AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Bone Marrow TransplantationBone MarrowHistocompatibility TestingBone Marrow CellsTissue DonorsTransplantation, HomologousGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHematopoietic Stem CellsHistocompatibilityUnrelated DonorsTransplantation ConditioningBone and BonesTissue and Organ ProcurementTransplantation, AutologousWhole-Body IrradiationHLA AntigensAnemia, AplasticLeukemiaGraft SurvivalHematopoiesisBone Marrow DiseasesTransplantation ChimeraBone Marrow PurgingBone Marrow ExaminationBone RemodelingMice, Inbred C57BLBusulfanLiver TransplantationBone Marrow NeoplasmsStem CellsHematologic NeoplasmsColony-Forming Units AssayLeukemia, Myelogenous, Chronic, BCR-ABL PositiveRadiation ChimeraCyclophosphamideTransplantation, IsogeneicTime FactorsRegistriesRecurrenceGraft vs Host ReactionTreatment OutcomeCell DifferentiationLeukocyte TransfusionStem Cell TransplantationBone DensityLeukemia, Myeloid, AcuteGraft RejectionLiving DonorsAntigens, CD34Combined Modality TherapyKidney TransplantationImmunosuppressionAcute DiseaseT-LymphocytesBlood DonorsBone ResorptionPrecursor Cell Lymphoblastic Leukemia-LymphomaFlow CytometryRemission InductionImmunosuppressive AgentsLeukemia, MyeloidCells, CulturedRetrospective StudiesHepatic Veno-Occlusive DiseaseMyelodysplastic SyndromesSurvival AnalysisCord Blood Stem Cell TransplantationHematopoietic Stem Cell MobilizationTransplantation ImmunologyLymphocyte DepletionCell LineageChimeraSevere Combined ImmunodeficiencyLymphoma, Non-HodgkinHematologic DiseasesGranulocyte Colony-Stimulating FactorSpleenBone NeoplasmsCell SeparationPancytopeniaSurvival RateMice, KnockoutGranulocytesMice, Inbred BALB CStromal CellsDisease-Free SurvivalHeart TransplantationMultiple MyelomaLeukocyte CountBone DevelopmentLymphocyte TransfusionBone DiseasesAntineoplastic Combined Chemotherapy ProtocolsImmunophenotypingCyclosporineActuarial AnalysisGraft vs Leukemia EffectFollow-Up StudiesMice, Transgenic
TransplantHSCTEngraftmentTransplantsUmbilicalGraft-versus-AutologousAllogeneic hematopoietic cell transplantationProgenitor cellMobilizing hematopoietic progenitor cellsHaploidenticalMyelodysplastic syndromeChemotherapyAcquired bone marrow failure syndromesFailure syndromesClinicalPatient's bone marrowMatched unrelatedPatientsRecipientMurineTissuesAdultHSCsPlateletsTherapeuticRegistryCurative treatmentRegimenInfectionAplasticSurvivalConditioning regimensReconstitutionRecipientsSingle donorPluripotent stemBloodDisordersMobilizationLung transplantationTissue transplantationCell differentiation
Transplant56
  • You have had a bone marrow transplant . (medlineplus.gov)
  • A bone marrow transplant is a procedure to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. (medlineplus.gov)
  • Dry mouth or sores from medicines you need to take for the bone marrow transplant can lead to an increase in bacteria in your mouth. (medlineplus.gov)
  • A new study published in the American Journal of Transplantation reports there is no evidence of children between 6 and 11 years of age being at a disadvantage if they are seeking deceased donor lung transplant in the current US lung allocation system. (medindia.net)
  • The researchers analyzed information from the Scientific Registry of Transplant Recipients, which includes data on all donors, wait-listed candidates, and transplant recipients in the United States. (medindia.net)
  • Opportunities for improvement include bringing the lung donor yield in the 0-11 age group closer to the yield in adolescents, relaxing geographic allocation boundaries to ensure that pediatric lungs are offered first to children, and reserving deceased donor lobar transplant for circumstances where suitably sized donor organs are not available," they wrote. (medindia.net)
  • Are you considering a blood stem cell transplant? (nih.gov)
  • This study is investigating a new method for collecting blood stem cells from donors to see if it reduces transplant complications, such as rejection, in patients who have blood diseases. (nih.gov)
  • Have you received a stem cell transplant? (nih.gov)
  • This study aims to monitor the long-term health of patients who have received a donor stem cell transplant from the NIH Clinical Center. (nih.gov)
  • Are you scheduled for a stem cell transplant with cord blood? (nih.gov)
  • Various XSCID gene therapy clinical trials have been conducted over 20 years, both as an alternative to hematopoietic stem cell transplant (HSCT) or following a poor outcome. (stjude.org)
  • Mayo Clinic scientists are actively studying ways to improve bone marrow transplant outcomes. (mayoclinic.org)
  • Learn more about research in the Bone Marrow Transplant Program . (mayoclinic.org)
  • See a list of publications about bone marrow transplant by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine. (mayoclinic.org)
  • Hematopoietic stem cell transplant. (mayoclinic.org)
  • http://www.cancer.gov/about-cancer/treatment/types/stem-cell-transplant/stem-cell-fact-sheet. (mayoclinic.org)
  • Blood Marrow Transplant. (bcm.edu)
  • Ramos CA " Striking the right balance: optimizing conditioning regimens for unrelated donor bone marrow transplant for severe aplastic anemia. . (bcm.edu)
  • This is a prospective, multi-center, Phase II study of hematopoietic cell transplantation (HCT) using human leukocyte antigen (HLA)-mismatched unrelated donors (MMUD) for peripheral blood stem cell transplant in adults and bone marrow stem cell transplant in children. (uchicagomedicine.org)
