Bone marrow derived mesenchymal stem cells mesenchymal stem cell transplantation. Medical search. Frequent questions

The recent emergence of cell-based therapies such as autologous bone marrow-derived mesenchymal stem cells (ABM-MSCs) and mononuclear cells (ABM-MNCs) seems to offer a pragmatic approach to augment β-cell function/mass. (drcalapai.com)
Improvement in insulin sensitivity with MSCs and increase in C-peptide response with MNCs provide newer insights in cell-based therapies. (drcalapai.com)
In vitro cell culture and animal studies have demonstrated that mesenchymal stromal cells (MSCs) have the capacity to modify immune responses and to enhance tissue repair. (bmj.com)
Mesenchymal stromal cells (MSCs) are cells of non-haematopoietic origin, with the capacity to differentiate into multiple lineages of the mesenchyme, that is, chondrocytes, osteoblasts and adipocytes. (bmj.com)
1 Unique MSC-specific markers have not yet been identified, and MSCs constitute a heterogeneous cell population, including both multipotent (stem) cells and progenitor cells and might even contain pluripotent cell fractions. (bmj.com)
2 MSCs were first described in the bone marrow where they constitute a small fraction of cells (0.001%-0.01%) that closely interact with haematopoietic cells to support haematopoiesis and skeletal homeostasis. (bmj.com)
3 4 Since then, it has become evident that MSCs reside in many tissues, including mesenchymal tissues (bone, adipose tissue, connective tissue), umbilical cord and several organs including the liver, spleen and lung. (bmj.com)
Following early observations that MSCs inhibit T-cell proliferation, 9 MSCs were found to interact with the majority of innate and adaptive immune cells. (bmj.com)
The HUCMSCs derived different donors have individual heterogeneity, which potentially lead to distinct therapeutic outcomes in mouse liver fibrosis, indicating we could make use of the donor-variation of MSCs to screen out guaranteed general indicators of MSCs for specific diseases in further stem cell therapy. (researchsquare.com)
Mesenchymal stem cells (MSCs) have been widely tested for treating a variety of refectory medical indications such as type 1 diabetes mellitus, systemic lupus erythematosus, rheumatoid arthritis and Crohn's disease due to their multiple differentiation potentials and immunomodulation capability [1-5]. (researchsquare.com)
MSCs could be derived from a series of tissues including but not limited to umbilical cord, placenta, adipose tissue, bone marrow, gingiva, and dental pulp [5-12]. (researchsquare.com)
These MSCs derived different tissues do not have uniform characteristics, differing in expression profiles of surface markers and biological functions after certain stimulation such as pro-inflammatory mediators [5, 13]. (researchsquare.com)
Over the past few years, MSCs researches have achieved some inspiring results and some of which moved up to clinic period from preclinical phases, resulting in the marketing approval of a few cell-based therapy products (CTPs) by different national regulatory authorities [18]. (researchsquare.com)
We established a Good Manufacturing Practice (GMP) grade cell facility to produce clinic-grade human umbilical cord derived MSCs (HUCMSCs) for treating premature ovarian failure (POF) and recurrent uterine adhesion [18, 20]. (researchsquare.com)
Mesenchymal stem cells (MSCs) can differentiate into chondrocytes, while mechanical loading has been proposed as alternative strategy to induce chondrogenesis excluding the use of exogenous factors. (nature.com)
Differences in expression of some cell surface and cytoplasm specific markers were evident between UCM-MSCs and BM-MSCs. (cryo-cell.com)
thus, due to the unique characteristics of mesenchymal stem cells (MSCs), they have become the focus of attention and may be the most promising new therapy for periodontitis. (biomedcentral.com)
MSCs are multipotent stem cells with the ability to self-renew and differentiate in multiple directions [ 3 ]. (biomedcentral.com)
By performing local transplants, other non-periodontal-derived MSCs such as dental pulp stem cells (DPSCs), bone marrow stem cells (BMSCs), and adipose tissue-derived stem cells (ADSCs) also aid in the regeneration of periodontal tissue [ 12 ]. (biomedcentral.com)
However, when employing MSC transplantation to treat tissue defects, the research found that: less than one percent of MSCs could home and colonize in the tissue defect area, continuously promoting tissue regeneration, and the paracrine mechanism of MSCs plays a more important role than the replacement of damaged cells by differentiation [ 13 ]. (biomedcentral.com)
Despite almost 50 years of research and over 20 years of preclinical and clinical studies, the question of curative potential of mesenchymal stem/stromal cells (MSCs) is still widely discussed in the scientific community. (frontiersin.org)
In this mini review, we will discuss point by point possible pitfalls in the production of human MSCs for cell therapies, without consideration of material-based applications. (frontiersin.org)
Only a careful consideration and standardization of all pretreatment processes/methods for the different applications of MSCs will ensure robust and reproducible performance of these cell populations in the different experimental and clinical settings. (frontiersin.org)
Mesenchymal stem/stromal cells (MSCs) have the capacity to differentiate into cells and tissues of one germ layer, here the mesodermal lineage, and are consequently multipotent. (frontiersin.org)
Adult tissue-derived mesenchymal stromal cells (MSCs) are showing promise in clinical trials for systemic lupus erythematosus (SLE). (nature.com)
Human embryonic stem cell (hESC)-derived MSCs are an alternative to adult MSCs that can circumvent issues regarding scalability and consistent quality due to their derivation from a renewable starting material. (nature.com)
Mechanistically, in vitro data support these findings, as co-culture of hESC-MSCs with lipopolysaccharide (LPS)-stimulated BWF1 lymphocytes decreased lymphocyte secretion of TNFα and IL-6 and enhanced the percentage of putative regulatory T cells. (nature.com)
