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  • precursors
  • However, counting CD34+ mononuclear cells may overestimate myeloid blasts in bone marrow smears due to hematogones (B lymphocyte precursors) and CD34+ megakaryocytes. (wikipedia.org)
  • P. Szabolcs, M.A.S. Moore, and J.W. Young, Expansion of immunostimulatory dendritic cells among the myeloid progeny of human CD34+ bone marrow precursors cultured with c-kit ligand, granulocyte-macrophage colony-stimulating factor, and TNF-a, J. Immunol . (springer.com)
  • Parvovirus B19 inhibits erythropoiesis by lytically infecting RBC precursors in the bone marrow and is associated with a number of different diseases ranging from benign to severe. (wikipedia.org)
  • viable
  • Each unit contains a minimum of 5 x 10 8 total nucleated cells with at least 1.25 x 10 6 viable CD34+ cells at the time of cryopreservation. (nih.gov)
  • Each unit contains a minimum of 9 × 10 8 total nucleated cells with at least 1.25 × 10 6 viable CD34+ cells at the time of cryopreservation. (nih.gov)
  • The delivered cells (via local or systemic administration) remain viable for a relatively short period (days-weeks) and then die. (wikipedia.org)
  • Such cells can construct a complete, viable organism. (wikipedia.org)
  • chemotherapy
  • Bone marrow suppression is a serious side effect of chemotherapy and certain drugs affecting the immune system such as azathioprine. (wikipedia.org)
  • The decrease in blood cell counts does not occur right at the start of chemotherapy because the drugs do not destroy the cells already in the bloodstream (these are not dividing rapidly). (wikipedia.org)
  • Unlike chemotherapy the affects may not be due to direct destruction of stem cells but the results may be equally serious. (wikipedia.org)
  • Bone marrow suppression due to anti-cancer chemotherapy is much harder to treat and often involves hospital admission, strict infection control, and aggressive use of intravenous antibiotics at the first sign of infection. (wikipedia.org)
  • therapy
  • We will review the emerging literature in the nascent field of stem cell plasticity and describe new instrumentation to deliver and monitor stem cell activity in myocardial therapy. (ahajournals.org)
  • In MSC therapy the cells are extracted from the adult patient's bone marrow via a procedure called bone marrow aspiration. (wikipedia.org)
  • Cell therapy originated in the nineteenth century when scientists experimented by injecting animal material in an attempt to prevent and treat illness. (wikipedia.org)
  • Today two distinct categories of cell therapy are recognized. (wikipedia.org)
  • The first category is cell therapy in mainstream medicine. (wikipedia.org)
  • Cell therapy can be defined as therapy in which cellular material is injected into a patient. (wikipedia.org)
  • The origins of cell therapy can perhaps be traced to the nineteenth century, when Charles-Édouard Brown-Séquard (1817-1894) injected animal testicle extracts in an attempt to stop the effects of aging. (wikipedia.org)
  • In 1931 Paul Niehans (1882-1971) - who has been called the inventor of cell therapy - attempted to cure a patient by injecting material from calf embryos. (wikipedia.org)
  • In recent times, cell therapy using human material has been recognized as an important field in the treatment of human disease. (wikipedia.org)
  • The experimental field of Stem cell therapy has shown promise for new types of treatment. (wikipedia.org)
  • In mainstream medicine, cell therapy is supported by a distinct healthcare industry which sees strong prospects for future growth. (wikipedia.org)
  • Cell therapy is targeted at many clinical indications in multiple organs and by several modes of cell delivery. (wikipedia.org)
  • The main toxicity of this therapy is bone marrow suppression due to systemic absorption of the drug. (wikipedia.org)
  • Associated with antiretroviral therapy, IL-7 administration decreased local and systemic inflammations in patients that had incomplete T-cell reconstitution. (wikipedia.org)
  • disorders
  • MSCs have been used to treat a variety of disorders including cardiovascular diseases, spinal cord injury, bone and cartilage repair, and autoimmune diseases. (wikipedia.org)
  • Severe sickle cell crises, in some cases resulting in death, have been associated with the use of filgrastim in patients with sickle cell disorders. (wikipedia.org)
  • Injection
  • Injection of CD34+ hematopoietic Stem Cells has been clinically applied to treat various diseases including Spinal Cord Injury, Liver Cirrhosis and Peripheral Vascular disease. (wikipedia.org)
  • Conversely, the injection of SCF increases mast cell numbers near the site of injection by over 100 times. (wikipedia.org)
  • Injection of cardiomyogenic and/or angiogenic stem cells have been proposed as alternatives to existing treatments. (wikipedia.org)
  • The most commonly observed adverse effect is mild bone pain after repeated administration and local skin reactions at the site of injection. (wikipedia.org)
  • Regeneration
  • Myocardial regeneration is perhaps the most widely studied and debated example of stem cell plasticity. (ahajournals.org)
  • To further understand the role of stem cells in regeneration, it is incumbent on us to develop instrumentation and technologies to monitor myocardial repair over time in large animal models. (ahajournals.org)
  • Endothelial progenitor cell (or EPC) is a term that has been applied to multiple different cell types that play roles in the regeneration of the endothelial lining of blood vessels. (wikipedia.org)
  • This self-regeneration capacity gives rise to alternatives to classical cellular therapies whereby administration of growth factors such as Thymosin β4 for cell activation and migration are solely necessary. (wikipedia.org)
  • platelets
  • This condition can rapidly lead to life-threatening infection, as the body cannot produce leukocytes in response to invading bacteria and viruses, as well as leading to anaemia due to a lack of red blood cells and spontaneous severe bleeding due to deficiency of platelets. (wikipedia.org)
  • Because of the failure of hematologic components to develop-white blood cells, red blood cells, and platelets-the body's capabilities to fight infection, deliver oxygen, and form clots are all diminished. (wikipedia.org)
  • thymus
  • This results in a lack of B and T cells in the thymus and in the secondary lymphoid organs, such as the spleen and lymph nodes. (wikipedia.org)
  • Binding results in a cascade of signals important for T-cell development within the thymus and survival within the periphery. (wikipedia.org)
  • trials
  • Adult stem cells from these niches are currently being used to treat a number of diseases and more applications are in clinical trials. (icr.org)
  • Various HIV vaccines have been tested in clinical trials almost since the discovery of HIV. (wikipedia.org)
  • The first clinical trials of MSCs were completed in 1995 when a group of 15 patients were injected with cultured MSCs to test the safety of the treatment. (wikipedia.org)
  • Since then, over 200 clinical trials have been started. (wikipedia.org)
  • IL-7 as an immunotherapy agent has been examined in many pre-clinical animal studies and more recently in human clinical trials for various malignancies and during HIV infection. (wikipedia.org)
  • Recombinant IL-7 has been safely administered to patients in several phase I and II clinical trials. (wikipedia.org)
  • acute
  • Among those affected, the majority develops cancer, most often acute myelogenous leukemia, and 90% develop bone marrow failure (the inability to produce blood cells) by age 40. (wikipedia.org)
  • citation needed] As FA is now known to affect DNA repair, specifically nonhomologous end joining, and given the current knowledge about dynamic cell division in the bone marrow, finding patients are more likely to develop bone marrow failure, myelodysplastic syndromes, and acute myeloid leukemia (AML) is not surprising. (wikipedia.org)