• We designed a study to find theoretical evidence for the induction, movement, fusion, proliferation, and safety of human adipose mesenchymal stem cells (hADSCs) in intraocular application. (molvis.org)
  • Therefore, in this study, we assessed the ability of human adipose mesenchymal stem cells (hADSCs) to express the characteristics of ECs after induction in vitro to evaluate the theoretical feasibility of maintaining or restoring the function of ECs after intraocular application. (molvis.org)
  • Mesenchymal stromal cells in renal transplantation: opportunities and challenges. (genescells.ru)
  • 12 Bang and colleagues reported the safety and feasibility of intravenous infusion of autologous mesenchymal stem cells (MSCs) with no reported adverse effects in five patients treated with intravenous MSCs. (bmj.com)
  • Mesenchymal stem/stromal cells (MSCs) are increasingly used as an intravenously applied cellular therapeutic. (stemcellslab.net)
  • Later, Arnold Caplan's group described mesenchymal stem/stromal cells (MSCs) as multipotent mesenchymal cell populations which can differentiate into several tissue types, and demonstrated roles for MSCs in the regeneration of bone, cartilage or ligaments in animal and clinical studies [2-4]. (stemcellslab.net)
  • Pivotal studies by the group of Horwitz in children with osteogenesis imperfecta, an inherited enzyme deficiency of collagen synthesis by mesenchymal cells in bone, opened the field for intravenous use of MSCs. (stemcellslab.net)
  • Suture Mesenchymal Stem Cells" Encyclopedia , https://encyclopedia.pub/entry/13190 (accessed December 11, 2023). (encyclopedia.pub)
  • Suture mesenchymal stem cells (SuSCs), a heterogeneous stem cell population, belong to mesenchymal stem cells (MSCs) or skeletal stem cells (SSCs), with the ability to self-renew and undergo multi-lineage differentiation. (encyclopedia.pub)
  • Mesenchymal stem/stromal cells (MSCs)‐based therapy brings the reassuring capability to regenerative medicine through their self‐renewal and multilineage potency. (biomedcentral.com)
  • After that, Kaplan firstly proposes the term "mesenchymal stem cells," which are cells isolated from fully developed bone marrow (BM) that can usually differentiate into several types of mesenchymal origin cells [ 4 ]. (biomedcentral.com)
  • While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for their vanguard uses in blood and immune disorders, many others are looking to expand the uses of the various types of stem cells found in bone marrow and cord blood, in particular mesenchymal stem cells, to uses beyond those that could be corrected by replacing cells in their own lineage. (biomedcentral.com)
  • There are many studies involving autologous therapies and some allogenic therapies, based on the recovery of mobilized bone marrow cells, including mesenchymal stem cells (MSCs) and adipose derived stem cells that also include the stromal or adherent cell type that has an MSC phenotype. (biomedcentral.com)
  • Bone marrow mesenchymal stem cells (BMSCs) have been reported to attenuate myocardial I/R injury via their paracrine effects, which can be enhanced by hypoxic preconditioning. (researchsquare.com)
  • The administration of bone marrow-derived mesenchymal stem cells (BMSCs) is emerging as a promising approach for I/R injury-induced myocardial infarction due to its multiple differentiation potential(7, 8). (researchsquare.com)
  • Mesenchymal stem cells (MSCs) are ASCs, and were first described in 1966 by Friedenstein et al. (bvsalud.org)
  • citation needed] The transplantation may be autologous (an individual's own blood cells), allogeneic (blood cells donated by someone else with matching HLA), or syngeneic (blood cells donated by an identical twin). (wikipedia.org)
  • Transplanting their own (autologous) bone marrow-derived stem cells into 48 patients with end-stage liver disease resulted in therapeutic benefit to a high number of the patients, report researchers publishing in the current issue of Cell Transplantation (19:11). (medicaldaily.com)
  • For induce splenomegaly in most donors and in rare, severe cases splenicautologous stem cell transplants, the use of autologous PBSCT from rupture [13,14]. (fliphtml5.com)
  • In a second study [6], these authors showed that autologous, enzyme-deficient MSCs transduced with a copy of the intact gene resulted in normal collagen production in bone cavities. (stemcellslab.net)
  • Autologous transplants involve the use of a person's own stem cells. (medicaljump.com)
