Bone marrow derived differentiation into tissue. Medical search. Frequent questions

However, the results indicate that bone marrow -derived MSCs are superior to those from subcutaneous adipose tissue in terms of differentiation into pancreatic islet -like clusters. (bvsalud.org)
It is known that significant percentages of visceral adipocytes are derived from mesenchymal stem cells and high glucose enhances adipogenic differentiation of mouse bone marrow-derived MSCs (BM-MSCs). (hindawi.com)
However, the effect of high glucose on adipogenic differentiation of human bone marrow and gestational tissue-derived MSCs is still poorly characterized. (hindawi.com)
This study aims to investigate the effects of high glucose on proliferation as well as adipogenic and osteogenic differentiation of human MSCs derived from bone marrow and several gestational tissues including chorion, placenta, and umbilical cord. (hindawi.com)
We found that high glucose reduced proliferation but enhanced adipogenic differentiation of all MSCs examined. (hindawi.com)
Although high glucose transiently downregulated the expression levels of some osteogenic genes examined, its effect on the osteogenic differentiation levels of the MSCs is not clearly demonstrated. (hindawi.com)
The knowledge gained from this study will increase our understanding about the effect of high glucose on adipogenic differentiation of MSCs and might lead to an improvement in the diabetic treatment in the future. (hindawi.com)
It is known that adipocytes are derived, at least in part, from multipotent mesenchymal stem cells (MSCs). (hindawi.com)
In contrast to adipogenic differentiation, high glucose suppressed osteogenic differentiation and downregulated the expression levels of osteogenic gene runt-related transcription factor 2 ( RUNX2 ), collagen type I ( COL1A1 ), osteonectin ( ON ), and osteocalcin ( OCN ) of mouse BM-MSCs and MG63 cells [ 7 , 9 ]. (hindawi.com)
Although the effects of high glucose on the proliferation and differentiation of rat and mouse BM-MSCs have been previously reported, the effects of high glucose on biological properties of human MSCs derived from gestational tissues which, due to their ease of isolation by noninvasive procedure, are considered more suitable sources of MSCs for clinical applications have yet to be determined. (hindawi.com)
We found that myocilin is expressed in bone marrow-derived mesenchymal stem cells (MSCs) and affects their differentiation into osteoblasts. (nih.gov)
The main challenge for large bone defect repair and regeneration remains the inadequate recruitment of mesenchymal stem cells (MSCs), reduced vascularization, and decreased growth factors stimulation within the scaffold construct to support cell viability and tissue growth. (frontiersin.org)
Consequently, enhancing the adhesion of MSCs, augmenting the release of growth factors, and promoting angiogenic potential of biomaterial scaffolds after implantation are pivotal for successful bone regeneration. (frontiersin.org)
MesenCult™ Adipogenic Differentiation Medium (Human) is specifically formulated for the in vitro differentiation of primary human mesenchymal stromal cells, and hPSC-derived mesenchymal progenitor cells (also known as mesenchymal stem cells or MSCs) into adipogenic lineage cells. (stemcell.com)
This kit is suitable for the differentiation of MSCs derived from human bone marrow (BM), adipose tissue, umbilical cord, or pluripotent stem cells (PSCs) that have been previously culture-expanded in serum- and animal component-free medium (e.g. (stemcell.com)
Adipogenic differentiation of human bone marrow-derived MSCs using MesenCult™ Adipogenic Differentiation Medium (Human) or a competitor medium. (stemcell.com)
The differentiation, proliferation, prognosis, and safety of MSCs for in vivo therapy remain controversial. (molvis.org)
There is a growing body of evidence that multipotent mesenchymal stromal cells' (MSCs') remarkable therapeutic potential is attributed not only to their differentiation and regenerative capacity, but also to the paracrine effect, underlying their immunomodulatory properties. (biomedcentral.com)
Human peripheral blood mononuclear cells-derived macrophages were then treated with umbilical cord-derived MSCs' conditioned media and their effect on macrophages polarization was assessed. (biomedcentral.com)
Our findings suggest that umbilical cord-derived MSCs' conditioned media demonstrated the highest cytokine and growth factor levels and despite mostly pro-inflammatory cytokine profile were able to promote anti-inflammatory macrophage polarization. (biomedcentral.com)
Umbilical cord-derived MSCs' conditioned media hold great potential for therapeutic use, demonstrating significant anti-inflammatory effect on human macrophages. (biomedcentral.com)
Given the minimal criteria for defining MSCs [ 6 ], it may seem that MSCs derived from different sources should exhibit equivalent properties. (biomedcentral.com)
Thus, bone marrow is the first established and still one of the most commonly used sources of MSCs [ 7 ]. (biomedcentral.com)
Given MSCs differentiation directions, adipose tissue was considered another valid source of MSCs (AT-MSCs). (biomedcentral.com)
Neonatal tissues, such as umbilical cord and placenta, have gained particular interest, giving a chance to harvest MSCs in a noninvasive manner. (biomedcentral.com)
Furthermore, MSCs derived from neonatal tissues were reported to have improved proliferative and engraftment capacities compared to MSCs from adult tissues [ 14 ]. (biomedcentral.com)
Mesenchymal stem cells (MSCs) support chondrogenic differentiation and are an attractive cell source for cartilage tissue engineering. (nature.com)
The HUCMSCs derived different donors have individual heterogeneity, which potentially lead to distinct therapeutic outcomes in mouse liver fibrosis, indicating we could make use of the donor-variation of MSCs to screen out guaranteed general indicators of MSCs for specific diseases in further stem cell therapy. (researchsquare.com)
Mesenchymal stem cells (MSCs) have been widely tested for treating a variety of refectory medical indications such as type 1 diabetes mellitus, systemic lupus erythematosus, rheumatoid arthritis and Crohn's disease due to their multiple differentiation potentials and immunomodulation capability [1-5]. (researchsquare.com)
MSCs could be derived from a series of tissues including but not limited to umbilical cord, placenta, adipose tissue, bone marrow, gingiva, and dental pulp [5-12]. (researchsquare.com)
These MSCs derived different tissues do not have uniform characteristics, differing in expression profiles of surface markers and biological functions after certain stimulation such as pro-inflammatory mediators [5, 13]. (researchsquare.com)
and (iii) MSCs maintains the differentiation potentials of adipocytes, osteoblasts, and chondroblasts in vitro [14]. (researchsquare.com)
In spite of tissue origin, many other elements such as culture method and further modulations also influence the heterogeneity of MSCs, leading to differential gene expression profiles, growth phenotype, and differentiation potentials [15-17]. (researchsquare.com)
We established a Good Manufacturing Practice (GMP) grade cell facility to produce clinic-grade human umbilical cord derived MSCs (HUCMSCs) for treating premature ovarian failure (POF) and recurrent uterine adhesion [18, 20]. (researchsquare.com)
Inhibits proliferation and promotes osteogenic differentiation, while inhibiting adipogenic differentiation, of human amnion-derived mesenchymal stem cells (MSCs) and rabbit bone marrow-derived MSCs (Wu et al. (stemcell.com)
Mesenchymal stem cells (MSCs) are multipotent cells usually isolated from bone marrow, endometrium, adipose tissues, skin, and dental pulp. (techscience.com)
However, MSCs have gained considerable attention for tissue regeneration owing to their differentiation ability with immunomodulatory effects. (techscience.com)
Mesenchymal stem cells (MSCs) are multipotent stromal cells capable of self-renewal and exhibit multilineage differentiation properties. (techscience.com)
Many studies related to MSCs therapeutic potential in which MSCs derived extracellular vesicles accomplished a vital role. (techscience.com)
The Mesenchymal and Tissue Stem Cell Committee, which belongs to the International Society for Cellular Therapy, stated that plastic-adherent properties are the minimum criteria for determining MSCs. (techscience.com)
The MSCs represent less than 1% of the cells present in the placenta, while the average yield of MSCs from chorions and amnions is between 1 to 10 million per gram of tissue. (parentsguidecordblood.org)
Chorionic and amniotic MSCs suppress T cell proliferation to the same extent as bone marrow derived MSCs. (parentsguidecordblood.org)
6,7 Mesenchymal stem cells (MSCs) have also been isolated from other sources, such as bone marrow, 8 the placenta, 9 muscle, 10 or blood. (jcadonline.com)
11 However, the greater the abundance of adipose tissue in the human body, the significantly higher the yield of MSCs is compared to other tissues. (jcadonline.com)
Experiments with bone marrow-derived mesenchymal stem cells (MSCs) show that differentiation capacity decreases under hypoxic conditions compared to normoxic conditions. (umd.edu)

