Bone marrow b cell activating factor. Medical search. Frequent questions

Hematopoietic stem cell transplantation (HSCT) has been shown to be effective. (medscape.com)
In the prospective Autologous Stem Cell Transplantation International Scleroderma (ASTIS) trial, a phase 3 comparison of autologous HSCT with 12 successive monthly intravenous pulses of cyclophosphamide in 156 patients with early diffuse cutaneous systemic sclerosis, HCST was associated with higher treatment-related mortality than in the first year after treatment. (medscape.com)
MTOR inhibition by rapamycin treatment in vivo was able to rescue autophagy-deficient HSC loss and bone marrow failure and resulted in better reconstitution after transplantation. (ox.ac.uk)
These two therapeutic compounds both indirectly activate p53, thereby presenting a combinational non-genotoxic p53 activation strategy, in contrast to conventional chemotherapy and bone marrow transplantation. (uib.no)
Posttransplant cyclophosphamide (PTCy) is associated with a low incidence of chronic graft-versus-host disease (cGVHD) following hematopoietic stem cell (HSC) transplantation. (jci.org)
Today, more than 50 years after the first successful bone marrow transplantation, clinical application of hematopoietic stem cells is a routine procedure, saving the lives of many every day. (hindawi.com)
Therefore, hematopoietic stem cells mobilized into a subject's peripheral blood by the method of the invention is useful as a source of donor cells in bone marrow transplantation for the treatment of a variety of disorders, including cancer, anemia, autoimmunity and immunodeficiency. (justia.com)
In addition, the regenerative potential of purified stem cells was assessed 3 weeks after transplantation in immunodeficient mice which had been subjected to experimental myocardial infarction. (biomedcentral.com)
This special cell is a blood stem cell and we now routinely use radiation and bone marrow transplantation to cure many blood cancers. (nhsbt.nhs.uk)
cells for allogeneic transplantation without immunosuppression 6,153,428 .alpha. (europeanstrokenetwork.eu)
The essence of MDS is damage of In the current work we examined All our patients were of the high-risk colony-forming units [4], but the defect haematopoietic stem cells of high-risk group and none of them was eligible of the haematopoietic stem cells is not MDS cases for apoptotic and anti-apop- for stem cell transplantation. (who.int)
For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
In SCIDs bone marrow transplantation is the most effective treatment. (lu.se)

BMDM injection activated hepatic progenitor cells (HPCs), improved liver regeneration and liver function. (ukri.org)
However, transplanting other than hematopoietic stem and progenitor cells is still limited to a few applications, and it mainly applies to mesenchymal stromal cells (MSCs) isolated from bone marrow. (hindawi.com)
At the same time, by asymmetric cell division or after specific activation, stem cells must be able to generate more mature progenitor cells or differentiated effector cells (Figure 1 ). (hindawi.com)
They display differentiation capacities and therefore qualify as multipotent progenitor cells (Figure 1 ). (hindawi.com)
Improved methods and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as Rac1 and Rac2 alone or in combination. (justia.com)
When stimulated to divide, they give rise to more committed, differentiated daughter cells with less proliferative potential, called "early progenitor" cells. (justia.com)
Current treatments to manage the problems that result from prolonged bone marrow suppression include the reinfusion of a patient's own previously harvested hematopoietic stem and progenitor cells. (justia.com)
In such procedures, patients undergo successive treatments with cell mobilization agents to cause mobilization of hematopoietic progenitor cells from the bone marrow to the peripheral circulation for harvesting. (justia.com)
The pathogenesis of anaemia in cancer is multifactorial and includes classical features of the inflammatory anaemia of chronic disease, such as iron restriction within the reticuloendothelial system, an impaired biological activity of erythropoetin and a diminished proliferation of erythroid progenitor cells, all of which are the reflection of a cancer driven activated immune system ( 2 ). (iiarjournals.org)
This process relies on the formation of a blastema, a pool of progenitor cells that is formed in response to amputation. (lu.se)
This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
Downloaded from periodic thymic colonization by progenitor cells guarantees stage. (lu.se)

It mediates the interaction between receptor tyrosine kinases (RTKs) and non-RTK receptors serving as the gateway into the cell for activation of SHP2, Phosphatidylinositol 3-kinase (PI3K), Grb2, ERK, and AKT and acting as one of the first steps in these signaling pathways. (wikipedia.org)
By providing a platform to host a wide array of interactions from extracellular inputs to intracellular pathways, GAB proteins can act as a gatekeeper to the cell, modulating and integrating signals as they pass them along, to control the functional state within the cell. (wikipedia.org)
There are also, however, other pathways that are activated by this interaction such as the pathways c-Kit-induced Rac activation and β1-integrin. (wikipedia.org)
The effects of all the pathways activated by GAB proteins are not known, but it is easy to see that amplification of signal can progress quickly and these proteins can have large effects on the state of the cell. (wikipedia.org)
Significantly differentially expressed (SDE) immunological genes and transcription factor (TF) were selected for functional pathways and transcriptional signaling identification. (frontiersin.org)
Ly6C high MC exhibited activated neutrophil degranulation, lysosome, cytokine production/receptor interaction and myeloid cell activation pathways, and Ly6C low MC presented features of lymphocyte immunity pathways in both mice. (frontiersin.org)
Ly6C low MC manifested activated T-cell signaling pathways and potentially can adapt the function of lymphocytes. (frontiersin.org)
Interaction between BAFF and BAFF-R activates classical and noncanonical NF-κB signaling pathways. (wikidoc.org)
NF-κB pathways are associated with immunity, inflammation and cell survival. (springer.com)
MAPK pathways refer to various cellular functions, including cell proliferation, differentiation and migration. (springer.com)
Akt pathways have effects on apoptosis, protein synthesis, metabolism and cell cycle. (springer.com)
NF-κB pathways can be mainly activated by two pathways. (springer.com)
Now that we know Myb is critical in creating long-term immunity, we can begin dissecting the pathways it uses to mark plasma cells for storage and the genes involved in migrating to the bone marrow," he said. (edu.au)

