Bone marrow and peripheral blood bone marrow stem cells bone marrow transplantation. Medical search. Frequent questions

An early example of a successful peripheral stem cell transplant was carried out in the wake of the 1999 Tokaimura nuclear accident. (wikipedia.org)
GVHD is a common problem after a transplant using donor cells. (bmtinfonet.org)
Historical transplants used a matched donor's peripheral blood or bone marrow to transplant to a patient. (biologynews.net)
Zweidler-McKay also predicts this type of transplant could be used for adults who have already had a transplant or for those adult and pediatric patients who aren't candidates for other stem cell transplants due to blood counts or illness. (biologynews.net)
Late-occurring Venous Thromboembolism in Allogeneic Blood or Marrow Transplant Survivors - a BMTSS-HiGHS2 Risk Model. (stembook.org)
Transplant Cell Ther. (stembook.org)
Follistatin and Soluble Endoglin Predict 1-year Non-Relapse Mortality after Allogeneic Hematopoietic Cell Transplant. (stembook.org)
Biol Blood Marrow Transplant. (stembook.org)
Retrospective analysis by the Center for International Blood and Marrow Transplant Research (CIBMTR): Prompt complete remission plus consolidation therapy yields improved survival after allogeneic hematopoietic cell transplantation (allo-HCT) for patients with acute myeloid leukemia (AML) receiving a myeloablative conditioning regimen and not a reduced-intensity conditioning regimen. (ascopost.com)
What is an autologous stem cell transplant? (leukaemia.org.au)
It's important to realise that the processes involved in a stem cell transplant are often long and complex. (leukaemia.org.au)
In the week following the transplant, your blood counts drop dramatically. (leukaemia.org.au)
Bone marrow or peripheral blood stem cell transplantation includes mobilization, harvesting and transplant of bone marrow or peripheral blood stem cells, and the administration of high dose chemotherapy or radiotherapy before the actual transplant. (hinshawlaw.com)
This is a prospective, multi-center, Phase II study of hematopoietic cell transplantation (HCT) using human leukocyte antigen (HLA)-mismatched unrelated donors (MMUD) for peripheral blood stem cell transplant in adults and bone marrow stem cell transplant in children. (uchicagomedicine.org)
Forty-two female patients (median age of 46 years) with breast cancer refractory to neoadjuvant chemotherapy received HDCT (cyclophosphamide, carmustine and thiotepa) supported by an autologous peripheral blood stem cells transplant. (elsevierpure.com)
Hematopoietic cell transplantation is, to date, the only curative therapy for SCD, but its application is limited by availability of a suitable HLA-matched donor and lack of awareness of the benefits of transplant. (duke.edu)
Included in this study are 1000 recipients of HLA-identical sibling transplants performed between 1986 and 2013 and reported to the European Society for Blood and Marrow Transplantation, Eurocord, and the Center for International Blood and Marrow Transplant Research. (duke.edu)
Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (yashfiin.com)
A stem cell transplant is when cells are taken out of the blood for use in a transplant. (differencebetween.net)
A bone marrow transplant is when stem cells are removed from the bone marrow for transplant. (differencebetween.net)
This is when stem cells that are obtained from the bloodstream or umbilical cord of a donor are used for transplant into a patient. (differencebetween.net)
Umbilical cord blood stem cells are only used for transplant into children since there are not enough cells present to be of any use for transplant into an adult patient. (differencebetween.net)
Stem cell transplant can be used to treat conditions such as multiple myeloma, and other cancers such as certain kinds of lymphoma and leukemia. (differencebetween.net)
A bone marrow transplant is when stem cells are removed from a donor's bone marrow for transplant into a patient. (differencebetween.net)
A stem cell transplant is when stem cells are harvested from the bloodstream or the umbilical cord. (differencebetween.net)
A bone marrow transplant is when stem cells are harvested directly from the bone marrow. (differencebetween.net)
In the case of a stem cell transplant, granulocyte- colony-stimulating factor has to be given to the donor a few days before the procedure. (differencebetween.net)
In this model, 6 to 8 week old NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) immunocompromised mice receive the thy/liv implant as in the SCID-hu mouse model only to be followed by a second human hematopoietic stem cell transplant (4). (ca.gov)
People with life-threatening cancers, such as leukemia , lymphoma , and myeloma can be treated with a bone marrow transplant or, sometimes, a stem cell transplant. (medlineplus.gov)
Autologous bone marrow transplant is when people donate their own bone marrow. (medlineplus.gov)
Allogenic bone marrow transplant is when another person donates bone marrow. (medlineplus.gov)
But only about 30% of people who need a bone marrow transplant can find a matching donor in their own family. (medlineplus.gov)
Doctors can then use the registry to find a matching donor for a person who needs a bone marrow transplant. (medlineplus.gov)
If a donor's HLAs match well with a person who needs a transplant, the donor must give a new blood sample to confirm the match. (medlineplus.gov)
Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)
For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)

