Allogenic bone marrow transplaAutologousChemotherapyGVHDRecipientsRebuilding a person'sLymphocytesSevere aplastic anemiaStem CellSurvivalGraftsAspirationUnderwentLeukemiaCurativeCyclophosphamideBiopsyRelapseMultiple myelomaPeripheral bloodDisease2020AplasticHematopoietic cellsBloodTransplantsPost-transplantationGraftAdultComplicationDiagnosisPatientsCellsSerumIncidenceDonorsTumorsComplicationsSolid organMortality
Allogenic bone marrow transpla1
- Genomic DNA of a patient diagnosed with nonobstructive azoospermia and with the history of allogenic bone marrow transplantation from his sister due to chronic myeloid leukemia was isolated from peripheral blood in order to screen Y chromosome microdeletions. (istanbul.edu.tr)
Autologous9
- In recent years, especially after the advent of reduced intensity conditioning in the late 1990s, allogeneic HSCT is increasingly used in older patients and as an effective salvage strategy for patients with lymphoma or myeloma not responding to chemotherapy or autologous HSCT. (longdom.org)
- Severe adverse impact on sexual functioning and fertility of bone marrow transplantation, either allogeneic or autologous, compared with consolidation chemotherapy alone: analysis of the MRC AML 10 trial. (ox.ac.uk)
- METHODS: A cross-sectional study of sexual health and infertility was conducted in 479 patients with acute myeloid leukemia (AML) in first complete remission (CR) who were entered into the UK MRC AML 10 trial comparing allogeneic BMT (Allo-BMT), autologous BMT (A-BMT), and intensive consolidation chemotherapy (CCT). (ox.ac.uk)
- There are two main types of stem cell transplantation: autologous and allogeneic. (medicalnewstoday.com)
- Autologous transplantation involves extracting a person's stem cells from the bone marrow or blood and freezing them before a person has chemotherapy or radiation therapy. (medicalnewstoday.com)
- An autologous bone marrow or stem cell transplantation is performed using a person's own stem cells. (medlineplus.gov)
- Of these, 27.91% had a main diagnosis indicating the transplantation of Multiple Myeloma (MM), and 58.14 received autologous transplantation. (bvsalud.org)
- An initial appointment was scheduled for 22 March 2020 at An-Najah Hospital in Nablus, in the West Bank, but the hospital only offers autologous transplantation (using the patient's own bone marrow), while Saja needed an allogeneic transplant (with bone marrow from a donor). (who.int)
- Saja was rescheduled an appointment at Augusta Victoria Hospital in East Jerusalem, but again the hospital could only offer autologous transplantation. (who.int)
Chemotherapy6
- We report a patient with PNP deficiency, who received HLA-identical sibling marrow without chemotherapy because of disseminated cytomegalovirus (CMV) infection. (frontiersin.org)
- Chemotherapy, radiation therapy, targeted therapy, and stem cell or bone marrow transplant are common treatment options for leukemia. (medicalnewstoday.com)
- Because of the patient's risk status, the physicians intended to perform allogeneic stem cell transplantation after induction and consolidation chemotherapy, which was scheduled to end in January 2013, and a conditioning chemotherapy regimen, which was planned to be given in March. (cdc.gov)
- Saja received her initial chemotherapy in Rabat, before returning home to Gaza in February 2020 to continue her treatment and undergo bone marrow transplantation in the occupied Palestinian territory. (who.int)
- Throughout efforts to refer Saja for bone marrow transplant, she has been receiving chemotherapy at Rantisi Hospital in Gaza City. (who.int)
- Treatment includes induction chemotherapy to achieve remission and postremission chemotherapy (with or without stem cell transplantation) to avoid relapse. (msdmanuals.com)
GVHD9
- Among 1462 patients who had allogeneic hematopoietic cell transplantation (HCT) between January 2000 and December 2005, 116 (7.9%) developed stage 3-4 gut GVHD. (nature.com)
- The median time for onset of stage 3-4 gut GVHD was 35 (4-135) days after allogeneic HCT. (nature.com)
- In bone marrow transplantation for leukemia, counterflow centrifugation is a useful technique for the prevention of GVHD. (ashpublications.org)