7 , 8 BAFF prevents apoptosis of B cells, regulates B-cell homoeostasis, and maintains peripheral tolerance. (bmj.com)
BMDMs secreted tumour necrosis factor-like weak inducer of apoptosis (TWEAK) which induces HPC expansion and Wnt, which differentiates HPCs into hepatocytes. (ukri.org)
Primarily, p53 protects the cell from malignant transformation through cell cycle arrest and apoptosis. (uib.no)
VP79s was found to induce apoptosis in NCI-H929 and U266B1 MM cell lines in a dose- and time-dependent manner. (confex.com)
Combining VP79s with bortezomib synergistically enhanced apoptosis in MM cells compared with single agent treatment. (confex.com)
Erythropoetin (Epo) is a 30.4 kDa glycoprotein that regulates erythropoesis by stimulating growth, preventing apoptosis and inducing differentiation of red blood cell precursors. (iiarjournals.org)
Firstly, the overexpression of miRNA‑375 significantly suppressed cell proliferation, increased lactate dehydrogenase activity and induced apoptosis in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
It affects cell proliferation, differentiation and inhibits apoptosis, and its role in tumor development has received attention ( 9 ). (spandidos-publications.com)
Overexpression of IGF-1 in serum and tissue alters the growth of normal cells and causes uncontrolled proliferation, inhibits differentiation and reduces apoptosis, resulting in the incidence and development of malignant tumors ( 10 ). (spandidos-publications.com)
This phenomenon, called receptor editing, will rescue autoreactive B cells from apoptosis. (eur.nl)

1: In the haematopoietic microenvironment, bone marrow stromal cells play an important role in regulating haematopoiesis by expressing various cytokines, including leukaemia inhibitory factor (LIF) and interleukin-6 (IL-6). (unboundmedicine.com)
The bone marrow microenvironment (BMME) is a complex network system primarily comprising stromal cells such as mesenchymal stem cells (MSCs), osteoprogenitor cells, vascular endothelial cells, monocytes, macrophages, and cytokines. (techscience.com)
The bone marrow stromal cell (BMSC) population, which makes up a large part of the hematopoietic microenvironment, encompasses a variety of adherent cell types. (techscience.com)
Multiple myeloma (MM) is a hematological malignancy characterized by the proliferation of malignant plasma cells in the bone marrow microenvironment. (confex.com)
However, despite the effectiveness of the first-line treatments, patients invariably relapse and become drug refractory due to genetic heterogeneity and induction of prosurvival signalling cascades in the bone marrow microenvironment. (confex.com)
The Janus kinase (JAK)/Signal transducer and activator of transcription 3 (STAT3) pathway in MM can be both constitutively active due to autonomous mutations or activated by growth and survival factors, such as interleukin-6 (IL-6), secreted by bone marrow stromal cells and other cells within the bone marrow microenvironment. (confex.com)
Here, we investigate the function of MM-derived MIF in the MM microenvironment by examining its effects on bone marrow stromal cells (BMSC). (biomedcentral.com)
To investigate the effects of MIF secretion by MM on its microenvironment, we used cytokine arrays to establish if cytokine changes occur when MM cells are cultured with primary BMSC. (biomedcentral.com)

It is expressed on endothelial cells (especially on angiogenic endothelial cells) and upregulated by hypoxia, activated monocytes, macrophages, bone marrow stromal cells, and some cytotrophoblasts. (biolegend.com)
This recovery phase is coordinated ad achieved in large part through the action of cells termed macrophages. (ukri.org)
We have shown in mouse model of liver fibrosis that the injection of macrophages, grown in the lab from bone marrow, is able to reduce significantly the scarring and improve regeneration and liver function. (ukri.org)
Here we can isolate large amounts of monocytes from patients blood and turn them into macrophages that have similar properties to the mouse cells over a 1 week period. (ukri.org)
The macrophages will be re-infused under close monitoring in 3 groups of 3 patients using increasing cell numbers up to 100 million cells. (ukri.org)
In rodent models of liver injury and fibrosis bone marrow derived macrophages (BMDMs) induced regression of scarring and stimulated liver regeneration. (ukri.org)
Lentinan mitigates therarubicin-induced myelosuppression by activating bone marrow-derived macrophages in an MAPK/NF-κB-dependent manner. (curated.co)

Hairy Cell Leukemia (HCL) is is an uncommon lymphoid neoplasm characterized by the accumulation of small mature B cell lymphoid cells with abundant cytoplasm and "hairy" projections within the peripheral blood, bone marrow, and splenic red pulp. (lls.org)
This report demonstrates that stimulation of highly purified primary human peripheral plasmacytoid dendritic cells (pDCs) with either live or inactivated RRV induces substantial IFNalpha production by a subset of pDCs in which RRV does not replicate. (stanford.edu)
Additionally, this study demonstrates trypsin-independent infection of primary peripheral cells by rotavirus, which may allow for the establishment of extraintestinal viremia and antigenemia. (stanford.edu)
Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. (justia.com)
In particular, embodiments of the method involve inhibition of both Rac1 and Rac2 GTPases to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject. (justia.com)
The present invention relates generally to improved methods and pharmaceutical compositions for mobilizing hematopoietic stem and progenitor cell from bone marrow into peripheral blood by administration of at least one inhibitor of a GTPase, such as Rac1 and/or Rac2 GTPase. (justia.com)
HPSE is highly expressed in placenta and spleen and weakly expressed in lymph node, thymus, peripheral blood leukocytes, bone marrow, endothelial cells, fetal liver and tumor tissues. (rndsystems.com)