Differentiation of mesenchymal stem cells derived from human bone marrow and subcutaneous adipose tissue into pancreatic islet-like clusters in vitro. (bvsalud.org)
Although stem cells are present in various adult tissues and body fluids , bone marrow has been the most popular source of stem cells for treatment of a wide range of diseases . (bvsalud.org)
Recent results for stem cells from adipose tissue have put it in a position to compete for being the leading therapeutic source. (bvsalud.org)
The major advantage of these stem cells over their counterparts is their amazing proliferative and differentiation potency . (bvsalud.org)
However, their pancreatic lineage transdifferentiation competence was not compared to that for bone marrow -derived stem cells . (bvsalud.org)
The results reveal that mesenchymal stem cells (MSC) derived from bone marrow and subcutaneous adipose tissue can differentiate into pancreatic islet -like clusters, as evidenced by their islet-like morphology, positive dithizone staining and expression of genes such as Nestin , PDX1, Isl 1, Ngn 3, Pax 4 and Insulin . (bvsalud.org)
Bone marrow adipocytes (BMAds) originate from mesenchymal stem cell (MSC) progenitors that also give rise to osteoblasts, among other cell types. (wikipedia.org)
These hematopoietic cells are derived from hematopoietic stem cells (HSC) which give rise to diverse cells: cells of the blood, immune system, as well as cells that break down bone (osteoclasts). (wikipedia.org)
HSC renewal occurs in the marrow stem cell niche, a microenvironment that contains cells and secreted factors that promote appropriate renewal and differentiation of HSC. (wikipedia.org)
Eosinophils are derived from hematopoietic stem cells initially committed to the myeloid line and then to the basophil-eosinophil granulocyte lineage. (medscape.com)
In this review, we introduce the broad application of β-TCP in tissue engineering and discuss the different approaches that β-TCP scaffolds are customized, including physical modification (e.g., pore size, porosity and roughness) and the incorporation of metal ions, other materials (e.g., bioactive glass) and stem cells (e.g., mesenchymal stem cells). (frontiersin.org)
We subsequently discuss how β-TCP can regulate osteogenic processes to aid bone repair/healing, namely osteogenic differentiation of mesenchymal stem cells, formation of blood vessels, release of angiogenic growth factors, and blood clot formation. (frontiersin.org)
This study was designed to determine the in vivo performance of three different materials as scaffolds for dental pulp stem cells (DPSC) undergoing induced odontogenic differentiation. (scielo.br)
Although different stem cells, morphogens and scaffolds can be combined to simulate natural odontogenic regeneration, it is crucial to determine which options most closely replicate the characteristics of human dental tissues. (scielo.br)
Odontogenic capability: bone marrow stromal stem cells versus dental pulp stem cells. (scielo.br)
The odontogenic differentiation of human dental pulp stem cells on nanofibrous poly(L-lactic acid) scaffolds in vitro and in vivo. (scielo.br)
Differentiation was compared to mesenchymal stem cells derived from human bone marrow, which is known to differentiate into adipocyte, osteocyte, and chondrocyte lineages. (jove.com)
3D printed SiOC(N) ceramic scaffolds for bone tissue regeneration: improved osteogenic differentiation of human bone marrow‐derived mesenchymal stem cells. (appropedia.org)
The potential of intra-articular injection of chondrogenic-induced bone marrow stem cells to retard the progression of osteoarthritis in a sheep model. (sciendo.com)
2017). MMP-2 and MMP-14 Silencing Inhibits VEGFR2 Cleavage and Induces the Differentiation of Porcine Adipose-Derived Mesenchymal Stem Cells to Endothelial Cells. (sciendo.com)
Equine mesenchymal stem cells from bonemarrow, adipose tissue and umbilical cord:immunophenotypic characterization anddifferentiation potential. (sciendo.com)
Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stem Cells from Sheep: Culture Characteristics. (sciendo.com)
Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
Chapter 4 uses selective modification of our standard CG scaffold to probe the combined influences of structural and biochemical instructive cues to drive human bone marrow-derived mesenchymal stem cell (MSC) differentiation down tenogenic, osteogenic, and chondrogenic lineages respectively. (illinois.edu)
Together, these studies present the framework for building instructive biomaterials to regulate stem cell fate in the context of musculoskeletal tissue repair. (illinois.edu)
Here we document the effects of specified PEMF parameters over mesenchymal stem cells (MSC) chondrogenic differentiation. (nature.com)
