Bone marrow derived cells hematopoietic stem bone marrow transplantation. Medical search. Frequent questions

Cytomegalovirus reactivation is still a critical concern following allogeneic hematopoietic cell transplantation, and cellular immune reconstitution of cytomegalovirus-specific cytotoxic T-cells is necessary for the long-term control of cytomegalovirus reactivation after allogeneic hematopoietic cell transplantation. (nature.com)
In allogeneic hematopoietic cell transplantation (allo-HCT), a person's stem cells are replaced with healthy new stem cells. (mskcc.org)

CPT Code 38204 CPT 38204 describes the management of recipient hematopoietic progenitor cell donor search and cell acquisition. (codingahead.com)
We showed that wild-type Hematopoietic Stem and Progenitor Cell (HSPC) transplant in the mouse model of cystinosis, the Ctns -/- mice, led to the abundant tissue integration of bone marrow-derived cells, significant decrease of tissue cystine accumulation, and long-term preservation of the kidney, eye and thyroid function and structure. (ucsd.edu)
Smart Immune announced in October 2022 that SMART102, a human T-cell progenitor cell injection derived from cord blood using the ProTcell platform, has entered clinical testing with the first adult patient treated. (smart-immune.com)
Inducible nitric oxide synthase (iNOS) is a novel negative regulator of hematopoietic stem/progenitor cell trafficking. (livedna.net)
We know that innate immune cells are required for blastema progenitor cell formation, but are lacking an understanding of the immune cell processes and functions that are required for inducing and maintaining these progenitors cells. (lu.se)

Likewise, many children are now surviving hematopoietic stem-cell transplantation (HSCT) (see related histology slide below) and require structured long-term follow-up care. (medscape.com)
Donor cell-derived leukaemia (DCL) is an uncommon complication of allogeneic hematopoietic stem cell transplantation (HSCT). (lidsen.com)
HSCT is the transplantation of stem cells, usually derived from the bone marrow, peripheral blood, or umbilical cord blood, to produce additional normal healthy blood cells, including T-cells. (smart-immune.com)
HSCT may be autologous (the patient's stem cells are used) or allogeneic (the stem cells come from a donor). (smart-immune.com)
Smart Immune's ProTcell platform is designed to reconstitute a T-cell compartment in around three months , compared with 12-18 months through the standard HSCT approach, significantly reducing the time to full immune recovery and possibly opening access to allogeneic medicine to more patients. (smart-immune.com)
She is currently Research Scientist at Stanford University, where she is developing innovative cell therapy approaches to address neuropathic lysosomal storage diseases (LSDs) using hematopoietic stem cell transplantation (HSCT) and genome editing. (stanford.edu)
Background: Mesenchymal stem cells (MSCs) are increasingly considered to be used as biological immunosuppressants in hematopoietic stem cell transplantation (HSCT). (uni-hannover.de)
In the early reconstitution phase following HSCT, natural killer (NK) cells represent the major lymphocyte population in peripheral blood and display graft-vs-leukemia (GvL) effects. (uni-hannover.de)
The functional interactions between NK cells and MSCs have the potential to influence the leukemia relapse rate after HSCT. (uni-hannover.de)
Following allogeneic hematopoietic stem cell transplantation (HSCT), interferon (IFN)-γ levels in the recipient's body can strongly influence the clinical outcome. (uni-hannover.de)
2, 3] This has also extended into the therapeutic spectrum, with new immunosuppressive regimens and use of hematopoietic stem cell transplantation (HSCT). (medscape.com)
For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)

Three months after osteoblast engraftment (1.5-2.0% donor cells), representative specimens of trabecular bone showed histologic changes indicative of new dense bone formation. (nih.gov)
Starting with cell source, choice of donor and recipient, as well as isolation methods, we will then discuss existing expansion protocols (two-/three-dimensional cultivation, basal medium, medium supplements, static/dynamic conditions, and hypoxic/normoxic conditions) and influence of these strategies on the cell functionality after implantation. (frontiersin.org)
Therapeutic Candidate or Device OSSM007: cryopreserved, interferon-gamma-primed bone marrow mesenchymal stem cells (BM-MSC) Indication acute Graft versus host disease (aGVHD) resulting from hematopoietic cell transplantation Therapeutic Mechanism Immunomodulation of host-reactive T cells to induce operational tolerance of donor HSC-derived lymphocytes through direct cell-to-cell contact and secreted paracrine factors. (ca.gov)
Subsequent transplantation of the cells into lethally irradiated mice results in engraftment of the animals with donor haematopoietic tissue containing the bacterial gene. (nature.com)
T-cell therapies can be manufactured from different materials (mature T-cells, stem cells, possibly induced pluripotent stem cells) and from different sources (the patient or a donor). (smart-immune.com)
This study aims to monitor the long-term health of patients who have received a donor stem cell transplant from the NIH Clinical Center. (nih.gov)
Donor CTLA-4 genotype influences clinical outcome after T cell-depleted allogeneic hematopoietic stem cell transplantation from HLA-identical sibling donors. (cdc.gov)