Some authorities suggest that the primary endothelial cell defect with secondary thrombosis leads to infarctive changes manifesting as Degos disease. (medscape.com)
Efficient recognition of foreign pathogens by T cells requires adhesive interactions between T cells and other cell types, such as endothelial cells and antigen-presenting cells (APCs), and with components of the extracellular matrix. (scielo.br)
As the cancer volume increases, the cancer may release angiogenesis factors, such as vascular endothelial growth factor (VEGF), which promote formation of new blood vessels that are required for further growth. (msdmanuals.com)
Periodontal pathogens can, thus, disseminate through the blood and can contribute to development of adverse systemic effects by direct (endothelial injury or dysfunction) indirect (through lipopolysaccharide (LPS) activated cytokine profiles) mechanisms [8]. (bvsalud.org)

Monocytes (MC) are bone marrow (BM) derived mononuclear phagocytes that play an important role in innate immune response and are the major immune cell population in chronic tissue inflammatory ( 1 , 2 ). (frontiersin.org)
It is expressed as a membrane-bound type II transmembrane protein [2] on various cell types including monocytes , dendritic cells and bone marrow stromal cells. (wikidoc.org)
Cirrhotic patients will have monocytes isolated using a cell separator machine which takes 2 to 4 hours. (ukri.org)
It is produced by Idiopathic nephrotic syndrome (INS) a variety of cells, including monocytes and accounts for 90% of nephrosis in child- mesangial cells in the kidney [ 9 ]. (who.int)

However, the intracellular signal that regulates cytokine secretion in bone marrow stromal cells has not been determined. (unboundmedicine.com)
discuss the role of integrins in T cell- mediated immunity, with a focus on how these receptors participate in lymphocyte recirculation and T cell activation, how antigen stimulation regulates integrin activity, and how integrins define functionally unique subsets of T cells and APCs. (scielo.br)

The aim of this study was to evaluate the role of mitogen-activated protein kinase (MAPK) family in serum-induced secretion of LIF and IL-6 by bone marrow stromal cells. (unboundmedicine.com)
TY - JOUR T1 - Role of mitogen-activated protein kinase family in serum-induced leukaemia inhibitory factor and interleukin-6 secretion by bone marrow stromal cells. (unboundmedicine.com)
MKPs (mitogen-activated protein kinase phosphatases). (abdur.ca)

CXCR4 plays a key role in the mobilization and targeted migration of stem cells to their storage (e.g., fetal liver, bone marrow) or their sites of use in organ formation (organogenesis) and organ and wound healing. (reliatech.de)

In addition, co-existing factors such as vitamin deficiency, renal insufficiency, tumour infiltration into the bone marrow and local cytokine production by malignant cells within this compartment further contribute to cancer-related anaemia. (iiarjournals.org)

Here we address why autophagy depletion leads to a drastic loss of the stem cell compartment. (ox.ac.uk)
Using inducible deletion of autophagy specifically in adult hematopoietic stem cells (HSCs) and in mice chimeric for autophagy-deficient and normal HSCs, we demonstrate that the stem cell loss is cell-intrinsic. (ox.ac.uk)
Overview of studies published regarding MSCs using the term "stem cell" or "stromal cell" in the last 20 years accessed by a web search in July 2015 (Google Scholar). (hindawi.com)
It seems that the term "stem cell" became more popular although the "stemness" was only shown in a more strict sense for MSCs involved in osteogenesis and bone repair. (hindawi.com)
When the biological properties of MSCs were explored in more detail, questions arose whether these cells met the criterion of a true stem cell [ 8 ]. (hindawi.com)
To qualify as a stem cell, these cells must be able to self-renew, most likely by symmetric cell division to produce two daughter cells with the same stem cell qualities. (hindawi.com)
Overview on self-renewal or differentiation of stem cells in their respective stem cell niche. (hindawi.com)
MSCs were also investigated for stem cell qualities in vivo. (hindawi.com)
Could stem cell therapy be an effective treatment for Friedreich's ataxia? (bristol.ac.uk)
Researchers at the University of Bristol are looking for people with an inherited neurological condition called Friedreich's ataxia (FA) to take part in a study into whether a stem cell therapy could be a treatment for FA. (bristol.ac.uk)
The small, pilot study aims to recruit seven people to find out if the bone marrow stem cell mobilising drug, granulocyte-colony stimulating factor (GCSF), could improve blood markers and potentially treat the condition. (bristol.ac.uk)
Dr Alastair Wilkins , Reader in Neurology in the Bristol Medical School (THS) and North Bristol NHS Trust , said: "There has been much excitement and hope over a number of years that stem cell therapies might provide an effective treatment for a variety of neurodegenerative diseases including FA. (bristol.ac.uk)
Of all the types of stem cell therapies which have been put forward, we believe that bone marrow stem cell mobilisation currently holds the most promise, not least as these treatments are safe and have been used extensively for many years for other conditions. (bristol.ac.uk)
It also used to be thought that once a stem cell differentiates, it can never go back. (nhsbt.nhs.uk)
This paved the way for the idea that given the right factors, our own differentiated cells can have their internal clocks turned back, to turn them back into a stem cell just like the one that makes all of those trillion cells that make us who we are, and one day we might be able to use them to grow tissues for transplant. (nhsbt.nhs.uk)
Yamanaka and colleagues discovered in the mid-2000s how to "reprogram" fully differentiated cells (like a bit of your skin) back into a stem cell state, winning them a Nobel Prize - these are called induced pluripotent stem cells, or iPSCs. (nhsbt.nhs.uk)
A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. (immport.org)
This is a tool to help students find the right project for their Bachelor's and Master's thesis at Lund Stem Cell Center. (lu.se)
Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)

