• As part of their continuing effort to skip over the ethical and political hurdles surrounding embryonic stem cells, researchers have unlocked even more potential from the adult kind. (scientificamerican.com)
  • Stem cells from adult bone marrow normally generate bone, muscle, cartilage and fat cellsa limited set compared with embryonic stem cells, which can spawn the full spectrum of adult tissues. (scientificamerican.com)
  • Dendritic cell isolation from mouse body tissues can be difficult and the number of cells isolated small. (rti.org)
  • Stem cells in the adult have traditionally been thought to be restricted in their potential to differentiate and regenerate tissues in which they reside. (jci.org)
  • The prior art describes the development, from stem cell to differentiated cells, of various tissues throughout the body. (google.com)
  • Stem cells are special regenerative cells with which the body replaces or repairs its own tissues. (nytimes.com)
  • The native skin cells produced only collagen type I. Researchers do not know why bone marrow would produce collagen III, which is typically found in connective tissues such as skin. (innovations-report.com)
  • The recognition that stem cells, particularly those from the bone marrow, have the capacity to colonize different tissues, proliferate, and transdifferentiate into cell lineages of the host organ ( 8 , 9 ), prompted us in an earlier study ( 10 ) to inject Lin − c- kit POS bone marrow cells (BMC) in the contracting myocardium bordering acute infarcts. (pnas.org)
  • Two main determinants seem to be critical for colonization and transdifferentiation of BMC into a variety of tissues: recent damage and a high number of circulating stem cells ( 8 , 9 , 11 , 12 ). (pnas.org)
  • The ECM serves a unique role by constructing a "scaffold" for cells, thereby maintaining the structural integrity of many tissues. (emaxhealth.com)
  • Wnts are secreted glycoproteins that regulate stem cell self-renewal, differentiation, and cell-to-cell communication during embryonic development and in adult tissues. (sigmaaldrich.com)
  • We also discuss the mechanisms by which BMSCs control neuroinflammation and chronic pain and how these cells specifically migrate to damaged tissues. (rutgers.edu)
  • But a new study published in Cell Transplantation found that, when injected directly into damaged heart tissue, cells originating from the tissues surrounding the blood vessels of the human umbilical cord are superior to those of marrow. (healthcanal.com)
  • Bone marrow-derived cells (BMDCs) can differentiate into nonhematopoietic cells, suggesting that BMDCs may contribute to the maintenance of multiple tissues. (wiley.com)
  • The growing evidence suggesting that they can recirculate and migrate to injured tissues to replace lost parenchymal cells, together with the possibility of rapidly expanding them ex vivo without loss of differentiation potential, 1 - 4 make them of substantial clinical interest. (bloodjournal.org)
  • Photobiomodulation effects of Low-level light irradiation (LLLI) on regeneration have been reported in skin, nerve, and skeletal muscle tissues and bone. (scirp.org)
  • The study, released in Cell Transplantation this month, demonstrates that the cells originating from the tissues surrounding the blood vessels of the human umbilical cord, also known as "Wharton's Jelly," outperformed the current gold standard for stem cell therapies for repairing damage to heart muscles, after an induced heart attack when injected directly into the affected area. (bio-medicine.org)
  • PCs migrate to bone marrow and inflamed tissues where they complete maturation into long-lived PCs that are resistant to immunosuppressive treatments. (jax.org)
  • Scientists looked at rates of graft failure, where the transplanted cells fail to function, and graft-versus-host disease (GVHD), where the transplanted cells attack the patient's own tissues. (bionews.org.uk)
  • This protocol describes the growth of large number of dendritic cells from the culture of mouse bone marrow cells. (rti.org)
  • Mouse bone marrow contains spontaneous rosette-forming cells (RFC) which include more than 70% T-cell precursors, as assessed by their transformation into theta-positive cells after incubation with thymic hormone. (biomedsearch.com)
  • Such spontaneous RFC, examined in C57B1/6 mouse bone marrow by electron and scanning electron microscopy, have consistently been shown to be small, inactive mouse lymphocytes when macrophages have been eliminated by cell preincubation. (biomedsearch.com)
  • With the help of several genetic markers that are found in germ cells, the master cells that eventually give rise to the egg and sperm, the team shows evidence for the existence of germ cell progenitors, putative stem cells, in mouse bone marrow and blood. (bio-medicine.org)
  • It was also found that indomethacin reversed the PTH mediated reduction of CFU-F that could be extracted from mouse bone marrow. (bl.uk)
  • To test the effects of PTH in vivo, the number of CFU-F that could be extracted from murine bone marrow after administration of an anabolic dose of PTH were measured. (bl.uk)
  • Cultured lung fibroblasts expressed the chemokine receptors CXCR4 and CCR7 and responded chemotactically to their cognate ligands, stromal cell-derived factor-1α and secondary lymphoid chemokine, respectively. (jci.org)