Evidence shows that MSCs home to sites of inflammation where they inhibit immune and inflammatory responses by influencing the behavior of local innate and adaptive immune cells (reviewed in 20 ). (nature.com)
Mesenchymal stem cells (MSCs) have been suggested as an appropriate source for diabetes cell-based therapies. (biomedcentral.com)
The high proliferation and differentiation capacity of fetal MSCs and the role of fetal pancreatic-derived MSCs (FPMSCs) in islet generation make them good candidates for diabetes treatment. (biomedcentral.com)
Flow cytometry analysis and three-lineage differentiation ability demonstrated that fibroblast-like cells obtained from primary culture had MSCs' characteristics. (biomedcentral.com)
Mesenchymal stem cells (MSCs) have received more attention due to their proliferation and differentiation capacity and low immunogenicity. (biomedcentral.com)
Bone marrow-derived mesenchymal stem cells (BM-MSCs) are multipotent stromal cells that have a critical role in the maintenance of skeletal tissues such as bone, cartilage, and the fat in bone marrow. (ijbs.com)
In addition to providing microenvironmental support for hematopoietic processes, BM-MSCs can differentiate into various mesodermal lineages including osteoblast/osteocyte, chondrocyte, and adipocyte that are crucial for bone metabolism. (ijbs.com)
While BM-MSCs have high cell-to-cell heterogeneity in gene expression, the cell subtypes that contribute to this heterogeneity in vivo in humans have not been characterized. (ijbs.com)
To investigate the transcriptional diversity of BM-MSCs, we applied single-cell RNA sequencing (scRNA-seq) on freshly isolated CD271 + BM-derived mononuclear cells (BM-MNCs) from two human subjects. (ijbs.com)
We successfully identified LEPR hi CD45 low BM-MSCs within the CD271 + BM-MNC population, and further codified the BM-MSCs into distinct subpopulations corresponding to the osteogenic, chondrogenic, and adipogenic differentiation trajectories, as well as terminal-stage quiescent cells. (ijbs.com)
However, MSCs lack the intrinsic mechanisms that enable homing of the cells to the area of infarction. (edu.pl)
Transplantation of mesenchymal stem cells (MSCs) derived from adult bone marrow has been proposed as a potential therapeutic approach for post-infarction left ventricular (LV) dysfunction. (uni-hannover.de)
Adult stem cells comprise mesenchymal stem cells (MSCs), hematopoietic stem cells (HSCs) and ectodermal stem cells (ESCs). (biomedcentral.com)
The current study aimed to investigate the effect of mesenchymal stem cells (MSCs) transplantation as a new strategy for treatment of diabetes in Streptozotacin (STZ) induced diabetic male albino rats. (alliedacademies.org)
After six weeks of MSCs transplantation, the treated group showed a significant amelioration in these biochemical parameters. (alliedacademies.org)
Mesenchymal stem cells (MSCs) transplantation has been used for therapeutic applications in various diseases. (oncotarget.com)
The novel neoplasm was found on the tail of female rat after injection with male rat bone marrow-derived MSCs (rBM-MSCs) and the new tumor cell line, K3, was isolated from the neoplasm. (oncotarget.com)
The K3 cells expressed surface antigens and pluripotent genes similar to those of rBM-MSCs and presented tumor cell features. (oncotarget.com)
Mesenchymal stem cells (MSCs) are multipotent cells with the potential to differentiate into bone, cartilage, fat and muscle cells and are being investigated for their utility in cell-based transplantation therapy. (biomedcentral.com)
A dose-response to QDs in rat bone marrow MSCs was assessed in Control (no-QDs), Low concentration (LC, 5 nmol/L) and High concentration (HC, 20 nmol/L) groups. (biomedcentral.com)
Finally, in a cardiomyocyte co-culture QD labeled MSCs were easy to locate and formed functional cell-to-cell couplings, assessed by dye diffusion. (biomedcentral.com)
In part, this is due to limited methods to track MSCs in vivo , precluding long-term functional studies of transplanted cells. (biomedcentral.com)
In the present study, rat bone marrow MSCs were used to evaluate QD exposure on labeled MSC yield, QD retention and proliferation. (biomedcentral.com)
Introduction The advantage of transplantation of bone tissue marrow-derived mesenchymal stem cells (MSCs) after cardiac infarction continues to be evaluated in lots of preclinical and scientific research [1,2]. (mycareerpeer.com)
Potential systems of MSC-mediated safety from ischemic damage will be the differentiation of MSCs into cardiomyocytes, the excitement of cardiac stem cell proliferation, and/or cells that enhance vascularization [3]. (mycareerpeer.com)
Nevertheless, the reduced retention price of MSCs after transplantation and their low propensity to differentiate right into a cardiac phenotype [4] make it improbable that cell alternative is the major mechanism of great benefit. (mycareerpeer.com)
However, a postconditioning benefit of MSCs was also demonstrated when cells were injected 2?h after ischemic injury [21]. (mycareerpeer.com)
The purpose of this study was to evaluate the therapeutic effects of the transplantation of bone-marrow mesenchymal stem cells (MSCs), genetically engineered to over-express brain-derived neurotrophic factor (BDNF) or nerve growth factor (NGF) on motor deficits and neurodegeneration in YAC 128 transgenic mice. (cmich.edu)
MSCs, harvested from mouse femurs, were genetically engineered to over-express BDNF and/or NGF and these cells, or the vehicle solution, were injected into the striata of four-month old YAC 128 transgenic and wild-type mice. (cmich.edu)
These results indicate that intrastriatal transplantation of MSCs that over-express BDNF may create an environment within the striatum that slows neurodegenerative processes and provides behavioral sparing in the YAC 128 mouse model of HD. (cmich.edu)
We found that myocilin is expressed in bone marrow-derived mesenchymal stem cells (MSCs) and affects their differentiation into osteoblasts. (nih.gov)
Mesenchymal Stem Cells (MSCs) can be isolated from several body tissues, including dental tissues. (bvsalud.org)
The ability to restore cells and tissue function without the need of immunosuppressive drugs and without the concern for tissue compatibility makes Mesenchymal Stem Cells (MSCs, usual acronym) a strong promise for the future. (bvsalud.org)

