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  • disorders
  • A former chief resident in medicine at Massachusetts General Hospital (1994-95), Daley maintained an active clinical practice in hematology/oncology at Mass General and then at Boston Children's, until assuming his administrative role as director of the the Pediatric Stem Cell Transplantation Program at Dana-Farber/Boston Children's Cancer and Blood Disorders Center, a post he held until Jan. 2017. (harvard.edu)
  • Daley's research focuses on the use of mouse and human disease models to identify mechanisms that underlie blood disorders and cancer. (harvard.edu)
  • Chagas disease is caused by the protozoan Trypanosoma cruzi and is characterized by cardiac, gastrointestinal, and nervous system disorders. (biomedcentral.com)
  • Norethisterone, also known as norethindrone and sold under the brand names Aygestin and Primolut N among many others, is a progestin medication which is used in birth control pills, menopausal hormone therapy, and for the treatment of gynecological disorders. (wikipedia.org)
  • Inborn errors of metabolism form a large class of genetic diseases involving congenital disorders of metabolism. (wikipedia.org)
  • Traditionally the inherited metabolic diseases were classified as disorders of carbohydrate metabolism, amino acid metabolism, organic acid metabolism, or lysosomal storage diseases. (wikipedia.org)
  • citation needed] Disorders of carbohydrate metabolism E.g., glycogen storage disease, G6PD deficiency Disorders of amino acid metabolism E.g., phenylketonuria, maple syrup urine disease, glutaric acidemia type 1 Urea Cycle Disorder or Urea Cycle Defects E.g. (wikipedia.org)
  • Granulomatous-lymphocytic interstitial lung disease (GLILD) is a lung complication of common variable immunodeficiency disorders (CVID). (wikipedia.org)
  • As part of a group of disorders known as leukodystrophies, Krabbe disease results from the imperfect growth and development of myelin. (wikipedia.org)
  • Historically, patients suffering the cited eosinophil-related syndromes were evaluated for causes of their eosinophilia such as those due to allergic disease, parasite or fungal infection, autoimmune disorders, and various well-known hematological malignancies (e.g. (wikipedia.org)
  • Most of these disorders are autosomal recessively inherited such as Niemann-Pick disease, type C, but a few are X-linked recessively inherited, such as Fabry disease and Hunter syndrome (MPS II). (wikipedia.org)
  • Like other genetic disorders, individuals inherit lysosomal storage diseases from their parents. (wikipedia.org)
  • Furthermore, chaperone therapy, a technique used to stabilize the defective enzymes produced by patients, is being examined for certain of these disorders. (wikipedia.org)
  • genetic
  • The causes of idiopathic Parkinson-disease (IPD) are believed to be a combination of genetic and environmental factors. (hindawi.com)
  • Important contributions from the Daley laboratory have included the creation of customized stem cells to treat genetic immune deficiency in a mouse model (together with Rudolf Jaenisch), the differentiation of germ cells from embryonic stem cells, the generation of disease-specific pluripotent stem cells by direct reprogramming of human fibroblasts, and demonstration of the role of the LIN28/let-7 pathway in cancer. (harvard.edu)
  • The genetic association with celiac disease and HLA loci defines type I EATL. (wikipedia.org)
  • SCID is one of six genetic diseases known to affect horses of Arabian bloodlines, and the only one of the six for which there is a DNA test to determine if a given horse is a carrier of the allele. (wikipedia.org)
  • There are other genetic diseases that affect other horse breeds, and horses of part-Arabian bloodlines can be carriers of SCID. (wikipedia.org)
  • In 1986, the X-linked form of CGD was the first disease for which positional cloning was used to identify the underlying genetic mutation. (wikipedia.org)
  • Based on their association with eosinophils, unique genetic mutations, and known or potential sensitivity to tyrosine kinase inhibitors or other specific drug therapies, they are now in the process of being classified together under the term clonal hypereosinophilia or clonal eosinophilia. (wikipedia.org)
  • In some families where the disease-causing mutations are known and in certain genetic isolates, mutation analysis may be performed. (wikipedia.org)
  • GvHD
  • Therefore, a bone marrow will be the preferential source and a GvHD prophylaxis based on Anti-thrombocyte globulin (ATG) and Cyclosporine/Methotrexate will be used according to standard current experience in the field of family and unrelated donors. (clinicaltrials.gov)
  • Graft-versus-host-disease (GVHD) prophylaxis will consist of tacrolimus, mycophenolate mofetil and additionally methotrexate in recipients of unrelated adult transplants. (clinicaltrials.gov)
  • [ 2 ] Because the same mechanism is involved in graft-versus-host disease (GVHD), the incidence of GVHD could be as high as 60% in these patients. (medscape.com)