However, the quantity of MSCs is very low in bone marrow (about 0.001 to 0.01% of the mononuclear cells) and in vitro expansion is the prerequisite for their clinical application. (biomedcentral.com)
In a very interesting review, P. MARRACK & J. KAPPLER focus on naïve, activated, and memory T cells survival separately, and discuss experiments done in vitro and in mice lacking or containing normal populations of lymphocytes. (scielo.br)
Nutlin-3 and VPA in combination was found to show a synergistic effect in vitro in an AML cell line expressing wild type p53 (MOLM-13). (uib.no)
Expansion of MSCs was shown to be limited to a few passages of in vitro culture and the cells underwent replicative senescence [ 11 ]. (hindawi.com)
Therefore, available in vitro protocols for expansion of MSCs do not yield true stem cells. (hindawi.com)
Furthermore, we demonstrated that these automatically isolated cells bear proliferation and differentiation capacities comparable to manually isolated cells in vitro. (biomedcentral.com)
Results: LED produced in vitro increases of cell growth of 140-200% in mouse-derived fibroblasts, rat-derived osteoblasts, and rat-derived skeletal muscle cells, and increases in growth of 155-171% of normal human epithelial cells. (researchgate.net)
In vitro studies using infra-/red light have not shown any useful impact on wound healing by activating cells located in deeper skin layers such as fibroblasts or stem cells [2] . (researchgate.net)
This project will delve into innate immune cell function, establishing in vitro and in vivo systems test innate immune cell function in regeneration. (lu.se)
Inspired from developmental processes, human mesenchymal cell lines can be programmed to form cartilage, bone and bone marrow tissues in vitro and in vivo. (lu.se)

This study was aimed to observe if thrombin could stimulate FN secretion by human bone marrow MSCs and investigate the potential underlying mechanisms. (biomedcentral.com)
We have shown that when the chronically damaged liver is undergoing repair and regeneration the macropahges are important for reducing the scar tissue in the liver, stimulating the livers own stem cells to expand and multiply and finally help those stem cells turn into hepatocytes through the secretion of several factors. (ukri.org)
The regeneration potential of these cells is mainly based on their direct contribution to neovascularization and on their secretion of various paracrine factors activating pro-angiogenic mechanisms [ 13 - 16 ]. (biomedcentral.com)

We have developed a novel ligand based BAFF-CAR, that utilizes B cell activating factor (BAFF) as a ligand, which can bind to all three receptors of BAFF, which are expressed by malignant B cells including Hairy Cell Leukemia (HCL). (lls.org)
B-cell activating factor ( BAFF ) also known as tumor necrosis factor ligand superfamily member 13B is a protein that in humans is encoded by the TNFSF13B gene . (wikidoc.org)
BAFF is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. (wikidoc.org)
This cytokine is a ligand for receptors TNFRSF13B /TACI, TNFRSF17 /BCMA, and TNFRSF13C /BAFF-R. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. (wikidoc.org)
[4] BAFF is the natural ligand of three unusual tumor necrosis factor receptors named BAFF-R (BR3), TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor), and BCMA (B-cell maturation antigen), all of which have differing binding affinities for it. (wikidoc.org)
B-cell activating factor (BAFF) is a ligand in the TNF family that exists in a membrane-bound and soluble form and is required for B-cell survival as they leave the bone marrow and enter the periphery. (bmj.com)
The fibroblasts then produce hyaluronan and the cytokines interleukin (IL)-1 beta, IL-6, IL-8, IL-16, tumor necrosis factor (TNF) alpha, and CD4 ligand. (medscape.com)

Objective To evaluate the efficacy and safety of tabalumab, a monoclonal antibody that neutralises membrane-bound and soluble B-cell activating factor (BAFF), in patients with active rheumatoid arthritis (RA) who showed inadequate response to tumour necrosis factor (TNF) inhibitors. (bmj.com)
1 Biological therapies that selectively target key molecules associated with joint inflammation, such as tumour necrosis factor (TNF) inhibitors, are effective options for RA treatment. (bmj.com)
p53 is a tumour suppressor protein involved in maintenance of genomic stability of the cell. (uib.no)
This leads to activation of p53 and the p53 pathway in cancer cells with wild type p53, subsequently inhibiting tumour growth. (uib.no)
Serum interleukin (IL)-1, IL-6, tumour necrosis factor (TNF) and quantitative urinary -2-microglobulin (-2-m) excretion were estimated. (who.int)

As they mature, the B cells grow certain receptors on the cell surface and B cell activating factor receptor (BAFF-R) is one among them. (lls.org)
HCL cells are reported to express all three receptors of BAFF. (lls.org)
I developed BAFF-CAR-T cells, to target all three BAFF receptors consecutively. (lls.org)
BAFF.CAR-T cells will bind to BAFF-receptors on HCL cells and activate T cells which finally kills the HCL cells. (lls.org)
Since the receptors are not expressed by any normal cells in the bone marrow, this approach holds great promise to specifically kill HCL cells, without additional side effects. (lls.org)
Our preliminary data shows HCL cells express BAFF receptors and BAFF CAR-T cells can kill HCL cells effectively. (lls.org)
Ly6C high MC presented downregulated co-stimulatory receptors (CD2, GITR, and TIM1) which direct immune cell proliferation, and upregulated co-stimulatory ligands (LIGHT and SEMA4A) which trigger antigen priming and differentiation. (frontiersin.org)
PCR was performed to detect the expression of the protease-activated receptors (PARs) in MSCs. (biomedcentral.com)
BAFF steady-state concentrations depend on B cells and also on the expression of BAFF-binding receptors. (wikidoc.org)
These receptors are expressed mainly on mature B lymphocytes and their expression varies in dependence of B cell maturation (TACI is also found on a subset of T-cells and BCMA on plasma cells ). (wikidoc.org)
Immunoglobulins against insulin-like growth factor 1 (IGF-1) receptors activate signaling in the orbital fibroblasts. (medscape.com)
Acinar cells of the lacrimal glands express thyroid-stimulating hormone (TSH) receptors. (medscape.com)
Background: Adverse outcomes in breast cancer patients treated with recombinant human erythropoietin (rhEpo) have been linked to the expression of Epo-receptors (EpoR) in cancer cells, although limited data on the clinical significance of these observations are available. (iiarjournals.org)

