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  • acquired pure re
  • Response to cyclosporine A and corticosteroids in adult patients with acquired pure red cell aplasia: serial experience at a single center. (amedeo.com)
  • 2017
  • Highlights and ongoing studies include these projects: 2017 - CAR-T cell therapy and using Zika virus to fight brain cancer In a clinical trial at Siteman, at least 16 of 20 people who received a new treatment called CAR-T cell therapy saw their cancers disappear after treatment. (wikipedia.org)
  • hematopoiesis
  • Mammalian hematopoiesis is a unique developmental process in which stem cells continue to generate vast numbers of diverse cell types throughout adult life. (rochester.edu)
  • As in other systems, Notch appears to influence cell fate decisions at multiple steps during hematopoiesis, having effects that are determined by the presence of specific inductive signals and the precise maturational state of the cell. (rochester.edu)
  • Defining the role of Notch signaling during hematopoiesis is complicated both by the number of Notch receptors and DSL ligands expressed by hematopoietic and stromal cells, and by the interactions of Notch with other signaling pathways within the intricate hematopoietic regulatory network. (rochester.edu)
  • In vertebrates, the vast majority of hematopoiesis occurs in the bone marrow and is derived from a limited number of hematopoietic stem cells (HSCs) that are multipotent and capable of extensive self-renewal. (wikipedia.org)
  • gene
  • The unique capacity of Notch to function both as a cell-surface receptor and transcriptional regulator provides a mechanism by which cell-cell interactions can directly influence gene expression in neighboring cells. (rochester.edu)
  • The journal provides commentary and analysis to elucidate best clinical practice in hematology and to translate advances in research - in areas such as immunology, stem cell research, and cell and gene therapy - into the clinical context. (wikipedia.org)
  • The lack of recognition of a T cell to this self antigen is the reason why allogeneic stem cell transplantation for an HLA matched gene or a developing fetus's MiHAs during pregnancy may not be recognized by T cells and marked as foreign leading to an immune response. (wikipedia.org)
  • The male bone marrow cells were found to be presenting a peptide in the MHC groove encoded by a gene on Y chromosome. (wikipedia.org)
  • Once inside the body the vector introduces the therapeutic gene into host cells, and the protein encoded by the newly inserted gene is then produced by the body's own cells. (wikipedia.org)
  • Then in laboratory conditions the stem cells are manipulated and corrected with gene technology. (wikipedia.org)
  • Mast/stem cell growth factor receptor (SCFR), also known as proto-oncogene c-Kit or tyrosine-protein kinase Kit or CD117, is a receptor tyrosine kinase protein that in humans is encoded by the KIT gene. (wikipedia.org)
  • Recombinant technology has allowed for the identification of the T-cell receptor gamma (TRG) gene that is found associated with the CD3 complex on the cell surface. (wikipedia.org)
  • malignancies
  • Research in her laboratory is guided by two fundamental questions: what are the molecular mechanisms responsible for the generation of diverse cell types from pluripotent stem cells, and how do aberrations in normal developmental pathways contribute to pediatric malignancies? (rochester.edu)
  • clinically
  • citation needed] G-CSF is used clinically (see Neutropenia) but tests in mice suggest it may lead to bone loss. (wikipedia.org)
  • Genetic
  • Radiation therapy injures or destroys cells in the area being treated (the "target tissue") by damaging their genetic material, making it impossible for these cells to continue to grow and divide. (wikipedia.org)
  • therapy
  • and Hu-PHEC, a cell therapy product for bone marrow/hematopoietic stem cells transplantation. (marketbeat.com)
  • While replacement therapy remained unrealistic, the clinical efficacy of this therapeutic option could be potentially enhanced if we could better decipher the mechanisms underlying some of the beneficial effects of transplanted cells, and work toward augmenting or combining these in a strategic manner. (degruyter.com)
  • Radiation therapy (also called radiotherapy, X-ray therapy, or irradiation) is the use of ionizing radiation to kill cancer cells and shrink tumors. (wikipedia.org)
  • protein
  • Diamond-Blackfan anemia (DBA) is a congenital red cell aplasia arising from ribosomal protein (RP) defects. (springer.com)
  • Stem cell markers are genes and their protein products used by scientists to isolate and identify stem cells. (wikipedia.org)
  • Below is a list of genes/protein products that can be used to identify various types of stem cells, or functional assays that do the same. (wikipedia.org)
  • DOCK8, or "dedicator of cytokinesis 8", is a protein involved in regulating the actin skeleton of the cell. (wikipedia.org)
  • When it is mutated, an incorrect protein is produced, so there is, at most, a trace level of functional DOCK8 protein in the cell. (wikipedia.org)
  • AK2 protein allows hematopoietic stem cells to differentiate and proliferate. (wikipedia.org)
  • If there is a mutation in the protein, that means that the mitochondria metabolism most likely will be altered and will not be able to provide enough energy to the hematopoietic stem cells. (wikipedia.org)
  • Ubiquitin is a small (76-amino acid) protein highly conserved among eukaryotic cells. (wikipedia.org)
  • It contributes the gamma (γ) chain to the larger TCR protein (T-cell receptor). (wikipedia.org)