  • The primary objective of this study is to demonstrate the efficacy of Iomab-B, in conjunction with a Reduced Intensity Conditioning (RIC) regimen and protocol-specified allogeneic hematopoietic stem cell transplant (HCT), versus Conventional Care. (mayo.edu)
  • The purpose of this study is to compare relapse-free survival between participants with FLT3/ITD AML in first morphologic complete remission (CR1) who undergo hematopoietic stem cell transplant (HCT) and are randomized to receive gilteritinib or placebo beginning after the time of engraftment for a two year period. (mayo.edu)
  • Their vision is to save and improve the lives of everyone who needs a stem cell transplant. (managementcentre.co.uk)
  • Blood and Marrow Transplant Research [CIBMTR] in 2004), the European Research Project on Cord Blood Transplantation (Eurocord) in 1993, and the Japanese Cord Blood Banking Network in 1996-expedited the clinical evaluation of the efficacy and safety of transplantation of cord blood from unrelated donors. (nationalacademies.org)
  • RECENT FINDINGS: Stem cell sources, novel transplant methods, and sophisticated supportive care have simultaneously made giant strides toward improving the safety and efficacy of hematopoietic cell transplantation. (wustl.edu)
  • This has led to the utilization of marrow, cord, peripheral blood stem cell and haploidentical stem cell sources, and novel reduced toxicity or reduced intensity conditioning regimens to transplant non-malignant disorders such as immune dysfunctions, marrow failure syndromes, metabolic disorders and hemoglobinopathies. (wustl.edu)
  • The registry follows the excitement surrounding Nigeria's first bone marrow transplant last October, in which. (the-scientist.com)
  • And if a full sibling match can't be found, it's also possible to transplant hematopoietic stem cells from a donor who's only a half match. (reachmd.com)
  • So are there any downsides of undergoing an unrelated donor transplant? (reachmd.com)
  • Patients will receive intensity modulated total marrow irradiation (TMI) at a dose of 9 Gy with standard myeloablative fludarabine/ i.v. targeted busulfan (FluBu) conditioning prior to allogeneic hematopoietic stem cell transplant (HSCT). (mycancergenome.org)
  • Allogeneic transplants involve grafts from a genetically nonidentical donor of the same species and are the transplant type most often used in children. (oncologynurseadvisor.com)
  • A stem cell transplant is when cells are taken out of the blood for use in a transplant. (differencebetween.net)
  • A bone marrow transplant is when stem cells are removed from the bone marrow for transplant. (differencebetween.net)
  • What is Stem Cell Transplant? (differencebetween.net)
  • This is when stem cells that are obtained from the bloodstream or umbilical cord of a donor are used for transplant into a patient. (differencebetween.net)
  • Umbilical cord blood stem cells are only used for transplant into children since there are not enough cells present to be of any use for transplant into an adult patient. (differencebetween.net)
  • Stem cell transplant can be used to treat conditions such as multiple myeloma, and other cancers such as certain kinds of lymphoma and leukemia. (differencebetween.net)
  • A bone marrow transplant is when stem cells are removed from a donor's bone marrow for transplant into a patient. (differencebetween.net)
  • A stem cell transplant is when stem cells are harvested from the bloodstream or the umbilical cord. (differencebetween.net)
  • A bone marrow transplant is when stem cells are harvested directly from the bone marrow. (differencebetween.net)
  • In the case of a stem cell transplant, granulocyte- colony-stimulating factor has to be given to the donor a few days before the procedure. (differencebetween.net)
  • OBM Transplantation is committed to rapid review and publication, and we aim at serving the international transplant community with high accessibility as well as relevant and high quality content. (lidsen.com)
  • One hundred kidney transplant recipients were evaluated on the first and fifth days after transplantation by Tc-99m mononuclear cell scintigraphy. (shengsci.com)
  • Calcitriol started in the donor, expands the population of CD4+CD25+ T cells in renal transplant recipients. (shengsci.com)
  • Therefore, we sought to translate these results to a clinically relevant canine-to-canine allogeneic transplant model for Duchenne muscular dystrophy (DMD) and determine if CXCR4 is important for donor cell engraftment. (biomedcentral.com)
  • Intramuscular injection of donor muscle-derived cells into chimeric cxmd recipients restored dystrophin expression for at least 24 weeks in the absence of post-transplant immunosuppression, indicating that cell transplantation may be a viable therapeutic option for muscular dystrophy. (biomedcentral.com)
  • Related transplant donors must be proven not to have Fanconi anemia in order for a transplantation to succeed. (medscape.com)
  • The goal of this grant was to develop a non-genotoxic antibody-based conditioning regimen that can be used to treat people with FA who are undergoing a hematopoietic cell transplant (HCT). (fanconi.org)
  • This treatment is currently limited by the availability of compatible bone marrow donors and, as a result, transplant of unrelated donor umbilical cord blood is an attractive alternative. (lu.se)
  • Registry of the international society for heart and lung transplantation: twenty-second official adult lung and heart-lung transplant report-2005. (medigraphic.com)