Cord blood and haploidentical (half-matched) transplants are used to treat an increasing number of patients. (bmtinfonet.org)
Graft-versus-host disease is a common side effect of patients receiving stem cell transplants, which results when the T cells in the transplanted blood react against the patient's own cells. (biologynews.net)
The number of human tissue transplants is increasing in both developed and developing countries, but global data on this form of transplantation are less complete. (who.int)
Access to transplantation is limited in low- and many medium-income countries, where the rate of transplants remains far below that of richer nations. (who.int)
In autologous stem cell transplants, the patient is their own stem cell donor. (leukaemia.org.au)
Autologous transplants are used to treat a number of different blood cancers. (leukaemia.org.au)
bone marrow or stem cell transplants. (hinshawlaw.com)
Bone marrow transplants are also used in cases where a person has cancers such as some types of lymphomas and leukemias, and multiple myeloma. (differencebetween.net)
Stem cell transplants involve cells that are taken out of the blood or umbilical cord. (differencebetween.net)
Bone marrow transplants involve cells that are taken out of the bone marrow. (differencebetween.net)
Bone marrow transplants work best if the HLAs from the donor and the patient are a close match. (medlineplus.gov)

Successful stem cell transplantation for patients with severe combined immunodeficiency (SCID) from matched family donors without conditioning results in engraftment of T lymphocytes. (nih.gov)
Organ Transplantation.2 These Guiding Principles - whose emphases include voluntary donation, noncommercialization, genetic relation of recipients to donors and a preference for cadavers over living donors as sources - have considerably influenced professional codes, national, state and provincial legislation, and the policies of intergovernmental organizations. (who.int)
Peripheral Blood versus Bone Marrow from Unrelated Donors: Bone Marrow allografts have improved Long-term Overall and Graft-versus-Host Disease, Relapse-Free Survival. (stembook.org)
Infections following Transplantation of Bone Marrow or Peripheral-Blood Stem Cells from Unrelated Donors. (stembook.org)
Neither vitiligo nor evidences of autoimmune diseases were found in their stem cell donors. (koreamed.org)
Allogeneic hematopoietic stem cell transplantation is limited mainly by lack of histocompatible donors. (msdmanuals.com)
Protecting the Selfless: Toward More Comprehensive Care for Pediatric Related Stem Cell Donors. (childrensmercy.org)
These substances include, for instance, granulocyte- colony-stimulating factor (G-CSF), which is added so that the donors own bone marrow will make and produce more stem cells that will end up in the bloodstream. (differencebetween.net)
Exclusion of prospective blood donors based on their acknowledged risk behaviors for human immunodeficiency virus (HIV) infection began in 1983 (1). (cdc.gov)
In 1985, when tests for HIV antibody became available, screening prospective donors of blood, organs, and other tissues also began (2,3). (cdc.gov)
The CXCL12-3'A allele is associated with a higher mobilization yield of CD34 progenitors to the peripheral blood of healthy donors for allogeneic transplantation. (cdc.gov)
Donor CTLA-4 genotype influences clinical outcome after T cell-depleted allogeneic hematopoietic stem cell transplantation from HLA-identical sibling donors. (cdc.gov)

In contrast to the expected mixed chimerism that usually occurs in the absence of conditioning, we found in our patients 100% donor cell engraftment based on fluorescence in situ hybridization (FISH) and microsatellite techniques. (nih.gov)
Subset analysis of the engrafted cells using a multiparametric system enabling a combined analysis of morphology, immunophenotyping and FISH showed that both T and B lymphocytes and myeloid cells were of donor origin in two patients, while T lymphocytes and myeloid cells were of donor origin in the third. (nih.gov)
In the two cases with ABO incompatibility, erythroid engraftment was evidenced by blood group conversion from recipient to donor type. (nih.gov)
Immature hematopoietic stem cells in the circulating blood that are similar to those in the bone marrow are collected by apheresis from a donor (PBSC collection). (wikipedia.org)
The apheresis procedure typically lasts for 4-6 hours, depending on the blood volume of the donor. (wikipedia.org)
For example, calculations must be made to ensure consistency in the amount of total blood volume between the donor and recipient. (wikipedia.org)
If the total blood volume of the donor is less than that of the recipient (such as when a child is donating to an adult), multiple PBSCT sessions may be required for adequate collection. (wikipedia.org)
A transplantation of stem cells, from umbilical cord blood or from a peripheral stem cell or bone marrow donor, is appropriate for some boys with the disease, such as those with early symptoms and MRI abnormalities. (sunjournal.com)
1 After transplantation, donor T cells are activated by antigen-presenting cells. (oncologynurseadvisor.com)
Donor T-cells proliferate and inflammatory mediators are recruited. (oncologynurseadvisor.com)
Treatment focuses on blocking the expansion of donor T cells, as GVHD develops from the expansion of these cells. (oncologynurseadvisor.com)
eg, bone, bone marrow, and skin grafts) Genetically identical (syngeneic [between monozygotic twins]) donor tissue (isografts) Genetically. (msdmanuals.com)
Hematopoietic stem cell transplantation may be autologous (using the patient's own cells) or allogeneic (using cells from a donor). (msdmanuals.com)
The process is also less painful for the donor since a needle is not being placed into bone. (differencebetween.net)
The donor first has to be treated with G-CSF, and then the stem cells can only be harvested a couple of days after the donor since time is needed for the donor's body to form more stem cells and transport these cells into the bloodstream. (differencebetween.net)
The procedure in which bone marrow is extracted from a donor does require the use of either a local or a general anesthetic. (differencebetween.net)
The advantage is that granulocyte- colony-stimulating factor (G-CSF) does not have to be given to the donor since the procedure involves going to the source of the stem cells, which is the bone marrow. (differencebetween.net)
BLAISE, D. Healthy sibling donor anxiety and pain during bone marrow or peripheral blood stem cell harvesting for allogeneic transplantation: results of a randomized study. (bvsalud.org)
Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
For this type of treatment, bone marrow is collected from a donor. (medlineplus.gov)
Then, a counselor meets with the donor to discuss the bone marrow donation process. (medlineplus.gov)
Donor stem cells can be collected in two ways. (medlineplus.gov)
Most donor stem cells are collected through a process called leukapheresis. (medlineplus.gov)
First, the donor is given 5 days of shots to help stem cells move from the bone marrow into the blood. (medlineplus.gov)
During the collection, blood is removed from the donor through a line in a vein (IV). (medlineplus.gov)
The red blood cells are returned to the donor through an IV in the other arm. (medlineplus.gov)
After a bone marrow harvest, the donor stays in the hospital until they're fully awake and can eat and drink. (medlineplus.gov)
Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
Here, we report transmission of dengue virus to a peripheral blood stem cell recipient by a donor who had recently traveled to an area to which the virus is endemic. (cdc.gov)
The 24-year-old woman, who was registered as a volunteer donor in the German Bone Marrow Donor Registry, was selected. (cdc.gov)
Standard leukopheresis processing of blood from the donor was performed without problems. (cdc.gov)
A second apheresis or a bone marrow collection was considered, but neither was performed because the clinical condition of the donor worsened. (cdc.gov)

Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit. (smw.ch)
Reduction in late mortality among patients with Multiple Myeloma treated with Autologous Peripheral Blood Stem Cell Transplantation - a BMTSS Report. (stembook.org)

Researchers from The University of Texas M. D. Anderson Cancer Center have found a therapy that effectively kills human leukemia cells in mice using natural killer (NK) cells from umbilical cord blood. (biologynews.net)
The three sources of stem cells include bone marrow, umbilical cord blood, and peripheral blood. (oncologynurseadvisor.com)
Umbilical cord hematopoietic stem cell transplantation has been restricted mainly to children because there are too few stem cells in umbilical cord blood for an adult. (msdmanuals.com)
The technique for umbilical cord hematopoietic stem cell transplantation is still in its infancy, but it is gaining interest. (msdmanuals.com)
For umbilical cord blood harvest, the cord is clamped after delivery of the baby, and blood is drawn from the cord with a needle and collected in a sterile bag. (msdmanuals.com)
peripheral blood, or placental/umbilical cord blood). (cdc.gov)
and umbilical cord blood (PUCB), capable of 2017), associated with the results of the procedure restoring spinal cord function and immunology of and require a process of hospitalization and patients with indication for transplantation, with the prolonged hospital recovery. (bvsalud.org)

30,000 patients with blood-related malignancies receive HDC, which, if the response is satisfactory, could subsequently be followed by hematopoietic stem cell transplantation (HSCT). (bdbiosciences.com)
The most common adverse event following allogeneic hematopoietic stem cell transplantation (HSCT) is graft-versus-host disease (GVHD), which can increase morbidity and mortality in HSCT patients. (oncologynurseadvisor.com)
Allogeneic hematopoietic stem cell transplantation (HSCT) remains the only curative therapy for sickle cell disease (SCD). (haematologica.org)
Allogeneic hematopoietic stem cell transplantation (HSCT) offers a curative treatment for acute myeloid leukemia patients. (oncotarget.com)
We performed absolute quantification of BAALC copy numbers in peripheral blood prior (median 7 days) to HSCT in complete remission (CR) or CR with incomplete peripheral recovery in 82 acute myeloid leukemia patients using digital droplet PCR (ddPCR) technology. (oncotarget.com)
Evaluation of pre-HSCT BAALC / ABL1 copy numbers in peripheral blood by ddPCR represents a feasible and rapid way to identify acute myeloid leukemia patients at high risk of early relapse after HSCT. (oncotarget.com)
Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (yashfiin.com)
are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
Hematopoietic stem cell transplantation (HSCT) affects serious risks for the patient, including death. (bvsalud.org)
HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)
Also, drastic changes in daily living habits, qualified and responsible for the implementation of changes in body image, long duration of treatment, HSCT since 2004, agreed to the Brazilian Unified periods of hospitalization and protective isolation, Health System, which meets the needs of the feeling of loss of control, fear of death and lack of patients with an indication for transplantation. (bvsalud.org)

Role of Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem-Cell Transplantation in Older Patients With De Novo Myelodysplastic Syndromes: An International Collaborative Decision Analysis. (stembook.org)