  • Lysosomal
  • ERT is currently available for some lysosomal storage diseases: Gaucher disease, Fabry disease, MPS I, MPS II (Hunter syndrome), MPS VI and Pompe disease. (wikipedia.org)
  • Lysosomal storage diseases are fatal group of diseases and a main application of ERT. (wikipedia.org)
  • As of 2012, there are 50 lysosomal storage diseases, and more are still being discovered. (wikipedia.org)
  • For this reason, many symptoms of lysosomal storage diseases remain untreated by ERT, especially neurological symptoms. (wikipedia.org)
  • In this treatment, the accumulated compounds are inhibited from forming in the body of a patient suffering from a lysosomal storage disease. (wikipedia.org)
  • Krabbe disease (KD) (also known as globoid cell leukodystrophy or galactosylceramide lipidosis) is a rare and often fatal lysosomal storage disease which results in progressive damage to the nervous system. (wikipedia.org)
  • immunosuppression
  • Immunosuppression has been associated with development of opportunistic infection and other predictable side effects, and the balance of risks and benefits of therapy must be carefully weighed in each case. (wikipedia.org)
  • defective
  • However, unusual and combinations of tissues and organs are also affected in Diamond-Blackfan anemia, X-linked dyskeratosis congenita, and cartilage-hair hypoplasia-three diseases that may also be linked to defective ribosome function. (wikipedia.org)
  • fatal
  • The mice expressing both mutant and wildtype Srsf2 rapidly developed fatal bone marrow failure and eventually developed leukemia. (army.mil)
  • This condition was first discovered in 1950 in a series of 4 boys from Minnesota, and in 1957 it was named "a fatal granulomatosus of childhood" in a publication describing their disease. (wikipedia.org)
  • renal
  • A large number of services, such as cardiothoracic medicine and surgery, neurosciences and renal transplantation, also cover significant populations from Surrey and Sussex, totalling about 3.5 million people. (wikipedia.org)
  • However, as a major acute hospital, St George's Hospital also offers very specialist care for the most complex of injuries and illnesses, including trauma, neurology, cardiac care, renal transplantation, cancer care and stroke. (wikipedia.org)
  • Experimental
  • We used an acute experimental disease model to evaluate the effect of T. cruzi on intestinal lesions and assessed correlations between parasite load and inflammation and intestinal injury at 7 and 14 days post-infection. (biomedcentral.com)
  • These experimental data support the idea that the parasite load considerably influences the T. cruzi -induced intestinal inflammatory response and contributes to the development of the digestive form of the disease. (biomedcentral.com)
  • cell
  • There is overproduction of a precursor (immature form) of a marrow cell. (news-medical.net)
  • This may be due to a defect in the stem cell producing them or due to an injury to the bone marrow environment. (news-medical.net)
  • Stable mixed hematopoietic chimerism after bone marrow transplantation for sickle cell anemia. (springer.com)
  • However, the PD plus patients did not show any change in their clinical status after stem cell transplantation. (hindawi.com)
  • This lead to cell replacement therapies being identified as the most suitable option for PD as there is selective loss of dopaminergic neurons in the substantia nigra [ 6 - 10 ]. (hindawi.com)
  • He has served since 1995 as a member of the faculty of the Harvard-MIT Division of Health Sciences and Technology (HST), since 2004 as a founding member of the executive committee of the Harvard Stem Cell Institute, and since 2009 as an associate member of the Broad Institute of MIT and Harvard and as a core faculty member of the Manton Center for Orphan Disease Research at Boston Children's. (harvard.edu)
  • He has also testified before Congress and spoken in forums worldwide on the scientific and ethical dimensions of stem cell research and its promise in treating disease. (harvard.edu)
  • Dr. Daley is currently Professor of Biological Chemistry and Molecular Pharmacology and the Robert A. -Stranahan Professor of Pediatrics at Harvard Medical School as well as Director of the Stem Cell Transplantation Program at Boston Children's Hospital and the Dana-Farber Cancer Institute. (ascopost.com)
  • A former Chief Resident in Medicine at Massachusetts General Hospital, Dr. Daley maintained an active clinical practice in hematology/oncology at Mass General and then at Boston Children's until assuming his administrative role as Director of the Stem Cell Transplantation Program and Associate Chief of the Division of Pediatric Hematology/Oncology at Boston Children's and Dana-Farber. (ascopost.com)
  • He is a founding member of the Executive Committee of the Harvard Stem Cell Institute, and since 2009, he has been an associate member of the Broad Institute of Harvard and MIT and a core faculty member of the Manton Center for Orphan Disease Research at Boston Children's. (ascopost.com)