  • The immunosuppressants mycophenolate mofetil (MMF) and cyclosporine were given to the patient to prevent rejection of the allogeneic stem cell transplant, whereas the chemotherapeutic agent cytarabine was utilized to kill leukemic cells. (biomedcentral.com)
  • However, the donor was unable to postpone her trip, and the recipient was in urgent need of the transplant. (cdc.gov)
  • After being informed about possible infection of the donor, the transplant physicians administered immunoglobulin to the recipient intravenously. (cdc.gov)
  • Is a matched unrelated donor search needed for all allogeneic transplant candidates? (cdc.gov)
  • Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)
  • For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
HSCT14
Engraftment19
  • Successful stem cell transplantation for patients with severe combined immunodeficiency (SCID) from matched family donors without conditioning results in engraftment of T lymphocytes. (nih.gov)
  • Full hematopoietic engraftment was reported in one case after bone marrow transplantation without conditioning for a SCID patient. (nih.gov)
  • In contrast to the expected mixed chimerism that usually occurs in the absence of conditioning, we found in our patients 100% donor cell engraftment based on fluorescence in situ hybridization (FISH) and microsatellite techniques. (nih.gov)
  • In the two cases with ABO incompatibility, erythroid engraftment was evidenced by blood group conversion from recipient to donor type. (nih.gov)
  • Multilineage donor engraftment is possible in SCID patients even without conditioning. (nih.gov)
  • Subsequent transplantation of the cells into lethally irradiated mice results in engraftment of the animals with donor haematopoietic tissue containing the bacterial gene. (nature.com)
  • Chimerism analysis - testing of short tandem repeat regions to assess donor bone marrow engraftment. (ouh.nhs.uk)
  • Kamble RT, Guo S, Ramos CA, Carrum G " Acute gout at engraftment following hematopoietic transplantation. . (bcm.edu)
  • Currently, my work aims to establish strategies to reduce the risk of relapse after allogeneic hematopoietic stem cell transplantation without exacerbating graft-versus-host disease or interfering with donor stem cell engraftment. (stanford.edu)
  • Chemotherapy, radiation, or both are initiated prior to transplantation to enable engraftment of the transplanted cells, decrease tumor size, and reduce immunoreactivity of the recipient. (oncologynurseadvisor.com)
  • In murine-to-murine transplantation experiments, CXCR4 expression marks a population of adult murine satellite cells with robust engraftment potential in mdx mice, and CXCR4-positive murine muscle-derived SP cells home more effectively to dystrophic muscle after intra-arterial delivery in mdx 5cv mice. (biomedcentral.com)
  • Together, these data suggest that CXCR4 plays an important role in donor cell engraftment. (biomedcentral.com)
  • In this study, we used a canine-to-murine xenotransplantation model to quantitatively compare canine muscle cell engraftment, and test the most effective cell population and modulating factor in a canine model of DMD using allogeneic transplantation experiments. (biomedcentral.com)
  • We show that CXCR4 expressing cells are important for donor muscle cell engraftment, yet FACS sorted CXCR4-positive cells display decreased engraftment efficiency. (biomedcentral.com)
  • However, diprotin A, a positive modulator of CXCR4-SDF-1 binding, significantly enhanced engraftment and stimulated sustained proliferation of donor cells in vivo . (biomedcentral.com)
  • Therefore, these results establish the efficacy of diprotin A in stimulating muscle cell engraftment, and highlight the pre-clinical utility of a xenotransplantation model in assessing the relative efficacy of muscle stem cell populations. (biomedcentral.com)
  • We used the xenotransplant model to show that CXCR4 expression on canine donor muscle cells is also important for cell engraftment, but FACS sorting for CXCR4-positive cells decreased their engraftment efficiency. (biomedcentral.com)
  • The study, which involved 130 patients, also found that adding fludarabine to conditioning caused three-fold enhancement of hematopoietic cell engraftment. (medscape.com)
  • Engraftment of donor cells in mouse models also showed that when specific immunosuppressant regimens are used donor HSCs have a competitive advantage over FA HSC cells. (fanconi.org)
Transplants11
  • Blood-forming stem cell transplants. (mayoclinic.org)
  • It recruits individuals to a national donor register and carries out research to help make bone marrow transplants more effective. (managementcentre.co.uk)
  • With more than 6,000 transplants of cord blood from related and unrelated donors performed thus far, cord blood has emerged as an acceptable, alternative source of HPCs that has some advantages over adult sources of HPCs and the availability of which represents an important development in the field. (nationalacademies.org)
  • This review provides an overview of advances made in alternative donor transplants for nonmalignant disorders. (wustl.edu)
  • It advocates the consideration of alternative donor transplants in the absence of human leukocyte antigen matched siblings when indicated by disease severity. (wustl.edu)
  • The number of human tissue transplants is increasing in both developed and developing countries, but global data on this form of transplantation are less complete. (who.int)