- And even when a bone marrow transplant is curative for leukemia or lymphoma, GVHD-in which T cells in the donor graft attack the recipient's own tissues-can still be fatal. (genengnews.com)
- In experiments with mouse models of GVHD, the researchers showed that blocking a particular Notch activator known as DLL4 effectively prevented GVHD when administered within the first days after transplantation. (genengnews.com)
- The team confirmed that the Notch pathway involvement in GVHD was conserved across species, and demonstrated in their animal models that just a single dose of the DLL4-blocking antibody given immediately before stem cell transplantation greatly increased survival and prevented signs of GVHD in the intestines, but without causing global immunosuppression. (genengnews.com)
- GvHD is commonly associated with bone marrow transplants and stem cell transplants . (wikipedia.org)
- [11] About one-third to one-half of allogeneic transplant recipients will develop acute GvHD. (wikipedia.org)
- Efficacy with respect to GVHD response will be assessed using European Society for Blood and Marrow Transplantation-National Institutes of Health- Centre for International Blood and Marrow Transplant Research (EBMT-NIH-CIBMTR) Task Force Criteria. (who.int)
Recipients5
- Strikingly, 12 cases occurred in 1997 with the majority in recipients of allogeneic matched sibling donor stem cells. (nih.gov)
- This study reviews results of a radiation-free preparative regimen consisting of busulfan and cyclophosphamide in 65 unrelated allogeneic bone marrow transplant recipients. (elsevierpure.com)
- Detection of residual tumor cells, an indicator for efficacy of GVL, was carried out by adoptive transfer of peripheral blood or spleen cells obtained from treated chimeras into secondary naive BALB/c recipients at different time intervals following bone marrow transplantation. (ox.ac.uk)
- Treatment of the primary marrow inoculum with monoclonal anti-Thy1.2 or anti-Lyt2 abolished the GVL effects and all secondary BALB/c recipients developed leukemia within 60 days. (ox.ac.uk)
- Recipients will be patients who have had an allogeneic bone marrow transplant and who have steroid dependent (SD) or steroid refractory (SR) Graft-versus-Host Disease. (who.int)
Rebuilding a person's1
- From there, they travel to the bone marrow and multiply, rebuilding a person's immune system . (medicalnewstoday.com)
Lymphocytes4
- We conclude that despite the recovery of normal numbers of T lymphocytes early after engraftment of CD6-depleted marrow, these T cells exhibit several physiologic and functional abnormalities that persist for varying intervals post-BMT. (ashpublications.org)
- Donor marrow was depleted of lymphocytes using counterflow centrifugation. (ashpublications.org)
- It is now widely accepted that immunocompetent lymphocytes in allogeneic bone marrow grafts exert an antileukemic effect that contributes to the cure of leukemia. (ox.ac.uk)
- Bone marrow is mainly responsible for the haematopoiesis, (formation of blood cells), production of lymphocytes, and the storage of fats. (powershow.com)
Severe aplastic anemia1
- Effect of race on outcomes after allogeneic hematopoietic cell transplantation for severe aplastic anemia. (aamds.org)
Stem Cell19
- Prospective evaluation for upper gastrointestinal tract acute graft-versus-host disease after hematopoietic stem cell transplantation. (nature.com)
- Since then, allogeneic hematopoietic stem cell transplantation (HSCT) has evolved to become a frequently used and effective therapy for many hematologic malignancies. (longdom.org)
- This study compares the clinical outcomes of 60 consecutive patients who received an allogeneic blood or marrow stem cell transplant (BMT) from one Human Leukocyte Antigen (HLA) mismatched related donors with those of 120 matched patients who had HLA identical sibling donors. (mcmaster.ca)
- The lack of donor availability is a major limitation to the widespread use of allogeneic hematopoietic stem cell transplantation, and therefore it would be beneficial to identify less immunogenic HLA mismatches. (elsevierpure.com)
- Create healthcare diagrams like this example called Leukemia - Stem Cell Transplantation in minutes with SmartDraw. (smartdraw.com)