  • In addition to this innovation, a specific programme has been set up to facilitate this autologous transplant for people living outside Madrid . (mdanderson.es)
  • In addition to systemic treatments and/or targeted therapies, both autologous and allogeneic haematological progenitor transplantation (commonly called bone marrow transplantation) continues today to be part of the treatment plan for many patients with various haematological diagnoses such as leukaemia, lymphoma and multiple myeloma . (mdanderson.es)
  • While in an autologous transplant there is no donor and the patient is the focus of the whole process, in an allogeneic transplant there is a donor and therefore compatibility studies must be carried out before starting the process ," explains the doctor. (mdanderson.es)
  • Firstly, precisely these haematopoietic progenitors are key in autologous and allogeneic transplants, but not in CAR-T therapies. (mdanderson.es)
  • In autologous transplantation the tool is chemotherapy, in allogeneic transplantation it is the new immune system and in CAR-T cell therapy it is the patient's own re-educated T-lymphocytes ," concludes this expert. (mdanderson.es)
  • Accordingly, pre-conditioning of MSCs is strongly suggested to upgrade their performances in vivo, leading to more favored transplantation efficacy in regenerative medicine. (biomedcentral.com)
  • While analyzing the revenue growth of Stem Cell Research and Regenerative Medicine functions, it highly developed from $150 billion USD to $250 billion USD since from 2010-2015. (longdom.com)
  • In order to address the limits associated with current therapies, many research groups have investigated various regenerative medicine strategies utilizing different stem cell sources to engineer artificial salivary tissues that can mitigate the effects of xerostomia and hyposalivation. (biomedcentral.com)
  • The use of ASCs in regenerative medicine and tissue engineering research has important advantages in comparison with ESCs, since there are no ethical complications and the process of differentiation of these cells is better controlled. (bvsalud.org)
  • 8,9 Because dental stem cells (DSCs) are easy to obtain and present a great potential of differentiation, there has been a growing interest in their use in regenerative medicine for treatment of various human diseases. (bvsalud.org)
  • Similarly, in vivo studies revealed a higher level of BMSC differentiation into germ-like cells with significant higher expression of differentiation markers in transplanted groups compared to the control. (bvsalud.org)
  • This study confirmed the role of SCCM as an inductive factor for BMSC differentiation to germ cells both in vivo and in vitro conditions. (bvsalud.org)
  • The MSCs and osteoprogenitors residing along the OFs keep proliferating, subsequently differentiate into osteoblasts, and contribute to the new bone formation through intramembranous ossification [ 4 ] [ 5 ] , which happens with a direct differentiation into osteoblasts from MSCs and/or osteogenic precursors without assuming a chondrogenic fate. (encyclopedia.pub)
  • They also can inspire angiogenesis by direct differentiation, cell-to-cell interaction, or paracrine effects. (biomedcentral.com)
  • To investigate the proliferation and differentiation of hematopoietic stem and progenitor cells in their physiologic environment, we use state-of-the-art mouse models. (digs-bb.de)
  • Cells from the patient's sister's bone marrow were administered, and in the following weeks successfully began dividing and differentiating into white blood cells. (wikipedia.org)
  • However, several weeks later, the cells were found to have been mutated by the radiation still present within the patient's body, and were observed carrying out autoimmune responses. (wikipedia.org)
  • What if doctors had a remote control that they could use to steer a patient's own cells to a wound to speed up the healing process? (longdom.com)
  • The use of patient's own bone marrow aspirates, hematopoietic stem cells and MSCs, for heart muscle tissue repair can be puzzling because these cells do not normally contribute to the cardiac lineage types that are desired. (biomedcentral.com)
  • In this way, the mature cells help speed a patient's recovery - meaning the window when they are vulnerable to infection and other complications is much smaller. (fredhutch.org)
  • 1] Although this device will not restore vision to patients, it replaces the function of degenerated cells in the retina and may improve a patient's performance of basic activities by improving their ability to perceive images and movement. (medscape.com)