  • Access to transplantation is limited in low- and many medium-income countries, where the rate of transplants remains far below that of richer nations. (who.int)
  • Adebiyi also plans to establish another Nigerian source for stem cell transplants-an umbilical cord blood bank. (the-scientist.com)
  • Bone marrow transplants are also used in cases where a person has cancers such as some types of lymphomas and leukemias, and multiple myeloma. (differencebetween.net)
  • Stem cell transplants involve cells that are taken out of the blood or umbilical cord. (differencebetween.net)
  • Bone marrow transplants involve cells that are taken out of the bone marrow. (differencebetween.net)
Umbilical7
Graft-versus-2
  • If you received bone marrow from someone else, you may develop signs of graft-versus-host disease ( GVHD ). (medlineplus.gov)
  • The main practical advantages of UCB over other HSC sources are the immediate availability, lower incidence of graft-versus-host disease, minimal risk to the donor, and lower requirement for HLA compatibility. (wjgnet.com)
Autologous5
Allogeneic hematopoietic cell transplantation2
  • Cytomegalovirus reactivation is still a critical concern following allogeneic hematopoietic cell transplantation, and cellular immune reconstitution of cytomegalovirus-specific cytotoxic T-cells is necessary for the long-term control of cytomegalovirus reactivation after allogeneic hematopoietic cell transplantation. (nature.com)
  • A Multicenter, Pivotal Phase 3 Study of Iomab-B Prior to Allogeneic Hematopoietic Cell Transplantation Versus Conventional Care in Older Subjects With Active, Relapsed or Refractory Acute Myeloid Leukemia (SIERRA) Jacksonville, Fla., Rochester, Minn. (mayo.edu)
Progenitor cell3
  • The present invention relates generally to improved methods and pharmaceutical compositions for mobilizing hematopoietic stem and progenitor cell from bone marrow into peripheral blood by administration of at least one inhibitor of a GTPase, such as Rac1 and/or Rac2 GTPase. (justia.com)
  • The various mature blood cell types are all ultimately derived from a single class of progenitor cell known as hematopoietic stem cells. (justia.com)
  • CPT Code 38204 CPT 38204 describes the management of recipient hematopoietic progenitor cell donor search and cell acquisition. (codingahead.com)
Mobilizing hematopoietic progenitor cells1
  • Improved methods and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as Rac1 and Rac2 alone or in combination. (justia.com)
Haploidentical1
Myelodysplastic syndrome2
  • Myelodysplastic Syndrome is associated with this syndrome usually presenting as a Hypoplastic Bone Marrow that can resemble Aplastic Anemia, but can be differentiated with >10% dysplasia in affected cell lines, sometimes not possible though because of the Hypoplastic marrow reducing blood cells to be observed, genetic clones are usually not present more often than not with Hypoplastic Myelodysplastic Disorder associated with Dyskeratosis Congenita. (wikipedia.org)
  • Hematopoietic stem cell transplantation (bone marrow, cord blood, or peripheral blood stem cells) may cure aplastic anemia and prevent myelodysplastic syndrome or leukemia. (medscape.com)
Chemotherapy6
  • This is defined by their ability to repopulate an individual whose hematopoietic system has been destroyed by radiation or chemotherapy. (justia.com)
  • After harvesting, the patient is given high dose chemotherapy or radiotherapy and the bone marrow function is reconstituted by infusion of the cells harvested earlier. (justia.com)
  • The use of high-dosage chemotherapy or radiotherapy for bone marrow ablation requires subsequent incorporation of hematopoietic stem cells into the patient, in which case prior harvesting of such cells is required. (justia.com)
  • The blood cells are harvested from the donor and stored, and then the sickle cell disease patient is given high doses of chemotherapy to get rid of all the remaining blood cells in the bone marrow in order for them to be able to receive the healthy donated cells. (reachmd.com)
  • Hematopoietic stem cell transplantation is also sometimes used for solid tumors (eg, some germ cell tumors) that respond to chemotherapy. (msdmanuals.com)
  • Because of the patient's risk status, the physicians intended to perform allogeneic stem cell transplantation after induction and consolidation chemotherapy, which was scheduled to end in January 2013, and a conditioning chemotherapy regimen, which was planned to be given in March. (cdc.gov)
Acquired bone marrow failure syndromes1
  • a broad range of disorders for which transplantion of HPCs from an adult donor is also successful, including hematological malignancies, solid tumors, constitutional and acquired bone marrow failure syndromes, hemoglobinopathies, congenital immune deficiencies, and inherited disorders of metabolism (Gluckman et al. (nationalacademies.org)
Failure syndromes3
Clinical11
  • These methods and results can help us to better understand immune reconstitution following hematopoietic cell transplantation, leading to future studies on the clinical application of adoptive T-cell therapies. (nature.com)
  • So what are the realities and clinical outcomes associated with hematopoietic stem cell transplantation in sickle cell disease? (reachmd.com)
  • Areas related to clinical and experimental transplantation are also of interest. (lidsen.com)
  • Moreover, xenotransplantation accurately predicted results in canine-to-canine allogeneic transplantation experiments, an important pre-clinical model for future human clinical trials. (biomedcentral.com)
