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  • Acute
  • This method has proven to be a simple and safe method for harvesting BMCs and reduces the risk of acute graft versus host disease in allogeneic BMT. (omicsonline.org)
  • Granzyme B-Mediated Activation-Induced Death of CD4+ T Cells Inhibits Murine Acute Graft-versus-Host Disease. (semanticscholar.org)
  • Isolated extramedullary breast relapses in inv(16) positive and c-KIT negative acute myeloid leukemia after allogenic hematopoietic stem cell transplantation - description of two cases. (stembook.org)
  • In the current study, we report that EM23, a natural sesquiterpene lactone isolated from EM, inhibits the proliferation of human chronic myeloid leukemia (CML) K562 cells and acute myeloid leukemia (AML) HL-60 cells by inducing apoptosis. (frontiersin.org)
  • One patient did not receive a sufficient number of cells, and one patient unfortunately developed an acute T cell leukaemia related to the treatment. (medica-tradefair.com)
  • lymphoma
  • Plasma cell myeloma mimicking classical Hodgkin lymphoma in the bone marrow. (amedeo.com)
  • This phase I/II trial studies the best dose and side effects of dendritic cell therapy, cryosurgery and pembrolizumab in treating patients with non-Hodgkin lymphoma. (mayo.edu)
  • Giving dendritic cell therapy, cryosurgery and pembrolizumab may work better at treating non-Hodgkin lymphoma. (mayo.edu)
  • clonal
  • 2. MPNs are clonal diseases Originating in multipotential hematopoietic progenitor cell Characterized by independence of numerous cytokines. (slideshare.net)
  • Altogether, the clonal ABL/ABL dendritic cells display the unique and selective ability to activate NK cells and may participate in the NK cell control of CML. (aacrjournals.org)
  • Bone-marrow studies showed myelodysplasia, erythroblastosis, and clonal evolution of del(20)(q11.2q13.3). (springer.com)
  • We studied 46 consecutive patients with AL who underwent quantification of serum M-protein and clonal bone marrow plasma cells, as well as a comprehensive evaluation for end organ damage by MM. Using standard morphology and CD138 immunohistochemical staining, 57% and 80% of patients were found to have concomitant MM, respectively. (stanford.edu)
  • immune
  • Unfortunately, these medications may cause severe side-effects such as hypersensitivity reactions, bone marrow suppression, auto-immune disease and sideroblastic anemia. (clinicaltrials.gov)
  • Zhao Q, Ren H, Han Z. Mesenchymal stem cells: Immunomodulatory capability and clinical potential in immune diseases. (springer.com)
  • Najar M, Raicevic G, Fayyad-Kazan H, Bron D, Toungouz M, Lagneaux L. Mesenchymal stromal cells and immunomodulation: a gathering of regulatory immune cells. (springer.com)
  • Immune-related antigens, surface molecules and regulatory factors in human-derived mesenchymal stromal cells: the expression and impact of inflammatory priming. (springer.com)
  • Qi K, Li N, Zhang Z, Melino G. Tissue regeneration: the crosstalk between mesenchymal stem cells and immune response. (springer.com)
  • Research in Dr. Hoxie's lab is focused on identifying viral and cellular determinants that are relevant to the ability of HIV and SIV to infect cells and to evade host immune responses. (upenn.edu)
  • Dr. Hoxie has proposed that these signals could be relevant in pathogenesis by enabling virus-producing cells to survive host anti-viral immune responses. (upenn.edu)
  • Vaccines, such as dendritic cell therapy made from a person's tumor cells and white blood cells may help the body build an effective immune response to kill tumor cells. (mayo.edu)
  • In line with a site-directed delivery of the cytokine, F16-IL2 led to an extensive infiltration of immune effector cells in the bone marrow. (aacrjournals.org)
  • Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells. (bioportfolio.com)
  • The protein is important for a functional cytoskeleton, which is required for maturation and activation of white blood cells forming the immune system and platelets required for blood clotting. (medica-tradefair.com)
  • Because of this, allogeneic transplantation means that not only the donor's blood system but also his or her immune system is transferred. (lls.org)
  • The active ingredient of AlloStim is living, human immune cells that have been differentiated and expanded outside the body. (clinicaltrials.gov)
  • Therefore, the allogeneic cells in AlloStim are expected to be rejected by the patient's immune system within 24-48 hours of infusion. (clinicaltrials.gov)
  • clinical
  • By this way, non-immunogeneic mesenchymal stem cells which have healthy genetic structure, can manufacture the required enzyme, will be repopulated in the damaged tissue and contribute to the clinical improvement. (clinicaltrials.gov)
  • Here we review the perfusion method (for harvesting BMCs) and IBM-BMT (for their transplantation) and show that this combination will become a powerful new clinical strategy for allogeneic BMT. (omicsonline.org)
  • Stem cell selection is another technique being studied in clinical trials that can reduce the number of T lymphocytes that a patient receives. (lls.org)
  • We identify a recurrent loss of granulocyte-macrophage progenitors (GMPs) in the bone marrow of low risk MDS patients that can distinguish low risk MDS from clinical mimics, thus providing a simple diagnostic tool. (stanford.edu)
  • corticosteroids
  • Response to cyclosporine A and corticosteroids in adult patients with acquired pure red cell aplasia: serial experience at a single center. (amedeo.com)
  • The data provided in the NDA submission demonstrate that orBec® may provide a higher rate of survival when compared with the current standard of care, and a lowered exposure to systemic corticosteroids following allogeneic transplantation. (marketwired.com)
  • CD56
  • 10 ) have recently shown that ABL/ABL directly alters the function of NK cells (i.e., induces partial IL-2 independent growth and increases killer immunoglobulin-like receptor expression in primary CD56 bright NK cell subsets). (aacrjournals.org)