- Prevalence of decisional regret among patients who underwent allogeneic hematopoietic stem cell transplantation and associations with quality of life and clinical outcomes. (cdc.gov)
- Background: Allogeneic hematopoietic stem cell transplantation (alloHCT) is potentially curative but with known negative effects on quality of life. (cdc.gov)
- The only curative therapy is hematopoietic stem cell transplantation. (frontiersin.org)
- Acute graft versus host disease (aGVHD) is a common complication following allogeneic hematopoietic stem cell transplantation (AHSCT) caused by cellular and inflammatory factors, including those arising from monocytes and dendritic cells as integral parts of the immune system. (magiran.com)
- Stem cell transplantation, or bone marrow transplantation, is a treatment option for leukemia and other blood cancers. (medicalnewstoday.com)
- The goal of stem cell transplantation is to replace diseased or damaged stem cells with healthy ones. (medicalnewstoday.com)
- Bone marrow transplant also referred to as hematopoietic stem cell. (powershow.com)
- Now, my only hope was an allogeneic stem cell transplantation. (ascopost.com)
- Studies indicate that early unrelated hematopoietic stem cell transplantation in both the infantile and late-onset forms is associated with at least short-term benefits on neurocognitive parameters, lifespan, and quality of life. (medscape.com)
- Hematopoietic stem cell transplantation has become a major treatment option for patients with hematopoietic malignancies and immune deficiencies. (cdc.gov)
- To the best of our knowledge, only the transmission of malarial parasites has been reported during stem cell transplantation. (cdc.gov)
- Hematopoietic stem cell transplantation (HSCT) affects serious risks for the patient, including death. (bvsalud.org)
- Australasian Trends in Allogeneic Stem Cell Transplantation for Myelofibrosis in the Molecular Era: A retrospective analysis from The Australasian Bone Marrow Transplant Recipient Registry. (cdc.gov)
- The Impact of Methylenetetrahydrofolate Reductase C677T Polymorphism on Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation with Methotrexate Prophylaxis. (cdc.gov)
Survival6
- An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens. (nature.com)
- The projected 3-year probability of leukemia-free survival (LFS) was 56% (95% CI, 35% to 77%) after transplantation for AML-CR1, 42% (95% CI, 16% to 69%) in patients transplanted for ALL-CR1, and 49% (95% CI, 18% to 80%) after transplantation for CML-CP1. (ashpublications.org)
- These results suggest that allogeneic BMT can result in extended relapse-free survival for some patients with high-risk ALL. (umn.edu)
- The 5-year probabilities of overall survival adjusted for interval from diagnosis to transplantation, and performance score was 58% for African Americans and 73% for Caucasians. (aamds.org)
- The stem cells in our bone marrow produce blood cells essential for survival. (apollohospitals.com)
- Psychosocial factors in predictive of survival after allogeneic bone marrow transplantation. (bvsalud.org)
Grafts1
- In the present study, we examined immune function after BMT in a series of patients who had received HLA compatible sibling marrow grafts purged of T cells with anti-CD6 monoclonal antibody and complement. (ashpublications.org)
Aspiration3
- Bone marrow aspiration is carried out by a puncture on the level of the sternum or the posterior iliac peaks under local anesthesia by the doctor. (longdom.org)
- Because the chromosomal t(14;18) translocation is found in the majority of patients with follicular lymphoma, bone marrow aspiration and chromosome analysis can also help establish the diagnosis. (medscape.com)
- Bone marrow aspiration and biopsy are necessary to obtain bone marrow for histologic analysis. (medscape.com)
Underwent3
- Forty remission patients with high-risk acute lymphoblastic leukemia (ALL) underwent matched allogeneic bone marrow transplantation (BMT) following preparation with cyclophosphamide and fractionated total body irradation (TBI). (umn.edu)
- Conclusions: Among patients who underwent alloHCT and lived to 100 days, the majority did not report regretting their transplantation. (cdc.gov)
- Participants included 38 patients who underwent primary allogeneic bone marrow transplantation. (magiran.com)