Differentiation of rat embryonic neural stem cells promoted by co-cultured Schwann cells. (wikipedia.org)
Differentiation of embryonic neural stem cells promoted by co-cultured Schwann cells [J]." Chinese Journal of Neurosurgery 2 (2002). (wikipedia.org)
Likewise, they have the ability to activate the angiogenesis, proliferation, migration, and differentiation of the main cell types involved in skin regeneration. (frontiersin.org)
2017). MMP-2 and MMP-14 Silencing Inhibits VEGFR2 Cleavage and Induces the Differentiation of Porcine Adipose-Derived Mesenchymal Stem Cells to Endothelial Cells. (sciendo.com)
Osteogenic proliferation and differentiation of canine bone marrow and adipose tissue derived mesenchymal stromal cells and the influence of hypoxia. (sciendo.com)
The HUCMSCs derived multiple donors were performed comprehensively analysis and potent assays including expressions of surface markers, viability, growth curve, karyotype analysis, tumorigenicity, differentiation potentials, and immune regulation capability. (researchsquare.com)
The HUCMSCs derived multiple donors kept a high consistency in surface marker expressions, viability, growth curve, tumorigenicity in nude mic, but had robust heterogeneities in differentiation potentials and immune regulations. (researchsquare.com)
Despite growing experience and knowledge concerning human MSC and their use in cell-based strategies, the molecular mechanisms that govern MSC self-renewal, expansion and multilineage differentiation are not well understood and remain an active area of investigation. (biomedcentral.com)
We monitored these cells during their expansion ex vivo with respect to proliferation kinetics, surface marker profile and differentiation potential. (biomedcentral.com)
A side-by-side comparison was made to evaluate the effect of each serum on proliferation rate, cell cycle, senescence, multi-lineage differentiation capacity, immunophenotype, and tumorigenesis of FPMSCs. (biomedcentral.com)
This process is known as differentiation, and it serves as the foundation for cell treatment in Delhi NCR. (stemcellcareindia.com)
works in concert with bone morphogenetic protein-2 (BMP-2) to potentiate osteogenic differentiation of bone marrow-derived mesenchymal stem/stromal cells (BMSCs). (omicsdi.org)
Increasing evidence suggests that SDF-1 is involved in bone formation through regulation of recruitment, engraftment, proliferation, and differentiation of stem/progenitor cells. (omicsdi.org)
can potentiate bone morphogenetic protein-2 (BMP-2)-stimulated osteogenic differentiation and chemotaxis of BMSCs in vitro. (omicsdi.org)
Here, we investigate the cytotoxic effects of in vitro QD labeling on MSC proliferation and differentiation and use as a cell label in a cardiomyocyte co-culture. (biomedcentral.com)
For stem cells to be used in tissue engineering a scaffold is essential to provide the necessary support for the transport of nutrients, oxygen and the elimination of metabolic waste 30 , promoting a conducive environment for cell growth and differentiation. (bvsalud.org)
The stem cells from exfoliated deciduous teeth (SHEDs) have a great potential for therapeutic use because of its differentiation capability and its easy access, since the collection is performed at the physiological exfoliation stage of the deciduous teeth. (bvsalud.org)

Use of a chronic model of articular cartilage and meniscal injury for the assessment of long-term effects after autologous mesenchymal stromal cell treatment in Steep. (sciendo.com)
Human mesenchymal stromal cell transplantation modulates neuroinflammatory milieu in a mouse model of amyotrophic lateral sclerosis. (jamanetwork.com)
We have recently demonstrated that stromal cell-derived factor-1? (omicsdi.org)
Mesenchymal stem cell expression of stromal cell-derived factor-1? (omicsdi.org)
Increasing evidence suggests that stromal cell-derived factor-1 (SDF-1) is involved in bone formation. (omicsdi.org)
Stromal cell-derived factor-1? (omicsdi.org)
When administered post-stroke, mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) induce neuroprotection, promote brain remodeling and plasticity, and enhance neurological recovery in rodents and non-human primates via mechanisms that involve immunomodulation and anti-inflammation. (explorationpub.com)
Recently, mesenchymal stromal cell (MSC)-derived small extracellular vesicles (EVs) have emerged as a potential new therapeutic agent for stroke treatment. (explorationpub.com)