She underwent hematopoietic stem cell transplantation which uses stem cells derived from bone marrow, peripheral blood, or umbilical cord blood. (turnto23.com)
Mature B-cell-derived cells progressively accumulate in the patients' peripheral blood, lymphatic tissues, and bone marrow. (ovgu.de)
They are found primarily in the bone marrow and also in small numbers in the peripheral blood. (lecturio.com)
Umbilical cord-derived stem cells are the youngest cells available for transfusion and yet their uptake lags behind bone marrow and peripheral blood-derived HSCs. (bioinformant.com)
We have tested the feasibility of using the granulocyte colony-stimulating factor (G-CSF), which is known to mobilize hematopoietic stem cells (HSCs) from the bone marrow into the peripheral blood, as a therapeutic agent for AD. (silverchair.com)
These drugs strongly inhibit HIV-1 replication in a GFP indicator T cell line and peripheral blood mononuclear cells (PBMC). (biomedcentral.com)
Citation: Mera T, Heimfeld S, Faustman DL (2014) The Spleen Contributes Stem Cells to Peripheral Blood Stem Cell Transplants. (fliphtml5.com)
G-CSF was found to mobilize both CD34+ stem cells (p=0.02)and even more dramatically mobilize Hox11+ splenic stem cells (p=0.000013) into the peripheral blood. (fliphtml5.com)
TheIntroduction later step is unique to splenic function since splenectomy results in similar accumulations of naïve B cells, reduction of memory B cells and Treatment of malignancies with allogeneic peripheral blood stem well-known susceptibilities to select infections [12]. (fliphtml5.com)
Interestingly, thiscell transplants (PBSCTs) from donors given granulocyte-colony- immature peripheral phenotype was similar to bone marrow transplantsstimulating-factor (G-CSF) has decreased relapse rates and improved before G-CSF. (fliphtml5.com)
More recent studies have uncovered links between FOXP3 dysfunction and an inflammatory helper T-cell subtype (Th17), as well as loss of peripheral B-cell tolerance. (medscape.com)
The CXCL12-3'A allele is associated with a higher mobilization yield of CD34 progenitors to the peripheral blood of healthy donors for allogeneic transplantation. (cdc.gov)

Thus, allogeneic bone marrow transplantation can lead to engraftment of functional mesenchymal progenitor cells, indicating the feasibility of this strategy in the treatment of osteogenesis imperfecta and perhaps other mesenchymal stem cell disorders as well. (nih.gov)
Decreased engraftment rates and the low cell dose available for transplantation are limitations that are preventing umbilical cord blood-derived cells from reaching their full potential. (bioinformant.com)
Angiocrine is developing a cell therapy aimed to improve the availability and engraftment of blood stem cell transplants for cancer patients who have had their cancerous bone marrow removed by chemotherapy. (ca.gov)
Improved engraftment and therapeutic efficacy by human genome-edited hematopoietic stem cells with Busulfan-based myeloablation. (stanford.edu)
Proof-of-concept studies using human genome-edited hematopoietic stem cells have been hindered by the low efficiency of engraftment of the edited cells in the bone marrow and their modest efficacy in the CNS. (stanford.edu)
Compared with sub-lethal irradiation, Busulfan conditioning enhanced the engraftment of edited CD34+ cells in the bone marrow, as well the long-term homing and survival of bone-marrow-derived cells in viscera, and in the CNS, resulting in higher transgene expression and biochemical correction in these organs. (stanford.edu)
He has also much experience in context of homing, mobilization, and engraftment of hematopoietic stem cells and cancer research. (livedna.net)
The presence of inflammatory cytokines after high-dose chemotherapy leads to proliferation and activation of MDSCs originating from autologous hematopoietic progenitors at the time of engraftment. (biomedcentral.com)

Once inside the body the vector introduces the therapeutic gene into host cells, and the protein encoded by the newly inserted gene is then produced by the body's own cells. (wikipedia.org)
Despite improved therapeutic approaches, allogeneic hematopoietic stem cell transplantation remains the only curative treatment option. (ovgu.de)
Organ transplantations have become the therapeutic option of choice for many individuals with end-stage organ failure. (lecturio.com)
Therapeutic Candidate or Device The therapeutic candidate is a patient specific (autologous) induced pluripotent stem cell derived retinal pigment epithelium (AiPSC-RPE) product. (ca.gov)
Therapeutic Candidate or Device Allogeneic iPSC derived dopamine progenitors delivered to the brain of Parkinson's disease patients Indication Idiopathic Parkinson's disease Therapeutic Mechanism The cellular product reconstitutes dopaminergic neuron circuits lost owing to the disease Unmet Medical Need There are currently disease modifying therapies. (ca.gov)
Therapeutic Candidate or Device Autologous hematopoietic stem cells transduced with a HexA/HexB expressing lentiviral vector Indication Tay-Sachs disease Therapeutic Mechanism The transplanted gene modified autologous hematopoietic stem cells will engraft in the bone marrow and start producing HexA/HexB expressing immune progeny. (ca.gov)
Therapeutic Candidate or Device Autologous blood stem cells edited to restore iduronidase expression Indication Severe Mucopolysaccharidosis Type 1 (MPS1/ Hurler's syndrome) Therapeutic Mechanism Autologous blood stem cells undergo genome editing to restore the production of the missing enzyme. (ca.gov)
Therapeutic Candidate or Device Hematopoietic stem and progenitor cells collected from X-CGD patients modified with a highly regulated lentiviral vector Indication X-linked Chronic Granulomatous Disease Therapeutic Mechanism Lentiviral vector (LV) modification of autologous hematopoietic stem and progenitor cells (HSPCs) to restore physiologic gp91phox expression. (ca.gov)
Orthotopic liver transplantation is a beneficial therapeutic option, which shows that restoration of only a fraction of whole-body BCKD enzyme activity is therapeutic. (stanford.edu)
Human rhabdomyosarcoma cells express functional pituitary and gonadal sex hormone receptors: Therapeutic implications. (livedna.net)
Umbilical cord derived (UC)-MSCs might be an alternative source of therapeutic MSCs. (uni-hannover.de)

We are developing a multi-systemic strategy consisting of transplantation of autologous hematopoietic stem cells genetically modified ex vivo using lentivirus vectors. (ucsd.edu)
Autologous hematopoietic stem cell transplantation using genome-edited cells can become a definitive therapy for hematological and non-hematological disorders with neurological involvement. (stanford.edu)

