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  • Autologous
  • 1 The autologous T cells were modified to express a CD-19-specific CD28/CD3ζ second-generation dual-signaling chimeric antigen receptor (CAR) termed 19-28z (19-18z CAR-modified T cells). (ascopost.com)
  • Promising outcomes have been reported using CD19-targeted autologous T cells in patients with low-grade B-cell tumors, but to date there had been no reports of outcomes using CD19-targeted adoptive T-cell therapy in patients with relapsed B-cell ALL, which is more aggressive and associated with a worse prognosis. (ascopost.com)
  • Treatment consisted of infusion of 1.5 to 3 × 10 6 autologous 19-28z + T cells/kg. (ascopost.com)
  • It appears to be an alternative to the more traditional treatment with melphalan in people who are ill-suited for autologous stem cell transplant. (wikipedia.org)
  • antibodies
  • They also cause functional antibodies, which are produced by normal plasma cells, to rapidly break down. (encyclopedia.com)
  • Direct targeting of tumor-associated antigens (TAA) on malignant cells by monoclonal antibodies (mAb) is regarded as a promising approach ( Simpson and Caballero, 2014 ). (frontiersin.org)
  • A type of white blood cell, the B cell that produces antibodies that bind to the antigen are then harvested from the mouse. (wikipedia.org)
  • The hybridomas can be grown in culture, each culture starting with one viable hybridoma cell, producing cultures each of which consists of genetically identical hybridomas which produce one antibody per culture (monoclonal) rather than mixtures of different antibodies (polyclonal). (wikipedia.org)
  • Since the antibodies in a well are produced by the same B cell, they will be directed towards the same epitope, and are thus monoclonal antibodies. (wikipedia.org)
  • The B cell that produces the desired antibodies can be cloned to produce many identical daughter clones. (wikipedia.org)
  • tumors
  • We derived novel TRAMP tumor cell lines, representative of WD and PD variants, and through pharmacologic stabilization or genetic ablation of MCs in recipients mice, we showed that MCs promote WD adenocarcinoma growth but are dispensable for PD tumors. (aacrjournals.org)
  • An association between IDCSs and solid tumors or others hematologic malignancies (usually B-cell neoplasms) has been reported (Saygin C et al. (atlasgeneticsoncology.org)
  • this disorder is a form of plasma cell dyscrasia in which no myeloma protein is detected in serum or urine (at least as determined by conventional laboratory methods) of individuals who have clear evidence of an increase in clonal bone marrow plasma cells and/or evidence of clonal plasma cell-mediated tissue injury (e.g. plasmacytoma tumors). (wikipedia.org)
  • and c) lower rates of bone but higher rates of soft tissue plasma cell tumors termed plasmacytomas. (wikipedia.org)
  • antigen
  • A recent study has pointed out that allografting with human leukocyte antigen-identical sibling stem cells and immune cells of patients with newly diagnosed MM may considerably increase patients' outcome ( 13 ). (aacrjournals.org)
  • Each B-cell carries a specific antibody that recognizes a specific foreign substance called an antigen. (encyclopedia.com)
  • When a B-cell encounters its antigen, it begins to divide rapidly to form mature plasma cells. (encyclopedia.com)
  • It was found that antigen receptor stimulation-induced NF-AT/AP-1 activity is regulated through the nuclear receptor NR2F6 (NR2F6 acts as a direct repressor of NF-AT/AP-1 transactivation) and that by preventing NR2F6 function, transcriptional activation of NF-AT/AP-1 is enhanced in immune cells which leads to an augmented immune response. (wikipedia.org)
  • genome
  • We show that lentiviral delivery of a genome-scale CRISPR-Cas9 knockout (GeCKO) library targeting 18,080 genes with 64,751 unique guide sequences enables both negative and positive selection screening in human cells. (jove.com)
  • involvement
  • Bone marrow involvement by malignant lymphoma is much more common with Non-Hodgkin disease than Hodgkin disease and spreads to the marrow 95% of the time hematogenously. (amazonaws.com)
  • Involvement of the bone can lead to osteoporosis. (wikipedia.org)
  • Plain radiography and bone densitometry can be used to assess bone involvement and the presence of osteoporosis. (wikipedia.org)
  • Angioimmunoblastic T-cell lymphoma (AITL, sometimes misspelled AILT) (formerly known as "angioimmunoblastic lymphadenopathy with dysproteinemia") is a mature T-cell lymphoma of blood or lymph vessel immunoblasts characterized by a polymorphous lymph node infiltrate showing a marked increase in follicular dendritic cells (FDCs) and high endothelial venules (HEVs) and systemic involvement. (wikipedia.org)
  • lymphoma
  • The typical patient with angioimmunoblastic T-cell lymphoma (AITL) is either middle-aged or elderly, and no gender preference for this disease has been observed. (wikipedia.org)
  • Angioimmunoblastic lymphadenopathy (AILD)-type T-cell lymphoma: prognostic impact of clinical observations and laboratory findings at presentation. (wikipedia.org)
  • The lack of the normal distribution of these B cells is one basis for demonstrating clonality, the key element for establishing a diagnosis of any B cell malignancy (B cell non-Hodgkin lymphoma). (wikipedia.org)
  • Adult
  • Adult marrow does not appreciably enhance to visual inspection after intravenous gadolinium contrast is administered. (amazonaws.com)
  • Epigenetic regulation of adult stem cells in the context of normal and diseased biology. (dkfz.de)