When given to mice with aggressive human leukemias, these NK cells reduced the circulating human acute lymphocytic leukemia (ALL) and acute myelogenous leukemia (AML) cells by 60 to 85 percent. (biologynews.net)

Stem cells can be destroyed through cancer treatments such as chemotherapy or radiation, as well as any blood-related diseases, such as leukemia, lymphoma, neuroblastoma and multiple myeloma. (wikipedia.org)
Validation of prognostic factors and survival of patients with multiple myeloma in a real-life autologous stem cell transplantation setting: a Swiss single centre experience. (smw.ch)
Of these, 27.91% had a main diagnosis indicating the transplantation of Multiple Myeloma (MM), and 58.14 received autologous transplantation. (bvsalud.org)

Estimate the failure-free survival rate in a cohort of relapsed Hodgkin's lymphoma and non-Hodgkin's lymphoma patients after retrieval therapy which includes peripheral blood stem cell transplantation (PBSCT) in patients who achieve a complete remission or partial remission. (knowcancer.com)

Stem cell transplantation is performed after high-dose chemotherapy (HDC) to restore a cancer patient's blood and immune cell production capacity. (bdbiosciences.com)
Cells from the patient's sister's bone marrow were administered, and in the following weeks successfully began dividing and differentiating into white blood cells. (wikipedia.org)
However, several weeks later, the cells were found to have been mutated by the radiation still present within the patient's body, and were observed carrying out autoimmune responses. (wikipedia.org)
Successful transplantation of organs and living tissues depends on continued medical follow-up and the patient's compliance with a regimen of immunosuppressive drugs. (who.int)
They are used to replace stem cells that have been damaged by high doses of chemotherapy , used to treat the patient's underlying disease. (leukaemia.org.au)
Stem cells are usually collected when the patient's disease is in remission or their disease is in a more stable state. (leukaemia.org.au)
The patient's own white blood cells and stem cells from their blood are modified in the laboratory using genetic techniques to express a specific receptor against cancer cells. (ca.gov)
An environment for GVHD is formed when antigen-presenting cells are activated by the patient's disease and the pretreatment destruction of cells caused by chemotherapy and radiotherapy. (oncologynurseadvisor.com)
Patients who undergo bone marrow transplantation are generally immunosuppressed with a dose of cyclophosphamide which is usually calculated based on the patient's weight. (slideshare.net)
Because of the patient's risk status, the physicians intended to perform allogeneic stem cell transplantation after induction and consolidation chemotherapy, which was scheduled to end in January 2013, and a conditioning chemotherapy regimen, which was planned to be given in March. (cdc.gov)

Choice of conditioning regimens for bone marrow transplantation in severe aplastic anemia. (stembook.org)
Hematopoietic stem cell transplantation (bone marrow, cord blood, or peripheral blood stem cells) may cure aplastic anemia and prevent myelodysplastic syndrome or leukemia. (medscape.com)
The first patient was received an allogeneic bone marrow transplantation and subsequent allogeneic peripheral blood stem cell transplantation for severe aplastic anemia from his sister. (koreamed.org)

For example, in developing and developed countries alike, kidney transplantation not only yields survival rates and quality-of-life that are far superior to those obtained with other treatments for end-stage renal disease, such as haemodialysis, but is also less costly in the long run. (who.int)
The aim of the academic journal is to provide a platform for researchers, scientists, physicians, and other health professionals to find latest research information in the areas of stem cell research, transplantations such as stem cell transplantation, transplantation immunology, kidney transplantation and its treatment. (slideshare.net)

These cells are collected in advance (while they are in remission ) and returned to the patient at a later stage. (leukaemia.org.au)

An overview of bone marrow, peripheral blood stem cell and cord blood transplantation. (bmtinfonet.org)
Patrick Zweidler-McKay, M.D., Ph.D., assistant professor of pediatrics from the Children's Cancer Hospital at M. D. Anderson, has shown an effective method for expanding the number of NK cells from a single cord blood unit while retaining the cells' anti-leukemia effects, as presented at the American Society of Pediatric Hematology/Oncology annual conference on May 16. (biologynews.net)
Previous efforts to expand cord blood have resulted in ineffective NK cells. (biologynews.net)
However, Zweidler-McKay and co-senior investigator Elizabeth Shpall, M.D., professor in M. D. Anderson's Department of Stem Cell Transplantation and Cellular Therapy, have found a novel process to increase NK cells in cord blood more than 30-fold, generating more than 150 million NK cells from one cord blood unit while maintaining their activation to find and kill acute leukemia cells. (biologynews.net)
Cord blood is a promising source of natural killer cells because the NK cells have enhanced sensitivity to stimulation, decreased potential to cause graft-versus-host disease and are available from cord banks throughout the country and world," says Zweidler-McKay. (biologynews.net)
However, in 1988, researchers found cord blood to be another source for stem cell transplantation. (biologynews.net)
Zweidler-McKay's study involves selecting out NK cells from cord blood. (biologynews.net)
As the cord blood is expanded to multiply in number, the NK cells are given a cytokine, interleukin-2, and a target cell, K562, which keep the NK cells active throughout the three week expansion. (biologynews.net)
These results support the evaluation of cord blood-derived NK cells as a potential immuno-therapeutic approach in acute leukemias. (biologynews.net)
1 This includes human cells for transplantation such as haematopoietic stem cells from bone marrow, peripheral blood or cord blood. (who.int)
The positive result came too late to save cord blood. (sunjournal.com)
Because cord blood contains immature stem cells, HLA matching appears less crucial than for the other types of hematopoietic stem cell transplantation. (msdmanuals.com)
One concern about the procedure is that immune cells in cord blood do not have experience with the viruses responsible for latent infections, leading to a higher percentage of naive T cells and thus increased vulnerability to reactivation of cytomegalovirus or Epstein-Barr virus infection. (msdmanuals.com)
peripheral blood and cord blood progenitors were used in 73 (7%) and 88 (9%) patients, respectively. (duke.edu)

ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)
The essence of MDS is damage of In the current work we examined All our patients were of the high-risk colony-forming units [4], but the defect haematopoietic stem cells of high-risk group and none of them was eligible of the haematopoietic stem cells is not MDS cases for apoptotic and anti-apop- for stem cell transplantation. (who.int)

2 Evaluation of harvest adequacy requires the use of reliable progenitor cell assays and this is usually achieved by CD34 cell counting using flow cytometry. (bdbiosciences.com)
PBSCT is now a much more common procedure than its bone marrow harvest equivalent due to the ease and less invasive nature of the procedure. (wikipedia.org)
OUTLINE: Patients receive 2 courses of reinduction chemotherapy followed by bone marrow biopsy and aspirate prior to peripheral blood stem cell (PBSC) harvest. (knowcancer.com)
If marrow involvement is still present at harvest, then 2 additional courses of induction chemotherapy are given. (knowcancer.com)
In autologous stem cell transplantation, stem cells are collected (or "harvested") from either the bone marrow , bloodstream (called a peripheral blood stem cell harvest), or sometimes a combination of both. (leukaemia.org.au)
Peripheral blood has largely replaced bone marrow as a source of stem cells, especially in autologous hematopoietic stem cell transplantation, because stem cell harvest is easier and neutrophil and platelet counts recover faster. (msdmanuals.com)
Bone marrow harvest. (medlineplus.gov)

Characterize the time to recovery of normal bone marrow function after transplantation in these patients. (knowcancer.com)

In order to assess the incidence and analyze reasons which cause prolongation of hospital stay in patients engrafted after peripheral blood stem cell transplantation (PBSCT), we performed this retrospective analysis. (nature.com)
Peripheral blood stem cell transplantation (PBSCT), also called "Peripheral stem cell support", is a method of replacing blood-forming stem cells. (wikipedia.org)
Studies suggest that PBSCT has a better outcome in terms of the number of hematopoietic stem cell (CD34+ cells) yield. (wikipedia.org)
Since allogeneic PBSCT involves transformation of blood between different individuals, this naturally carries more complications than autologous PBSCT. (wikipedia.org)
Purpose: To determine the tolerability and feasibility of double-cycle, high-dose chemotherapy followed by peripheral blood stem-cell transplantation (PBSCT) after conventional chemotherapy or chemoradiotherapy for small cell lung cancer (SCLC). (the-medical-dictionary.com)

OBJECTIVE: To assess the prognostic value of various parameters including positron emission tomography / computed tomography (PET/CT) and identify risk factors for survival of patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) treated with autologous stem cell transplantation (ASCT). (smw.ch)
Of the NHL patients, 59 (44%) had diffuse large B-cell lymphoma (DLBCL). (smw.ch)
Other risk factors for survival were primary refractory disease, initial lymphoma stage, number of previous chemotherapy lines, and high amounts of blood product transfusions. (smw.ch)
Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. (smw.ch)
High-dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphoma. (smw.ch)
High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study. (smw.ch)
High dose sequential chemotherapy and autologous stem cell transplantation in patients with relapsed/refractory lymphoma. (smw.ch)
The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups. (smw.ch)
The versatile drug is now also approved for the treatment of B-cell Hodgkin lymphoma, non-Hodgkin lymphoma, chronic lymphocytic leukemia, and rheumatoid arthritis in the adult population. (oncologynurseadvisor.com)
I. Determine the response rate (complete and partial) in patients with relapsed or refractory Burkitt's, mantle cell or diffuse large cell non-Hodgkin's lymphoma treated with FR901228 (depsipeptide). (knowcancer.com)
This is a Phase I dose-finding study of FT596 as monotherapy and in combination with Rituximab or Obinutuzumab in subjects with relapsed/refractory B-cell Lymphoma or Chronic Lymphocytic Leukemia. (uchicagomedicine.org)
This is a single arm, open-label, multi-center, Phase 1 study to determine the safety and tolerability of an experimental therapy called NKX019 (allogeneic CAR NK cells targeting CD19) in patients with relapsed/refractory non-Hodgkin lymphoma (NHL), chronic lymphocytic. (uchicagomedicine.org)
This department provides medical care for patients with blood disorders, including anemia and thrombocytopenia, and neoplastic disorders such as leukemia and malignant lymphoma. (japanhospitalsearch.org)
Treatment recommendations for patients with diffuse large B-cell lymphoma (DLBCL) begin with evaluating the extent of the disease, performance status of the patient, and histologic subtypes. (medscape.com)
This ulcerated nodule of localized primary cutaneous CD30+ anaplastic large cell lymphoma is relatively nonspecific in appearance. (medscape.com)