Human mesenchymal stem cells (MSC) with the capacity to differentiate into osteoblasts provide potential for the development of novel treatment strategies, such as improved healing of large bone defects. (biomedcentral.com)
To compare the heterogeneities of human umbilical cord mesenchymal stem cells (HUCMSCs) derived from different donors and test their therapeutic variations in mouse liver fibrosis model. (researchsquare.com)
Bone marrow-derived mesenchymal stem/stromal cells (BMSCs) are fundamental to bone regenerative therapies, tissue engineering, and postmenopausal osteoporosis. (elsevierpure.com)
This directly contrasts the complex protein signature of real tissues and neglects many properties that contribute to the function of the organ via directing cell migration, stem cell fate, and organoid development. (umass.edu)
Compared to a non-tissue specific hydrogel, the marrow-customized hydrogel provides a better niche for bone marrow-derived mesenchymal stem cell differentiation and proliferation in response to soluble cues. (umass.edu)
Bone marrow mesenchymal stem cells (BMSCs) have potential therapeutic benefits for the treatment of endometrial diseases and injury. (biologists.com)
Decreased proliferation and Nanog expression in mouse embryonic stem (ES) cells, with increased erythroid differentiation (Chae et al. (stemcell.com)
In the present study, the potential of using exosomes isolated from adipose‑derived stem cells (ADSCs) as a therapeutic tool for reducing chronic inflammation and promoting chondrogenesis was investigated using patient‑derived primary cells. (spandidos-publications.com)
Adipose tissue-derived stem cells (ADSCs) have been characterized as having the ability to self-renew and differentiate into different connective tissue cells, including osteoblasts, adipocytes, chondrocytes and myocytes, under specific inductive stimuli ( 4 ). (spandidos-publications.com)
In total, 1-10% of nucleated cells in adipose tissue are ADSCs, whereas only 0.0001-0.01% of nucleated cells in bone marrow are stem cells ( 5 ). (spandidos-publications.com)
A more realistic service is offered by a few cord blood banks that preserve the stem cells from placental blood and placental tissue. (parentsguidecordblood.org)
Here are their technical properties: AECs have multipotent differentiation potential and expression of pluripotent stem cell specific transcription factors including Oct4 and Nanog. (parentsguidecordblood.org)
In summary, the placenta and other perinatal tissues are a rich source of stem cells and stem-like cells, which can potentially be banked in a similar manner to cord blood. (parentsguidecordblood.org)
Methods: Exosomes were isolated from mouse bone marrow stromal stem cells (BMSCs). (silverchair.com)
Morscheid S., Rey-Rico A., Schmitt G., Madry H., Cucchiarini M., Venkatesan J.K. Therapeutic Effects of rAAV-Mediated Concomittant Gene Transfer and Overexpression of TGF-β and IGF-I on the Chondrogenesis of Human Bone-Marrow-Derived Mesenchymal Stem Cells. (uniklinikum-saarland.de)
Stem cell research is, in part, a quest to understand cellular differentiation, the process by which a human being develops from one fertilized cell into a multicellular organism composed of over 200 different cell types - for example muscle, nerve, blood cell, or kidney. (jcpa.org)
Cellular differentiation begins with the fertilized egg which serves as the identifying characteristic of an embryonic stem cell. (jcpa.org)
The stem cells derived from the inner mass of a blastocyst lack the ability to form a fetus when implanted into a woman, but are self-renewing and can be maintained for long periods of time in the laboratory as undifferentiated stem cells. (jcpa.org)
In addition, specific proteins or biological substances can be added to these stem cell cultures to transform them in the laboratory into a large variety of specialized cell types, such as nerve, liver, muscle, bone, and blood cells. (jcpa.org)
Work with neural stem/ progenitor cells (NSPCs) has shown varied results in terms of both proliferation and differentiation depending on donor age and species, oxygen level and media conditions. (umd.edu)
However, limited studies have been conducted on the osteogenic capability of stem cells derived from BFP (BFPSCs). (utwente.nl)
The features of BFPSCs were compared with bone marrow-derived stem cells (BMSCs) as a well known cell source for bone tissue engineering. (utwente.nl)
These results define BFP as a new, rich, and accessible source of stem cells for tissue engineering purposes. (utwente.nl)
Here, we demonstrated the feasibility of using autologous urine-derived stem cells (USCs) seeded on small intestinal submucosa (SIS) to repair a urethral defect in a rabbit model. (biomedcentral.com)
Association of stromal cell-derived factor-1-3'A polymorphism to higher mobilization of hematopoietic stem cells CD34+ in Tunisian population. (cdc.gov)
Leukocytes are produced in stem cells in bone marrow. (lu.se)