Equine mesenchymal stem cells from bonemarrow, adipose tissue and umbilical cord:immunophenotypic characterization anddifferentiation potential. (sciendo.com)
Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stem Cells from Sheep: Culture Characteristics. (sciendo.com)
Development and assessment of cell- and bioengineering-based intervention strategies to promote functional tissue repair in vivo models of traumatic nervous tissue injury (PNS and CNS). (ukaachen.de)
In periodontitis, EVs play a pivotal role in regulating the biological functions of both periodontal tissue cells and immune cells, as well as the local microenvironment, thereby promoting periodontal injury repair and tissue regeneration. (biomedcentral.com)
Non-reproducible treatment outcomes or even absence of treatment effects in comparison to control groups challenges the potential of these cells for routine application both in tissue engineering and in regenerative medicine. (frontiersin.org)
One great advantage of MSC is that these cells may be directly obtained from individual patients, thereby eliminating the complications associated with immune rejection of allogenic tissue and infectious diseases. (biomedcentral.com)
Transmissible spongiform encephalopathy (TSE) characterized by the accumulation in the central nervous agents have contaminated human tissue-derived medical system and, less often, in lymphoid tissues of TSE- products, human blood components, and animal vaccines. (cdc.gov)
In order to reach these needs, recently, experiments with cell based therapies to rescue or replace dopamine-secreting cells, or with cells able to secrete paracrine factors modulating brain tissue repair were initiated [ 8 - 12 ]. (biomedcentral.com)
Tissue engineering combining functional cells, biomaterials and osteoinductive cues may provide alternative treatment strategies. (omicsdi.org)
Bone Marrow is a sponge-like tissue found within the center of large bones like the hip bone, breast bone, shoulder blades and ribs. (futuremedicalgroup.com)
It contains progenitor cells and other growth factors needed to heal tissue. (futuremedicalgroup.com)
Since progenitor cells multiply and are signaled to form tissue such as cartilage, tendon and bone when necessary, they allow your body to create the tissue it needs to heal itself. (futuremedicalgroup.com)
These cells can differentiate into many types of tissue in your body and naturally stimulate a healing response. (futuremedicalgroup.com)
As a result of being capable of differentiating into a variety of cell types, it can be presumed that stem cell therapy has an advantage when compared to other tissue repair methods. (bvsalud.org)
The aim of this paper is to provide a review about current and future materials for scaffolds to carry stem cells in tissue engineering in Dentistry, especially for bone tissue repair. (bvsalud.org)
The high regeneration potential has aroused a great interest in the scientific community 3 , due to its many clinical applications in cell therapy or tissue engineering. (bvsalud.org)
Cell therapy is a therapy where cellular material is injected systemically or directly into the injured tissue, to promote local repair or to restore systemic health. (bvsalud.org)
Platelets elaborate a number of proinflammatory substances, such as adenosine diphosphate, tissue growth factor beta (TGF-ß), and platelet-derived growth factors (PDGF). (medscape.com)
Bone marrow is the soft, spongy, gelatinous tissue found in the hollow spaces in the interior of bones. (medscape.com)
Bone marrow consists of stem cells, which are large, "primitive," undifferentiated cells supported by fibrous tissue called stroma. (medscape.com)
There are 2 main types of stem cells and, therefore, the bone marrow consists of 2 types of cellular tissue. (medscape.com)
Bone marrow can be 1 of 2 types, red or yellow, depending on whether it consists of mainly hematopoietic (and therefore, red-colored) tissue or fatty (and therefore a yellow-colored) tissue. (medscape.com)

The use of olfactory progenitors as a cell-based therapy for Parkinson's disease (PD) would allow harvest without invasive surgery, provide an autologous cell population, eliminate need for immunosuppression and avoid the ethical concerns associated with embryonic tissues. (scirp.org)
Comparison of human mesenchymal stromal cells from four neonatal tissues: Amniotic membrane, chorionic membrane, placental decidua and umbilical cord. (sciendo.com)
The peripheral chimerism of bone marrow-derived stem cells after transplantation: regeneration of gastrointestinal tissues in lethally irradiated mice. (southernbiotech.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Stem cells from dental tissues have a real potential in Advanced Therapies. (bvsalud.org)
Until now, several progenitor cells derived from dental tissues have been isolated and characterized ( table I ). (bvsalud.org)
Stem cells derived from dental tissues are isolated from specialized tissues and have a strong ability to give rise to other cell lines, but with a different potential of bone marrow stem cells 16 . (bvsalud.org)
Stem cells are classified into two main: embryonic stem cells, which are found in the embryos and adult stem cells, found in adult tissues. (bvsalud.org)
Adult stem cells are found in differentiated tissues and are able to generate specialized cells in some types of tissues (Multipotent Stem Cells). (bvsalud.org)
Cells Tissues Organs. (cancercentrum.se)
When the oxygen content of body tissues is low, if there is loss of blood or anemia, or if the number of red blood cells decreases, the kidneys produce and release erythropoietin, a hormone that stimulates the bone marrow to produce more red blood cells. (medscape.com)

Accordingly, investigations on cellular therapies have therefore moved to progenitor cell populations such as bone marrow derived mesenchymal stem cells (BMSCs), which have the ability to differentiate into cartilage cells 4 . (nature.com)
In most cases, clinically relevant cell numbers for MSC-based therapies can be only obtained by in vitro expansion of isolated cells. (frontiersin.org)
However, for cell therapies MSC have to be expanded and/or manipulated to obtain a sufficient amount of cells that can be subsequently used for treatment. (biomedcentral.com)
Considerable time and effort has been spent in developing targeted therapies to fight SLE, yet only one therapy, belimumab (Benlysta), a monoclonal antibody targeting B cell-activating factor, or BAFF, has been approved for the treatment of SLE in the last half-century 16 . (nature.com)
In recent decades, stem cell-based therapies have raised hopes for treating incurable diseases such as diabetes [ 3 ]. (biomedcentral.com)
Therapeutic Candidate or Device Allogeneic iPSC derived dopamine progenitors delivered to the brain of Parkinson's disease patients Indication Idiopathic Parkinson's disease Therapeutic Mechanism The cellular product reconstitutes dopaminergic neuron circuits lost owing to the disease Unmet Medical Need There are currently disease modifying therapies. (ca.gov)
The resulting stem cells are known as hematopoietic or blood-forming stem cells because they are similar to bone marrow cells, which have been widely used in the treatment of a variety of genetic disorders, blood diseases, and autoimmune diseases such as lupus, diabetes , and kidney disease , as well as in post-cancer therapies. (stemcellcareindia.com)
BMSC therapies alone showed limited bone healing, which was increased with co-delivery of BMP-2. (omicsdi.org)
Numerous studies have revealed that bone marrow-derived mesenchymal stem/stromal cells (BMSCs) hold great potential for regenerative therapies. (omicsdi.org)
All these therapies target the symptoms and have effects on the mechanical properties of bone due to modification of bone remodelling, therefore influencing skeletal outcome and orthopaedic surgery. (smw.ch)
Innovative therapies, such as progenitor and mesenchymal stem cell transplantation, targeting the specific altered pathway rather than the symptoms, are in the process of development. (smw.ch)