  • The Stanford team received a grant from the Department of Defense Bone Marrow Failure Research Program in September 2021 to continue their work on antibody-based conditioning in Fanconi anemia and initiated a clinical trial in 2022. (fanconi.org)
  • Researchers from Lund Stem Cell Center have identified a novel target for the expansion of human blood stem cells ex vivo and shed light on the mechanism of action of a stem cell promoting molecule, currently in phase II clinical trials. (lu.se)
  • They compared LSD1 inhibition to treatment with UM171, a human hematopoietic stem cell promoting molecule identified in 2014 and currently in phase II clinical trials, despite an as yet unidentified mechanism of action. (lu.se)
  • Techniques of successful clinical double-lung transplantation. (medigraphic.com)
  • Significantly, as the invasiveness of bone marrow transplantation renders it inapplicable for most HIV patients, illustration of the clinical benefits of these pharmacological interventions may lead to a novel methodology for HIV reservoir elimination. (biomedcentral.com)
  • A second apheresis or a bone marrow collection was considered, but neither was performed because the clinical condition of the donor worsened. (cdc.gov)
  • Donor CTLA-4 genotype influences clinical outcome after T cell-depleted allogeneic hematopoietic stem cell transplantation from HLA-identical sibling donors. (cdc.gov)
Patient's bone marrow2
Matched unrelated4
  • Because only one fourth of patients have such a sibling donor, mismatched related or matched unrelated donors (identified through international registries) are often used. (msdmanuals.com)
  • A 63-year-old man with adult T-cell leukemia-lymphoma underwent allogeneic bone marrow transplantation from an HLA-matched unrelated donor. (bvsalud.org)
  • He received 7.16 × 10 8 nucleated bone marrow cells/kg body weight from a 9/10 human leukocyte antigen-matched unrelated donor. (cdc.gov)
  • 1 fully matched unrelated female donor was identified in the German National Registry. (cdc.gov)
Patients28
  • Subset analysis of the engrafted cells using a multiparametric system enabling a combined analysis of morphology, immunophenotyping and FISH showed that both T and B lymphocytes and myeloid cells were of donor origin in two patients, while T lymphocytes and myeloid cells were of donor origin in the third. (nih.gov)
  • Gurkan E, Patah PA, Saliba RM, Ramos CA, Anderson BS, Champlin R, de Lima M, Lichtiger B " Efficacy of prophylactic transfusions using single donor apheresis platelets versus pooled platelet concentrates in AML/MDS patients receiving allogeneic hematopoietic stem cell transplantation. . (bcm.edu)
  • Depending on the degree of bone marrow damage (i.e., suppression), patients who undergo cytoreductive therapy must also receive therapy to reconstitute bone marrow function (hematopoiesis). (justia.com)
  • In such procedures, patients undergo successive treatments with cell mobilization agents to cause mobilization of hematopoietic progenitor cells from the bone marrow to the peripheral circulation for harvesting. (justia.com)
  • In many cases, successfully mobilization is not effected in the patient and inadequate numbers of hematopoietic stem cells are harvested from these patients using current methods. (justia.com)
  • Bio My research is focused on using preclinical models to develop novel therapies which improve outcomes for patients receiving allogeneic hematopoietic stem cell transplantation. (stanford.edu)
  • The persistent and widening gap between patients' need for organs and the number available for transplantation has become a major concern to many Member States. (who.int)
  • Even between countries which have similar levels of health resources, patients' access to transplantation also varies. (who.int)
  • Moreover, for patients who have kidney failure, access to transplantation is reduced when funds are spent on other forms of treatment that are less cost-effective. (who.int)
  • And while 70 percent of Caucasian patients are successfully matched, only 17 percent of black people in the United States are as lucky, according to The New York Stem Cell Foundation , likely because only 8 percent of donors in US registries are black. (the-scientist.com)
  • But unfortunately, only about 20% of patients with sickle cell disease in the United States have a matched donor. (reachmd.com)
  • It's also important to think about what patients are appropriate for hematopoietic stem cell transplantation and to understand what some of the donor requirements are. (reachmd.com)
  • And that's because we need generally healthier patients in order for them to meet the requirements to undergo transplantation. (reachmd.com)
  • Patients must have a related or unrelated peripheral blood stem cell donor as follows: 1. (mycancergenome.org)
  • It can also be used to help patients whose own bone marrow has been destroyed because of cancer treatments. (differencebetween.net)
  • Patients can be cured with bone marrow transplantations of haematopoietic stem cells. (lu.se)
  • Supportive care for patients with symptomatic Fanconi anemia includes transfusions of packed RBCs that have been leukodepleted (and are not from family members, to avoid sensitization in case of a future transplantation). (medscape.com)