  • Granulocyte colony stimulating factor (GCSF) are naturally occurring glycoproteins that stimulate white blood cell proliferation. (wikipedia.org)
  • The increase in white blood cell proliferation as a result of the Filgrastim ensures a better results from the donation. (wikipedia.org)
  • Splenomegaly might reflect dramatic G-CSF-inducedG-CSF stimulation also in multiple studies shows faster recovery of Hox11+ stem cell proliferation. (fliphtml5.com)
  • Proliferation-linked shifts in eligibility of T-cell progenitors, population dynamics, DN1 cells to undergo specification thus control kinetics of T-cell generation. (lu.se)
  • Therefore, the authors concluded that transplantation of isolated healthy allogeneic MSCs might cure the disease. (stemcellslab.net)
  • This implies homing of transplanted MSCs to sites in bone marrow and/or bone. (stemcellslab.net)
  • The tissue source of the MSCs was in most cases not decisive, and cells from various tissue sources were explored. (stemcellslab.net)
  • and signals from the injected cells were found early after administration of the MSCs at the highest frequencies in the lungs, followed by liver and spleen. (stemcellslab.net)
  • First, MSCs were procured from murine bone marrow (BM) by Friendenstein et al. (biomedcentral.com)
  • Although there is no particular quantitative assay to provide MSCs identification in mixed cells population [ 8 ], the International Society for Cellular Therapy (ISCT) has provided minimum principles to determine MSCs. (biomedcentral.com)
  • However, natural MSCs in vivo survival and their biological effects on tissue recovery decrease with long-term cultivation called aging and also injected cells demonstrate poor targeted migration [ 21 ]. (biomedcentral.com)
  • This includes bone and cartilage repair, cell types into which MSCs readily differentiate, and immune conditions such as graft versus host disease and autoimmune conditions that utilize the MSC's immune suppressive properties. (biomedcentral.com)
  • MSCs can be isolated from different locations, such as bone marrow, umbilical cord, placenta, adipose and dental tissues. (bvsalud.org)
  • Since these cells require induction factors to differentiate into germ cells, we co-transplanted bone marrow stem cells (BMSCs) with Sertoli cell-conditioned medium (SCCM) into the testis of azoospermic mice. (bvsalud.org)
  • We hypothesized that the donor heart preservation with hypoxic conditioned medium derived from BMSCs (CM-BMSCs) would improve post-transplant graft function. (researchsquare.com)
  • Interestingly, thiscell transplants (PBSCTs) from donors given granulocyte-colony- immature peripheral phenotype was similar to bone marrow transplantsstimulating-factor (G-CSF) has decreased relapse rates and improved before G-CSF. (fliphtml5.com)
  • This may also be complementary to the approach of haploidentical adult stem cell transplants, which involve donors from a close but still mismatched family member. (scitechdaily.com)
  • Stem cells can be destroyed through cancer treatments such as chemotherapy or radiation, as well as any blood-related diseases, such as leukemia, lymphoma, neuroblastoma and multiple myeloma. (wikipedia.org)
  • The most common situations are for patients receiving chemotherapy, requiring surgery (especially cardiac surgery) or having experienced severe haemorrhage (e.g. from pregnancy or childbirth, trauma, largely from road traffic accidents, or severe anaemia in the young, often caused by malaria), often being combined with other blood products such as fresh frozen plasma (FFP) and red blood cells (RBCs) in a massive transfusion protocol. (nhsbt.nhs.uk)
  • Bone marrow transplants are a procedure, which is done for replacing one's bone marrow that was destroyed or damaged by disease, chemotherapy or infection. (openmindsciences.com)
  • In these cases, the stem cells can be grown or harvested before starting radiation treatment or chemotherapy. (openmindsciences.com)
  • You might also undergo treatments like chemotherapy to get rid of the marrow cells or cancer cells before getting the new stem cells. (openmindsciences.com)
  • Recovery may depend on some factors such as where transplants are performed, donor match, radiation, chemotherapy, and conditions being treated. (openmindsciences.com)
  • A bone marrow transplant is a medical procedure performed to replace bone marrow that has been damaged or destroyed by disease, infection, or chemotherapy. (medicaljump.com)