BMSCs, augments the cell-mediated therapeutic effects resulting in enhanced bone formation, as evidenced by ex vivo ?CT and bone histomorphometry. (omicsdi.org)

Intra-articular injection of expanded autologous bone marrow mesenchymal cells in moderate and severe knee osteoarthritis is safe: a phase I/II study. (sciendo.com)
Autologous bone marrow-derived mesenchymal stem cells versus autologous chondrocyte implantation: an observational cohort study. (futuremedicalgroup.com)
A prospective multi-site registry study of a specific protocol of autologous bone marrow concentrate for the treatment of shoulder rotator cuff tears and osteoarthritis. (futuremedicalgroup.com)
Transplanting their own (autologous) bone marrow-derived stem cells into 48 patients with end-stage liver disease resulted in therapeutic benefit to a high number of the patients, report researchers publishing in the current issue of Cell Transplantation (19:11). (medicaldaily.com)

Here we describe the initial results of allogeneic bone marrow transplantation in three children with osteogenesis imperfecta, a genetic disorder in which osteoblasts produce defective type I collagen, leading to osteopenia, multiple fractures, severe bony deformities and considerably shortened stature. (nih.gov)
Thus, allogeneic bone marrow transplantation can lead to engraftment of functional mesenchymal progenitor cells, indicating the feasibility of this strategy in the treatment of osteogenesis imperfecta and perhaps other mesenchymal stem cell disorders as well. (nih.gov)
Treatment of knee osteoarthritis with allogeneic bone marrow mesenchymal stem cells: a randomized controlled trial. (futuremedicalgroup.com)

In this review, we discuss the rationale for MSC-based cell therapy in COPD, the main findings from in vitro and in vivo preclinical COPD model studies, clinical trials in patients with COPD and directions for further research. (bmj.com)
Immunoselected STRO-3+ mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis. (sciendo.com)
Cryopreserved allogeneic mesenchymal stem cells enhance wound repair in full thickness skin wound model and cattle clinical teat injuries. (sciendo.com)
In principle, transplantation of mesenchymal progenitor cells would attenuate or possibly correct genetic disorders of bone, cartilage and muscle, but clinical support for this concept is lacking. (nih.gov)
However, their low frequency in bone marrow necessitate ex vivo expansion for further clinical application. (biomedcentral.com)
However, the inability to manufacture large quantities of functional cells from a single donor as well as donor-dependent variability in quality limits their clinical utility. (nature.com)
Although these initial results suggest that Modulatist TM transplantation is a promising therapy, more clinical studies in COPD patients are warranted to evaluate efficacy. (vinastemcelllab.com)
Systemic treatment with adipose-derived mesenchymal stem cells ameliorates clinical and pathological features in the amyotrophic lateral sclerosis murine model. (jamanetwork.com)
Transplantation of these cells improves the clinical outcome in experimental models of cerebral ischemia and spinal cord injury. (edu.pl)
However, age-related functional decline of stem cells has restricted their clinical benefits after transplantation into the infarcted myocardium. (uni-hannover.de)
It may start with a range of non-motor symptoms such as disorders of the autonomic nervous system, olfaction, sleep, mood and subtle cognitive deterioration, before a degeneration of the dopamine producing cells in the upper brainstem (nigral substance) may manifest with motor parkinsonism, the clinical hallmark of this disease, and way before involvement of the neocortex induces dementia [ 5 ]. (biomedcentral.com)
The majority of the cited preclinical and clinical studies use expanded and/or induced mesenchymal stem cells. (biomedcentral.com)
Skeletal injuries are among the most prevalent clinical problems and bone marrow-derived mesenchymal stem/stromal cells (BMSCs) have successfully been used for the treatment thereof. (omicsdi.org)

Human mesenchymal stem cells (MSC) with the capacity to differentiate into osteoblasts provide potential for the development of novel treatment strategies, such as improved healing of large bone defects. (biomedcentral.com)
Progenitor cells take several weeks to months to differentiate. (futuremedicalgroup.com)
As needed, the stem cells differentiate to become a particular kind of cell-a white blood cell, red blood cell, or platelet. (medscape.com)
T lymphocytes originate via lymphoid stem cells that migrate to the thymus and differentiate under the influence of the thymic hormones thymopoietin and thymosin. (medscape.com)