By way of this review, a deeper understanding of the basic mechanisms of β-TCP for bone repair will be achieved which will aid in the optimization of strategies to promote bone repair and regeneration. (frontiersin.org)
Consequently, PLDL and PDL seemed to be promising scaffold candidates for odontogenic regeneration at least as HA-TCP, when they were applied with the DPSC induced for odontogenic differentiation. (scielo.br)
Nakashima M. Bone morphogenetic proteins in dentin regeneration for potential use in endodontic therapy. (scielo.br)
Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
The studies here use collagen-glycosaminoglycan (CG) scaffolds, regulatory compliant analogs of the native ECM that have been applied to the regeneration of dermis, peripheral nerve, and osteochondral tissue. (illinois.edu)
Research on Pulsed Electromagnetic Field Therapy for Osteoporosis shows, PEMF (Pulsed electromagnetic field) therapy enhances bone matrix density and promotes bone and cartilage regeneration. (earthpulse.net)
PEG is a versatile material that can be used for both cell encapsulation and tissue regeneration applications. (umass.edu)
The present study provided evidence in support for the use of patient‑derived exosomes, produced from ADSCs, for potential chondrogenic regeneration and subsequent amelioration of osteoarthritis. (spandidos-publications.com)

Results: LED produced in vitro increases of cell growth of 140-200% in mouse-derived fibroblasts, rat-derived osteoblasts, and rat-derived skeletal muscle cells, and increases in growth of 155-171% of normal human epithelial cells. (researchgate.net)
To address this question we first developed human oligonucleotide microarrays with 30.000 elements and then performed large-scale expression profiling of long-term expanded MSC and MSC during differentiation into osteoblasts. (biomedcentral.com)
This remodeling process occurs through bone cells, which are called osteoblasts. (cannasouth.co.nz)
Osteoblasts are responsible for the formation of bone and bone mineralization. (cannasouth.co.nz)
Within osteoblasts of bones are CB2 receptors , which are responsible for handling the building and breakdown of bone tissue6. (cannasouth.co.nz)
Osteoblasts were obtained from human bone marrow cells even in the absence of growth factors and showed a typical morphology. (bvsalud.org)

Osteogenic proliferation and differentiation of canine bone marrow and adipose tissue derived mesenchymal stromal cells and the influence of hypoxia. (sciendo.com)