  • In such cases, stem cells can be harvested, or grown, before you start chemotherapy or radiation treatment. (medicaljump.com)
  • They typically involve harvesting your cells before beginning a damaging therapy to cells like chemotherapy or radiation. (medicaljump.com)
  • Preconditioning of recipients by lethal irradiation or chemotherapy forces transplanted hematopoietic stem and progenitor cells to realize their maximum potential, but this does not necessarily reflect their fate and behavior in the native bone marrow environment. (digs-bb.de)
  • After applying high doses of chemotherapy, we rescue the person with his or her own cells to repopulate his or her bone marrow and start the normal production of red blood cells, white blood cells and platelets again ," states the doctor. (mdanderson.es)
  • For its part, an allogeneic transplant does not focus its curative intention on chemotherapy but on the contrary: here, chemotherapy serves to prepare the patient who will receive the cells from a donor and to help him/her nest these cells properly . (mdanderson.es)
  • Peripheral blood stem cell transplantation (PBSCT), also called "Peripheral stem cell support", is a method of replacing blood-forming stem cells. (wikipedia.org)
  • Citation: Mera T, Heimfeld S, Faustman DL (2014) The Spleen Contributes Stem Cells to Peripheral Blood Stem Cell Transplants. (fliphtml5.com)
  • G-CSF was found to mobilize both CD34+ stem cells (p=0.02)and even more dramatically mobilize Hox11+ splenic stem cells (p=0.000013) into the peripheral blood. (fliphtml5.com)
  • TheIntroduction later step is unique to splenic function since splenectomy results in similar accumulations of naïve B cells, reduction of memory B cells and Treatment of malignancies with allogeneic peripheral blood stem well-known susceptibilities to select infections [12]. (fliphtml5.com)
  • SAN FRANCISCO (GenomeWeb) - Noninvasive shotgun sequencing can be used to detect organ transplant rejection without prior knowledge of the donor's genotype, according to researchers from Stanford University and Cornell University. (genomeweb.com)
  • The product - more fully described as an ex vivo expanded umbilical cord blood stem cell product - uses blood stem and progenitor cells from donated umbilical cord blood. (fredhutch.org)
  • Recent research uncovers a new approach for expanding blood-forming, adult stem cells from human umbilical cord blood. (scitechdaily.com)
  • Researchers from the Stowers Institute for Medical Research and collaborators have identified a way to expand blood-forming, adult stem cells from human umbilical cord blood (hUCB). (scitechdaily.com)
  • This work represents a path forward by demonstrating the ability to reliably expand adult stem cells from umbilical cord blood in the laboratory without terminally differentiating the cells into more mature and relatively short-lived blood cells," says Joseph McGuirk, MD, professor of medicine and medical director of blood and marrow transplant at the University of Kansas Health System, who was not directly involved with the study. (scitechdaily.com)
  • These findings represent a major advance in the field and have significant potential to improve the outcomes of thousands of children and adults who undergo umbilical cord blood transplantation every year. (scitechdaily.com)
  • This is because cord blood is a rich source of stem cells known as haematopoietic stem cells (HSCs). (cordlife.co.id)
  • Hematopoietic stem cells (HSCs) are at the top of the hematopoietic hierarchy and can differentiate into all types of mature blood cells throughout life. (digs-bb.de)
  • HSCs were first identified by transplantation, in which recipient mice were preconditioned with ionizing radiation and reconstituted with donor bone marrow. (digs-bb.de)
  • We recently unraveled an alternative pathway of thrombopoiesis, in which HSCs directly differentiate into megakaryocytes, bypassing the classical multipotent progenitor intermediates (Morcos, Li, Munz et al. (digs-bb.de)
  • According to this concept, HSCs are activated by an increased demand for mature blood cells in situations such as systemic infection or severe blood loss. (digs-bb.de)
  • The Gerbaulet group studies the biology of hematopoietic stem and progenitor cells in their native environment. (digs-bb.de)
  • For decades, hematopoietic stem and progenitor cells have been studied primarily through such transplantation-based assays. (digs-bb.de)
  • At steady-state, HSC infrequently divide and slowly but continuously spawn rapidly dividing progenitor cells. (digs-bb.de)