Leukemia8
- Allogeneic bone marrow transplantation for the treatment of akr spontaneous leukemia. (jax.org)
- A 22-yr-old man with acute myelocytic leukemia received a bone marrow transplant from a genotypically HLA-identical female sibling after cyclophosphamide preparation. (notifylibrary.org)
- Eighty consecutive patients were transplanted with human leukocyte antigen (HLA)-identical sibling marrow for acute myelogenous leukemia (AML, N = 29), acute lymphoid leukemia (ALL, N = 23), or chronic myelogenous leukemia (CML, N = 28). (ashpublications.org)
- After transplantation for AML-CR1, ALL-CR1, or CML-CP1, the median follow-up time for leukemia-free survivors was 31+, 30+, and 21+ months, respectively. (ashpublications.org)
- Characterization of effector cells of graft vs leukemia following allogeneic bone marrow transplantation in mice inoculated with murine B-cell leukemia. (ox.ac.uk)
- Graft vs leukemia (GVL) effects independent of graft vs host disease were investigated in allogeneic bone marrow chimeras tolerant of host and donor alloantigens. (ox.ac.uk)
- Aplastic anemia due to the progressive failure of the bone marrow, malignant neoplasias such as acute myeloid leukemia, liver tumors and squamous cell carcinoma are some of the possible evolutions of Fanconi Anemia. (bvsalud.org)
- In acute myeloid leukemia (AML), malignant transformation and uncontrolled proliferation of an abnormally differentiated, long-lived myeloid progenitor cell results in high circulating numbers of immature blood cells and replacement of normal marrow by malignant cells. (msdmanuals.com)
Curative1
- The Allogeneic bone-marrow transplantation represents the only curative treatment and requires a compatible donor HLA. (longdom.org)
Cyclophosphamide2
- The patient received a second bone marrow transplant from the same donor after preparation with busulfan and cyclophosphamide and attained a complete remission with full hematologic engraftment. (notifylibrary.org)
- Busulfan/cyclophosphamide is an effective preparative regimen in unrelated bone marrow transplantation permitting adequate engraftment and a low relapse rate. (elsevierpure.com)
Biopsy3
- Thinking I could now proceed with my in vitro fertilization, the plans were stalled once again when my fertility physician, so sure that I, in fact, did have cancer, insisted he would not go through with the embryo transfer until I had a bone marrow biopsy. (ascopost.com)
- The results of a follow-up bone marrow biopsy detected malignant cells. (ascopost.com)
- If your provider suspects this type of cancer, a bone marrow biopsy will be performed. (medlineplus.gov)
Relapse4
- At 34 mo after transplant, marrow relapse and chloroma were documented. (notifylibrary.org)
- All metaphase cells and karyotypes from peripheral blood and marrow samples showed no evidence of host cells from 3 wk after transplant through the time of marrow relapse. (notifylibrary.org)
- Data from autosomal and sex chromosome studies indicate that the marrow relapse occurred in cells of donor origin. (notifylibrary.org)
- The projected 3-year probability of relapse was 30% (95% confidence interval [CI], range 8% to 53%) in transplants for AML in first complete remission (CR1), 35% (95% CI, 1% to 69%) after transplantation for ALL in CR1, and 38% (95% CI, 2% to 74%) after transplantation for CML in first chronic phase (CP1). (ashpublications.org)
Multiple myeloma4
- Multiple myeloma (MM) is a plasma cell malignancy in which monoclonal plasma cells proliferate in bone marrow, resulting in an overabundance of monoclonal paraprotein (M protein), destruction of bone, and displacement of other hematopoietic cell lines. (medscape.com)
- Bone marrow aspirate demonstrating plasma cells of multiple myeloma. (medscape.com)
- Multiple myeloma is a blood cancer that starts in the plasma cells in the bone marrow. (medlineplus.gov)
- In people with multiple myeloma, abnormal plasma cells grow out of control in the bone marrow and form tumors in the areas of solid bone. (medlineplus.gov)
Peripheral blood3
- Peripheral blood mononuclear cells (PBMCs) were isolated by Ficoll-Hypaque gradient from the blood samples collected at days 0, 7, 14, 28, and final day of transplantation. (magiran.com)
- HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)
- Examination of peripheral blood smear and bone marrow is diagnostic. (msdmanuals.com)
Disease5
- Induction of GVL effects by allogeneic cells tolerant of host MHC suggests that these effects may be independent of graft vs host disease. (ox.ac.uk)
- Symptoms related to bone marrow dysfunction, such as anemia, leukopenia, or thrombocytopenia, are rare at presentation but can also be observed in the later stages of the disease. (medscape.com)
- The risk of regretting transplantation was 17.5 percentage points (95% confidence interval, 5.5-29.7 percentage points) greater in patients who developed disease recurrence after HCT compared with patients who did not. (cdc.gov)
- In a newly reported study, an experimental antibody treatment largely prevented gastrointestinal acute graft versus host disease (GI-aGVHD) in the intestines of mice and non-human primates (NHPs) given a bone marrow transplant-allogeneic hematopoietic cell transplant (allo-HCT)-but without causing broad immune suppression. (genengnews.com)
- Newer research indicates that other graft-versus-host disease target organs include the immune system (the hematopoietic system , e.g., the bone marrow and the thymus ) itself, and the lungs in the form of immune-mediated pneumonitis . (wikipedia.org)
20201
- She needs a bone marrow transplant, not available in the Gaza Strip, and has not been able to access the treatment she needs since March 2020. (who.int)
Aplastic1
- Decision analysis of allogeneic bone marrow transplantation versus immunosuppressive therapy for young adult patients with aplastic anemia. (bvsalud.org)
Hematopoietic cells1
- Bone marrow is the place for the production of the hematopoietic cells which differentiate in to three groups: red blood cells, white blood cells and platelets. (longdom.org)
Blood6
- If Pearson syndrome is strongly suspected with normal findings in the blood, analysis of bone marrow should be performed. (medscape.com)
- Methods Center for International Blood and Marrow Transplant Research data from 184 adults who completed the Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) before undergoing alloHCT and at day 100 were used. (cdc.gov)
- When it is sick and unable to produce the normal healthy blood cells, a patient is considered for a bone marrow transplant where the diseased marrow is replaced with healthy marrow. (apollohospitals.com)
- The bone marrow makes blood cells. (medlineplus.gov)
- It also makes it harder for the bone marrow to make healthy blood cells and platelets. (medlineplus.gov)
- and umbilical cord blood (PUCB), capable of 2017), associated with the results of the procedure restoring spinal cord function and immunology of and require a process of hospitalization and patients with indication for transplantation, with the prolonged hospital recovery. (bvsalud.org)
Transplants2
- The condition is among the leading causes of death and long-term adverse health consequences associated with bone marrow transplants. (genengnews.com)
- Each year, more than 50,000 allogeneic transplants are performed worldwide. (cdc.gov)
Post-transplantation2
- If one of the brothers and sisters is compatible, we speak about geno-identical allogeneic transplantation having the advantage of reducing the complications post-transplantation. (longdom.org)
- At post transplantation day plus 3, antibiotic drug therapy was switched from piperacillin/tazobactam to meropenem. (cdc.gov)
Graft1
- African Americans and Caucasians were matched for age, donor-recipient HLA match, graft type and transplantation year. (aamds.org)
Adult1
- Hematopoietic stem cells (HSCs) are very rare cells, representing approximately one in 100,000 bone marrow (BM) cells in the adult. (longdom.org)
Complication1
- Diffuse alveolar hemorrhage (DAH) is a non-infectious pulmonary complication of bone marrow transplantation (BMT) with resultant high mortality. (nih.gov)
Diagnosis1
- Most patients with follicular lymphoma present at an advanced stage, and most patients have bone marrow involvement at diagnosis. (medscape.com)
Patients9
- Persistent nausea and anorexia after marrow transplantation: a prospective study of 78 patients. (nature.com)