2018). Development of bovine embryos in vitro in coculture with murine mesenchymal stem clls and embryonic fibroblasts. (sciendo.com)
The study of neural cell-engineered substrate interactions in vitro. (ukaachen.de)
Currently, the only FDA-approved cell-based therapy for cartilage defects involves autologous chondrocyte implantation: chondrocytes harvested from low-contact areas are expanded in vitro and then re-injected directly into the damaged site 1 . (nature.com)
These studies have demonstrated that mechanical forces are able to shape the mesenchymal stem cell (MSC) fate when appropriately applied in in vitro models of cartilage regeneration. (nature.com)
HADSCs were induced to confirm that they can express the characteristics of endothelial cells (ECs) in vitro. (molvis.org)
Therefore, in this study, we assessed the ability of human adipose mesenchymal stem cells (hADSCs) to express the characteristics of ECs after induction in vitro to evaluate the theoretical feasibility of maintaining or restoring the function of ECs after intraocular application. (molvis.org)
In vitro cell proliferation studies showed that supplementing BMP-2 to Tet-Off BMSCs significantly increased the cell number during the first 24 h. (omicsdi.org)
potentiates bone morphogenetic protein-2-stimulated osteoinduction of genetically engineered bone marrow-derived mesenchymal stem cells in vitro. (omicsdi.org)
Quantum Dots (QDs) offer an alternative to organic dyes and fluorescent proteins to label and track cells in vitro and in vivo . (biomedcentral.com)
Taken together, the inhibition of hsa_circ_0046060 expression in exosomes from GDM-derived UMSCs can alleviate GDM by reversing abnormal glucose metabolism and insulin resistance in vivo and in vitro . (hindawi.com)

Till the end of 2013 he has treated over 7,000 patients with stem cell therapy with his medical team, involving many diseases, such as cerebral palsy, spinal cord injury, traumatic brain injury, diabetes, ulcerative colitis and cirrhosis. (wikipedia.org)
Modulation of the major histocompatibility complex by neural stem cell-derived neurotrophic factors used for regenerative therapy in a rat model of stroke. (wikipedia.org)
Mesenchymal stromal cells: a novel therapy for the treatment of chronic obstructive pulmonary disease? (bmj.com)
This study represents an important step in the development of a commercially scalable and efficacious cell therapy for SLE/LN. (nature.com)
Sadan O, Melamed E, Offen D. Bone-marrow-derived mesenchymal stem cell therapy for neurodegenerative diseases. (jamanetwork.com)
Mesenchymal stem cells induced to secrete neurotrophic factors attenuate quinolinic acid toxicity: a potential therapy for Huntington's disease. (jamanetwork.com)
Sadan O, Shemesh N, Cohen Y, Melamed E, Offen D. Adult neurotrophic factor-secreting stem cells: a potential novel therapy for neurodegenerative diseases. (jamanetwork.com)
high-risk patients included male subjects, recipients of stem cells from female donors, patients younger than 10 years, those with nonidentical donors, and those who received radiation therapy in the transplant preparative regimen. (medscape.com)
In conclusion: treatment with MSC.s transplantation as a cell-therapy could restore pancreatic β-cell function and improved liver and kidney functions in diabetes as a new strategy for diabetes treatment. (alliedacademies.org)
provides synergistic effects supporting BMP-2-induced, BMSC-mediated bone formation and appears suitable for optimization of bone augmentation in combination therapy protocols. (omicsdi.org)
augments bone formation in a model of local regenerative therapy. (omicsdi.org)
Is to compare between cell-assisted lipotransfer (CAL) and ALA therapy in improvement of fat graft survival. (magnusconferences.com)
Dr. Novas holds key positions in prestigious organizations related to regenerative medicine and stem cell research, including the Gene-Therapy Biomedical Research College in Wellington, Florida, and the Far Eastern University in Manila, Philippines. (regenestem.com)
She also actively participates as an academic member of the European Society of Gene and Cell Therapy and the International Society for Cellular Therapy, among others. (regenestem.com)
Medical treatment consists of bone-remodelling drug therapy. (smw.ch)

This study suggests that specific transcription factors and treatment with morphogens can restrict human adult olfactory-derived progenitors to a dopaminergic neuronal lineage. (scirp.org)
It is distinguished by pathologic loss of alveolar bone and the periodontal ligament (PDL), thus causing tooth mobility and even adult tooth loss [ 1 ]. (biomedcentral.com)
Adult bone marrow-derived mesenchymal stem cells (hMSCs) display a spectrum of functional properties. (edu.pl)
Due to their capability to transdifferentiate, to immune modulate and to increase neuroplasticity by producing neurotrophic factors, adult stem cells (ASC) might fill this gap. (biomedcentral.com)
Cord blood contains unusually high quantities of adult stem cells, which eventually grow into hematopoietic blood cells. (stemcellcareindia.com)
In an adult, roughly half of the bone marrow is still red. (medscape.com)

however, their role in β-cell regeneration remains elusive. (drcalapai.com)
This study was designed to improve our understanding of genetic modification of human bone marrow derived mesenchymal stem cells (hMSCs) by polyethylenimine (PEI, branched with Mw 25 kD), one of non-viral vectors that show promise in stem cell genetic modification, in the context of cardiac regeneration for patients. (uni-hannover.de)
The combination of inductive scaffold materials with stem cells might optimize the approaches for bone regeneration. (bvsalud.org)

Anderson, L. and Caldwell, M.A. (2007) Human neural progenitor cell transplants into the subthalamic nucleus lead to functional recovery in a rat model of Parkinson's disease. (scirp.org)
Bone marrow harvested progenitor cell treatment. (futuremedicalgroup.com)
If you are interested in discussing if a Bone Marrow Harvested Progenitor Cell treatment may be right for you, please contact us for additional information. (futuremedicalgroup.com)
Progenitor cell (stem cell) lines in the bone marrow produce new blood cells and stromal cells. (medscape.com)