  • We want to understand how the hierarchical organization of mature blood cell regeneration from stem and progenitor cells shapes the accumulation of somatic mutations and hence the risk of developing blood cancer. (digs-bb.de)
  • Downloaded from periodic thymic colonization by progenitor cells guarantees stage. (lu.se)
  • It is pointed out that protocols based on the using BM cells, permit to work out the tolerance state and now they are estimate at clinical kidney transplantation, during multicentre investigations. (genescells.ru)
  • Enrichment of PBSCT by purification of CD34+stem cells fails to produce superior clinical benefits. (fliphtml5.com)
  • The inferior clinical performance of CD34+-enriched and purified PBSCTs compared tounenriched PBSCTs may be explained by the omission of Hox11+ stem cells. (fliphtml5.com)
  • Several recent clinical trials have reported safety and some improvement in outcomes following cell therapy administration in ischaemic stroke, which are reviewed. (bmj.com)
  • 9 Clinical trials of cell therapy completed in the 2000s mostly treating small cohorts of patients with chronic stroke demonstrated adequate safety and a suggestion of efficacy with the use of cell therapy. (bmj.com)
  • 13 These early clinical trials mostly focused on chronic subcortical strokes, but more recent trials are now investigating cell therapy for treatment of both cortical and subcortical infarcts. (bmj.com)
  • Building off previous methods that have demonstrated that shotgun sequencing of cell-free DNA shed in the bloodstream from the donor organ can identify rejection, the team demonstrated that the donor does not first have to be genotyped, which they said would make it more useful in a clinical setting. (genomeweb.com)
  • In recent years, clinical trials with stem cells have taken the emerging field in many new directions. (biomedcentral.com)
  • The rapid advance of stem cell clinical trials for a broad spectrum of conditions warrants an update of the review by Trounson (2009) [ 1 ]. (biomedcentral.com)
  • There has been a rapid surge in clinical trials involving stem cell therapies over the last two to three years and those trials are establishing the clinical pathways for an emergent new medicine. (biomedcentral.com)
  • Placenta-derived stem cells are being considered for similar uses and are in Phase III clinical trial for critical limb ischemia by Israel's Pluristem Therapeutics. (biomedcentral.com)
  • A significant proportion of clinical studies that are underway involve bone marrow and cord blood stem cells for blood and immune disorders [ 3 ] and cancers. (biomedcentral.com)
  • We have chosen to concentrate on the emerging therapeutics that broadly involves a wide range of cell types in clinical trials registered on the National Institutes of Health's clinical trials web site. (biomedcentral.com)
  • She is also a member of Fred Hutch's Clinical Research Division and the founding director of the Hutch's Cord Blood Transplant Program. (fredhutch.org)
  • To date, the only way to receive the expanded cell product was to be enrolled in a clinical trial at a limited number of academic medical centers. (fredhutch.org)
  • Studies suggest that PBSCT has a better outcome in terms of the number of hematopoietic stem cell (CD34+ cells) yield. (wikipedia.org)
  • In the study, published online on July 31, 2018, in Cell Research, researchers zeroed in on a protein that affects multiple targets and pathways involved in hematopoietic stem cell self-renewal, a broader approach than other studies that focus on a single target or pathway in the process. (scitechdaily.com)
  • The protein, called Ythdf2, recognizes a particular type of modification on a group of mRNAs encoding key transcription factors for hematopoietic stem cell self-renewal and promotes the decay of these mRNAs within cells. (scitechdaily.com)
  • Cellulose nanofibers (CNF) hydrogel has great potential as a cell-encapsulation delivery carrier for sustained release of paracrine factors and for tissue regeneration, with unique versatility for injection, scaffolding, and 3D bioprinting. (longdom.com)
  • This article is intended to provide a review of the most current approaches to utilizing stem cells and bioengineering principles for the purpose of salivary tissue regeneration. (biomedcentral.com)
  • These cells have been studied for the treatment of periodontitis, bone repair, regeneration of the pulp after necrosis as well as the development of new teeth. (bvsalud.org)