Adipocytes in the accumulated fat tissues, especially around waist area and visceral organs, release several cytokines which reduce the sensitivity of several cell types to insulin leading to insulin resistant and type 2 diabetes [ 4 , 5 ]. (hindawi.com)

To create a favorable osteogenic environment, β-TCP scaffolds have been modified in a number of ways to boost bone healing, including modulating physical features (e.g., pore sizes, porosity and surface roughness), combining with ionic components, and the addition/delivery of growth factors. (frontiersin.org)
Chapter 5 utilizes a series of CG scaffolds that were inspired by elements of distinct components of orthopedic interfaces (cartilage, tendon/ligament, and bone) to examine the role of biomaterial physical properties (relative density, mineral content) on biasing MSC phenotype in the presence of mixed soluble signals to drive osteogenesis or chondrogenesis. (illinois.edu)
3D scaffolds with coincident gradients of pore anisotropy and mineral content to drive spatially-graded MSC differentiation were fabricated for the first time. (illinois.edu)
A major barrier to creating large tissue-engineered scaffolds is sustaining proper oxygenation. (umd.edu)
Here we demonstrate that 2D MSC expansion can be entirely bypassed by culturing freshly isolated bone marrow nucleated cells within 3D porous scaffolds in a perfusion-based bioreactor system. (unibas.ch)

Donor variation among patients, cell heterogeneity, and unpredictable capacity for differentiation reduce effectiveness of BMSCs for regenerative cell therapies. (elsevierpure.com)
Functional specialization among BMSCs populations may support their regenerative potential and therapeutic success by accommodating cell activities that promote skeletal tissue formation, homeostasis, and repair. (elsevierpure.com)
It has been found that some of the SVF cell types possess regenerative and anti-inflammatory potentials in damaged tissues due to their ability to secrete growth factors and anti-inflammatory molecules. (jcadonline.com)

Light-emitting diodes (LED), originally developed for NASA plant growth experiments in space show promise for delivering light deep into tissues of the body to promote wound healing and human tissue growth. (researchgate.net)
In vitro and in vivo (animal and human) studies utilized a variety of LED wavelength, power intensity, and energy density parameters to begin to identify conditions for each biological tissue that are optimal for biostimulation. (researchgate.net)
An odontogenic medium modified by the addition of recombinant human bone morphogenetic protein 2 was used in the experimental groups to induce differentiation. (scielo.br)
The goal of this protocol is to test the ability of progenitor cells derived from human perivascular adipose tissue to differentiate into multiple cell lineages. (jove.com)
Obtain a 500 milligram piece of Human Perivascular Adipose Tissue or PVAT from the operating room as described in the text protocol. (jove.com)
Macrophages play a significant role in many processes, such as the human immune function, parasite infection, and tissue remodeling by secreting cytokines and producing reactive oxygen and nitrogen intermediates. (frontiersin.org)
Comparison of human mesenchymal stromal cells from four neonatal tissues: Amniotic membrane, chorionic membrane, placental decidua and umbilical cord. (sciendo.com)
Human MSC are easy to isolate from small aspirate of bone marrow via their adherence ability. (biomedcentral.com)
Despite growing experience and knowledge concerning human MSC and their use in cell-based strategies, the molecular mechanisms that govern MSC self-renewal, expansion and multilineage differentiation are not well understood and remain an active area of investigation. (biomedcentral.com)
The cell surface glycoprotein CD24 exhibits the most prominent differential expression during osteogenic versus adipogenic differentiation of human BMSCs. (elsevierpure.com)
In undifferentiated human BMSCs, CD24 cell surface expression is variable among donors (range: 2%-10%) and increased by two to fourfold upon osteogenic differentiation. (elsevierpure.com)
Bioinformatics on human tissue histology identified 20 different cell-instructive peptides that represent the protein signature of bone marrow and can be incorporated into a hydrogel matched to the compressive modulus of marrow. (umass.edu)
Even low concentrates of cannabinoids have been shown to be effective at activating human osteoclasts, thus boosting bone density and offering therapeutic benefits to bone disease9. (cannasouth.co.nz)
CQ treatment decreased the virus-like titers of the spleen also, lung, thymus, and human brain tissue, as well as the oropharyngeal and cloacal swab examples likened to NDV-infected hens by itself at 3 dpi. (immune-source.com)
Objective: This study evaluated the osteogenic induction of human bone marrow cells by human recombinant bone morphogenetic protein-4 (rhBMP-4) and proteins released by Saos-2 (human osteosarcoma cell line). (bvsalud.org)
Study design: Osteoinduction in the presence or absence of Saos-2 and/or rhBMP-4 was evaluated in cultured human bone marrow cells. (bvsalud.org)
Conclusions: This study showed that an osteoblastic cell lineage may be obtained from human bone marrow derived from adherent cells, and that the presence of the rhBMP-4 seems to have an effect during the first stages of differentiation only. (bvsalud.org)
tissue identifi ed human adenovirus 36 (Adv 36) DNA. (cdc.gov)
Several human studies have shown a correlation of an- pose tissue deposits were caused by Adv 36 infection. (cdc.gov)