Despite almost 50 years of research and over 20 years of preclinical and clinical studies, the question of curative potential of mesenchymal stem/stromal cells (MSCs) is still widely discussed in the scientific community. (frontiersin.org)
In this mini review, we will discuss point by point possible pitfalls in the production of human MSCs for cell therapies, without consideration of material-based applications. (frontiersin.org)
Only a careful consideration and standardization of all pretreatment processes/methods for the different applications of MSCs will ensure robust and reproducible performance of these cell populations in the different experimental and clinical settings. (frontiersin.org)
Mesenchymal stem/stromal cells (MSCs) have the capacity to differentiate into cells and tissues of one germ layer, here the mesodermal lineage, and are consequently multipotent. (frontiersin.org)
During the era (2008-2011) at University of Veterinary Medicine Hannover, he gained much experience in experimental surgery, CT imaging and regenerative medicine using adipose derived-MSCs. (livedna.net)
He has also gained salient experience in various experimental setups using hematopoietic stem cells, bone marrow, cord blood-derived and adipose tissue-derived MSCs, very small embryonic-like stem cells, leukemic cells, and germline-derived cells. (livedna.net)
While the common cell surface markers such as CD146, CD271 and PDGFRa used for isolating MSCs were not detected, LIFR+PDGFRB+ were identified to be specific markers of MSCs as the early progenitors. (bjmu.edu.cn)
In vivo transplantation demonstrated that LIFR+PDGFRB+CD45-CD31-CD235a- MSCs could form bone tissues and reconstitute the hematopoietic microenvironment (HME) effectively in vivo. (bjmu.edu.cn)
Stromal cells with CFU-F activity and multi-lineage differentiation ability in vitro were traditionally identified as MSCs. (bjmu.edu.cn)
The explicit alteration of fresh cells following ex vivo expansion, as well as the demonstration of in vivo niche for the MSCs in this work, is critical for guiding us to identify optimal culture conditions for maintaining the original characteristics of in vivo MSCs. (bjmu.edu.cn)
This work not only expands our understanding of human bone marrow MSCs, but also provides great hints for further expansion of primary MSCs in vitro, which would be great help for MSCs-based bone regeneration. (bjmu.edu.cn)
Until date, MSC-NK cell interaction studies are largely focussed on bone marrow derived (BM)-MSCs. (uni-hannover.de)
Thus, we studied the interaction of UC-MSCs with unstimulated allogeneic NK cells.Results: UC-MSCs could potently suppress NK cell cytotoxicity in overnight cultures via soluble factors. (uni-hannover.de)
Maximal PGE2 release involved IL-1β priming of MSCs after close contact between the NK cells and UC-MSCs. (uni-hannover.de)
However, transplanting other than hematopoietic stem and progenitor cells is still limited to a few applications, and it mainly applies to mesenchymal stromal cells (MSCs) isolated from bone marrow. (hindawi.com)
But research progressed and different trials explore the clinical potential of human MSCs isolated from bone marrow but also from other tissues including adipose tissue. (hindawi.com)
Recently, MSCs isolated from bone marrow (bmMSCs) were shown to be a blend of distinct cells and MSCs isolated from different tissues show besides some common features also some significant differences. (hindawi.com)
We therefore briefly discuss differences found in subsets of human bmMSCs and in MSCs isolated from some other sources and touch upon how this could be utilized for cell-based therapies. (hindawi.com)
The MSCs have been described for the first time as colony forming fibroblasts (CFU-F), a rare population of cells residing in the bone marrow of guinea-pigs or mice [ 1 , 2 ]. (hindawi.com)
Human bmMSCs were described in the late nineties as well [ 6 ] and at the same time a breakthrough study investigated the expression of typical cell surface markers and the proliferation and differentiation properties of human MSCs in more detail [ 7 ]. (hindawi.com)
Overview of studies published regarding MSCs using the term "stem cell" or "stromal cell" in the last 20 years accessed by a web search in July 2015 (Google Scholar). (hindawi.com)
It seems that the term "stem cell" became more popular although the "stemness" was only shown in a more strict sense for MSCs involved in osteogenesis and bone repair. (hindawi.com)
When the biological properties of MSCs were explored in more detail, questions arose whether these cells met the criterion of a true stem cell [ 8 ]. (hindawi.com)
Nowadays, experts agree that MSCs may generate upon appropriate stimulation quite different mature cells including osteoblasts, chondrocytes, tenocytes, adipocytes, smooth muscle cells, and stromal cells of the bone marrow [ 9 ]. (hindawi.com)
Expansion of MSCs was shown to be limited to a few passages of in vitro culture and the cells underwent replicative senescence [ 11 ]. (hindawi.com)
Therefore, available in vitro protocols for expansion of MSCs do not yield true stem cells. (hindawi.com)
MSCs were also investigated for stem cell qualities in vivo. (hindawi.com)
Mesenchymal stem cells (MSCs) are ASCs, and were first described in 1966 by Friedenstein et al. (bvsalud.org)
MSCs can be isolated from different locations, such as bone marrow, umbilical cord, placenta, adipose and dental tissues. (bvsalud.org)

Umbilical cord blood (UCB) is a valuable source of hematopoietic stem cells (HSCs) and potential alternative for bone marrow transplantation for patients who lack human leukocyte antigen (HLA)-matched donors. (wjgnet.com)
Umbilical cord blood (UCB) has been an accepted source of hematopoietic stem cells (HSC) for transplantation for more than 30 years. (bioinformant.com)