  • Due to the ability to self-renew and to differentiate into cells that are found throughout the body, there is a great interest in using stem cells for the regeneration of injured tissues as well as to develop tissue-engineered implants and bio-hybrid organs, in order to restore tissue function. (bvsalud.org)
  • Bone marrow is the spongy, fatty tissue inside your bones. (medicaljump.com)
  • Also, following transplantation and migration to target tissue, they encounter a harsh milieu accompanied by death signals because of the lack of proper tensegrity structure between the cells and matrix. (biomedcentral.com)
  • These early trials are showing roles for stem cells both in replacing damaged tissue as well as in providing extracellular factors that can promote endogenous cellular salvage and replenishment. (biomedcentral.com)
  • Similar to tissue-resident macrophages, mast cells are of dual ontogeny and are generated during both fetal and adult ("definitive") hematopoiesis. (digs-bb.de)
  • The general underlying strategy behind the development of tissue engineered organ substitutes is the utilization of a combination of cells, biomaterials, and biochemical cues intended to recreate the natural organ environment. (biomedcentral.com)
  • The purpose of this review is to highlight current bioengineering approaches for salivary gland tissue engineering and the adult stem cell sources used for this purpose. (biomedcentral.com)
  • Nohla Therapeutics, the latest Fred Hutch spinoff , is a stem cell therapy company focused on developing off-the-shelf, on-demand universal-donor therapies that require no tissue-type matching. (fredhutch.org)
  • In explant method, the dental tissue is placed on a plastic surface and the cells migrate out from the tissue fragment adhering to culture flasks or dishes ( Figure 1 ). (bvsalud.org)
  • Only 30 percent of patients have a bone marrow donor match available in their families, according to the US Department of Health and Human Services. (scitechdaily.com)
  • Euro Stem Cells 2019 aims in proclaim knowledge and share new ideas amongst the professionals, industrialists and students from research area of ' Stem Cell Research and Molecular Biology ' to share their research experiences and indulge in interactive discussions at the event. (longdom.com)
  • Therefore, each type of transplant has a tool to act. (mdanderson.es)
  • This paved the way for the idea that given the right factors, our own differentiated cells can have their internal clocks turned back, to turn them back into a stem cell just like the one that makes all of those trillion cells that make us who we are, and one day we might be able to use them to grow tissues for transplant. (nhsbt.nhs.uk)
  • In human postnatal dental tissues, five main sources of DSCs have been identified: dental pulp stem cells (DPSCs), 11 stem cells from human exfoliated deciduous teeth (SHEDs), 12 periodontal ligament stem cells (PDLSCs), 13 dental follicle stem cells (DFSCs) 14 and stem cells from apical papilla (SCAPs). (bvsalud.org)
  • The findingssupport the hypothesis that G-CSF mobilizes two distinct stem cell populations, one from the bone marrow andthe other from the spleen. (fliphtml5.com)
  • Radiation affects cells that divide quickly, especially blood - red cells only last about 120 days in circulation, and platelets only 5 days. (nhsbt.nhs.uk)
  • This special cell is a blood stem cell and we now routinely use radiation and bone marrow transplantation to cure many blood cancers. (nhsbt.nhs.uk)
  • This development could make these cells available to more people, and be more readily accepted in those who undergo adult stem cell treatments for conditions such as leukemia, blood disorders, immune system diseases, and other types of cancers, but who do not have an appropriate available bone marrow match. (scitechdaily.com)
  • Unlike the well-established perivascular niche of SSCs in the long bone, stem cells of the cranial bone are generally located and confined within the cranial suture mesenchyme, subsequently defined as SuSCs. (encyclopedia.pub)
  • They observed that impairing Ythdf2 function did not alter the types of cells that were subsequently produced, nor did it lead to increased blood cell malignancies. (scitechdaily.com)
  • Similarly, as the major stem cell population of cranial bones, the physiological significance of SuSCs is undoubted and self-evident. (encyclopedia.pub)
  • Throughout the growth and development of the skull, the cranial suture mesenchyme remains unossified, which interposes between the OFs of the adjoining bone plates. (encyclopedia.pub)
