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  • progenitor cells
  • For the first time, the researchers show that ANG simultaneously reduces proliferation of stem cells and promotes proliferation of myeloid progenitor cells that give rise to mature myeloid cells. (medindia.net)
  • We knew that ANG was involved in promoting cell growth, so it was not unexpected to find that ANG stimulates proliferation of myeloid progenitor cells," said Guo-fu Hu, PhD, Investigator in the Molecular Oncology Research Institute at Tufts Medical Center, and the paper's senior author. (medindia.net)
  • They demonstrated how ANG stimulates proliferation of myeloid progenitor cells. (medindia.net)
  • In hematopoietic stem/progenitor cells, ANG induces processing of a specific type of RNA (tiRNA) that is quiescence-related whereas in myeloid progenitor cells, ANG induces processing of a specific type of RNA (rRNA) that is proliferation related. (medindia.net)
  • Proper blood cell production is dependent on functioning hematopoietic stem and progenitor cells that are destroyed during conditioning procedures for transplantation or following bone marrow injury," said the study's first author Kevin A. Goncalves, who performed this research as part of his PhD studies in cellular and molecular physiology at the Sackler School. (medindia.net)
  • Working with Dr. Metcalf in Australia he showed that "colony stimulating factors" were necessary for the growth of normal and leukemic stem cells and progenitor cells. (wikipedia.org)
  • engraftment
  • The end points of this study are engraftment, degree of donor-host chimerism, incidence of acute and chronic GVHD, transplant related morbidity and mortality, disease free survival, as well as overall survival, and overall level and persistence of progeny of gene modified cells. (knowcancer.com)
  • macrophages
  • The immunologic mechanism for alloimmunization to antigens present in transfused cells involves presentation of the donor antigens by donor antigen-presenting cells (APCs), ie, monocytes, macrophages, dendritic cells, B cells, to recipient T cells. (medscape.com)
  • Monocytes exit the circulation and migrate into tissue, whereupon they mature into macrophages and dendritic cells. (wikipedia.org)
  • Clinical Trials
  • In the majority of clinical trials investigating the effects of intracoronary cell transplantation, the primary end point comprises changes in LV volumes and EF in comparison with a control group over time ( 5-7 ). (onlinejacc.org)
  • stimulates
  • GM-CSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes. (wikipedia.org)
  • In 1983-84 his group succeeded in identifying and purifying a human growth factor, G-CSF, that stimulates white blood cell production (neutrophils). (wikipedia.org)
  • therapy
  • Changes in functional and morphometric parameters of LV performance after cell therapy appear to be in the range of effects observed with reperfusion therapy, pharmacotherapeutic interventions influencing the renin-angiotensin-aldosterone pathway, and beta-blockers after AMI. (onlinejacc.org)
  • In the following discussion, the effects of intracoronary transplantation of bone marrow- and blood-derived stem cells in AMI on functional and morphometric LV parameters are put into the context of established therapy, such as reperfusion therapy and adjunctive pharmacotherapy. (onlinejacc.org)