  • Ischemic rat brain extracts induce human marrow stromal cell growth factor production," Neuropathology , vol. 22, no. 4, pp. 275-279, 2002. (hindawi.com)
  • In the simultaneous culture system, stromal cell exposure to hydroquinone and benzoquinone produced dose dependent decreases in granulocyte monocyte colonies. (cdc.gov)
  • Recombinant fragment, corresponding to a region within amino acids 1-146 of Human Bone marrow stromal cell antigen 1. (abcam.com)
  • If so, it would not be necessary to use the ethically more problematic embryonic stem cells. (eurekalert.org)
  • Moreover, bone marrow cells may also represent an attractive source for cell replacement therapy of type 1 and type 2 diabetes, not least in view of the limited supply of human islets and ethical issues surrounding embryonic stem cell research ( 28 - 31 ). (diabetesjournals.org)
  • Combined with the recent evidence of BM stem cell plasticity cited above, this provides a compelling argument for re-examination of the origin of the fibroblasts in pulmonary fibrosis, especially in terms of their possible extrapulmonary origin. (jci.org)
  • Our study shows that the recruitment of bone marrow-derived fibroblasts is important for promoting tumor growth, likely by enhancing blood vessel formation," Neta Erez, researcher at Sackler School of Medicine, Tel Aviv University, said in a press release. (upi.com)
  • Breast cancer tumors with these bone marrow-associated fibroblasts can therefore grow more blood vessels that allow them to develop more quickly than tumors without fibroblast interactions. (upi.com)
  • Erez and her colleagues observed that human breast cancer tumors also have fibroblasts without PDGFRα, meaning human tumors may also pull in bone marrow cells. (upi.com)
  • Understanding the function of these cancer-associated fibroblasts could form the basis of developing novel therapeutic manipulations that co-target bone marrow-derived fibroblasts as well as the cancer cells themselves," Erez said. (upi.com)
  • These bone marrow-derived fibroblasts are different from other cancer-associated fibroblasts. (medindia.net)
  • But bone marrow-derived fibroblasts are particularly effective at stimulating the formation of new blood vessels because they produce large amounts of a protein called clusterin. (medindia.net)
  • Tumors containing bone marrow-derived fibroblasts were therefore more vascularized and grew faster than tumors that only contained breast-derived fibroblasts. (medindia.net)
  • Erez and colleagues found that human breast cancers also contain fibroblasts lacking PDGFRα, suggesting that human tumors may also recruit bone marrow-derived cells. (medindia.net)
  • Moreover, tumors containing lower levels of PDGFRα tended to be more deadly, suggesting that the recruitment of bone marrow-derived fibroblasts is a crucial step in breast cancer progression. (medindia.net)
  • Our study shows that the recruitment of bone marrow-derived fibroblasts is important for promoting tumor growth, likely by enhancing blood vessel formation," Erez says. (medindia.net)
  • A mouse breast tumor contains bone marrow-derived fibroblasts (red) as well as other cancer-associated fibroblasts (green). (eurekalert.org)
  • The study, which will be published November 23 in the Journal of Experimental Medicine , reveals that the recruitment of bone marrow-derived fibroblasts lowers the odds of surviving breast cancer, but suggests that targeting these cells could be an effective way of treating the disease. (eurekalert.org)
  • Myelofibrosis causes an abnormal increase in the cells that produce collagen fibers called fibroblasts. (news-medical.net)
  • The cells known as fibroblasts are thought to be these young osteoblasts. (news-medical.net)
  • While much is understood about dendritic cells and their role in the immune system, the study of these cells is critical to gain a more complete understanding of their function. (rti.org)
  • However, the mechanism by which GP affects dendritic cells (DCs) has not been elucidated. (mdpi.com)
  • They can modulate T and B lymphocytes, natural killer cells, and dendritic cells via both contact-dependent and independent mechanisms lending to their therapeutic potential in autoimmune disease. (jax.org)
  • Previously, researchers had not known that bone marrow contributed to the development of new skin in wounds. (innovations-report.com)
  • We've known that bone marrow cells are involved in wound healing and inflammation - now we have data that shows bone marrow cells are involved in normal skin maintenance, in maintaining the matrix environment and integrity of the skin. (innovations-report.com)
  • It was already known that bone marrow may play a role in skin wound healing, but until now it was not known which specific bone marrow cells this involves, how the process is triggered, and how the key cells are recruited to the affected skin area. (thaindian.com)
  • Conditioning protocols were tested for their efficacy in increasng the incidence of engraftment of histoincompatible dog bone marrow cells. (osti.gov)
  • Intramyocardial transplantation of hBMSCs after myocardial infarction resulted in robust engraftment of transplanted cells, which exhibited colocalization with markers of cardiomyocyte (CMC), EC, and smooth muscle cell (SMC) identity, consistent with differentiation of hBMSCs into multiple lineages in vivo. (jci.org)