Loading...
  • disease
  • Bone marrow transplantation (BMT) can cure the blood system but can make the lung and liver disease and risk of cancer worse, because of DNA damaging agents such as alkylators and radiation that are typically used in the procedure. (clinicaltrials.gov)
  • normal bone marrow
  • One of the causes for this disease involves replacement of normal bone marrow tissue by adipose (fat) tissue, thus minimizing the functional capacity of the bone marrow to produce cells. (petmd.com)
  • Aplastic anemia is a life-threatening condition resulting when normal bone marrow is replaced by adipose (fat) tissue, thus preventing it from releasing the required number of WBCs, RBCs, and platelets and resulting in an overall decrease in the total number of these cells in the blood. (petmd.com)
  • morphologic
  • Secondary endpoints are markers of pre-malignant conditions, such as leukoplakia, serum or tissue evidence of carcinogenic viruses, and bone marrow morphologic myelodyplastic syndrome or cytogenetic clones. (clinicaltrials.gov)
  • aspiration
  • Participants were randomized to receive ixmyelocel-T (60 patients) or placebo (66 patients) at the time of bone marrow aspiration (58 and 51 patients, respectively, were included in the per-protocol primary efficacy analysis). (empr.com)
  • 2018
  • Dr. Lucy Godley, University of Chicago, and Dr. Luca Malcovati, University of Pavia, discuss the highlights of their session on Genetics and Genomics of Bone Marrow Failure at the 2018 AAMDSIF International Bone Marrow Failure Disease Scientific Symposium, March 2018. (curetoday.com)
  • stem cell
  • For children whose bone marrow fails or who develop pre-malignant chromosomal changes, a stem cell transplant may be required. (childrens.com)
  • These patients are cared for by Stem Cell Transplant Program physicians for approximately two years during and after the transplant before returning to the care of hematologists in the Bone Marrow Failure Program. (childrens.com)
  • Primary graft failure is defined as no evidence of neutrophil engraftment by day +28 after stem cell infusion. (clinicaltrials.gov)
  • Moreover, bone marrow cells may also represent an attractive source for cell replacement therapy of type 1 and type 2 diabetes, not least in view of the limited supply of human islets and ethical issues surrounding embryonic stem cell research ( 28 - 31 ). (diabetesjournals.org)
  • cells
  • The bone marrow is also the home for a special type of cells called stem cells. (clicsargent.org.uk)
  • This demonstrates the extensive amount of work done by the bone marrow in keeping the numbers of these cells within normal ranges in the body. (petmd.com)
  • Recent studies in normal mice have suggested that transplanted bone marrow cells can transdifferentiate into pancreatic β-cells at relatively high efficiency. (diabetesjournals.org)
  • In contrast to previous studies, transplanted bone marrow cells expressing green fluorescence protein (GFP) under the control of the mouse insulin promoter failed to express GFP in the pancreas of normal as well as diabetic mice. (diabetesjournals.org)
  • Although bone marrow cells expressing GFP under the ubiquitously expressed β-actin promoter efficiently engrafted the pancreas of normal and hyperglycemic mice, virtually all expressed CD45 and Mac-1/Gr-1, demonstrating that they adopt a hematopoietic rather than β-cell fate, a finding further substantiated by the complete absence of GFP + cells expressing insulin and the β-cell transcription factors pancreatic duodenal homeobox factor-1 and homeodomain protein. (diabetesjournals.org)
  • Thus, transplanted bone marrow cells demonstrated little, if any, capacity to adopt a β-cell fate. (diabetesjournals.org)
  • However, these data are controversial, as other studies ( 9 - 14 ) have failed to document such transdifferentiation, although in some cases bone marrow-derived hematopoietic cells have been demonstrated to contribute at very low frequencies to other cell lineages through cell fusion ( 12 , 15 - 19 ). (diabetesjournals.org)
  • In parallel with this work, other studies ( 20 - 24 ) have extended the concept of developmental plasticity of transplanted bone marrow cells. (diabetesjournals.org)
  • 25 ) suggested that as much as 1.7-3% of the insulin-expressing cells in the islets of transplanted mice were derived from reconstituting bone marrow cells. (diabetesjournals.org)
  • If these findings can be confirmed, bone marrow cells might clearly play a role in the adaptive increase in β-cell mass that occurs physiologically during, for example, obesity and pregnancy. (diabetesjournals.org)
  • Although some subsequent studies ( 32 , 33 ) have obtained results compatible with the generation of insulin-expressing pancreatic cells from transplanted bone marrow cells, the reported efficiency has been several orders of magnitude lower than initially reported, and other studies have failed to detect any transdifferentiation into β-cells at all ( 34 ). (diabetesjournals.org)
  • Thus, the capacity of transplanted bone marrow cells to contribute to β-cell regeneration remains controversial. (diabetesjournals.org)
  • However, until this controversy has been resolved, bone marrow cells continue to be promoted as a candidate source for cell replacement therapy for diabetes ( 31 ). (diabetesjournals.org)
  • Here, we have adopted different experimental strategies to follow the fate of transplanted bone marrow cells in the pancreas of normal as well as hyperglycemic mice. (diabetesjournals.org)
  • In this study, we demonstrated a significant decrease in the generation of CD4+ T cells from bone marrow (BM) CD34+ progenitors in macaques infected with SIVmac251. (irsn.fr)