Hard tissue formation in a porous HA/TCP ceramic scaffold loaded with stromal cells derived from dental pulp and bone marrow. (scielo.br)

Intra-articular injection of expanded autologous bone marrow mesenchymal cells in moderate and severe knee osteoarthritis is safe: a phase I/II study. (sciendo.com)
Autologous chondrocytes implantation and osteochondral autograft transplantation are limited by scarce cartilage production, low proliferative capacity of chondrocytes, chondrocyte de-differentiation and complications due to donor site morbidity 5 . (nature.com)
Autologous USCs can be used as an alternative cell source for cell-based tissue engineering for urethral reconstruction. (biomedcentral.com)
tibodies to Adv 36, and infected children had higher body In February 2000, he underwent autologous bone marrow mass index z-scores than uninfected children ( 5 ). (cdc.gov)

Title: Purification and characterization of a novel alginate lyase from a marine streptomyces species isolated from seaweed Abstract: Alginate, a natural polysaccharide derived from brown seaweed, is finding multiple applications in biomedicine via its transformation through chemical, physical, and, increasingly, enzymatic processes. (up.pt)
abstract = "Adipose tissues hold great promise in bone tissue engineering since they are available in large quantities as a waste material. (utwente.nl)

An increase in adipogenic differentiation levels was accompanied by an upregulation of the expression levels of several adipogenic genes including peroxisome proliferator-activated receptor gamma ( PPAR γ ), adipocyte protein 2 ( AP2 ), adipose tissue-specific secretory factor ( ADSF ), sterol regulatory element-binding protein 1C ( SREBP1C ), lipoprotein lipase ( LPL ), adiponectin ( ADIPOQ ), and glucose transporter type 4 ( GLUT4 ) [ 8 , 9 , 11 ]. (hindawi.com)

Thus, it is thought that BMAT results from preferential MSC differentiation into the adipocyte, rather than osteoblast, lineage in the setting of osteoporosis. (wikipedia.org)
BMAT is thought to result from preferential MSC differentiation into an adipocyte, rather than osteoblast lineage in osteoporosis based on the inverse relationship between bone and BMAT in bone-fragile osteoporotic states. (wikipedia.org)
Additionally, we were able to reconstruct the three developmental phases during osteoblast differentiation: proliferation, matrix maturation, and mineralization, and illustrate the activation of the SMAD signaling pathways by TGF-β2 and BMPs. (biomedcentral.com)

The epidermis is a stratified, squamous epithelium that consists primarily of keratinocytes in progressive stages of differentiation from deeper to more superficial layers. (medscape.com)

Strikingly, FACS sorted CD24pos cells exhibit delayed mineralization and reduced capacity for adipocyte differentiation. (elsevierpure.com)
Promotes differentiation and mineralization of MC3T3-E1 osteoblastic cells (Kanazawa et al. (stemcell.com)

Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the presence of cells with characteristics similar to bone marrow-derived Langerhans cells juxtaposed against a backdrop of hematopoietic cells, including T-cells, macrophages, and eosinophils. (medscape.com)
Therefore, in addition to epidermal Langerhans cells, other potential cellular origins for LCH include dermal langerin + dendritic cells, lymphoid tissue-resident langerin + dendritic cells, and monocytes that can be induced by local environmental stimuli to acquire a Langerhans cell phenotype. (medscape.com)
Dendritic cells are present in the skin (as Langerhans cells), lymph nodes, and tissues throughout the body. (msdmanuals.com)
The epidermis is derived primarily from surface ectoderm but is colonized by pigment-containing melanocytes of neural crest origin, antigen-processing Langerhans cells of bone marrow origin, and pressure-sensing Merkel cells of neural crest origin. (medscape.com)

Bone marrow transplantation 2009 Sep 44 (5): 273-8. (cdc.gov)
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2012 Jan 18 (1): 100-5. (cdc.gov)
In SCIDs bone marrow transplantation is the most effective treatment. (lu.se)

We monitored these cells during their expansion ex vivo with respect to proliferation kinetics, surface marker profile and differentiation potential. (biomedcentral.com)

During aging, bone quantity declines and fat redistributes from subcutaneous to ectopic sites such as bone marrow, muscle, and liver. (wikipedia.org)

Nonpathologic functions of eosinophils and the cationic enzymes of their granules include mediating parasite defense reactions, allergic response, tissue inflammation, and immune modulation. (medscape.com)
Macrophages are phagocytes found in tissues and maintain tissue homeostasis, regulate inflammation, and play a significant role in host protection. (frontiersin.org)
Activation of macrophages into different states is a finely tuned process essential for proper resolution of inflammation and tissue repair. (biomedcentral.com)
Nowadays, the immune system is thought to be activated by "danger signals" which are relevant not only to the induction of inflammation and immune responses but also to the activation of counter regulatory (anti-inflammatory/modulatory) mechanisms required to shutdown inflammation and allow tissue healing. (frontiersin.org)