They create cells that range from muscle cells to brain cells and they can, in some cases, fix damaged tissues. (centenary.org.au)
Stem cells can develop into any type of cell in the body, making them valuable for repairing damaged tissues and organs. (centenary.org.au)
The adult cells are found in small numbers in most tissues, such as bone marrow or fat. (centenary.org.au)
Stem cell therapy has also shown potential for regenerating damaged tissues, promoting healing, and reducing inflammation. (mespoir.com)
Inspired from developmental processes, human mesenchymal cell lines can be programmed to form cartilage, bone and bone marrow tissues in vitro and in vivo. (lu.se)
Overview of Transplantation Transplantation is the removal of living, functioning cells, tissues, or organs from the body and then their transfer back into the same body or into a different body. (msdmanuals.com)
Researchers hope to use stem cells to repair or replace cells or tissues damaged or destroyed by such disorders as Parkinson disease, diabetes, and spinal injuries. (msdmanuals.com)
Due to the ability to self-renew and to differentiate into cells that are found throughout the body, there is a great interest in using stem cells for the regeneration of injured tissues as well as to develop tissue-engineered implants and bio-hybrid organs, in order to restore tissue function. (bvsalud.org)
In human postnatal dental tissues, five main sources of DSCs have been identified: dental pulp stem cells (DPSCs), 11 stem cells from human exfoliated deciduous teeth (SHEDs), 12 periodontal ligament stem cells (PDLSCs), 13 dental follicle stem cells (DFSCs) 14 and stem cells from apical papilla (SCAPs). (bvsalud.org)

In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to graft versus host disease (GVHD) and autoimmunity. (medscape.com)
Our hypothesis about a splenic stem cell contributionor maintained survival compared to bone marrow transplants, to PBSCT also derives from the observation that G-CSF mobilizationsalthough graft versus host disease (GVHD) still occurs [1]. (fliphtml5.com)

Its role is to educate T-cell progenitors to become mature, specialized T-cells. (smart-immune.com)

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2012 Jan 18 (1): 100-5. (cdc.gov)

We aim to understand the composition and alteration of the bone marrow microenvironment in myelofibrosis. (lls.org)

Non-reproducible treatment outcomes or even absence of treatment effects in comparison to control groups challenges the potential of these cells for routine application both in tissue engineering and in regenerative medicine. (frontiersin.org)
Cell therapy technologies overlap with those of gene therapy, cancer vaccines, drug delivery, tissue engineering and regenerative medicine. (univation.co)
Transplantation is a procedure that involves the removal of an organ or living tissue and placing it into a different part of the body or into a different person. (lecturio.com)
Both solid organs and bone marrow Bone marrow The soft tissue filling the cavities of bones. (lecturio.com)
Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. (lecturio.com)
Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells. (lecturio.com)
Transplanted tissue may be cells (e.g., hematopoietic stem cells Hematopoietic stem cells Progenitor cells from which all blood cells derived. (lecturio.com)
While a handful of companies are now developing cord blood and tissue-derived cell therapeutics, it will likely take several years for these products to reach commercialization. (bioinformant.com)
PMF is a stem cell-derived blood malignancy with the characteristics of too many cells in the blood and a large amount of scar tissue formation (fibrosis) in the bone marrow. (lls.org)
An infectious retrovirus vector has been used to transfer a bacterial gene encoding resistance to the neomycin analogue G418 into pluripotent haematopoietic stem cells present in explanted murine bone marrow tissue. (nature.com)
We are also investigating the mechanisms of tissue repair by bone marrow-derived stem cells after hematopoietic stem cell transplantation in the context of a non-hematopoietic disease. (ucsd.edu)
The study of the mechanism by which Ctns-expressing HSPCs led to tissue repair in the Ctns -/- mice showed that a large subset of HSPCs differentiated into macrophages that can transfer cystinosin-bearing lysosomes to the deficient host cells via long tubular extensions known as tunneling nanotubes (TNTs). (ucsd.edu)
Another critical question about the MSC-based bone tissue engineering is the necessity to expand the cells prior to use. (bjmu.edu.cn)
The use of ASCs in regenerative medicine and tissue engineering research has important advantages in comparison with ESCs, since there are no ethical complications and the process of differentiation of these cells is better controlled. (bvsalud.org)
In explant method, the dental tissue is placed on a plastic surface and the cells migrate out from the tissue fragment adhering to culture flasks or dishes ( Figure 1 ). (bvsalud.org)

We previously established a direct single-cell analysis to simultaneously identify and quantify in vivo CMV-CTL clones after allo-HCT 9 , 10 . (nature.com)
Last, we will interfere with the identified (metabolic) mechanisms in vivo using a preclinical model and evaluate the impact on the CLL cell metabolism, T cell compartment, and response to therapies. (ovgu.de)
Because allogeneic transplants are associated with high risks of mortality and morbidity, we developed an autologous transplantation strategy of HSPCs genetically modified ex vivo to express a functional CTNS gene using a SIN-lentivirus vector. (ucsd.edu)
We also showed for the first time that TNTs could cross the thick, dense and stiff renal tubular basement membrane in vivo and transfer cystinosin-bearing lysosomes to the proximal tubular cells, providing a mechanism underlying the long-term kidney preservation after HSPC transplantation in the Ctns -/- mice. (ucsd.edu)
Research Objective We will develop a biotherapeutic/monoclonal antibody that blocks the growth of human AML cancer stem cells in vitro and in vivo. (ca.gov)
Dr. Abdelbaset-Ismail has developed remarkable technical skills in cell transplantation for various animal models, molecular characterization, propagating cells in vitro and in vivo. (livedna.net)
We found that many bone marrow stromal cells have the ability of multi-lineage differentiation potential and CFU-F activity in vitro, but failed to form new bone when transplanted in vivo. (bjmu.edu.cn)
This project will delve into innate immune cell function, establishing in vitro and in vivo systems test innate immune cell function in regeneration. (lu.se)

