Loading...
  • serum
  • Staging was reviewed centrally, and MYCN gene copy number, Shimada histopathologic classification, serum ferritin levels, and bone marrow immunocytology were determined. (uni-bonn.de)
  • Secondary endpoints are markers of pre-malignant conditions, such as leukoplakia, serum or tissue evidence of carcinogenic viruses, and bone marrow morphologic myelodyplastic syndrome or cytogenetic clones. (clinicaltrials.gov)
  • blood
  • A letter to the editor is presented about a study on hematologic cancers following allogeneic blood-cell transplantation or bone marrow transplantation. (ebscohost.com)
  • breast
  • INNSBRUCK, Austria, Aug. 25-The presence of bone marrow micrometastases in women newly diagnosed with breast cancer is a highly significant predictor of poor outcome, according to a pooled analysis of data from nine breast cancer studies. (medpagetoday.com)
  • patients
  • The U.S. Food and Drug Administration has approved a new dosing regimen for a medication designed to treat patients who suffer from a certain set of bone marrow diseases that alter the production of functional blood cells. (usinsuranceonline.com)
  • It's a pretty special event where patients and their families can come and learn about these diseases from leading experts, and perhaps more importantly, meet with others who are working through the same issues. (4imprint.com)
  • This could limit the damage that the disease causes and reduce the number of patients needing surgery. (futurity.org)
  • Dr. Abdel-Wahab's laboratory expressed a spliceosomal gene mutation in the Srsf2 gene, a mutation common in MDS and AML patients, in the bone marrow cells of a leukemia mouse model. (army.mil)
  • Since the mechanism(s) underlying these skeletal defects are not completely understood, and bone and cartilage are mesenchymal lineages, we focused on the characterization of mesenchymal cells isolated from the bone marrow (BM) of 5 Hurler patients. (sigmaaldrich.com)
  • IDUA-mutated BM stromal cells (BMSC) derived from MPS IH patients exhibited decreased IDUA activity, consistent with the disease genotype. (sigmaaldrich.com)
  • Similar associations were already documented in case reports and case series, but have never been evaluated in a broad spectrum of autoimmune diseases in that many patients and in context of individual medications," says Raoul Tibes, M.D., Ph.D., senior author of the study and former director of the Acute and Chronic Leukemia Program at Mayo Clinic's Arizona campus. (eurekalert.org)
  • The researchers emphasize that, while the results of the study are intriguing, they should not change or replace the clinical judgments, monitoring and current standard treatments at this stage for patients with an autoimmune disease. (eurekalert.org)
  • To analyze the dissemination of lymphoma cells, and the role of the bone marrow for disease progression, we simultaneously analyzed the somatic hypermutation patterns of lymph node and bone marrow specimens of three patients at onset and relapse. (haematologica.org)
  • They recruited 17 patients for the study: 12 with sickle cell disease and five with beta thalassemia, with a median age of 16. (medicalxpress.com)
  • They found that all the patients, except one with sickle cell disease, had successfully engrafted-a rate significantly higher than that seen with the previous protocol. (medicalxpress.com)
  • All of those with successful engraftment had either extreme reduction or no symptoms of their disease-the sickle cell disease patients no longer had the pain crises that are hallmarks of their condition. (medicalxpress.com)
  • No patients taking maribavir at any dose developed CMV disease, compared to the placebo group in which three subjects (11 percent) developed the disease. (medicalnewstoday.com)
  • Despite the increasing clinical success rate of BMT, lung disease has remained a significant cause of morbidity and mortality among patients. (juliaswings.org)
  • A Phase III trial of PLX-(PAD)-peripheral arterial disease cells in the treatment of critical limb ischemia has been cleared to start enrolling patients by the U.S. Food and Drug Administration. (wikipedia.org)
  • An eighteen-year-old young man with a bone marrow disease, an adolescent girl suffering from nine years of pain, a teenager with sickle-cell anemia, a cancer patient, and a heart disease patient are among the patients with whom the doctors visit and develop close relationships. (wikipedia.org)
  • simultaneously
  • McFall then sued Shimp in order to force him to donate his bone marrow, but when the case ended up in court, Judge John P. Flaherty Jr. stated that Shimp's position was "morally indefensible," but simultaneously refused to force Shimp to donate his bone marrow. (wikipedia.org)
  • Treatment
  • PLX-R18 were initially developed with Prof Raphael Gorodetsky at Hadassah Hospital for the treatment of acute radiation syndrome and enhancement of bone marrow regeneration. (wikipedia.org)
  • In September 2012 Pluristem reported saving the life of a third bone marrow disease patient using its PLacental eXpanded cell treatment, again at Jerusalem's Hadassah Medical Center and again under the terms of compassionate use. (wikipedia.org)
  • In 2007, she gave up her volleyball career because of her bone marrow disease, and began treatment. (wikipedia.org)
  • researchers
  • PHOENIX - Mayo Clinic researchers have found that azathioprine, a drug commonly used to treat autoimmune disease, may increase the risk of myeloid neoplasms. (eurekalert.org)
  • Researchers analyzed more than 40,000 patient cases with 27 common autoimmune diseases, such as Lupus, rheumatoid arthritis, among others, that were seen over a decade at Mayo Clinic. (eurekalert.org)
  • Support
  • With support from the Bone Marrow Failure Research Program through a fiscal year 2011 (FY11) Postdoctoral Fellowship Award (for Dr. Abdel-Wahab) and an FY15 Idea Development Award (shared by both Drs. Bradley and Abdel-Wahab), the two investigators sought to test this theory and develop therapeutic approaches to target the spliceosomal mutant MDS. (army.mil)
  • common
  • David Shimp generally refused to talk with reporters, but he did state that his decision not to donate bone marrow was "common sense" in an interview with the Pittsburgh Press. (wikipedia.org)
  • body