Patients who undergo hematopoietic stem cell transplantation frequently have hemorrhagic cystitis because most are exposed to cyclophosphamide, total-body irradiation, or both. (medscape.com)

3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
Granulocyte colony stimulating factor (GCSF) are naturally occurring glycoproteins that stimulate white blood cell proliferation. (wikipedia.org)
Patients receiving granulocyte components, components that are HLA matched, or directed donations (from blood relatives) . (utmb.edu)
Later, they were administered high-dose etoposide, 1,500 mg/[m.sup.2], followed by granulocyte colony-stimulating factor for collection of peripheral blood stem cells. (the-medical-dictionary.com)

Bone Marrow Transplantation (2000) 26, 877-880. (nature.com)
Globally, it is estimated that 120 000 corneal transplantations and 18 000 transplantations of allogeneic haematopoietic progenitor cells took place in the year 2000. (who.int)

Peripheral blood stem cell and bone marrow transplantation for solid tumors and lymphomas: hematologic recovery and costs. (nature.com)
Hematopoietic stem cell transplantation is also sometimes used for solid tumors (eg, some germ cell tumors) that respond to chemotherapy. (msdmanuals.com)

The place of high-dose BEAM therapy and autologous bone marrow transplantation in poor-risk Hodgkin's disease. (smw.ch)
High-dose chemotherapy with autologous bone marrow transplantation: 11 years' experience in Zurich. (smw.ch)

The excellent outcome of a cohort transplanted over the course of 3 decades confirms the role of HLA-identical sibling transplantation for children and adults with SCD. (duke.edu)
Influence of molecular subgroups on outcome of acute myeloid leukemia with normal karyotype in 141 patients undergoing salvage allogeneic stem cell transplantation in primary induction failure or beyond first relapse. (cdc.gov)

Current surveillance strategies for patients with SDS and other leukemia predisposition syndromes rely on monitoring hematologic status by serial peripheral blood counts to identify worsening cytopenias and bone marrow examinations to identify morphologic changes or development of clonal chromosomal abnormalities 11 . (nature.com)
To complement The ASCO Post 's continued comprehensive coverage of the 2021 American Society of Hematology (ASH) Annual Meeting & Exposition, here are several abstracts selected from the meeting proceedings focusing on allogeneic transplantation for hematologic neoplasms in adults. (ascopost.com)
5 however, it has been used to treat many pediatric hematologic conditions, including chronic immune thrombocytopenic purpura, posttransplant lymphoproliferative disease, juvenile rheumatoid arthritis, and other blood dyscrasias. (oncologynurseadvisor.com)

These immature stem cells were easier to match to patients, especially those from non-Caucasian ethnicities, and could be stored for use as needed. (biologynews.net)

Blood advances 2018 9 2 (17): 2254-2261. (cdc.gov)

To understand the mechanisms that mediate germline genetic leukemia predisposition, we studied the inherited ribosomopathy Shwachman-Diamond syndrome (SDS), a bone marrow failure disorder with high risk of myeloid malignancies at an early age. (nature.com)
A blood stem cell may become a myeloid stem cell or a lymphoid stem cell. (piedmontcancerinstitute.com)

Flow cytometric applications for CD34+ cell identification and enumeration provide a rapid, quantitative and reproducible method to evaluate the progenitor cell population. (bdbiosciences.com)

A strategy in the treatment of cancer by harnessing the immune system, called adoptive cell therapy, is to use an individual's own immune cells (T cells) and genetically modify them to target them to kill the cancer. (ca.gov)
The purpose of the current study is to give gene-modified T cells in combination with gene-modified stem cells to reprogram the immune system to recognize and kill cancer cells that have the NY-ESO-1 protein with sustained killing activity. (ca.gov)
Gene modification of cells involves the transfer of foreign genetic material (DNA) into a cell, in this case the immune system cells and stem cells. (ca.gov)
This process will endow the recipient immune cells and descendants of the stem cells with the ability to eliminate cancer cells that express the cancer specific protein, NY-ESO-1. (ca.gov)
The specific receptor against cancer cells that will be transferred to the immune cells and stem cells is called NY-ESO-1 T cell receptor (or TCR). (ca.gov)
In this study, the gene-modified immune cells will be given in combination with the gene-modified stem cells. (ca.gov)
In an attempt to control infection, masses of neutrophils and other immune cells continue to gather at the site of infection, forming large groups of these cells called granulomas, hence the name of the disease. (primaryimmune.org)
One of the main limitations of both of these models was the lack of stable reconstitution of human immune cells in the periphery to make them a more physiologically relevant model to study HIV disease. (ca.gov)
Methods: To gain insights into critical immune markers involved in COVID-19 etiopathogenesis, we studied the evolution of the immune profile of peripheral blood samples from patients who had recovered from COVID-19 and compared them to subjects with severe acute respiratory illness but negative for SARS-CoV-2 detection (controls). (bvsalud.org)
Hematopoietic stem cell transplantation has become a major treatment option for patients with hematopoietic malignancies and immune deficiencies. (cdc.gov)