We examined whether bone marrow-derived adherent stromal cell transplantation (BMSCT) could restitute irradiated intestinal stem cells niche and mitigate radiation-induced gastrointestinal syndrome. (elsevierpure.com)
Association of stromal cell-derived factor-1-3'A polymorphism to higher mobilization of hematopoietic stem cells CD34+ in Tunisian population. (cdc.gov)

Aged hematopoietic stem cells (HSC) exhibit compromised reconstitution capacity and differentiation-bias towards myeloid lineage, however, the molecular mechanism behind it remains not fully understood. (haematologica.org)
They display differentiation capacities and therefore qualify as multipotent progenitor cells (Figure 1 ). (hindawi.com)
Overview on self-renewal or differentiation of stem cells in their respective stem cell niche. (hindawi.com)
Wu Y., Chen L., Scott P.G., Tredget E.E. Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis. (genescells.ru)
8,9 Because dental stem cells (DSCs) are easy to obtain and present a great potential of differentiation, there has been a growing interest in their use in regenerative medicine for treatment of various human diseases. (bvsalud.org)

The inventors have identified a way to use bone marrow derived endothelial progenitor cells for use in cell-based therapy ranging from reparative medicine to drug screening. (univation.co)
Endothelial Progenitor cells (EPC) express a subject of integrins and fibronectin, proteins that make them adhesion-competent cells. (univation.co)
Addition of EPC to endothelial cells activates Rho GTPase to promote cell retraction. (univation.co)
Endothelial cells (ECs) also represent a component of the tumor stroma and previous data suggest an involvement in CLL pathobiology. (ovgu.de)
Conclusion/Significance: Mitigation of lethal intestinal injury, following high doses of irradiation, can be achieved by intravenous transplantation of marrow-derived stromal cells, including mesenchymal, endothelial and macrophage cell population. (elsevierpure.com)
Other transplanted cells could be found among keratinocytes, hair follicle cells, endothelial cells and in derma. (genescells.ru)

Additionally, we described further CLL-related immune escape mechanisms that include the induction of myeloid derived suppressor cells (MDSCs) or an enhanced expression of the immune checkpoint molecule PD‑L1. (ovgu.de)
The aim of this study is to evaluate the prognostic impact of myeloid-derived suppressor cells (MDSCs) in multiple myeloma (MM) in the context of autologous stem cell transplantation (ASCT). (biomedcentral.com)
Large numbers of myeloid-derived suppressor cells (MDSCs), a mixture of monocytic and granulocytic cells, accumulate during many pathologic conditions, including cancer, infectious diseases, trauma, and sepsis. (biomedcentral.com)

First, we will analyze the metabolic phenotype and the underlying signaling pathways of human/murine CLL cells in response to their interaction with ECs. (ovgu.de)
and single cell RNA-seq technology helped us to gain a global recognition of the heterogeneous populations in the murine bone marrow (BM), however, the cell census of human fetal BM remains underestimated owing to material limitations. (bjmu.edu.cn)

We hypothesize that the abnormal bone marrow niche in PMF provides protection to disease-causing LSCs at the cost of the normal blood-forming HSCs. (lls.org)

We found this is at least partly mediated via bioenergetic reprogramming and formation of immune escape variants, both of which are of particular importance for drug sensitivity and immunotherapeutic concepts including among others monoclonal antibodies or genetically engineered CAR T-cells. (ovgu.de)
Angiocrine Bioscience Inc. will use genetically engineered cells, derived from cord blood, to see if they can help alleviate or accelerate recovery from the toxic side effects of chemotherapy for people undergoing treatment for lymphoma and other aggressive cancers of the blood or lymph system. (ca.gov)

These methods and results can help us to better understand immune reconstitution following hematopoietic cell transplantation, leading to future studies on the clinical application of adoptive T-cell therapies. (nature.com)
A better and deeper understanding of immune reconstitution following allo-HCT is required for further clinical application of these adoptive T-cell therapies. (nature.com)
In most cases, clinically relevant cell numbers for MSC-based therapies can be only obtained by in vitro expansion of isolated cells. (frontiersin.org)
Cell based therapies: Academic or commercial? (ehaweb.org)
In addition to these already established stem cell therapies, there is ongoing research and development of new stem cell therapies, which are currently being investigated in clinical trials involving people. (centenary.org.au)
Smart Immune is the first company to develop thymus-empowered allogeneic T-cell therapies and advance them into clinical testing through its T-cell progenitor platform, ProTcell. (smart-immune.com)
Researchers are working to train T-cells to recognize specific types of cancer by developing CAR T-cell therapies. (smart-immune.com)
CAR T-cell therapies can be compared to a personalized radar that target a specific type of cancer. (smart-immune.com)
Several CAR T-cell therapies are already on the market and available for patients in the USA and the European Union. (smart-immune.com)
ProTcell is Smart Immune's thymus-empowered T-cell therapy platform to fully and rapidly re-arm the immune system, aimed at enabling next-generation allogeneic T-cell therapies for all. (smart-immune.com)
Many cancers resist current therapies due to therapy-resistant cancer stem cells (CSCs). (ca.gov)
Conclusion: stem cells from dental origin are an interesting alternative for research and application in regenerative therapies in Dentistry. (bvsalud.org)

