Bone marrow derived mononuclear. Medical search. Frequent questions

Flow cytometry analysis showed a significantly higher number of hematopoietic stem/endothelial progenitor cell markers in concentrated BMMCs when compared with bone marrow aspirate indicating an enrichment of these cell types. (bioskinrevive.com)
HP-DC refers to cells derived from hematopoietic progenitor cells. (wikipedia.org)
Dendritic cells are derived from hematopoietic bone marrow progenitor cells (HSC). (wikipedia.org)
Stem and progenitor cells derived from bone marrow or from pluripotent stem cells have shown therapeutic benefit in boosting angiogenesis as well as restoring tissue function. (nih.gov)
Notably, adult stem and progenitor cells including mononuclear cells, endothelial progenitor cells, and mesenchymal stem cells have progressed into clinical trials and have shown positive benefits. (nih.gov)
Colonies derived from different types of progenitor cells are classified and counted based on morphological and phenotypic criteria. (stemcell.com)
These cells were therefore described as bone marrow derived endothelial progenitor cells (EPCs). (hindawi.com)
The bone morrow contains several stem cell types including hematopoetic stem cells, endothelial progenitor cells, mesenchymal (stromal) stem cells and multipotent adult progenitor cells. (escardio.org)
Interestingly, contradictory data exist for transformation of bone marrow derived progenitor cells (BMPC) into new cardiomyocytes and alternative mechanisms as enhanced neovascularization, enhanced scar tissue formation due to augmented inflammatory response and decreased apoptosis have been suggested for the benefical effects of these cells on myocardial function after myocardial infarction (4). (escardio.org)
Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
Initial studies suggested that, in adults, a common monocyte/dendritic cell (MDP) progenitor in the bone marrow leads to the development of monocytes, macrophages, and dendritic cells. (musculoskeletalkey.com)
Following this approach, porcine DCs were directly isolated from peripheral blood or differentiated in vitro by culturing bone marrow (BM) progenitor cells or blood monocytes treated with growth factors. (bvsalud.org)

Monocytes (MC) are bone marrow (BM) derived mononuclear phagocytes that play an important role in innate immune response and are the major immune cell population in chronic tissue inflammatory ( 1 , 2 ). (frontiersin.org)
In the liver, KASV replicated in the cytoplasm of hepatocytes, to a lesser extent in mononuclear phagocytes, and rarely in presumptive endothelial cells. (cdc.gov)

The criteria to classify the multitude of subsets within the mononuclear phagocyte system are currently phenotype, ontogeny, transcription patterns, epigenetic adaptations, and function. (uni-wuerzburg.de)
The goal of this chapter is to provide an up-to-date review of macrophage biology and a revision of the current dogma of the mononuclear phagocyte system (MPS) as it relates to the pathogenesis of rheumatoid arthritis (RA). (musculoskeletalkey.com)
In this study, formalin-fixed paraffin-embedded tissues from a previous experiment in which KASV infection was confirmed in 18 experimentally infected ERBs were used for an in-depth analysis using histopathology, in situ hybridization (ISH) for detection of viral RNA, immunohistochemistry (IHC) to assess the mononuclear phagocyte system response, and quantitative digital image analysis to investigate virus clearance from the liver and spleen within a spatial context. (cdc.gov)

13 ] isolated mononuclear cells from human peripheral blood that were enriched for expression of the hematopoietic stem cell marker CD34 [ 13 ]. (hindawi.com)
These include bone marrow-derived cells, peripheral blood derived stem cells and skeletal myoblasts (3). (escardio.org)
More recently, ontogenetic, transcriptional, and proteomic research approaches uncovered major developmental differences between Flt3L-dependent conventional DCs as compared with Mphs and monocyte-derived DCs (MoDCs), the latter mainly generated in vitro from murine bone marrow-derived DCs (BM-DCs) or human CD14\(^{+}\) peripheral blood monocytes. (uni-wuerzburg.de)
We also sequenced the bisulfite converted genome of circulating bone-marrow-derived cells such as peripheral blood mononuclear cells (PBMC) and bone marrow mononuclear cells (BMMC). (hilarispublisher.com)

The recent emergence of cell-based therapies such as autologous bone marrow-derived mesenchymal stem cells (ABM-MSCs) and mononuclear cells (ABM-MNCs) seems to offer a pragmatic approach to augment β-cell function/mass. (drcalapai.com)
Previous studies from our group have shown that autologous adipose-derived regenerative cells (ADRCs) represent a promising approach to improve wound healing and, thereby, impact HTS development. (biomedcentral.com)