Hematopoietic cells (also known as blood cells) reside in the bone marrow along with BMAds. (wikipedia.org)

We show that a population of multipotent progenitors can be derived successfully from perivascular adipose tissue from patients with cardiovascular disease. (jove.com)
Eosinophilic differentiation occurs in the bone marrow from myeloid progenitors through the actions of GM-CSF, IL-3, and IL-5. (medscape.com)
thymus from marrow-derived progenitors circulating in the blood. (lu.se)

First, it was tested whether patient‑derived ADSCs could differentiate into chondrogenic and osteogenic lineages. (spandidos-publications.com)
However, it can be challenging to differentiate when they are connected with wounded tissue, opposed to when they instruct tissue-specific progenitor cells responsible for the redevelopment of damaged tissue. (techscience.com)

They have a higher odontogenic differentiation capacity compared to other cell groups due to their content of specific progenitor cells. (scielo.br)

Monocytes in the circulation are precursors to tissue macrophages. (msdmanuals.com)
Monocytes migrate into tissues, where over approximately 8 hours, they develop into macrophages. (msdmanuals.com)

Induces upregulation of the pluripotency network genes (Klf4, Klf2, Nanog, Oct4, Myc, Sox2) and epigenetic-associated proteins (Dnmt3a, Mbd3) in mouse ES cells, and inhibits retinoic acid-induced differentiation (Adamo et al. (stemcell.com)

Israeli policy is based on the belief that such a pre-embyro does not confer personhood and that many therapeutic applications can be derived from such research. (jcpa.org)
The use of tissue-engineered grafts to repair urethral defects is considered to be an approach with therapeutic potential. (biomedcentral.com)

In this study, we investigated the role of autophagy and apoptosis in Newcastle disease virus (NDV)-infected chicken cells and tissues. (immune-source.com)
In bottom line, we confirmed that autophagy brought about by genotype VII NDV infections was important for virus-like replication, NDV-induced apoptosis, and cell survival in buy 480-11-5 chicken cells and tissues. (immune-source.com)

Olfactomedin 1 (Olfm1) and the closely related genes Olfactomedin 2 (Olfm2) and Olfactomedin 3 (Olfm3) show overlapping expression patterns demonstrating preferential expression in the developing and adult neuronal tissues. (nih.gov)
Retrieved from http://www.mayoclinic.org/healthy-lifestyle/adult-health/in-depth/bone-health/art-20045060. (cannasouth.co.nz)

hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
The results showed that MSC did not alter their osteogenic differentiation capacity, surface marker profile, and the expression profiles of MSC during expansion. (biomedcentral.com)
As compared to 2D-expanded MSC (control), those derived from 3D-perfusion culture after the same time (3 weeks) or a similar extent of proliferation (7-8 doublings) better maintained their progenitor properties, as assessed by a 4.3-fold higher clonogenicity and the superior differentiation capacity towards all typical mesenchymal lineages. (unibas.ch)

BMAT, by its "specific marrow location, and its adipocyte origin from at least LepR+ marrow MSC is separated from non-bone fat storage by larger expression of bone transcription factors", and likely indicates a different fat phenotype. (wikipedia.org)
While PEG hydrogels can easily be tuned to mimic tissue mechanics, most PEG platforms contain between 1-3 biofunctional peptide moieties, chosen to maximize cell phenotype, rather than represent features of specific tissues. (umass.edu)

The HUCMSCs derived multiple donors were performed comprehensively analysis and potent assays including expressions of surface markers, viability, growth curve, karyotype analysis, tumorigenicity, differentiation potentials, and immune regulation capability. (researchsquare.com)
The HUCMSCs derived multiple donors kept a high consistency in surface marker expressions, viability, growth curve, tumorigenicity in nude mic, but had robust heterogeneities in differentiation potentials and immune regulations. (researchsquare.com)