Access to transplantation entails more than the surgery itself, because success is measured by longer survival of the patient and a long-term improvement in the quality of life. (who.int)

The increase in white blood cell proliferation as a result of the Filgrastim ensures a better results from the donation. (wikipedia.org)
Higher Risks of Toxicity and Incomplete Recovery in 13- to 17-Year-Old Females after Marrow Donation: RDSafe Peds Results. (childrensmercy.org)
Although donation of bone marrow (BM) or peripheral blood stem cells (PBSCs) from children to family members undergoing allogeneic transplantation are well-established procedures, studies detailing levels of pain, symptoms, and long-term recovery are lacking. (childrensmercy.org)
Bone marrow donation can be done either by collecting a donor's bone marrow surgically, or by removing stem cells from a donor's blood. (medlineplus.gov)

8 The BD ® Stem Cell Enumeration Kit incorporates BD Trucount™ tubes to determine the absolute cell count, thereby eliminating variability associated with hematology-derived absolute counts. (bdbiosciences.com)

Blood Adv. 2020;4(12):2810-2820. (stembook.org)

Full hematopoietic engraftment was reported in one case after bone marrow transplantation without conditioning for a SCID patient. (nih.gov)
Chemotherapy, radiation, or both are initiated prior to transplantation to enable engraftment of the transplanted cells, decrease tumor size, and reduce immunoreactivity of the recipient. (oncologynurseadvisor.com)

Flow cytometric enumeration of CD34+ HSCs and progenitor cells is an established method for the evaluation of bone marrow and stem cell grafts. (bdbiosciences.com)

At post transplantation day plus 3, antibiotic drug therapy was switched from piperacillin/tazobactam to meropenem. (cdc.gov)

This department provides medical care for patients with heart disorders, disorders of the aortas and peripheral vessels, and hypertension. (japanhospitalsearch.org)
PC-ALCL is one of the primary cutaneous CD30 + T-cell lymphoproliferative disorders, a wide spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end of the spectrum and PC-ALCL at the malignant end. (medscape.com)

These NK cells demonstrate significant cytotoxic activity against human AML and ALL cell lines and patient leukemia blasts. (biologynews.net)
The second patient underwent allogeneic bone marrow transplantation for acute myelogeneous leukemia from his sister. (koreamed.org)
Adult acute lymphoblastic leukemia (ALL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). (piedmontcancerinstitute.com)
also called acute lymphocytic leukemia) is a cancer of the blood and bone marrow. (piedmontcancerinstitute.com)
Hairy Cell Leukemia Treatment. (piedmontcancerinstitute.com)

It results from damage to the bladder's transitional epithelium and blood vessels by toxins, pathogens, radiation, drugs, or disease. (medscape.com)
Hemorrhagic cystitis results from damage to the bladder's transitional epithelium and blood vessels by toxins, viruses, radiation, drugs (in particular, chemotherapeutic drugs), bacterial infections, or other disease processes. (medscape.com)
Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial. (smw.ch)
Validation and refinement of the disease risk index for allogeneic stem cell transplantation: a study from the CIBMTR. (stembook.org)
In people with blood or mucus in the diarrhea, I'd consider inflammatory bowel disease and recommend a colonoscopy. (sunjournal.com)
Breast cancer, a common cancer in women, is a disease in which cancer (malignant) cells are found in the tissues of the breast. (stopgettingsick.com)
Chronic granulomatous disease (CGD) is an inherited disease in which the body's cells that eat invaders (also called phagocytes) do not make hydrogen peroxide and other chemicals. (primaryimmune.org)
Chronic granulomatous disease (CGD) is a type of primary immunodeficiency (PI) in which one group of the body's white blood cells, called neutrophils, fail to make the hydrogen peroxide, bleach, and other chemicals needed to fight bacterial and fungal infections. (primaryimmune.org)
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. (curehunter.com)
Scholars@Duke publication: Sickle cell disease: an international survey of results of HLA-identical sibling hematopoietic stem cell transplantation. (duke.edu)
Despite advances in supportive therapy to prevent complications of sickle cell disease (SCD), access to care is not universal. (duke.edu)
Granulocytes (white blood cells) that fight infection and disease. (piedmontcancerinstitute.com)
Hypercapnia, the elevation of CO2 in blood and tissue, commonly occurs in patients with severe acute and chronic lung disease, including those with pulmonary infections, and is also associated with high mortality risk. (bvsalud.org)