They can also be used for increasing white blood cell survival and for chemotherapy. (justia.com)
After harvesting, the patient is given high dose chemotherapy or radiotherapy and the bone marrow function is reconstituted by infusion of the cells harvested earlier. (justia.com)
The use of high-dosage chemotherapy or radiotherapy for bone marrow ablation requires subsequent incorporation of hematopoietic stem cells into the patient, in which case prior harvesting of such cells is required. (justia.com)
The most common situations are for patients receiving chemotherapy, requiring surgery (especially cardiac surgery) or having experienced severe haemorrhage (e.g. from pregnancy or childbirth, trauma, largely from road traffic accidents, or severe anaemia in the young, often caused by malaria), often being combined with other blood products such as fresh frozen plasma (FFP) and red blood cells (RBCs) in a massive transfusion protocol. (nhsbt.nhs.uk)
Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)

In fact, MSCs can secrete various cytokines, growth factors and a series of extracellular matrix molecules including collagens and FN[ 22 - 26 ], which are the main substrates for MSC adhesion to the plastic. (biomedcentral.com)
Here, we show that MM-derived macrophage migratory inhibitory factor (MIF) stimulates bone marrow stromal cells to produce the disease critical cytokines IL-6 and IL-8, prior to any cell-cell contact. (biomedcentral.com)
A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses. (immport.org)

But research progressed and different trials explore the clinical potential of human MSCs isolated from bone marrow but also from other tissues including adipose tissue. (hindawi.com)
Recently, MSCs isolated from bone marrow (bmMSCs) were shown to be a blend of distinct cells and MSCs isolated from different tissues show besides some common features also some significant differences. (hindawi.com)
Although most circulating cancer cells die, an occasional cell may penetrate into tissues, generating a metastasis at a distant site. (msdmanuals.com)
Periodontitis in itself, is a chronic infectious disease of the supporting tissues of the teeth, with multiple related factors [6]. (bvsalud.org)

We conclude that, in spite of their similar biological effects, they are differentially regulated at the level of MAPK activity in bone marrow stromal cells. (unboundmedicine.com)

2: Transformed human bone marrow stromal cells (HS-5) were stimulated with foetal calf serum (FCS) to produce LIF and IL-6. (unboundmedicine.com)
PCR analysis showed that human bone marrow MSCs expressed two subtypes of PARs, PAR-1 and PAR-2. (biomedcentral.com)

Depending on the degree of bone marrow damage (i.e., suppression), patients who undergo cytoreductive therapy must also receive therapy to reconstitute bone marrow function (hematopoiesis). (justia.com)

The PH domain of GAB2 recognizes phosphatidylinositol 3,4,5-triphosphate(PIP3) in the membrane and is responsible for localizing the GAB protein on the intracellular surface of the membrane and in regions where the cell contacts another cell. (wikipedia.org)
BAFF is a protein which can bind to this receptor and helps the survival of mature B cells. (lls.org)
Although increased levels of systemic type I interferon (IFNalpha and beta) correlate with accelerated resolution of rotavirus disease, multiple rotavirus strains, including rhesus rotavirus (RRV), have been demonstrated to antagonize type I IFN production in a variety of epithelial and fibroblast cell types through several mechanisms, including degradation of multiple interferon regulatory factors by a viral nonstructural protein. (stanford.edu)
The overexpression of miRNA‑375 significantly increased caspase‑3 and caspase‑9 activities, induced B‑cell lymphoma 2 (Bcl‑2)/Bcl‑2‑associated X protein, tumor protein 53 and cyclin‑dependent kinase inhibitor 1 protein expression and suppressed cyclin D1 and survivin protein expression in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
The overexpression of miRNA‑375 significantly suppressed the levels of protein expression of ubiquitin‑protein ligase E3A (UBE3A) and Insulin‑like growth factor‑1 receptor (IGF‑1R) in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
UBE3A is associated with cervical cancer and may combine with the E6 proto-oncogene encoded by HPV16 within cervical cancer cells to form the E6/E6-AP protein complex through the ubiquitin proteasome pathway ( 4 ). (spandidos-publications.com)
In addition, numerous important cellular proteins, such as B-cell lymphoma-2 homologous antagonist/killer, Myc proto-oncogene protein, cyclin-dependent kinase inhibitor 1B, DNA replication licensing factor MCM-7, retinoblastoma 1 and Annexin A1, are degenerated through the UBE3A-mediated ubiquitin proteasome pathway ( 7 ). (spandidos-publications.com)
Professor David Tarlinton (left) and Dr Kim Good-Jacobson have discovered a protein called Myb is essential for preserving antibody-producing plasma cells. (edu.au)
Melbourne researchers have identified a protein responsible for preserving the antibody-producing cells that lead to long-term immunity after infection or vaccination. (edu.au)
Dr Kim Good-Jacobson, Professor David Tarlinton and colleagues from the Walter and Eliza Hall Institute discovered the presence of a protein called Myb was essential for antibody-producing plasma cells to migrate into bone marrow, preserving them for many years or even decades. (edu.au)
The research team discovered that when the gene that produces the protein Myb was removed, plasma cells were no longer able to move into the bone marrow to provide long-term immunity. (edu.au)
Myb is a type of protein called a transcription factor, which binds to DNA and, in effect, switches genes 'on' or 'off'," Dr Good-Jacobson said. (edu.au)
The Myb protein marks the plasma cells that produce high-quality antibodies for preservation. (edu.au)
The adapter protein Slp65 and Bruton's tyrosine kinase (Btk) are key components of the precursor-B (pre-B) cell receptor (pre-BCR) signaling pathway. (eur.nl)
Activated protein c, legala steroider till salu paypal. (abdur.ca)
Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein. (abdur.ca)
Activated protein c pris bästa steroider till salu få muskler. (abdur.ca)
Activated protein c billigt pris beställ anabola steroider online frakt över hela världen. (abdur.ca)
Factor V Leiden mutation is more resistant to activated protein C and therefore takes longer to switch off clotting. (medscape.com)
Clotting is tested in the presence and absence of activated protein C to establish if there is resistance. (medscape.com)
10%. In the remaining 10% of children with lecular weight protein found on the surface nephrotic syndrome, it is largely mediated of all nucleated cells which synthesize it. (who.int)