Over the past 2 decades, substantial progress has been made in understanding the mechanisms of eosinophil production, eosinophil programmed cell death (apoptosis), and how eosinophil immunology contributes to both host defenses against infections and to tissue damage within the host in cases of allergic and autoimmune diseases. (medscape.com)
After one hour, no visible tissue pieces should be present and the solution will appear as a cloudy cell suspension. (jove.com)
Polyethylene glycol (PEG) hydrogels are tunable cell culture platforms that recapitulate tissue geometry, water content, and bulk modulus. (umass.edu)
Here, I developed a new class of tissue-specific PEG-based materials and provided biocompatible strategies to improve the user handling and cell viability post-encapsulation when using these hydrogels. (umass.edu)
Here, I took a tissue-centric approach to create three-dimensional cell culture microenvironments using a simple base set of materials. (umass.edu)
I also highlighted how tissue-inspired hydrogels can improve in vitro studies of cell-cell and cell-matrix interactions. (umass.edu)
they are derived from the cell membrane during endocytic internalization. (spandidos-publications.com)
Enhanced expression of IL-6, IGF-1, TGF-β, and VEGF has also been observed in LC treated BMSCc+ groups, suggested the cardiac differentiation of BMSCc+, and can be utilized in tissue engineering for cardiac cell therapy. (techscience.com)
The immune system is constituted by a very complex network of cells, tissues, and organs that through soluble factors and direct cell-to-cell contacts interact among themselves and with cells belonging to other (organ) systems. (frontiersin.org)
The classical tissue engineering paradigm integrates a cell source, support structure, and suitable chemical and physical factors to functionally regenerate lost tissue. (umd.edu)
A cell-based tissue-engineered urethra may be an alternative for patients who have complicated long strictures and need urethral reconstruction. (biomedcentral.com)
Another critical element required for successful urethral tissue engineering is the cell source. (biomedcentral.com)
VM), showed that the recovery of motor functions induced implanted either (1) as a solid piece in the lateral ven- by the grafted fetal dopamine neurons was well cor- tricle6 or a cortical cavity8 adjacent to the denervated related with the extent of graft-derived reinnervation caudate-putamen, or (2) as a crude cell suspension of the host caudate-putamen. (lu.se)
Mantle cell lymphoma (MCL) is a lymphoproliferative disorder derived from a subset of naive pregerminal center cells localized in primary follicles or in the mantle region of secondary follicles. (medscape.com)
Although some antigens (Ags) can stimulate the immune response directly, T cell-dependent acquired immune responses typically require antigen-presenting cells (APCs) to present antigen-derived peptides within major histocompatibility complex (MHC) molecules. (msdmanuals.com)

Use of Bone Marrow Aspirate Concentrate (BMAC) Associated with Hyperbaric Oxygenation Therapy in Maxillary Appositional Bone Reconstruction. (mdpi.com)
Objectives: The objective of this study was to evaluate bone reconstruction using xenograft alone and associated with bone marrow aspirate concentrate (BMAC) and hyperbaric oxygen therapy. (mdpi.com)

Group 1 (G1)-xenogeneic bone block combined with BMAC ( n = 8), and Group 2 (G2)-xenogeneic bone block combined with BMAC and hyperbaric oxygenation ( n = 8). (mdpi.com)

Macrophages are phagocytic cells present in tissues throughout the body. (msdmanuals.com)

Visceral abdominal fat (VAT) is a distinct type of WAT that is "proportionally associated with negative metabolic and cardiovascular morbidity", regenerates cortisol, and recently has been tied to decreased bone formation Both types of WAT substantially differ from brown adipose tissue (BAT) as by a group of proteins that help BAT's thermogenic role. (wikipedia.org)
In addition to these cytokines, eosinophils are a source of several cationic proteins that also contribute to the immunologic responses against infectious disease agents and to tissue damage in allergic and autoimmune diseases. (medscape.com)
Bone morphogenetic proteins (BMP), known as active components of odontogenic differentiation and tooth development, have been used as a growth factor in an appropriate medium. (scielo.br)
The tendon-bone junction (TBJ) is a classic example of such an interface, and contains overlapping patterns of growth factors, extracellular matrix (ECM) proteins, and mineral content that serve to minimize stress concentrations and enable normal locomotion. (illinois.edu)
Cells derived from bone marrow can undergo osteoinduction in vitro in the absence of osteoinductive factors such as bone morphogenetic proteins. (bvsalud.org)

Adipose tissue is a loose connective tissue composed of cells supported by an intracellular matrix as well as by vascular, lymphatic, and neural networks. (jcadonline.com)
Melanocytes, derived from neural crest cells, primarily function to produce a pigment, melanin, which absorbs radiant energy from the sun and protects the skin from the harmful effects of UV radiation. (medscape.com)

Modern tissue engineering requires the design of new biomaterials permitting simultaneous control of microstructural, mechanical, and biochemical properties in a spatially-defined manner. (illinois.edu)
Ultimately, this work can be applied to any tissue or organ, creating a new class of designer biomaterials that can be used to elucidate ECM-driven disease mechanisms that currently lack appropriate in vitro models. (umass.edu)

In comparison, the inhibition of autophagy reduced the phrase amounts of ATG protein in the tissue targeted by NDV. (immune-source.com)

Anatomy56

Organisms13

Diseases32

Chemicals and Drugs60

Analytical, Diagnostic and Therapeutic Techniques and Equipment47

Phenomena and Processes52

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science3

Named Groups1

Health Care1

MSCs45

Stem52

Regeneration8

Osteoblasts6

Proliferation and differentiation1

Adipocytes1

Scaffolds5

Regenerative3

Human19

Dental pulp1

Autologous4

ABSTRACT2

Adipogenic1

Osteoblast3

Stages of differentiation1

Mineralization2

Langerhans4

Transplantation3

Kinetics1

Liver1

Inflammation4

Hematopoietic1

Progenitors3

Differentiate2

Progenitor cells1

Monocytes2

Induces1

Therapeutic2

Cells and tissues2

Adult2

Capacity3

Phenotype2

Donors2

Cell15

Aspirate concentrate2

BMAC1

Macrophages1

Proteins5

Neural2

Biomaterials2

Protein1