  • A study by MacMillan et al reported that alternative donor hematopoietic cell transplantation had a high success rate in patients with Fanconi anemia who did not have a history of opportunistic infections or transfusions and who underwent conditioning with single fraction total body irradiation 300 cGy, cyclophosphamide, fludarabine, and antithymocyte globulin. (medscape.com)
  • Although the only therapy that can cure the pancytopenia is stem cell transplantation, androgens, to which approximately 50-75% of patients respond, are used for those in whom transplantation is not an option. (medscape.com)
  • Bone marrow transplantation has been used for 60+ years to treat >1,000,000 patients suffering from many types of blood or immune diseases, and this therapy is the best current treatment for FA patients experiencing blood problems. (fanconi.org)
  • This procedure relies on replacing sick blood-forming stem cells in patients with healthy ones from a donor, resulting in a completely new blood system. (fanconi.org)
  • We think we can make this procedure safe and eliminate all of the bad side effects through use of antibodies that can target specific cells of the body, and together allow safe turnover of the bone marrow and eliminate bone marrow disease in FA patients. (fanconi.org)
  • Hematopoietic stem cell transplantation is a curative therapy for many patients suffering from life threatening blood disorders. (lu.se)
  • One focus of the Stem Cell Regulators research group, led by Prof. Jonas Larsson, is the development of new strategies to expand stem cells ex vivo , allowing for the treatment of patients who otherwise would lack a suitable donor. (lu.se)
  • However, the allogeneic hematopoietic stem cells given to the Boston patients were derived from donors that express functional CCR5 receptors. (biomedcentral.com)
  • Hematopoietic stem cell transplantation has become a major treatment option for patients with hematopoietic malignancies and immune deficiencies. (cdc.gov)
  • many of these patients did not develop leukemia but died from complications of impaired marrow function. (medscape.com)
  • Influence of molecular subgroups on outcome of acute myeloid leukemia with normal karyotype in 141 patients undergoing salvage allogeneic stem cell transplantation in primary induction failure or beyond first relapse. (cdc.gov)
Recipient5
  • In this stem cell from bone marrow are injected into a recipient after treating them with growth factor. (medindia.net)
  • The subject's blood can be processed and used to repopulate the destroyed lymphohematopoietic system of a recipient and may in the future be utilized to repair a variety of non-hematopoietic tissues. (justia.com)
  • Well, it's transplanting blood stem cells from a donor without sickle cell disease into a recipient who does have sickle cell disease. (reachmd.com)
  • This approach has the advantages of rapid availability and reduced stringency for a complete donor/recipient match, but is limited by a relatively low number of stem cells within a single cord blood unit. (lu.se)
  • Here, we report transmission of dengue virus to a peripheral blood stem cell recipient by a donor who had recently traveled to an area to which the virus is endemic. (cdc.gov)
Murine4
  • An infectious retrovirus vector has been used to transfer a bacterial gene encoding resistance to the neomycin analogue G418 into pluripotent haematopoietic stem cells present in explanted murine bone marrow tissue. (nature.com)
  • Antigen sampling on the Peyer's patches in a murine small bowel transplantation model. (shengsci.com)
  • Furthermore, the canine-to-murine xenotransplantation model accurately predicted results in canine-to-canine muscle cell transplantation. (biomedcentral.com)
  • Yet, it remains unclear from murine transplantation experiments which cell population most effectively engrafts into diseased skeletal muscle. (biomedcentral.com)
Tissues5
  • Our studies also suggest that these hESC reporter lines will become valuable for investigators working on optimizing stem cell differentiation and culture for other tissues, as many of these reporter genes are not only restricted to HSC. (ca.gov)
  • GALNS deficiency induces the accumulation of glycosaminoglycans (GAGs), keratan sulfate (KS) and chondroitin-6-sulfate (C6S) in multiple tissues, particularly bone, cartilage, heart valves, and cornea, whereas β-galactosidase deficiency induces the accumulation of only KS in those tissues. (medscape.com)
  • Nonetheless, the transplantation of organs and tissues does raise ethical concerns. (who.int)
  • Successful transplantation of organs and living tissues depends on continued medical follow-up and the patient's compliance with a regimen of immunosuppressive drugs. (who.int)
  • Inspired from developmental processes, human mesenchymal cell lines can be programmed to form cartilage, bone and bone marrow tissues in vitro and in vivo. (lu.se)
Adult3
  • Earlier this year, though, a US Federal Court directed the Secretary of Health and Human Services to allow a 10-year-old patient to be considered alongside older candidates for lungs from adolescent and adult donors without consideration of her age. (medindia.net)
  • National Institutes of Health (NIH) Frequently Asked Questions (FAQs) Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation: Questions and Answers about these Adult/NONembryonic Stem Cells Key Points Hematopoietic or blood-forming stem cells are. (physiciansforlife.org)
  • This turned out to be the case for both cord blood derived and adult bone marrow stem cells, with LSD1 inhibition expanding stem and progenitor cells from different sources and different stages of development. (lu.se)
HSCs4