This is attributable, in part, to the highly protective nature of the BM micro-environment niche in which the malignant plasma cells proliferate. (biomedcentral.com)

As leukemic Slp65-deficient pre-B cells express the recombination activating genes (Rag)1 and Rag2, and manifest ongoing immunoglobulin (Ig) light-chain rearrangement, it has been hypothesized that deregulated recombinase activity contributes to malignant transformation. (eur.nl)

This knowledge could provide new strategies for the development of therapeutic interventions for diseases mediated by mast cells. (canada.ca)
When germ-free cell cultures became a laboratory routine, hopes were high for using this novel technology for treatment of diseases or replacement of cells in patients suffering from injury, inflammation, or cancer or even refreshing cells in the elderly. (hindawi.com)
GCSF, which is commonly used in diseases related to the blood, as well as in healthy people prior to bone marrow donation, activates stem cells within the bone marrow and causes them to circulate around the body. (bristol.ac.uk)
The molecular study of fat cell development in the human body is essential for our understanding of obesity and related diseases. (mdpi.com)
Of CD117 (c-kit) and osteocalcin in activated bone marrow stem cells in different diseases, https://miroiterie-sogemi.com/anabola-steroider-i-tablettform-acheter-seringue-steroide-anabola-steroider-brittich-dragon . (abdur.ca)
Of CD117 (c-kit) and osteocalcin in activated bone marrow stem cells in different diseases. (abdur.ca)
like bleeding disorders, bone marrow diseases, or clot related diseases. (medifee.com)

Despite the success of Chimeric antigen receptor T cell (CAR-T) immunotherapies, disease relapse occurs in a majority of patients. (lls.org)
This receptor is activated by the chemokine CXCL12 and the cytokine macrophage migration inhibitory factor (MIF). (reliatech.de)
In addition, CXCR4 is the primary co-receptor for T cell-using (T-tropic) HI viruses. (reliatech.de)
PAR (Protease-activated receptor): aktiverar thrombin. (abdur.ca)

Macroautophagy/autophagy is a fundamental survival mechanism that allows cells to adapt to metabolic changes by degrading and recycling intracellular components. (ox.ac.uk)
This interaction triggers signals essential for the formation and maintenance of B cell, thus it is important for a B-cell survival. (wikidoc.org)

The normal liver as an incredible capacity to regenerate following short term damage and can accomplish this efficiently through division of the cells in he liver such as hepatocytes ad biliary epithelial cells. (ukri.org)
HPV promotes latency and consequently does not cause a disease phenotype following initial infection by an immune evasion response reaction, featuring binding to epithelial cells and integrating into the host genome, resulting in the proliferation of epidermal cells containing the viral genome and neovascularization ( 3 ). (spandidos-publications.com)

It maintains normal hematopoietic function by interacting with hematopoietic stem cells (HSCs) to control their proliferation and differentiation ( Morrison and Scadden, 2014 ). (techscience.com)
It has been also shown to play an important role in the proliferation and differentiation of B cells. (wikidoc.org)
Human bmMSCs were described in the late nineties as well [ 6 ] and at the same time a breakthrough study investigated the expression of typical cell surface markers and the proliferation and differentiation properties of human MSCs in more detail [ 7 ]. (hindawi.com)

A polyuscaccharide from Shitake mushrooms stimulates the differentiation of immune suppressor cells (T regs) and reverses their immunosuppressive functions, shedding new light on developing novel anti-cancer strategies by targeting immune suppressor cells. (curated.co)

CXCR4 is common in many cells of the hematopoietic system and is expressed in particular by many stem cells and tumor cells. (reliatech.de)
Previous studies have identified that UBE3A exhibits abnormal expression in numerous tumor cells, including prostate, cervical and breast cancer ( 6 , 7 ). (spandidos-publications.com)
A: "Double-phase" refers to direct killing of tumor cells while improving body immune function and "broad spectrum" means that different kinds of tumors are quickly responded to KLT treatment with satisfactory therapeutic effect. (kanglaite.com)

The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. (techscience.com)
Bone marrow loss and a high proclivity to leukemic progression are the characteristics of myelodysplastic syndrome (MDS). (techscience.com)
ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)
15]. The percentage of bone common of which are trisomy 8, mono- marrow blast cells for estimation of the Myelodysplastic syndrome (MDS) is somy 7 and 5q- [11]. (who.int)

VP79s was shown to overcome adhesion mediated drug resistance in MM cells in a co-culture model system with bone marrow stromal cells which induces MM cell resistance to treatment with the proteasome inhibitor bortezomib. (confex.com)

[19] Increased levels of BAFF may initiate aloreactive B cell and T cell immunity, therefore may promote allograft rejection. (wikidoc.org)
Second, the authors discuss that inability to resolve infection and prevent disease may not be a consequence of the generation of an inadequate number of Th1 cells but of an intrinsic deficiency in macrophage function that prevents these cells from expressing immunity. (scielo.br)
The authors also argue that memory B and T cell responses are long-lived in the absence of antigen, but they are modulated and influenced by other infections and that memory B and T cells can either provide protective immunity or contribute to immunopathology on infection with homologous or heterologous viruses. (scielo.br)
Previous studies have shown the important roles of B cell immunity in cGVHD development. (jci.org)
When our immune system encounters a new pathogen, it can create plasma cells that secrete antibodies to specifically prevent future infections, generating immunity," she said. (edu.au)
If we can understand how to flip the molecular switch in plasma cells and activate Myb production, we might be able to encourage the immune system to create long-term immunity for a range of infections. (edu.au)
If we don't create long-lived plasma cells, we don't develop lasting immunity to the disease. (edu.au)
Deficiencies are highly variable with regard to symptoms, phenotype, genotype, severity, etc, because many cells and molecules are required for both natural and adaptive immunity . (lu.se)