[ 2 , 8 ] Survivors of bone marrow transplantation were more likely to have a severe or life threatening condition (relative risk [RR] = 3.9), more than one chronic condition (RR = 2.6), functional impairment (RR=3.5), and activity limitations (RR = 5.8) than conventionally treated patients. (medscape.com)

To stimulate and facilitate further research, the NCI and NHLBI held the First International Consensus Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation on April 28 and 29, 2011. (medscape.com)
Therapeutic Candidate or Device OSSM007: cryopreserved, interferon-gamma-primed bone marrow mesenchymal stem cells (BM-MSC) Indication acute Graft versus host disease (aGVHD) resulting from hematopoietic cell transplantation Therapeutic Mechanism Immunomodulation of host-reactive T cells to induce operational tolerance of donor HSC-derived lymphocytes through direct cell-to-cell contact and secreted paracrine factors. (ca.gov)

2013) Conditioned medium from bone marrow-derived mesenchymal stem cells improves recovery after spinal cord injury in rats: an original strategy to avoid cell transplantation. (ukaachen.de)
Functionalization of Electrospun Poly(epsilon-Caprolactone) Fibers with the Extracellular Matrix-Derived Peptide GRGDS Improves Guidance of Schwann Cell Migration and Axonal Growth. (ukaachen.de)
Sadan O, Melamed E, Offen D. Intrastriatal transplantation of neurotrophic factor-secreting human mesenchymal stem cells improves motor function and extends survival in R6/2 transgenic mouse model for Huntington's disease. (jamanetwork.com)
Mesenchymal stem cell (MSC) transplantation following ischemia/reperfusion (We/R) injury reduces infarct size and improves cardiac function. (mycareerpeer.com)

Group II: CAL group received autologous fat mixed with adipose derived stem cells (ASCs). (magnusconferences.com)
She has been instrumental in imparting knowledge and proper protocols for harvesting and isolating adipose-derived stem cells for autologous re-implantation to physicians worldwide. (regenestem.com)

Besides the cell source choice, also mechanical stimuli are crucial in the development and maintenance of articular cartilage. (nature.com)
Osteoarthritis is a chronic arthropathy characterized by disruption and potential loss of joint cartilage along with other joint changes, including bone hypertrophy (osteophyte formation). (msdmanuals.com)
Obesity triggers some of these defects in cartilage metabolism, leading to cartilage matrix damage and subchondral bone remodel-ing mediated by adipokines, such as leptin and adipsin, and compounded by mechanical factors due to excess weight. (msdmanuals.com)

Bovine fetal mesenchymal stem cells exert antiproliferative efect against mastitis causing pathogen Staphylococcus aureus. (sciendo.com)
Fetal cells enter maternal blood during pregnancy and persist in women with autoimmune disease. (mendeley.com)
To test the hypothesis that fetal mesenchymal stem cells persist in maternal organs, we studied female bone marrow and ribs. (mendeley.com)
We conclude that fetal stem cells transferred into maternal blood engraft in marrow, where they remain throughout life. (mendeley.com)
Bone marrow first appears in the clavicle near the end of fetal life and becomes active about 3 weeks later. (medscape.com)

After attaching to target cells, EVs can change the physiological state of recipient cells through various pathways. (biomedcentral.com)

They include endothelial cells, fibroblasts, and keratinocytes. (frontiersin.org)
Transfer of endothelial progenitor and bone marrow cells influences atherosclerotic plaque size and composition in apolipoprotein E knockout mice. (southernbiotech.com)
We optimized the PEI-mediated reporter gene transfection into hMSCs, evaluated whether transfection efficiency is associated with gender or age of the cell donors, analysed the influence of cell cycle on transfection and investigated the transfer of therapeutic vascular endothelial growth factor gene (VEGF). (uni-hannover.de)
IL-1 stimulates the proliferation of inflammatory cells and promotes angiogenesis through endothelial cell replication. (medscape.com)
bFGF is a chemotactic and mitogenic factor for fibroblasts and endothelial cells. (medscape.com)

Transplantation of human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and endogenous neurogenesis after cerebral ischemia in rats. (wikipedia.org)
Human mesenchymal stem cell transplantation protects against cerebral ischemic injury and upregulates interleukin-10 expression in Macaca fascicularis. (wikipedia.org)
To compare the heterogeneities of human umbilical cord mesenchymal stem cells (HUCMSCs) derived from different donors and test their therapeutic variations in mouse liver fibrosis model. (researchsquare.com)
2010) Cell-cell interactions of human neural progenitor-derived astrocytes within a microstructured 3D-scaffold. (ukaachen.de)
2010) Expansion of human bone marrow-derived mesenchymal stromal cells: serum-reduced medium is better than conventional medium. (ukaachen.de)
We designed a study to find theoretical evidence for the induction, movement, fusion, proliferation, and safety of human adipose mesenchymal stem cells (hADSCs) in intraocular application. (molvis.org)
Human MSC are easy to isolate from small aspirate of bone marrow via their adherence ability. (biomedcentral.com)
In this study we asked if human MSC are developing in an aberrant or unwanted way during ex vivo long-term cultivation and if cultivation conditions exert any influence on their stem cell maintenance. (biomedcentral.com)
No PrPTSE or vCJD infections have been transmitted by transfusions of infectivity has been detected in any exposed cell line under nonleukoreduced erythrocyte concentrates and by a human- study so far. (cdc.gov)
In our recent study, we examined the impact of the three-dimensional co-culture of FPMSCs on human embryonic stem cell-derived pancreatic progenitors' development. (biomedcentral.com)
Methods: Human mesenchymal stem cells (hMSC, PT-2501, Lonza) were thawed and cultured in medium MSCBM (PT-3238, Lonza) supplemented with 10% MCGS (PT-4106E, Lonza), L-glutamine (PT4107E, Lonza), and gentamicin sulfate (GA-1000, PT-4504E, Lonza). (edu.pl)