  • Analyzing 435 samples from 59 heart transplant patients, they found that the two methods were still highly correlated, although not as close as for the lung transplants. (genomeweb.com)
  • Therefore, attenuating myocardial I/R injury during the heart transplant procedure would have a favorable impact on improving short- and long-term graft function and recipient's survival(6). (researchsquare.com)
  • Stem Cell Research and Molecular Biology is the latest trending research in many fields especially in Organ cancer: breast, oral, head and neck Cancer Myeloid, lymphoid leukaemia's, cancer treatments etc. (longdom.com)
  • HADSCs were induced to confirm that they can express the characteristics of endothelial cells (ECs) in vitro. (molvis.org)
  • For in vitro study, differentiating factors (c-kit and ID4) were examined after 15 days of co-culture of bone marrow cells with Sertoli cell-conditioned medium, while for in vivo study, the azoospermia model was first created by intraperitoneal administration of a single-dose busulfan (40 mg/kg) followed by single-dose CdCl2 (2 mg/kg) after 4 weeks. (bvsalud.org)
  • The results showed that BMSC co-cultured with SCCM in vitro differentiated BMSC to germ-like cells. (bvsalud.org)
  • Comparative study of the immunoregulatory capacity of in vitro generated tolerogenic dendritic cells, suppressor macrophages, and myeloid-derived suppressor cells. (genescells.ru)
  • In vitro PUVA treatment preferentially induces apoptosis in alloactivated T cells. (genescells.ru)
  • Kondziolka and colleagues used N-Tera 2 cells derived from a lung metastasis of a human testicular germ cell tumour that when treated with retinoic acid generate postmitotic neurons that maintain a fetal neuronal phenotype indefinitely in vitro (LBS neurons). (bmj.com)
  • This experimental paradigm revealed the existence of a rare population of somatic stem cells that can stably reconstitute all blood lineages lifelong. (digs-bb.de)
  • When he underwent a cord blood transplant at Fred Hutchinson Cancer Research Center in 2011 to cure his cancer, his blood and immune system had to be destroyed first, leaving him vulnerable until his new healthy donor cells took hold and rebuilt his body's protective mechanisms. (fredhutch.org)
  • It is these donor cells that, once infused into the patient, will populate the bone marrow and rebuild the immune system, which is called the graft-versus-disease effect ," highlights this specialist. (mdanderson.es)
  • The fundamental problem here is that the graft-versus-host effect, that is, the infused cells and the new immune system, reject the patient. (mdanderson.es)
  • Mr Souradip Mookerjee is an MB/PhD student in Dr Cedric Ghevaert's Lab at the University of Cambridge, working on the translational research of making platelets from stem cells. (nhsbt.nhs.uk)
  • There have been no major advances to improve the storage of platelets beyond 7 days, compared with 35-40 days for red blood cells, making these a comparatively perishable blood product. (nhsbt.nhs.uk)
  • It helps your body make white blood cells, red blood cells or platelets to avoid bleeding disorders, anemia or infections. (openmindsciences.com)
  • Once infused into patients, the expanded stem cells rapidly differentiate into the mature cells that are needed to prevent the life-threatening infections and bleeding that are especially common after cord blood transplant. (fredhutch.org)
  • PBSCT is now a much more common procedure than its bone marrow harvest equivalent due to the ease and less invasive nature of the procedure. (wikipedia.org)
  • Marques M.B., Schwartz J. Update on extracorporeal photopheresis in heart and lung transplantation. (genescells.ru)
  • That previous work, in both heart and lung transplantation, relied on genotyping both the organ donor and the recipient in order to distinguish which cfDNA fragments were being shed from the donor organ, and which were naturally occurring from the recipient. (genomeweb.com)
  • De Vlaminck said that previous studies by the group and others have identified thresholds for heart and lung transplants but he said that studies in larger cohorts will be needed to further refine those thresholds. (genomeweb.com)
  • Looking retrospectively at 382 blood samples taken at various time points from 51 lung transplant patients, the researchers found that the two models were highly correlated. (genomeweb.com)
  • Our hypothesis about a splenic stem cell contributionor maintained survival compared to bone marrow transplants, to PBSCT also derives from the observation that G-CSF mobilizationsalthough graft versus host disease (GVHD) still occurs [1]. (fliphtml5.com)