They conclude that although armed with highly distinct effector functions, there are many parallels between the T cell and B cell components of the immune response and their conversion into memory. (scielo.br)
Recent studies indicate that memory T lymphocytes contain distinct populations of central memory (T CM cells) and effector memory (T EM ) cells characterized by distinct homing capacity and effector function. (scielo.br)
We first demonstrated that the immune homeostatic abnormality leading to cGVHD is characterized by an initial increase in effector T cells in the bone marrow and subsequent B and Treg cytopenia. (jci.org)

In our review, we summarize the recent findings and potential mechanisms of the effect of n-3 PUFAs on mast cell activation. (canada.ca)
These findings define the mechanisms by which PTCy restores homeostasis of the B cell lineage and reestablishes immune tolerance. (jci.org)
However, the regulatory mechanisms of HPV infection and consequent immune escape reaction, persistent infection and cell proliferation and the regulatory mechanisms of vascular proliferation are poorly understood and require additional investigation ( 4 ). (spandidos-publications.com)

provides an overview of the dynamic in vivo life of NK cells from their development in the bone marrow to their mature cellular responses in the periphery and their ultimate demise, with emphasis on mouse NK cells and viral infections. (scielo.br)
Disclosed are plasmids that contain and express in vivo in a feline host cell nucleic acid molecules. (justia.com)

We have exploited these features of the macrophage to develop a cell therapy for liver cirrhosis that we would like to take forward for a clinical trial in man for the first time. (ukri.org)
in this study patients will receive 3 macrophage infusions of cells at 8, 30 and 60 days post monocyte isolation. (ukri.org)

Numerous experiments show that the factors affecting T cell viability vary depending on the type and status of the T cell involved. (scielo.br)
VP79s showed selective cytotoxicity in patient derived MM cells compared to normal donor lymphocytes and reduced the viability of MM patient samples in a dose-responsive manner suggesting its potential as an anti-MM therapeutic. (confex.com)
The entire manufacturing process, the examination of cell number and viability of the final CP as well as the depletion of non-target cells were part of the validation process, which was performed in compliance with EU guidelines for GMP. (biomedcentral.com)
Cell viability test was performed on mesenchymal stem cells exposed to various concentrations (40 ppm, 20 ppm, 10 ppm, 5 ppm, 2.5 ppm, 1.25 ppm, 0.625 ppm and 0.312 ppm) of bee venom. (trdizin.gov.tr)

Donor-specific antibodies bind with high affinity to the vascular endothelium of graft and activate complement . (wikidoc.org)
the donor.4,11 In the case of nerve cells obtained from either delivery of dopamine released from cells the developing central nervous system (CNS), the opti- implanted into the ventricle, adjacent to the stria- mal age was shown to be at, or close to, the cell-cycle tum,6,7 or restoration of synaptic dopamine release exit. (lu.se)

however, little has been done to investigate the MM cell's ability to 're-program' cells within its environment to benefit disease progression. (biomedcentral.com)

1) Antibody deficiency disorders are defects in immunoglobulin-producing B cells . (lu.se)

In the B cell system protective memory is mediated by plasma cells that secrete antibodies, whereas reactive memory is mediated by memory B cells that proliferate and differentiate to plasma cells in response to secondary antigenic stimulation. (scielo.br)

For the treatment of chronic wounds, cell-based therapy was an attractive approach. (illumina.com)
According to the European Medicines Agency (EMA) BM-derived CD133 + stem cells intended for the regeneration of human ischemic heart tissue are classified as an advanced therapy medicinal product (ATMP) [ 17 ]. (biomedcentral.com)
Cell Therapy for Parkinsons Disease: What Next? (lu.se)

Mast cells are known to play a vital role in the development of inflammation in allergic responses. (canada.ca)
HPSE facilitates cell migration associated with metastasis, wound healing and inflammation. (rndsystems.com)
Activated inflammatory cel s, in- persistent inflammation cluding neutrophils and macrophag- es, produce reactive oxygen species and reactive nitrogen species. (who.int)

The objective of this study is to determine the effects of bee venom on the proliferation capacity of mesenchymal stem cells and wound healing. (trdizin.gov.tr)

Other cell types derived from hematopoietic stem cells include platelets and erythrocytes. (justia.com)
Mr Souradip Mookerjee is an MB/PhD student in Dr Cedric Ghevaert's Lab at the University of Cambridge, working on the translational research of making platelets from stem cells. (nhsbt.nhs.uk)
Radiation affects cells that divide quickly, especially blood - red cells only last about 120 days in circulation, and platelets only 5 days. (nhsbt.nhs.uk)
There have been no major advances to improve the storage of platelets beyond 7 days, compared with 35-40 days for red blood cells, making these a comparatively perishable blood product. (nhsbt.nhs.uk)

Unlike lupus, (1) Degos disease does not involve the face, (2) it does not respond to therapies such as corticosteroids that at least abate lupus, (3) it does not manifest with photosensitivity, (4) viral inclusions are present in some cells in patients with Degos disease, and (5) systemic Degos disease is universally fatal, usually within 1-2 years, whereas lupus (even if severe) takes years to be fatal. (medscape.com)
The Hairy Cell Leukemia Foundation (HCLF) and The Leukemia & Lymphoma Society (LLS) have joined forces to create the HCL2025 program to support targeted research to build a more comprehensive foundational understanding of the molecular basis of hairy cell leukemia (HCL), develop additional therapies, and optimize outcomes for patients with this disease. (lls.org)
We therefore briefly discuss differences found in subsets of human bmMSCs and in MSCs isolated from some other sources and touch upon how this could be utilized for cell-based therapies. (hindawi.com)
These therapies decrease a patient's white blood cell counts, suppress bone marrow hematopoietic activity, and increase the patient's risk of infection and/or hemorrhage. (justia.com)
CD133 + stem cells represent a promising subpopulation for innovative cell-based therapies in cardiovascular regeneration. (biomedcentral.com)