Other treatment options for patients with enzyme or protein deficiencies include substrate reduction therapy, gene therapy, and bone-marrow derived stem cell transplantation. (wikipedia.org)
Here we show the features of repertoire diversity and the gene expression profile of HLA-A24 cytomegalovirus-specific cytotoxic T-cells in actual recipients according to the cytomegalovirus reactivation pattern. (nature.com)
Single-cell RNA-sequence analyses demonstrate the homogenous distribution of the gene expression profile in individual cytomegalovirus-specific cytotoxic T-cells within each recipient. (nature.com)
On the other hand, bulk RNA-sequence analyses reveal that gene expression profiles among patients are different according to the cytomegalovirus reactivation pattern, and are associated with cytokine production or cell division. (nature.com)
Our research focuses on the use of hematopoietic stem cells and gene therapy for the treatment of degenerative multi-systemic disorders and hereditary nephropathies. (ucsd.edu)
Research Objective We will use integrated gene editing techniques to develop a new CAR-T cell therapy for multiple myeloma treatment Impact Develop an improved CAR-T cell therapy for patients with refractory multiple myeloma and a new manufacturing strategy that circumvents the costs and inefficiencies of viral production. (ca.gov)
Dr. Pasqualina Colella is a scientist with extensive expertise in cell therapy and gene therapy approaches for the treatment of inherited diseases. (stanford.edu)
The most perspective among them are gene and stem cell therapy. (genescells.ru)
7] When the FOXP3 gene is absent or dysfunctional, this specific subset of regulatory T-cells (Treg) fails to develop normally, though variable function has been noted in more recent studies. (medscape.com)

Hematopoietic stem cell transplantation is replacing the old fashioned bone marrow transplants. (univation.co)
For induce splenomegaly in most donors and in rare, severe cases splenicautologous stem cell transplants, the use of autologous PBSCT from rupture [13,14]. (fliphtml5.com)
A randomized clinical trial at Memorial Sloan Kettering Cancer Center (MSK) has shown that fecal microbiota transplants (FMTs) can reestablish the health-promoting bacteria that are often damaged by intense antibiotic treatment in people who have stem cell or bone marrow transplants for blood cancer. (mskcc.org)
Earlier work from MSK physician-scientists Eric Pamer, MD, and Marcel van den Brink, MD, PhD , has shown that out-of-balance intestinal microbes can contribute to serious side effects that can affect outcomes after stem cell transplants. (mskcc.org)

Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)

The field of stem cell research has advanced significantly with the use of adult or pluripotent stem cells (PSCs). (centenary.org.au)
An induced pluripotent stem cell (iPSC), is an adult stem cell which has been altered in a lab to behave more like embryonic stem cells. (centenary.org.au)
In our image, induced pluripotent stem cells can be seen, derived from patients, that replicate unique heart cell behaviours in relation to genetic heart disease. (centenary.org.au)
3 Embrionic stem cells (ESCs) are derived from the inner cell mass of the blastocyst and form all cell types, derived from the three germ layers, and are therefore pluripotent. (bvsalud.org)
Chad and I have both been principal investigators on the induced pluripotent stem cell (IPSC) grant. (medscape.com)
I fell in love with the idea of human pluripotent stem cells and started surveying the United States and even Europe for who was playing in that area. (medscape.com)

In our experiments we combined both approaches by application of human cord blood mononuclear cells (hUCB-MC) transfected with pBud-VEGF165-FGF2 plasmid to enhance healing of full thickness skin wounds in rats. (genescells.ru)

Today, more than 50 years after the first successful bone marrow transplantation, clinical application of hematopoietic stem cells is a routine procedure, saving the lives of many every day. (hindawi.com)

This project explores the connection between the niche - the area in the bone marrow where blood cells are formed - and the development of leukemia stem cells (LSCs) that give way to primary myelofibrosis (PMF). (lls.org)
These cells are found in the bone marrow in a region called their "niche," which is near the bone marrow vascular system. (lls.org)
In the PMF diseased state, the fibrotic bone marrow niche is a critical component to PMF pathogenesis. (lls.org)
Our recent data show that bone marrow cells in the niche that express the Leptin receptor protein are the source of fibrosis via activation of a signaling network mediated by a protein called PDGFRa. (lls.org)

Here we describe the initial results of allogeneic bone marrow transplantation in three children with osteogenesis imperfecta, a genetic disorder in which osteoblasts produce defective type I collagen, leading to osteopenia, multiple fractures, severe bony deformities and considerably shortened stature. (nih.gov)
Hematopoietic cells and osteoblasts are derived from a common marrow progenitor after bone marrow transplantation. (postgradualninefrologie.cz)
Results: LED produced in vitro increases of cell growth of 140-200% in mouse-derived fibroblasts, rat-derived osteoblasts, and rat-derived skeletal muscle cells, and increases in growth of 155-171% of normal human epithelial cells. (researchgate.net)

high-risk patients included male subjects, recipients of stem cells from female donors, patients younger than 10 years, those with nonidentical donors, and those who received radiation therapy in the transplant preparative regimen. (medscape.com)
Cell therapy technologies and methods have already started to play an important role in the practice of medicine. (univation.co)
What is T-cell therapy? (smart-immune.com)
Which hospital is best for stem cell therapy in India? (mespoir.com)
There are several hospitals in India that offer stem cell therapy, and determining the "best" hospital for stem cell therapy may depend on various factors such as the specific medical condition, the type of stem cell therapy required, and the individual's health status. (mespoir.com)
It is also important to verify the hospital's credentials, reputation, and experience in providing stem cell therapy. (mespoir.com)
How successful is stem cell therapy in India? (mespoir.com)
Stem cell therapy has shown promising results in India for treating various medical conditions, but its effectiveness may vary depending on the individual's health status, the type of stem cell therapy used, and the specific medical condition being treated. (mespoir.com)
Several clinical trials and research studies have demonstrated the potential of stem cell therapy for treating a wide range of medical conditions such as neurological disorders, cardiovascular diseases, orthopedic injuries, autoimmune disorders, and more. (mespoir.com)
However, it is important to note that stem cell therapy is still considered an experimental treatment in many cases and its long-term safety and effectiveness are still being evaluated through ongoing research. (mespoir.com)
How much does stem cell therapy cost in India? (mespoir.com)
The cost of stem cell therapy in India can vary depending on several factors such as the type of stem cell therapy required, the medical condition being treated, the location of the hospital, and the expertise of the medical professionals. (mespoir.com)
On average, stem cell therapy in India can cost anywhere between INR 2,50,000 to INR 10,00,000 (approximately USD 3,400 to USD 13,500) per session or course of treatment. (mespoir.com)
Recently, the team published a research paper titled 'Characteristics of Dental Stem Cells in Human Fetal Bone Marrow by Single Cell Transcriptive and Functional Analysis' in the 'Signal Transmission and Targeted Therapy (STTT)', we reported the expression landscape of human fetal BM nucleated cells (BMNCs) based on the single-cell transcriptomic analysis. (bjmu.edu.cn)