  • This knowledge will be critical for generating HSCs in culture dish for transplantation therapies to treat leukemias and other life-threatening blood disorders. (ca.gov)
  • The major shortcoming in generating functional hematopoietic stem cells (HSC) from pluripotent stem cells is the lack of adequate markers for specification and maintenance of functional human HSCs. (ca.gov)
  • Using these reporter lines to monitor the induction of HSC "stemless' program, we are making progress in optimizing differentiation conditions toward generating functional HSCs for transplantation. (ca.gov)
  • Results from this study showed that antibodies targeting the CD117 receptor on FA hematopoietic stem cells (HSCs) enables safe and effective HCT in FA mice when combined with T-cell depleting antibodies. (fanconi.org)
Platelets4
Therapeutic2
  • Our goal is to develop tools that address major bottlenecks that have prevented the generation of blood forming stem cells in culture for therapeutic use. (ca.gov)
  • In a recent study from the non-profit, Breast Cancer Now, a new potential therapeutic targeting cancer stem cells (CSCs) may have been uncovered. (rndsystems.com)
Registry4
  • Nigeria launches its first ever bone marrow registry, which should make it easier to find matches for black people around the world. (the-scientist.com)
  • The Bone Marrow Registry of Nigeria (BMRN), the country's first ever bone marrow registry and the continent's second (South Africa having the only other accredited registry), aims to change all that. (the-scientist.com)
  • Almost 50,000 volunteers participate at Redome, the Brazilian Bone Marrow Donor Registry. (shengsci.com)
  • The 24-year-old woman, who was registered as a volunteer donor in the German Bone Marrow Donor Registry, was selected. (cdc.gov)
Curative treatment2
Regimen1
Infection5
  • These therapies decrease a patient's white blood cell counts, suppress bone marrow hematopoietic activity, and increase the patient's risk of infection and/or hemorrhage. (justia.com)
  • The main requirement for a donor is to not have sickle cell disease or infection, such as HIV or hepatitis C. But what's important to know is that it's perfectly fine for the donor to have sickle cell trait. (reachmd.com)
  • Recent studies have suggested that a functional cure for HIV-1 infection, purportedly resultant from allogeneic bone marrow transplantation, may be possible. (biomedcentral.com)
  • The donor had returned from her trip 3 days before the start of G-CSF-injections without any signs of infection. (cdc.gov)
  • infection with axillary temperature, bone pain, and headache. (cdc.gov)
Aplastic1
Survival4
  • For example, in developing and developed countries alike, kidney transplantation not only yields survival rates and quality-of-life that are far superior to those obtained with other treatments for end-stage renal disease, such as haemodialysis, but is also less costly in the long run. (who.int)
  • Access to transplantation entails more than the surgery itself, because success is measured by longer survival of the patient and a long-term improvement in the quality of life. (who.int)
  • However, long-term disease-free survival rates may be lower than those with HLA-identical sibling donors. (msdmanuals.com)
  • The survival rate after transplantation from alternative donors is improving, depending on the completeness of the HLA-matching. (medscape.com)
Conditioning regimens1
  • this practice is changing as new, less toxic conditioning regimens and more precise HLA typing are developed and as the size of the donor pool increases. (medscape.com)
Reconstitution1
Recipients3
  • Organ Transplantation.2 These Guiding Principles - whose emphases include voluntary donation, noncommercialization, genetic relation of recipients to donors and a preference for cadavers over living donors as sources - have considerably influenced professional codes, national, state and provincial legislation, and the policies of intergovernmental organizations. (who.int)
  • fludarabine 40 mg/m2 IVBP daily for day -5 (5 days before stem cell infusion) through Day -2, IV busulfan targeting a 4800μM/min/ day from day -5 through day -2, and ATG ( Thymoglobulin ®) at 0.5 mg/kg IV on day -3, and 2 mg/kg on days -2 and day -1 (Only for recipients of stem cells from unrelated or mismatched donors). (mycancergenome.org)
  • The leukemogenesis of DCL is not well understood due to the limited numbers of cases reported and lack of detailed molecular genetic information from recipients and donors. (lidsen.com)
Single donor1
  • An entire left eye and a portion of the face were transplanted from a single donor during the 21-hour surgery. (medindia.net)
Pluripotent stem4
  • A research team from the Salk Institute and Kyoto University have published findings utilizing cerebral organoids derived from induced pluripotent stem cells (iPSCs) to monitor nerve cell activity. (rndsystems.com)
  • Induced pluripotent stem cells (iPSC) express genes associated with pluripotency, have the capacity for infinite expansion, and can differentiate into cells from all three germ layers. (biomedcentral.com)
  • A potential future source of stem cells is induced pluripotent stem cells (certain cells taken from adults and reprogrammed to act like stem cells). (msdmanuals.com)
  • Handling, maintenance and understanding of human pluripotent stem cells. (lu.se)
Blood30
  • In some cases, haematopoietic (blood) stem cell transplantation had been used, but with modest results. (europa.eu)