Stem cells represent a very small percentage of bone marrow cells, and are normally quiescent. (justia.com)

Mesenchymal stem cells (MSCs) are adult multipotent cells that were initially isolated from bone marrow[ 1 ] and characterized by the fibroblast-like appearance in culture and the capacities to form bone, adipose and cartilage. (biomedcentral.com)

Polysaccharide from Lentinus edodes inhibits the immunosuppressive function of myeloid-derived suppressor cells. (curated.co)
An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. (immport.org)

A subset of orbital fibroblasts in the orbit can differentiate into mature, lipid-accumulating cells or de novo adipogenesis. (medscape.com)

GAB2 has been shown to be important in physiological functions such as growth in bone marrow and cardiac function. (wikipedia.org)
PI3K activation by GAB2 promotes cell growth. (wikipedia.org)
CD105 also binds other growth factors such as actvin A, BMP-2, and BMP-7. (biolegend.com)
Insulin-like growth factor-1 (IGF-1), synthesized and secreted by human hepatocytes, is the primary regulator of insulin and serves an important function in regulating the growth and development of the body ( 8 ). (spandidos-publications.com)
An extract of Shiitake mushrooms increases the number of various immune cells, as well as the factors that stimulate their growth. (curated.co)
Initial exponential tumor growth is followed by a plateau phase when cell death nearly equals the rate of formation of daughter cells. (msdmanuals.com)
Experiments suggest that the abilities to invade, migrate, and successfully implant and stimulate new blood vessel growth are all important properties of the cells that cause metastases, which are likely a subpopulation of the primary cancer. (msdmanuals.com)
Hemoglobin = 80 g/L. Participants requiring transfusions or growth factor support to maintain hemoglobin = 80 g/L are not eligible. (who.int)

Dr Good-Jacobson said plasma cells were created when the immune system was exposed to pathogens such as viruses or bacteria. (edu.au)
If we can trigger the expression of Myb in plasma cells responding to pathogens - either by infection or by immunisation - we might be able to convince the immune system to store these plasma cells in the bone marrow to offer protection against future infections. (edu.au)
Cancer cells often present neoantigens on their cell surface that can be detected as "non-self" by the immune system, resulting in an attack by the immune system. (msdmanuals.com)

Osteogenesis in transplants of bone marrow cells. (trdizin.gov.tr)

For this purpose, mesenchymal stem cells were isolated from canine adipose tissue and bee venom samples were collected from Apis mellifera anatoliaca in Muğla province of Türkiye. (trdizin.gov.tr)

Improvement of Chronic Wound Healing by Pre-activated Bone Marrow Cells with Sodium Nitroprusside in Rabbits. (illumina.com)
In this paper, we review and present our new data of LED treatment on cells grown in culture, on ischemic and diabetic wounds in rat models, and on acute and chronic wounds in humans. (researchgate.net)
Mesenchymal stem cells for chronic wound healing: current status of preclinical and clinical studies. (trdizin.gov.tr)
Chronic lymphoid leukaemia and hairy cell leukaemia due to chronic exposure to benzene: Report of three cases. (cdc.gov)
1976. Combination of genetic factors and chronic exposure to benzene in the aetiology of leukaemia. (cdc.gov)
Whilst MCV was higher in healthy patients but non-significant, higher mean MCH of 27.75 ± 3.25 pg/cell was reported in healthy patients compared to mean of 25.73 ± 3.22 pg/cell in patients with chronic periodontitis. (bvsalud.org)
However, microbial substances gain access to the gingival tissue and initiate and perpetuate an inflammatory reaction, which leads to the destruction of the periodontal ligament and alveolar bone, leading to chronic periodontitis and, finally, to tooth loss if left untreated [2]. (bvsalud.org)

Finally, M. BUSSLINGER focuses on the transcription factors that regulate early B-lymphopoiesis in the bone marrow. (scielo.br)
HDACs deacetylate histones and transcription factors such as p53, leading to increased chromatin compaction, representing an additional means for silencing p53 activity. (uib.no)
VPA is a well-tolerated non-genotoxic HDAC inhibitor inhibiting deacetylation of chromatin and transcription factors such as p53, and has been found to show an anti-leukemic effect in AML patients. (uib.no)
Furthermore, we provide evidence that this IL-6/8 production is mediated by the transcription factor cMYC. (biomedcentral.com)

PTCy, but not cyclosporine A or rapamycin, inhibits the initial alloreactive T cell response, which restores intra-bone marrow B lymphogenesis with a concomitant vigorous increase in Tregs. (jci.org)

Anatomy48

Organisms16

Diseases38

Chemicals and Drugs64

Analytical, Diagnostic and Therapeutic Techniques and Equipment44

Phenomena and Processes49

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science2

Named Groups1

Health Care3

Transplantation13

Progenitor cells12

Pathways13

Apoptosis10

Microenvironment8

Macrophages7

Peripheral7

Endothelial4

Monocytes4

Regulates2

Mitogen-activa3

Fetal liver1

Cytokine production1

Stem cell19

Vitro10

Secretion3

Ligand7

Tumour5

Receptors13

Chemotherapy5

Cytokines3

Tissues4

MAPK1

Human bone2

Hematopoiesis1

Protein21

Malignant plasma cells1

Genes1

Diseases7

Receptor4

Survival2

Epithelial2

Proliferation and differentiation3

Stimulates1

Tumor cells3

Myelodysplastic syndrome4

Induces1

Immunity8

Effector3

Mechanisms3

Vivo2

Macrophage2

Viability4

Donor2

Disease progression1

Disorders1

Plasma cells that secrete antibodies1

Therapy3

Inflammation3

Capacity of mesenchymal stem1

Platelets4

Therapies5

Percentage of bone1

Capacities1

Myeloid2

Differentiate1

Growth8

Immune system3

Osteogenesis1

Adipose1

Chronic7

Transcription4

Inhibits1