrow. (zenonco.io)
Platelet2
Allogeneic1
  • 3 In the majority of patients with AML, unless intense consolidative strategies such as allogeneic stem cell transplant are undertaken, the relapse rates are high. (ashpublications.org)
Lineage1
  • Hematopoietic Lineage Diversification, Simplified. (ox.ac.uk)
Solid tumors2
  • a broad range of disorders for which transplantion of HPCs from an adult donor is also successful, including hematological malignancies, solid tumors, constitutional and acquired bone marrow failure syndromes, hemoglobinopathies, congenital immune deficiencies, and inherited disorders of metabolism (Gluckman et al. (nationalacademies.org)
  • Some involve leukaemias, bone marrow failures, hemoglobinopathies (thalassemia, sickle cell disease), immunodeficiencies, and other HSC transplant-based treatments for solid tumors and other genetic disorders such as lysosomal storage disease along with autoimmunity. (zenonco.io)
Hemoglobinopathies1
  • It helps increase the bone marrow function that depends upon the treatment of the disease in eliminating the tumor cells with malignancy or generating the functional cells that replace the dysfunctional cells in certain disorders such as immune deficiency syndromes, hemoglobinopathies, and other diseases. (zenonco.io)
Blasts1
  • 2 The International Prognostic Scoring System (IPSS) 3 distinguishes four risk groups for survival and AML evolution based on cytogenetic subgroups, percentage of bone marrow blasts and number of cytopenias. (haematologica.org)
Inhibition1
  • PRCA has been shown to be secondary to T-cell inhibition of marrow erythroid cells. (medscape.com)
Somatic2
  • In addition, somatic gain of chromosome 21 is associated with aggressive leukemias, such as iAMP21 B cell acute lymphoblastic leukemia that has multiple extra copies of 21q22 and a very poor prognosis 13 . (nature.com)
  • B-cell-autonomous somatic mutation deficit following bone marrow transplant. (ox.ac.uk)
Murine1
  • We previously performed an RNA interference screen in murine B cell progenitors modeling Down syndrome and found that Hmgn1 was the amplified gene most critical to support hematopoietic colony forming activity 15 . (nature.com)
Pathways1
  • Cancer cells frequently acquire abnormalities in the same chromatin regulatory pathways, which promote malignancy and may impart targetable therapeutic dependencies 2 . (nature.com)
Recipients1
  • It entirely depends upon the effect of the graft and donor immunity against malignant cells in recipients. (zenonco.io)
Disorder1
  • Pure red cell aplasia (PRCA) is an uncommon disorder in which maturation arrest occurs in the formation of erythrocytes. (medscape.com)
Undergo1
  • This medical treatment involves preparing and caring for a healthy donor volunteer who must undergo a medical procedure for stem cell collection. (zenonco.io)
Tumor cells1
Depletion2
  • Depletion of CD8 or natural killer cells, but not CD4 cells, resulted in loss of antitumor activity in the VSV/anti-PD-L1 group. (ashpublications.org)
  • Cell-intrinsic depletion of Aml1-ETO-expressing pre-leukemic hematopoietic stem cells by K-Ras activating mutation. (ox.ac.uk)
Engraftment1
  • Differences in patient populations and treatment modalities in different transplant centers mean it is important to improve the knowledge of the different factors affecting engraftment after APBSCT for the success of this procedure. (omjournal.org)
Source1
  • With more than 6,000 transplants of cord blood from related and unrelated donors performed thus far, cord blood has emerged as an acceptable, alternative source of HPCs that has some advantages over adult sources of HPCs and the availability of which represents an important development in the field. (nationalacademies.org)
Treatment1
  • Data obtained included disease type, treatment, and stem cell characteristics. (omjournal.org)
Cases1
  • De novo cases of Diamond-Blackfan syndrome are believed to be caused by intrauterine damage to early erythroid stem cells. (medscape.com)
Increase1
Multiple1
  • ABO antigens are multiple sugar chains or oligosaccharides that are attached to the surface of red blood cells (RBCs) or N-glycans or O-glycans. (bloodresearch.or.kr)
Type1
  • These cultured cells, or colony-forming units (CFUs), are coded according to the type of cells that they will ultimately produce (e.g. (nationalacademies.org)
Complete1