  • Considering these clinical outcomes, the addition of 19-28z CAR-modified T cells for inclusion into currently upfront adult [B-cell] ALL treatment protocols warrants serious consideration. (ascopost.com)
  • protein
  • 2015). Neoplastic cells typically express, intensively and diffusely, the S100 protein (Fachetti et al. (atlasgeneticsoncology.org)
  • The two patients with the highest tumor burden at the start of T-cell therapy showed the highest cytokine elevations (including elevations of soluble interleukin-2 receptor α, interferon-γ, interleukin 6, and interferon-inducible protein 10) beginning at 5 days after T-cell infusion. (ascopost.com)
  • 1998). "Bone morphogenetic protein-6 production in human osteoblastic cell lines. (wikipedia.org)
  • therapeutic
  • By studying multiple cell types in addition to the fibroblast itself we may discover new therapeutic strategies or combination therapies to effectively prevent post-MI fibrosis and heart failure. (rochester.edu)
  • NEW DELHI: The government's latest guidelines on stem cell research has imposed restrictions on stem cell banking and therapeutic use in a move to check 'rampant' unethical practices in this field and safeguard patients receiving such treatments. (indiatimes.com)
  • melanoma
  • IDCS is a diagnosis of exclusion, being mandatory the preclusion of follicular dendritic cell sarcoma, histiocytic sarcoma, melanoma, and metastases, among another neoplasm. (atlasgeneticsoncology.org)
  • lymphocytes
  • Plasma cells develop from B-lymphocytes or B-cells, a type of white blood cell. (encyclopedia.com)
  • or 2) lymphoid precursor cells which differentiate into T lymphocytes, B lymphocytes, or natural killer cells. (wikipedia.org)
  • Plasma cells develop from B lymphocytes which are stimulated to undergo this maturational development by T lymphocytes during the latter cells' processing of these antigens. (wikipedia.org)
  • Normal lymphoblasts develop into mature, infection-fighting B-cells or T-cells, also called lymphocytes. (wikipedia.org)
  • In ALL, both the normal development of some lymphocytes and the control over the number of lymphoid cells become defective. (wikipedia.org)
  • Diagnosis is typically based on blood tests finding high numbers of mature lymphocytes and smudge cells. (wikipedia.org)
  • Normal B lymphocytes consist of a stew of different antibody-producing cells, resulting in a mixture of both kappa- and lambda-expressing cells. (wikipedia.org)
  • These B cells resemble normal lymphocytes under the microscope, although slightly smaller, and are fragile when smeared onto a glass slide, giving rise to many broken cells, which are called "smudge" or "smear" cells. (wikipedia.org)
  • neoplastic
  • Prostatic carcinoma is often a multifocal disease, in which multiple histologic patterns, reflective of the varied differentiated aptitude of the neoplastic clone, may coexist within a single tumor ( 2 ). (aacrjournals.org)
  • Neoplastic cells are since ovoid to a spindle, also shows abundant eosinophilic cytoplasm where we could found an important amount of endoplasmic reticula and mitochondria (Skala SL et al. (atlasgeneticsoncology.org)
  • These former symptoms are due to release of a substance called histamine from neoplastic mast cells. (wikipedia.org)
  • The Epstein-Barr virus (EBV) is observed in the majority of cases, and the virus has been found in the reactive B-cells that comprise part of the polymorphous infiltrate of this disease and in the neoplastic T-cells. (wikipedia.org)
  • HSCT
  • This differs for adults and children, with children being allowed HSCT for fewer types of cancers and more types of non-malignant diseases. (indiatimes.com)
  • endothelial
  • CFs interact with not only cardiac myocytes (CMs) but also with other cells in the heart, including vascular endothelial cells (ECs), smooth muscle cells (SMCs), and immune cells, via direct or indirect cellular communications. (rochester.edu)
  • Lastly, there is significant evidence that Gelatinase B is required for the recruitment of endothelial stem cells, a critical component of angiogenesis MMP9 is greatly upregulated during human respiratory epithelial healing. (wikipedia.org)
  • genes
  • In addition, the Weissman laboratory has pioneered the study of the genes and proteins involved in cell adhesion events required for lymphocyte homing to lymphoid organs in vivo, either as a normal function or as events involved in malignant leukemic metastases. (thesciencenetwork.org)
  • They are using this model to study the genes, proteins, and cells that govern protochordate allorecognition, and the effects of these genes on their population dynamics in the field. (thesciencenetwork.org)
  • ALL emerges when a single lymphoblast gains many mutations to genes that affect blood cell development and proliferation. (wikipedia.org)
  • These genes, in turn, increase the risk that more mutations will occur in developing lymphoid cells. (wikipedia.org)
  • Other genes utilized for MRD detection include microsatellites, immunoglobulin and T cell receptor. (wikipedia.org)
  • normal
  • Figure 12:This T1w sagittal image demonstrates the Ricci Pattern 3 consisting of a speckled marrow pattern in a normal elderly woman. (amazonaws.com)
  • Figure 13:This T1w sagittal image in an elderly woman demonstrates normal marrow with large round areas of yellow marrow consistent with Ricci pattern 4. (amazonaws.com)
  • Physiologic demand for more mature blood cells (especially red blood cells) beyond the body's normal capacity to produce them acts to reverse the normal pattern of conversion of red marrow to yellow marrow. (amazonaws.com)