- Pulmonary complications occur in half of allogeneic bone marrow transplantation (BMT) patients. (nih.gov)
- Patients who undergo allogeneic bone marrow transplantation (BMT) are clinically immunodeficient for a prolonged period after engraftment. (ashpublications.org)
- Allogeneic bone marrow transplantation (BMT) from an HLA-matched sibling donor is recommended as an initial treatment for young patients . (bvsalud.org)
- In conclusion, the OS of patients receiving marrow/stem cells from one antigen mismatched related donors was inferior to that of controls with HLA-identical related donors. (mcmaster.ca)
- in addition 46 patients received corticosteroid, 38 methotrexate, six anti-CD5 ricin A-immunotoxin, and four T cell-depleted bone marrow. (elsevierpure.com)
- The aim of this study was to assess whether the lnc-DC plays a role in patients with aGVHD by measuring its expression levels compared to non-aGVHD patients on specific time intervals following transplantation. (magiran.com)
- Allogeneic hematopoietic cell transplantation (allo-HCT) has lifesaving potential for patients with hematological malignancies and bone marrow disorders, the authors wrote. (genengnews.com)
- Also, drastic changes in daily living habits, qualified and responsible for the implementation of changes in body image, long duration of treatment, HSCT since 2004, agreed to the Brazilian Unified periods of hospitalization and protective isolation, Health System, which meets the needs of the feeling of loss of control, fear of death and lack of patients with an indication for transplantation. (bvsalud.org)
Cells8
- Mice were reconstituted with C57BL/6 bone marrow cells depleted of well-defined T-cell subsets or enriched for stem cells by the soybean agglutination method. (ox.ac.uk)
- Allogeneic transplantation involves using stem cells from a donor - often a family member but sometimes a nonrelative. (medicalnewstoday.com)
- As the cancer cells grow in the bone marrow, you may have bone pain, most often in the ribs or back. (medlineplus.gov)
- An allogeneic transplant uses someone else's stem cells. (medlineplus.gov)
- Regulatory T cells (T(regs)) manipulated ex vivo have potential as cellular therapeutics in autoimmunity and transplantation. (lu.se)
- Although it is possible to expand naturally occurring T(regs), an attractive alternative possibility, particularly suited to solid organ and bone marrow transplantation, is the stimulation of total T cell populations with defined allogeneic antigen-presenting cells (APCs) under conditions that lead to the generation or expansion of donor-reactive, adaptive T(regs). (lu.se)
- Here we demonstrate that stimulation of mouse CD4(+) T cells by immature allogeneic dendritic cells combined with pharmacological inhibition of phosphodiesterase 3 (PDE) resulted in a functional enrichment of Foxp3(+) T cells. (lu.se)
- Notably, PDE inhibition also enhanced the enrichment of human Foxp3(+) CD4(+) T cells driven by allogeneic APCs. (lu.se)
Serum1
- National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines also recommend the use of serum free light chain assay and plasma cell fluorescence in situ hybridization (FISH) on bone marrow: del 13, del 17p13, t(4;14), t(11;14), t(14;16), t(14;20), 1q21 amplification, 1p deletion as part of the initial diagnostic workup. (medscape.com)
Incidence1
- Further follow-up is required to establish whether this increase in the incidence of DAH in allogeneic transplantation is an isolated occurrence or an ongoing problem. (nih.gov)
Donors2
- Allogeneic bone marrow transplantation, as we understood it, allows saving lives, but cannot take place without donors. (longdom.org)
- If the geno-identical transplantation is impossible, we will direct ourselves towards the national and international register donors of bone marrow. (longdom.org)
Tumors1
- The growth of these bone tumors weakens the bones. (medlineplus.gov)
Complications1
- They are most often given to prevent complications such as bone fractures and kidney damage. (medlineplus.gov)
Solid organ1
- No prior allogeneic bone marrow transplantation or prior solid organ transplantation. (swog.org)
Mortality1
- Reduced mortality after allogeneic hematopoietic-cell transplantation. (nature.com)