  • Champlin had arranged to donate his body to Upstate Medical Center to help others through medical research to find cures for disease. (wikipedia.org)
  • Judge Flaherty also stated that forcing a person to submit to an intrusion of his body in order to donate bone marrow "would defeat the sanctity of the individual and would impose a rule which would know no limits, and one could not imagine where the line would be drawn. (wikipedia.org)
  • large
  • For diseases with a large number of gene targets, multiple tiered plates are available. (bio-rad.com)
  • The team also works to raise awareness within the medical community and the community at large around these serious, serious diseases. (4imprint.com)
  • Fraker focused on bone marrow, which is a large, highly active, and responsive tissue. (futurity.org)
  • match
  • McFall's first cousin, a 42-year-old crane worker named David Shimp, was the only available bone marrow match for McFall at the time, but Shimp refused to donate his bone marrow, which would have dramatically increased the odds of saving McFall's life (with Shimp's bone marrow donation, doctors estimated that McFall would have had a 50% to 60% chance of surviving). (wikipedia.org)
  • Hope
  • Robert McFall's sister, Beverly Hope, stated that McFall forgave Shimp near the very end of his life and asked his family to forgive Shimp for refusing to donate his bone marrow as well. (wikipedia.org)
  • FDCs
  • Neuroinvasion velocity correlated exclusively with the relative locations of FDCs and nerves: transfer of CXCR5-/- bone marrow to wild-type mice induced perineural FDCs and enhanced neuroinvasion, whereas reciprocal transfer to CXCR5-/- mice abolished them and restored normal efficiency of neuroinvasion. (uzh.ch)
  • liver
  • However, the major problem with using it as an indicator of iron overload is that it can be elevated in a range of other medical conditions unrelated to iron levels including infection, inflammation, fever, liver disease, kidney disease, and cancer. (wikipedia.org)
  • In a patient with negative HFE gene testing, elevated iron status for no other obvious reason, and family history of liver disease, additional evaluation of liver iron concentration is indicated. (wikipedia.org)
  • either
  • In his 1995 encyclical Evangelium Vitae , John Paul said, "This moral condemnation also regards procedures that exploit living human embryos and fetuses - sometimes 'produced' for this purpose by in vitro fertilization - either to be used as 'biological material' or as providers of organs or tissue for transplants in the treatment of certain diseases. (ncregister.com)
  • cell
  • Embryonic stem-cell research, which involves the destruction of a unique human being in an attempt to cure different diseases, has proven not only destructive and costly, but has not produced a cure. (ncregister.com)
  • treat
  • Enzyme replacement therapy is available to treat mainly Fabry disease and Gaucher disease, and people with these types of sphingolipidoses may live well into adulthood. (wikipedia.org)
  • signal
  • Interleukin 3 is an interleukin, a type of biological signal (cytokine) that can improve the body's natural response to disease as part of the immune system. (wikipedia.org)
  • carrier
  • Prenatal testing is also available to determine if the fetus will have the disease or is a carrier. (wikipedia.org)
  • First degree relatives of those with primary haemochromatosis should be screened to determine if they are a carrier or if they could develop the disease. (wikipedia.org)
  • treatments
  • Sometimes referred to as Lou Gehrig's disease, ALS is a fatal neurodegenerative condition for which there are no proven treatments or cure. (ncregister.com)
  • research
  • Mazumdar spearheaded Biocon's evolution from an industrial enzymes manufacturing company to a fully integrated bio-pharmaceutical company with a well-balanced business portfolio of products and a research focus on diabetes, oncology and auto-immune diseases. (wikipedia.org)
  • known
  • This work resulted in two papers, Dell'anemia splenica and Archivo di anatomica patologica (1882) describing the condition that would be known as Banti's disease. (wikipedia.org)
  • Condition
  • It's important to keep up with the latest Degenerative Disc Disease information to be aware of your options and what you can do to ease the stress of living with the condition. (blogspot.com)
  • Gianotti-Crosti disease is a harmless and self-limiting condition, so no treatment may be required. (wikipedia.org)
  • growth
  • Professor Firth, who studies bone development, explains that childhood and adolescence are periods of rapid bone growth. (membs.org)
  • certain
  • Certain forms of this disease can also be diagnosed through urine testing which will detect the stored material. (wikipedia.org)
  • found
  • The researchers, from the Liggins Institute at the University of Auckland, found that bone retains a 'memory' of exercise's effects long after the exercise is ceased, and this bone memory continues to change the way the body metabolises a high-fat diet, and published these results in Frontiers in Physiology. (membs.org)
  • Researchers from the Liggins Institute at the University of Auckland have found that bone retains a 'memory' of exercise's effects long after the exercise is ceased, and this bone memory continues to change the way bodies metabolise a high-fat diet. (membs.org)
  • important
  • Education is an incredibly important part of a patient's degenerative disc disease treatment. (blogspot.com)
  • With rising rates of overweight and obesity in children, it is important to understand the effects of these conditions on bone health, says Professor Vickers, an obesity specialist. (membs.org)
  • development
  • Load-bearing from exercise and higher bodyweight is good for growing bones, but this and other evidence shows that if the extra weight comes from higher body fat mass, bone development may be subnormal,' he says. (membs.org)
  • change
  • These lesions change shape as the disease progresses, typically beginning as what appears to be a rash which can be very itchy and eventually forming plaques and tumors before spreading to other parts of the body. (wikipedia.org)
  • Center
  • The Firestone Institute for Respiratory Health (FIRH) is a center for the investigation and treatment of respiratory diseases. (wikipedia.org)