Discuss major current indications for intestine transplantation. (optumhealtheducation.com)

Although longitudinal natural history data are limited, published guidelines are available to assist with decisions related to the pursuit of transplantation and whether to use bone marrow or umbilical cord blood-derived cells. (medscape.com)
It has been 40 years since it was first proposed that stem and progenitor cells were present in human cord blood. (bioinformant.com)
These treatments use stem cells from umbilical cord blood or bone marrow or haematopoietic stem cell transplantation. (centenary.org.au)
Viral infection can lead to fatal complications in patients with weakened immune systems resulting from chemotherapy, bone marrow or cord blood transplant, and other forms of inherited or acquired disorders. (ca.gov)
Are you scheduled for a stem cell transplant with cord blood? (nih.gov)
Cultured human epithelium: human umbilical cord blood stem cells differentiate into keratino-cytes under in vitro conditions. (genescells.ru)
Stem cells from umbilical cords are usually used only in children because umbilical cord blood does not contain enough stem cells to use in adults. (msdmanuals.com)

However, the allogeneic hematopoietic stem cells given to the Boston patients were derived from donors that express functional CCR5 receptors. (biomedcentral.com)
This study is investigating a new method for collecting blood stem cells from donors to see if it reduces transplant complications, such as rejection, in patients who have blood diseases. (nih.gov)

Accumulated data indicate that hematopoietic stem cell transplantation may be effective under optimal conditions in preventing the progression of central nervous system symptoms in neuronopathic forms of lysosomal storage diseases (such as Krabbe disease), including some of the mucopolysaccharidoses, oligosaccharidoses, sphingolipidoses, and lipidoses as well as peroxisome disorders such as X-linked adrenoleukodystrophy. (medscape.com)
In general, transplantation yields the best results when performed early in the course of the disease (ie, in an asymptomatic affected sibling of a child with a lysosomal storage disorder), in centers with experience in performing transplantations to treat inherited metabolic disorders, and in patients healthy enough to tolerate the conditioning and transplantation regimen. (medscape.com)
The availability of both ERT and hematopoietic stem cell transplantation has prompted ongoing consideration of newborn screening efforts to diagnose lysosomal storage diseases. (medscape.com)
While cross-correction, either upon secretion- recapture after bone marrow transplantation was shown in several lysosomal storage disorders caused by defective soluble hydrolases, our study is the first demonstration of cross-correction in the context of a lysosomal transmembrane protein and of TNTs as key cellular device in the transfer. (ucsd.edu)
Accumulated data indicate that hematopoietic stem cell transplantation may be effective under optimal conditions in preventing the progression of central nervous system symptoms in neuronopathic forms of lysosomal storage diseases, including some of the mucopolysaccharidoses, oligosaccharidoses, sphingolipidoses, and lipidoses. (medscape.com)

Activation of the complement cascade enhances motility of leukemic cells by downregulating expression of HO-1. (livedna.net)

Wound healing effect of adipose-derived stem cells: a critical role of secretory factors on human dermal fibroblasts. (genescells.ru)

IL-1 receptor activation and subsequent downstream signalling events were found to require gamma-secretase activity.Conclusion: Although the role of PGE2 in NK cell-MSC has been reported, the requirement of cell-cell contact for PGE2 induced immunosuppression remained unexplained. (uni-hannover.de)

Novel evidence that the mannan-binding lectin pathway of complement activation plays a pivotal role in triggering mobilization of hematopoietic stem/progenitor cells by activation of both the complement and coagulation cascades. (livedna.net)

Dr. Abdelbaset-Ismail is one of the founding members of International Perinatal Stem Cells Society, and he has received the very prestigious 2015 Abstract Achievement Award from the American Society of Hematology. (livedna.net)

In this study, we observed that the expression of pseudouridine (Ψ) synthase 10 is increased in aged hematopoietic stem and progenitor cells (HSPC) and enforced protein of Ψ synthase 10 (PUS10) recapitulates the phenotype of aged HSC, which is not achieved by its Ψ synthase activity. (haematologica.org)

No significant alteration of hematopoietic homeostasis and HSC function is observed in young Pus10-/- mice, while aged Pus10-/- mice exhibit mild alteration of hematopoietic homeostasis and HSC function. (haematologica.org)
Methodology/Principal Findings: Autologous bone marrow was cultured in mesenchymal basal medium and adherent cells were harvested for transplantation to C57Bl6 mice, 24 and 72 hours after lethal whole body irradiation (10.4 Gy) or abdominal irradiation (16-20 Gy) in a single fraction. (elsevierpure.com)