Cytokines and growth factors (interleukin-8 transforming growth factor-beta stromal cell-derived factor-1alpha and vascular endothelial growth factor) that mediate endogenous bone regeneration were also produced by expanded MSCs from SCD patients. (bioskinrevive.com)
Adult tissue-derived mesenchymal stromal cells (MSCs) are showing promise in clinical trials for systemic lupus erythematosus (SLE). (nature.com)
Human embryonic stem cell (hESC)-derived MSCs are an alternative to adult MSCs that can circumvent issues regarding scalability and consistent quality due to their derivation from a renewable starting material. (nature.com)
This study tested the hypothesis that double overexpression of miR-19a & miR-20a (dOex-mIRs) in human induced pluripotent stem cell (iPS)-derived mesenchymal stem cells (MSCs) effectively preserved left-ventricular-ejection-fraction (LVEF) in dilated cardiomyopathy (DCM) (i.e., induced by doxorubicin) rat. (researchsquare.com)
Despite this imperfect knowledge, sufficient medical encounter offers been accumulated from the several medical tests using numerous adult come cell populations, including bone tissue marrow-derived mononuclear cells (BMMNCs), mesenchymal come cells (MSCs), and come cells separated from cardiac cells (Number 1). (bioinf.org)
1999). First identified and isolated from the bone marrow (BM), MSCs can now be expanded from a variety of other tissues including adipose tissue (AT), umbilical cord blood (UCB), skin, tendon, muscle, and dental pulp (Im et al. (pdffox.com)
Bone marrow-derived mesenchymal stem cells (BM-MSCs) are multipotent stromal cells that have a critical role in the maintenance of skeletal tissues such as bone, cartilage, and the fat in bone marrow. (bvsalud.org)
In addition to providing microenvironmental support for hematopoietic processes, BM-MSCs can differentiate into various mesodermal lineages including osteoblast/osteocyte, chondrocyte, and adipocyte that are crucial for bone metabolism. (bvsalud.org)
To investigate the transcriptional diversity of BM-MSCs, we applied single-cell RNA sequencing (scRNA-seq) on freshly isolated CD271+ BM-derived mononuclear cells (BM-MNCs) from two human subjects. (bvsalud.org)
This study is the first systematic in vivo dissection of human BM-MSCs cell subtypes at the single-cell resolution, revealing an insight into the extent of their cellular heterogeneity and roles in maintaining bone homeostasis. (bvsalud.org)

Cell therapy using adipose-derived stromal cells (ADSC) is an intensively developing approach to promote angiogenesis and regeneration. (biomedcentral.com)
Mesenchymal stem/stromal cells including adipose-derived stromal cells (ADSC) are a promising cell source for this application. (biomedcentral.com)

Professor Ma holds leadership or scientific membership positions in a number of national and international scientific communities including the World Network for Blood & Marrow Transplantation (a WHO affiliated NGO), the AsiaPacific BM Transplant and the Royal College of Pathology of Australasian Quality Assurance Programme. (edu.au)
In experimental and clinical studies unselected mononuclear bone marrow cells as well as specific subpopulations have been used for transplantation. (escardio.org)
Aim: The aim of this study was to confirm an effect of the bone marrow derived mononuclear cell (BM-MNC) transplantation for CSPI of the dog. (openveterinaryjournal.com)
Methods: We test that treatment efficiency with CSPI of 12 dogs by bone marrow derived mononuclear cell (BM-MNC) transplantation. (openveterinaryjournal.com)

Additionally, the origin of synovial macrophages was linked to monocytes derived from the bone marrow, based on studies using radiation chimeras of beige mice. (musculoskeletalkey.com)
These studies determined that adult monocytes develop as precursors in the bone marrow and then enter the circulation to replenish macrophages in tissue through the use of radiolabeled monocyte progenitors. (musculoskeletalkey.com)

Bone marrow mononuclear cells (BMMNCs) consist of hemopoietic stem cells and mesenchymal stem cells together with progenitors of endothelial cells or somatic cells [ 1 , 2 ]. (biomedcentral.com)

Ma DD , 2007 , 'Expression of Neurofilament Proteins in Adult Bone Marrow Mesenchymal Stem Cells and Embryonic Stem Cells and Their Clinical Potential' , in Davenport LP (ed. (edu.au)