Patients undergoing fludarabine therapy (purine analog) , bone marrow transplantation or peripheral blood stem cell transplantation. (utmb.edu)
My condition improved a lot after stem cell therapy and ozone bath. (placidway.com)
Conditioning therapy is used to help destroy any leftover cancer cells in your body and to make or create a space in your bone marrow for the new stem cells to grow. (leukaemia.org.au)
Large doses of chemotherapy and/or radiation therapy are then applied to kill the cancer cells. (epnet.com)
The best response after surgery, HDCT, and radiation therapy was assessed 60 days after transplantation. (elsevierpure.com)
Using the BLT Humanized Mouse as a Stem Cell based Gene Therapy Tumor Model. (ca.gov)

Before apheresis, the donor's blood count showed mild thrombocytopenia after G-CSF mobilization. (cdc.gov)

The study cohort comprised patients at MD Anderson Cancer (MDACC) who had VGS isolated from their blood between July 1, 2011, and December 1, 2012. (cdc.gov)
This experience points to the need to have a continuous source of gene-modified cells to maintain the ability to kill cancer cells. (ca.gov)
If a lump in the breast is found, the doctor may need to cut out a small piece of the lump and look at it under the microscope to see if there are any cancer cells. (stopgettingsick.com)
If the biopsy shows that there is cancer, it is important that certain tests (called estrogen and progesterone receptor tests) be done on the cancer cells. (stopgettingsick.com)
Tissue from the tumor needs to be taken to the laboratory for estrogen and progesterone tests at the time of biopsy because it may be hard to get enough cancer cells later, although newer techniques can be used on tissue that is not fresh. (stopgettingsick.com)
The chance of recovery (prognosis) and choice of treatment depend on the stage of the cancer (whether it is just in the breast or has spread to other places in the body), the type of breast cancer, certain characteristics of the cancer cells, and whether the cancer is found in the other breast. (stopgettingsick.com)
Cancer occurs when cells in the body divide out of control or order. (epnet.com)
Chemotherapy involves the use of drugs to kill cancer cells. (epnet.com)
They will kill mostly cancer cells. (epnet.com)
Radiation is directed at the tumor from a source outside the body to kill the cancer cells. (epnet.com)
They interfere with the division of cancer cells and can slow tumor growth. (epnet.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Combination chemotherapy with cisplatin and etoposide (cisplatin-etoposide [PE]) has long been the mainstay of treatment for small cell lung cancer (SCLC). (the-medical-dictionary.com)
The procedure can also be used to replace bone marrow which has been somewhat depleted because of some types of cancer treatments. (differencebetween.net)
It can also be used to help patients whose own bone marrow has been destroyed because of cancer treatments. (differencebetween.net)
Natural killer cells that attack cancer cells and viruses. (piedmontcancerinstitute.com)

Quantitating the CD34+ cell population can also be useful during mobilization as well as for determining the optimal timing of apheresis sessions to make sure that enough CD34+ cells have been harvested. (bdbiosciences.com)
Stem cells are collected from your bloodstream by passing all your blood through a special machine called a cell separator (or apheresis machine). (leukaemia.org.au)
The apheresis machine draws blood from the body, spins the blood very quickly, collects the part that contains the blood stem cells , and returns the rest of the blood back to the body. (leukaemia.org.au)
The stem cells are then separated from the other blood cells by the process of apheresis, and then they are given to the patient through a catheter placed into a vein. (differencebetween.net)

During this time you will be more at risk of infections (due to the lack of infection-fighting white blood cells ) and bleeding (due to a lack of platelets ). (leukaemia.org.au)
This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)

Further benefits are that the platelets and neutrophil cells (one of the white blood cells) are more easily able to recover if this method is used compared with the bone marrow procedure. (differencebetween.net)

We used a standardized data collection form to abstract clinical data from the comprehensive electronic medical records of patients with blood culture results positive for VGS. (cdc.gov)

A potential future source of stem cells is induced pluripotent stem cells (certain cells taken from adults and reprogrammed to act like stem cells). (msdmanuals.com)

Anatomy44

Organisms13

Diseases48

Chemicals and Drugs39

Analytical, Diagnostic and Therapeutic Techniques and Equipment66

Psychiatry and Psychology1

Phenomena and Processes49

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture2

Information Science5

Named Groups1

Health Care10

Transplant36

Transplants11

Donors12

Donor32

Autologous peripheral-blood2

Umbilical7

HSCT11

Allogeneic hema1

Acute myelogen1

Multiple myeloma3

Complete remission1

Patient's10

Aplastic anemia3

Kidney transplantation2

Remission1

Cord14

Haematopoietic stem cells2

Harvest7

Normal bone marrow1

PBSCT5

Lymphoma15

Cyclophosphamide1

Granulocyte4

20002

Solid tumors2

High-dose2

Outcome2

Hematologic3

Immature stem cells1

20181

Myeloid2

Progenitor cell1

Immune10

Survival1

Donation4

Hematology1

20201

Engraftment2

Grafts1

Post-transplantation1

Disorders2

Leukemia5

Disease13

Therapy6

Donor's blood1

Cancer16

Apheresis4

Infections2

Neutrophil1

Abstract1

Adults1