However, cellular immune reconstitution of CMV-specific cytotoxic T-cells (CMV-CTL) is generally considered to be necessary for the long-term control of CMV reactivation after allo-HCT. (nature.com)

Over the past half-century, organ transplantation has become a successful and evolving practice which provides benefit to over 100,000 individuals yearly worldwide. (lecturio.com)

Influence of molecular subgroups on outcome of acute myeloid leukemia with normal karyotype in 141 patients undergoing salvage allogeneic stem cell transplantation in primary induction failure or beyond first relapse. (cdc.gov)

[ 7 ] of 798 patients who survived more than 5 years after transplantation, 328 were children. (medscape.com)
[ 2 , 8 ] Survivors of bone marrow transplantation were more likely to have a severe or life threatening condition (relative risk [RR] = 3.9), more than one chronic condition (RR = 2.6), functional impairment (RR=3.5), and activity limitations (RR = 5.8) than conventionally treated patients. (medscape.com)
All patients had increases in total body bone mineral content ranging from 21 to 29 grams (median, 28), compared with predicted values of 0 to 4 grams (median, 0) for healthy children with similar changes in weight. (nih.gov)
Some evidence indicates that at least in certain disorders, combination ERT and hematopoietic stem cell transplantation together might be superior to hematopoietic stem cell transplantation alone in patients who are appropriate candidates. (medscape.com)
Current treatment options for PMF are limited, and the only potential cure, stem cell transplantation, is often prohibitively toxic for most patients. (lls.org)
Patients with severe T-cell deficiencies are vulnerable to infections and cancers. (smart-immune.com)
A team at Children's Hospital of Los Angeles is testing the feasibility of providing these immune suppressed patients with engineered T-cells to fight these viruses. (ca.gov)
Impact By targeting blood cancer stem cells, these compounds can be used to treat and prevent recurrence of cancer in patients. (ca.gov)
Significantly, as the invasiveness of bone marrow transplantation renders it inapplicable for most HIV patients, illustration of the clinical benefits of these pharmacological interventions may lead to a novel methodology for HIV reservoir elimination. (biomedcentral.com)
When germ-free cell cultures became a laboratory routine, hopes were high for using this novel technology for treatment of diseases or replacement of cells in patients suffering from injury, inflammation, or cancer or even refreshing cells in the elderly. (hindawi.com)
Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
En outre, il y avait une aug- mentation significative de la forme soluble du c-kit dans le sérum des patients atteints de pemphigus vulgaire actif par rapport aux témoins. (who.int)

Similarly to the bone marrow stroma, ECs express several surface markers that may allow cell-to-cell contact between them and CLL cells (e.g. (ovgu.de)
We will employ different methods for metabolic profiling using an in vitro co-culture model (cooperation with Project 2 ) including single-cell RNA sequencing (cooperation with Project 12 ), targeted metabolomics, and flow cytometry-based analyses of metabolic markers/parameters as well as intracellular signaling components (focus on NF-κB signaling in cooperation with Project 1 ). (ovgu.de)
Our results showed that in 2 weeks after transplantation some transplanted cells still retain expression of stem cell and hematopoietic markers C-kit and CD34. (genescells.ru)

2017 . DOI : 10.1002/stem.2719. (epfl.ch)
2017 . DOI : 10.1016/j.stem.2017.07.004. (epfl.ch)

enhance the CLL cells' ability to suppress immune responses by e.g., substrate depletion and/or production of bioactive metabolites and it could (2. (ovgu.de)
Tolerance Tolerance Pharmacokinetics and Pharmacodynamics of the transplanted organ by the immune system Immune system The body's defense mechanism against foreign organisms or substances and deviant native cells. (lecturio.com)
It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components. (lecturio.com)
Although use of stem cell treatments in medicine is still in its early stages, they are currently being used to treat people with blood and immune system conditions, such as leukaemia and lymphoma. (centenary.org.au)
Rearming their immune system with a new compartment of fully functional T-cells would allow them to defend themselves against any threats. (smart-immune.com)
The cancer cells use that protein to evade the component of our immune system that routinely destroys tumors. (ca.gov)
MDSCs are characterized by myeloid origin, immature state, and most importantly by their potent ability to suppress different aspects of immune responses, especially T cell proliferation and cytokine production [ 7 ]. (biomedcentral.com)
6] These cells have been noted in previous studies to dampen immune responses, including in the setting of autoimmune diseases. (medscape.com)
This will be coupled with next generation sequencing based approaches to understanding the consequences of perturbing immune cell function. (lu.se)

Anatomy36

Organisms15

Diseases51

Chemicals and Drugs44

Analytical, Diagnostic and Therapeutic Techniques and Equipment71

Psychiatry and Psychology2

Phenomena and Processes43

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture1

Information Science3

Named Groups3

Health Care11

Allogeneic hematopoietic cell transplantation2

Progenitor cell5

HSCT14

Donor7

Peripheral12

Engraftment8

Therapeutic11

Autologous hematopoietic2

MSCs29

Source of hematopoietic stem2

Tissues9

Graft versus2

Progenitors1

Blood and Marrow Transplantation1

Microenvironment1

Tissue15

Vivo8

Stromal cell2

Differentiation5

Endothelial6

Myeloid-derived suppressor cells3

Murine2

HSCs1

Genetically engineered2

Therapies12

Gene9

Transplants4

Biology1

Pluripotent6

Mononuclear cells1

Clinical application1

Niche4

Osteoblasts3

Therapy14

Indications1

Cord blood7

Donors2

Lysosomal5

Enhances1

Adipose-derived1

Immunosuppression1

Mobilization1

Abstract1

Phenotype1

Mice2

Reconstitution1

Organ transplantation1

Induction1

Patients12

Markers3

20172

Immune9