  • Iwijn De Vlaminck, an assistant professor of biomedical engineering at Cornell and senior author of the study, said that previous work had identified that donor-derived cell-free DNA is a "good marker of transplant rejection" because increased levels of donor cfDNA indicates more damage to the graft and thus, rejection. (genomeweb.com)
  • In heart transplantation, donor hearts inevitably suffer from ischemia/reperfusion (I/R) injury, which leads to primary graft dysfunction and affects patients' survival rate. (researchsquare.com)
  • Later studies on the incident and subsequent use of PBSCT found that the transplant had also induced neoendothelialization of the aortic endothelium. (wikipedia.org)
  • Research found that by transplanting just one specific bone marrow cell, it was possible to regenerate the entire blood forming system. (nhsbt.nhs.uk)
  • HSC found in bone marrow would make new blood cells in your lifetime. (openmindsciences.com)
  • The HSC found in the bone marrow will make new blood cells throughout your lifespan. (medicaljump.com)
  • Biologists have found that aging takes a toll on intestinal stem cells and may contribute to increased susceptibility to disorders of the gastrointestinal tract. (longdom.com)
  • 3,4 The zygote and cells derived from the first two cellular divisions constitute the most primitive cells (totipotent cells) that are capable of forming the embryo and the embryonic annexes (e.g. placenta, amniotic membranes etc). (bvsalud.org)
  • Conclusion: stem cells from dental origin are an interesting alternative for research and application in regenerative therapies in Dentistry. (bvsalud.org)
  • Engraftment of donor-type MSC-derived osteoblasts was shown using bone specimens and microsatellite DNA marker analysis. (stemcellslab.net)
  • More research teams are accelerating the use of other types of adult stem cells, in particular neural stem cells for diseases where beneficial outcome could result from either in-lineage cell replacement or extracellular factors. (biomedcentral.com)
  • Adult stem cells from umbilical cords are more likely to be a match for more people because there are fewer compatibility requirements than for a bone marrow transplant. (scitechdaily.com)
  • If we can expand cord adult stem cells, that could potentially decrease the number of cords needed per treatment. (scitechdaily.com)
  • When the team knocked out Ythdf2 function in a mouse model or knocked down Ythdf2 function in hUCB cells, they observed increased expression of these transcription factors and expansion of hematopoietic stem cells, which are the major type of adult stem cells in hUCB. (scitechdaily.com)
  • Since the Ythdf2 protein is present in different kinds of adult stem cells, targeting it and how it affects hematopoietic stem cells seemed a safer approach and, if it worked, broadly applicable. (scitechdaily.com)
  • Linheng Li believes that this approach could potentially be applied to other types of adult stem cells, which may lead to increasing the number of adult stem cells available for treating patients. (scitechdaily.com)
  • Accepted: 24 October 2012 cell yield data, our models require that adult DN1 cells divide multiple times before becoming competent to progress into DN2 stage. (lu.se)
  • At the same time, the first three trials using cells derived from pluripotent cells have begun. (biomedcentral.com)
  • Stem cells (SCs) are undifferentiated cells with self-renewal ability and capacity to differentiate into specialized cell types. (bvsalud.org)
  • that is, 'stem cells' just before they are differentiated into blood cells, for processing in the laboratory. (mdanderson.es)
  • Once 'trained' in the laboratory, those T-lymphocytes are infused back into the patient to identify and attack the tumour cells. (mdanderson.es)
  • Life-saving bone marrow transplants have been the common practice for decades, but this doesn't work for everybody," says Stowers Institute Investigator Linheng Li, Ph.D., study lead who is also co-leader of the cancer biology program at the University of Kansas Cancer Center and an affiliate professor of pathology and laboratory medicine at the University of Kansas School of Medicine. (scitechdaily.com)
  • In animal models, delivery of several different types of stem cells reduce infarct size and improve functional outcomes. (bmj.com)
  • Objective: the aim of this study was to conduct a literature review of the types of stem cells of dental origin and their applications in Dentistry. (bvsalud.org)