  • Our goal is to generate a toolbox of human embryonic stem cell lines to monitor blood forming (hematopoietic) stem cell development in culture. (ca.gov)
  • To help overcome these bottlenecks, we will generate a suite of human embryonic stem cell reporter lines that can be used to monitor key milestones in blood stem cell development. (ca.gov)
  • These lines will serve as tools to identify factor combinations to improve the in vitro differentiation of hESCs to functional blood stem cells. (ca.gov)
  • Once individual lines have been validated, lines that contain multiple fluorescent reporters will be generated, and a multi factor screen will be performed to optimize conditions that induce these blood stem cell regulators. (ca.gov)
  • Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. (justia.com)
  • In particular, embodiments of the method involve inhibition of both Rac1 and Rac2 GTPases to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject. (justia.com)
  • Therefore, hematopoietic stem cells mobilized into a subject's peripheral blood by the method of the invention is useful as a source of donor cells in bone marrow transplantation for the treatment of a variety of disorders, including cancer, anemia, autoimmunity and immunodeficiency. (justia.com)
  • In the last decade, the number of transplantations of HPCs derived from cord blood has increased, particularly for children. (nationalacademies.org)
  • FIGURE 2-1 Formation of the multiple peripheral blood cells from multipotent hematopoietic stem cells. (nationalacademies.org)
  • 2003). After the early success of transplantation of cord blood from related donors, cord blood banks were established to provide rapidly accessible, human leukocyte antigen (HLA)-typed units predominantly for transplantation of HPCs from unrelated donors. (nationalacademies.org)
  • 1 This includes human cells for transplantation such as haematopoietic stem cells from bone marrow, peripheral blood or cord blood. (who.int)
  • With as little as $75,000, we could build [a cord blood bank] in Nigeria by the end of this year instead of discarding this valuable source of stem cells," he said in a Lancet press release. (the-scientist.com)
  • Because cord blood contains immature stem cells, HLA matching appears less crucial than for the other types of hematopoietic stem cell transplantation. (msdmanuals.com)
  • Before cells can be extracted from the blood various substances have to be introduced, to help trigger the growth of the stem cells. (differencebetween.net)
  • The G-CSF is added and used to ensure that there will be enough stem cells in the blood for harvesting to be successful. (differencebetween.net)
  • The stem cells are then separated from the other blood cells by the process of apheresis, and then they are given to the patient through a catheter placed into a vein. (differencebetween.net)
  • Harvesting stem cells from the blood is in many ways an easier process since it does not involve or require the use of anesthesia. (differencebetween.net)
  • There are some disadvantages to obtaining stem cells from blood rather than from bone marrow. (differencebetween.net)
  • The procedure is also a more painful one than simply removing stem cells from the blood since the needle has to go into bone. (differencebetween.net)
  • CPT Code 38205 CPT 38205 describes harvesting blood-derived hematopoietic progenitor cells for allogeneic transplantation per collection. (codingahead.com)
  • The principal studies used to establish the diagnosis of PNH are flow cytometry of peripheral blood and bone marrow analysis. (medscape.com)
  • Chronic lymphocytic leukemia ( CLL ) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell ). (wikipedia.org)
  • [4] [9] CLL results in the buildup of B cell lymphocytes in the bone marrow, lymph nodes, and blood . (wikipedia.org)
  • When grown outside the body hematopoietic stem cells proliferate and differentiate from an immature state to more mature blood cell types. (lu.se)
  • In a study published in the journal Blood, the Larsson group targeted the enzyme LSD1, part of the CoREST complex, known to mediate the epigenetic modification of DNA and pushing the differentiation of stem cells into mature blood cells. (lu.se)
  • Over time, these donor cells will replace the patient's blood cells and consequently establish a healthy state. (swisshealthmagazine.ch)
  • Standard leukopheresis processing of blood from the donor was performed without problems. (cdc.gov)
  • The CXCL12-3'A allele is associated with a higher mobilization yield of CD34 progenitors to the peripheral blood of healthy donors for allogeneic transplantation. (cdc.gov)
  • Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2012 Jan 18 (1): 100-5. (cdc.gov)
Disorders3
  • PURPOSE OF REVIEW: The role of hematopoietic cell transplantation in non-malignant disorders has increased exponentially with the recognition that multiple diseases can be controlled or cured if engrafted with donor-derived cells. (wustl.edu)
  • SUMMARY: This review presents the progress made in the realm of hematopoietic cell transplantation for non-malignant disorders. (wustl.edu)
  • bone marrow analysis differentiates classic PNH from PNH secondary to other bone marrow disorders. (medscape.com)
Mobilization2
  • The stem cell mobilization result was poor. (cdc.gov)
  • Association of stromal cell-derived factor-1-3'A polymorphism to higher mobilization of hematopoietic stem cells CD34+ in Tunisian population. (cdc.gov)
Lung transplantation3
Tissue transplantation1
Cell differentiation2