The proposed Phase 2 clinical trial will examine the effects of using bone marrow derived cells to treat severe traumatic brain injury in children. (childrenslearninginstitute.org)
However, their low frequency in bone marrow necessitate ex vivo expansion for further clinical application. (biomedcentral.com)
This study explored the molecular mechanisms by which PSTPIP2 regulates synovial macrophage activity in bone erosion from clinical issues. (biomedcentral.com)
The rheumatoid factor (RF), antistreptolysin (ASO) and DAS28 scores of RA patients were derived from clinical sources. (biomedcentral.com)
The aim of this study was to conduct a literature review on the use and clinical viability of human bone morphogenetic protein (rhBMP-2) for grafting bone in Dentistry. (bvsalud.org)
On one end, the clinical spectrum includes an acute, fulminant, disseminated disease called Letterer-Siwe disease, and, on the other end, solitary or few, indolent and chronic lesions of bone or other organs called eosinophilic granulomas . (medscape.com)
The intermediate clinical form called Hand-Schüller-Christian disease is characterized by multifocal, chronic involvement and classically presents as the triad of diabetes insipidus, proptosis, and lytic bone lesions. (medscape.com)

Conversely, in vitro GM-CSF-dependent monocyte-derived Mphs largely resemble MoDCs whereas tissue-resident Mphs show a common embryonic origin from yolk sac and fetal liver with Langerhans cells (LCs). (uni-wuerzburg.de)

More recently, ontogenetic, transcriptional, and proteomic research approaches uncovered major developmental differences between Flt3L-dependent conventional DCs as compared with Mphs and monocyte-derived DCs (MoDCs), the latter mainly generated in Dendritic cells (DCs) and macrophages (Mph) share many characteristics as components of the innate immune system. (uni-wuerzburg.de)
At least two populations of tissue macrophages exist: tissue-resident cells that are embryonically derived and a monocyte-derived population. (musculoskeletalkey.com)
Taken together, these fundamental studies provided the basis that the synovial macrophages were derived from hematopoietic progenitors and represented a heterogeneous population in both normal and inflamed synovium. (musculoskeletalkey.com)
The administration of nonlethal irradiation to induce death of hematopoietic cells and their precursors followed by administration of donor bone marrow (radiation chimeras) revealed populations of macrophages, including synovial macrophages, Langerhans cells, and microglia, that were resistant to irradiation and remained host origin, whereas the monocyte population was derived from donor hematopoietic cells. (musculoskeletalkey.com)
Moreover, parabiotic mice that share the same circulation showed that only a subset of macrophages such as heart, gut, and dermis exhibited a mixed population, whereas Langerhans cells, microglia, and alveolar macrophages were exclusively derived from the parent mouse. (musculoskeletalkey.com)
Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the presence of cells with characteristics similar to bone marrow-derived Langerhans cells juxtaposed against a backdrop of hematopoietic cells, including T-cells, macrophages, and eosinophils. (medscape.com)

Mostly homogeneous monocyte-derived DCs (MoDCs) were obtained with similar phenotype and phagocytic characteristics to that of blood DCs. (bvsalud.org)

After the scientific evidence of osseointegration in the ending of the 1970s, which made viable Implantology, increased the interest of researchers in search by new natural or synthetic substances that could replace tissues bone lost 9 . (bvsalud.org)
Biomaterials can be defined as "any material, natural or synthetic, that acts in tissues/organs in order to replace the bone defect lost and s function" 13 . (bvsalud.org)

Myeloid cells are a heterogeneous population of bone marrow-derived cells that play a critical role during growth and metastasis of malignant tumors. (hindawi.com)
On the contrary, BM-derived DC (BMDC) cultures generated two distinct heterogeneous populations identified as MHC-II+ and MHC-II++ cells. (bvsalud.org)

Thin section of a bone marrow-derived mouse macrophage. (musculoskeletalkey.com)

eg, bone, bone marrow, and skin grafts) Genetically identical (syngeneic [between monozygotic twins]) donor tissue (isografts) Genetically. (msdmanuals.com)

[ 3 ] Taken together, these findings have led some to speculate that LCH is not a specific disease of epidermal Langerhans cells, but rather one of mononuclear phagocyte dysregulation. (medscape.com)