The cells secrete extracellular vesicles (EV) that may have an endosomal origin, or from evaginations of the plasma membrane. (frontiersin.org)
The exosome vesicles are a type of extracellular vesicles (EV), which are defined as lipid-bilayer spheroid structures, without replicating capacity, that are released from cells, including both prokaryotes and eukaryotes. (frontiersin.org)
Various cells release lipid-enclosed particles known as extracellular vesicles (EVs), which are rich in bioactive substances. (biomedcentral.com)

PrPC is a susceptibility to infection of 5 cell lines used or proposed for nonessential protein but, at least in mice and cows, must be manufacture of biological products, as well as other lines. (cdc.gov)

Today, Umbilical Cord Blood (UCB) stem cells are used in the treatment of over 105 ailments in Thailand, including cardiovascular disease, cancer, hereditary/genetic diseases, and blood disorders such as sickle cell anaemia. (stemcellcareindia.com)

Cord stem cells are collected within minutes of delivery, specifically when the placenta has been removed. (stemcellcareindia.com)

Most of the identifiable cells are lymphocytes or plasma cells. (medscape.com)

Three months after osteoblast engraftment (1.5-2.0% donor cells), representative specimens of trabecular bone showed histologic changes indicative of new dense bone formation. (nih.gov)
Starting with cell source, choice of donor and recipient, as well as isolation methods, we will then discuss existing expansion protocols (two-/three-dimensional cultivation, basal medium, medium supplements, static/dynamic conditions, and hypoxic/normoxic conditions) and influence of these strategies on the cell functionality after implantation. (frontiersin.org)
In our treatment procedures, this is more difficult and time-consuming because the donor must be put under anaesthesia because blood is collected from the insides of the bone, which can be uncomfortable. (stemcellcareindia.com)
The supplement with compatible donor of islets in order to transplantation purpose is very limited. (alliedacademies.org)

born February 1970) is the chairmen of Stem Cell Transplantation Center (also called as Department of Neural Stem Cells) in the General Hospital of Chinese People's Armed Police Forces. (wikipedia.org)

For transfection experiments, hMSCs were transferred to 24-well plates and seeded at a density of 15 000 cells/well. (edu.pl)
After transfection, cells were maintained in culture conditions up to 21 days. (edu.pl)
Results: MSC pDNA-eGFP transfection results in a dramatically low efficiency, less than 1% of the cell population in each of the tested conditions. (edu.pl)
and transfection efficiency in each subpopulation was linearly related to the cell percentage in S phase. (uni-hannover.de)

Common problems include poor cell engraftment, which can be addressed by irradiation prior to transplantation. (omicsdi.org)

Moreover, the K3 cells contained side population cells (SP) like cancer stem cells (CSCs), which might contribute to K3 heterogeneity and tumorigenic capacity. (oncotarget.com)

These growth factors act on surrounding cells and stimulate chemotaxis of neutrophils, monocytes, and fibroblasts to the area of injury. (medscape.com)

Embryonic stem cells are present only in the early stages of development and are able to generate any cell type (Pluripotent Stem Cells). (bvsalud.org)

Therefore, research on exosomes produced by MSC has been intensified for use in cell-free regenerative medicine. (frontiersin.org)
She contributed as a speaker at global webinar on stem cell during November 11-12-2021, she also attended the BIT's 10th World Congress of Regenerative Medicine & Stem Cells -2016 in China and gave a talk titled as ' Bone Marrow Mesenchymal Stem Cell Transplantation in a Rabbit Corneal Alkali Burn Model . (magnusconferences.com)

Likewise, many children are now surviving hematopoietic stem-cell transplantation (HSCT) (see related histology slide below) and require structured long-term follow-up care. (medscape.com)
has completed her Ph.D. in Histology & cell biology at Ain Shams University from 2000 to 2005. (magnusconferences.com)

To investigate the metastatic potential of K3 cells, we established the nude mouse models of liver and lung metastases and isolated the corresponding metastatic cell lines K3-F4 and K3-B6. (oncotarget.com)
Bone marrow supersedes the liver as the major hematopoietic organ at 32-36 weeks' gestation. (medscape.com)

This finding has implications for normal pregnancy, for obstetric complications that increase fetomaternal trafficking, and for graft survival after transplantation. (mendeley.com)

Anatomy30

Organisms9

Diseases21

Chemicals and Drugs30

Analytical, Diagnostic and Therapeutic Techniques and Equipment58

Psychiatry and Psychology1

Phenomena and Processes41

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture4

Information Science1

Named Groups2

Health Care6

MSCs60

Differentiation17

Stromal cell8

Tissue22

Tissues11

Therapies11

Therapeutic effects1

Autologous bone marrow4

Allogeneic bone3

Clinical13

Differentiate4

Vitro10

Therapy15

Adult6

Regeneration3

Progenitor cell4

Functional1

Hematopoietic Cell Transplantation2

Improves4

Adipose derived stem cells2

Cartilage3

Fetal5

Pathways1

Endothelial5

Human11

Extracellular vesicles3

Biological1

Diseases1

Placenta1

Lymphocytes1

Donor4

Neural1

Transfection4

Engraftment1

Heterogeneity1

Fibroblasts1

Embryonic stem1

Regenerative medicine2

Histology2

Liver2

Graft survival1