NOD-SCID-Gamma (NSG) mice) and measuring the presence of human blood cells in the blood or bone marrow (BM) after extended periods of engraftment, e.g., 20 weeks or longer. (stemcell.com)
Also, in order to avoid human blood, bubaline-derived blood serum cryoprecipitate has been used as the fibrinogen source. (hindawi.com)
Human mesenchymal stem cells (MSC) with the capacity to differentiate into osteoblasts provide potential for the development of novel treatment strategies, such as improved healing of large bone defects. (biomedcentral.com)
Human MSC are easy to isolate from small aspirate of bone marrow via their adherence ability. (biomedcentral.com)
When administered post-stroke, mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) induce neuroprotection, promote brain remodeling and plasticity, and enhance neurological recovery in rodents and non-human primates via mechanisms that involve immunomodulation and anti-inflammation. (explorationpub.com)
The human bone morphogenet ic protein (rhBMP) developed by genetic engineering, was isolated by Urist, in 1965, and it is considered a substance capable of inducing differentiation of mesenchymal stem cells into osteoblasts, the cells that are responsible for the synthesis of bone matrix. (bvsalud.org)

Mariano García Arranz has the following conflict of interest: MGA is inventor on 2 patents entitled "Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue" (10157355957US) and "Use of adipose tissue-derived stromal stem cells in treating fistula" (US11/167061). (wjgnet.com)

In Dentistry, many studies have aimed to improve bone regeneration through the use of BMPs for bone replacement. (bvsalud.org)
Several studies demonstrate the biological advantages of rhBMP-2 on bone regeneration of the jaws. (bvsalud.org)

Here we show that transfer learning-the branch of machine learning that concerns passing information from one domain to another-can be used to efficiently map bone marrow biology between species, using data obtained from single-cell RNA sequencing. (bvsalud.org)

Single-strand confirmation polymorphism and next-generation sequencing analysis revealed differences between the serum and cerebrospinal fluid-derived viral sequences, which is compatible with the presence of a separate HPgV compartment in the central nervous system. (cdc.gov)

Importance Come cell therapy is a promising treatment strategy for individuals with heart failure, which accounts for over 10% of deaths in the U. marrow mononuclear cells, have found only a humble benefit in individuals receiving come cell therapy. (bioinf.org)

In Dentistry autogenous bone is the most useful tissue used in pre-prosthetic surgery and rehabilitation treatment of bone defects, thereby contributing to the function and aesthetics 8 . (bvsalud.org)

Depending upon the particular genotype and severity of the SCD the prevalence of ONFH ranges from 3 to 50 % among SCD patients [4 5 Osteonecrosis can be viewed as a vascular and bone disease with altered bone remodeling. (bioskinrevive.com)

We first trained a multiclass logistic regression model to recognize different cell types in mouse bone marrow achieving equivalent performance to more complex artificial neural networks. (bvsalud.org)
Some of these mice were transplanted with bone marrow from other mice that couldn't make uPAR, and some were transplanted with normal mouse bone marrow. (medscape.com)

Introduction Stem cell therapy with bone marrow-derived mononuclear cells (BMMCs) is an option for improving joint function in osteonecrosis of the femoral head (ONFH). (bioskinrevive.com)

Therefore, it is important to explore the effective treatment strategies specific to RA for synovial inflammation and bone damage. (biomedcentral.com)

This study aimed to identify the density of mononuclear cells (MNCs) and CD34+ cells in the bone marrow of patients with three neurologic conditions. (biomedcentral.com)
Bone marrow aspiration was conducted from the patients' bilateral anterior iliac crest under general anesthesia in an operating theater. (biomedcentral.com)
In this study, we aimed to identify the concentrations of mononuclear cells (MNCs) and CD34+ cells in the bone marrow of these patients and their correlation with treatment outcomes. (biomedcentral.com)
Bone marrow aspiration was conducted from the patients' bilateral anterior iliac crest under general anesthesia in an operating theater at Vinmec Times City International Hospital. (biomedcentral.com)
Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
En outre, il y avait une aug- mentation significative de la forme soluble du c-kit dans le sérum des patients atteints de pemphigus vulgaire actif par rapport aux témoins. (who.int)

Hahm and colleagues started with mice that were unable to make uPAR and irradiated them to destroy their bone marrow. (medscape.com)

Anatomy51

Organisms16

Diseases47

Chemicals and Drugs53

Analytical, Diagnostic and Therapeutic Techniques and Equipment50

Phenomena and Processes42

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science4

Named Groups1

Health Care7

Progenitor12

Phagocytes2

Phagocyte system3

Peripheral4

Autologous2

MSCs10

Stromal cells2

Transplantation4

Monocytes2

Endothelial1

Embryonic Stem1

Clinical7

Vitro1

Macrophages6

Monocyte-derived1

Tissues2

Heterogeneous2

Macrophage1

Grafts1

Langerhans1

Human6

Isolation1

Regeneration2

Species1

Viral1

Found1

Defects1

Vascular1

Mouse2

Stem cell1

Inflammation1

Patients6

Mice1