• In Dentistry, many studies have aimed to improve bone regeneration through the use of BMPs for bone replacement. (bvsalud.org)
  • Several studies demonstrate the biological advantages of rhBMP-2 on bone regeneration of the jaws. (bvsalud.org)
  • MSCs are ideal stem cells for tissues regeneration because of their excellent capacities for differentiation and proliferation. (researchassistantresume.com)
  • The regeneration of bone tissue defects specifically includes a series of complicated procedures that are controlled by a number of cytokines and natural signals. (researchassistantresume.com)
  • since bone tissue regeneration cannot effectively occur with out a bloodstream supply achieving the bone tissue defect angiogenesis CEP-28122 is certainly important for bone tissue regeneration in vivo [6-10]. (researchassistantresume.com)
  • It really is reported that angiogenesis may be the foundational part of bone tissue regeneration particularly in calvarial and limb bone tissue defects [11-13]. (researchassistantresume.com)
  • after that both angiogenesis and osteogenesis participate in the bone regeneration and promote the effects of each additional [13]. (researchassistantresume.com)
  • However, MSCs have gained considerable attention for tissue regeneration owing to their differentiation ability with immunomodulatory effects. (techscience.com)
  • Because adipose ECM contains many primordial matrix proteins important for embryonic development and regeneration (such as laminin, type IV collagen, and fibronectin), adipose ECM may prove to be an autologous tissue engineering matrix and stem cell culture substrate. (vcu.edu)
  • In a randomized, double-blinded, controlled clinical trial [ 3 ], 24 % of a total of 55 patients who underwent a partial medial meniscectomy followed by intra-articular (IA) injection with 5-15 × 10 7 allogeneic bone marrow-derived MSCs achieved a 15 % increase in the meniscal volume determined by magnetic resonance imaging (MRI) at the 2-year follow-up, suggesting evidence of meniscus regeneration after MSC treatment. (biomedcentral.com)
  • Another proof-of-concept clinical trial in which OA patients ( n = 9) treated with IA injection of 10 × 10 7 adipose-derived autologous MSCs demonstrated improved Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores and regeneration of hyaline-like cartilage in the affected joint [ 4 ]. (biomedcentral.com)
  • Following the expansion of stem cell therapy using autologous MSC for tissue regeneration [ 3 ]. (biomedcentral.com)
  • She was awarded with a postdoc fellow from the Ministry of Science at the Technical University of Catalonia in Biomaterials for bone tissue regeneration and since 2010 has been professor at this university. (ibecbarcelona.eu)
  • Her research group is particularly interested in developing biomaterials and cell-based therapeutics to improve regeneration of various musculoskeletal tissues including bone, cartilage, tendon, blood vessels etc. (stanford.edu)
  • It plays a dominant role in embryonic dorsal-ventral patterning, organogenesis, limb bud formation, and bone formation and regeneration (1, 2). (novusbio.com)
  • Bone regeneration is a complex process that requires the coordination of osteogenesis and osteoclastogenesis. (researchpad.co)
  • Electrospun nanocomposite for bone tissues regeneration via osteoconduction, osteoinduction, and osteogenesis. (dokumen.pub)
  • Here, we characterize patient-derivable mesenchymal stem cell types, termed adipose-derived stem cells (ASCs). (vcu.edu)
  • It is known that significant percentages of visceral adipocytes are derived from mesenchymal stem cells and high glucose enhances adipogenic differentiation of mouse bone marrow-derived MSCs (BM-MSCs). (hindawi.com)
  • It is known that adipocytes are derived, at least in part, from multipotent mesenchymal stem cells (MSCs). (hindawi.com)
  • A specific population of adipose-derived stem cells (ASCs) is expected to be an alternate source of bone marrow-derived mesenchymal stem cells (BMSCs). (jarde.jp)
  • The aim of this study was to compare the osteogenic potential of mesenchymal stem cells obtained from bone marrow (BM-MSC) with those extracted from adipose tissue (AT-MSC) of adult dogs. (scielo.br)
  • The human bone morphogenet ic protein (rhBMP) developed by genetic engineering, was isolated by Urist, in 1965, and it is considered a substance capable of inducing differentiation of mesenchymal stem cells into osteoblasts, the cells that are responsible for the synthesis of bone matrix. (bvsalud.org)
  • However, limited studies have been conducted on the osteogenic capability of stem cells derived from BFP (BFPSCs). (utwente.nl)
  • The features of BFPSCs were compared with bone marrow-derived stem cells (BMSCs) as a well known cell source for bone tissue engineering. (utwente.nl)
  • These results define BFP as a new, rich, and accessible source of stem cells for tissue engineering purposes. (utwente.nl)
  • Bone tissue marrow-derived mesenchymal stem cells (BMSCs) are widely used in regenerative medicine in light of their ability to differentiate along the chondrogenic and osteogenic lineages. (researchassistantresume.com)
  • Mesenchymal stem cells (MSCs) are multipotent cells usually isolated from bone marrow, endometrium, adipose tissues, skin, and dental pulp. (techscience.com)
  • The Mesenchymal and Tissue Stem Cell Committee, which belongs to the International Society for Cellular Therapy, stated that plastic-adherent properties are the minimum criteria for determining MSCs. (techscience.com)
  • These ASCs also shared an indistinguishable immunophenotype when compared to bone marrow-derived mesenchymal stem cells, suggesting that these cells are an excellent source for bone following tissue engineering experimentation. (vcu.edu)
  • We also show that this novel electrospun adipose tissue scaffold is capable of supporting stem cell growth. (vcu.edu)
  • The existence of cancer stem cells (CSCs) within CRC tissues was recently suggested to play importance roles for this process. (bvsalud.org)
  • Human adipose-derived mesenchymal stem cells (haMSCs) have shown efficacy in treating osteoarthritis (OA) both preclinically and clinically via intra-articular (IA) injection. (biomedcentral.com)
  • The current study represents the first attempt to correlate cell therapy efficacy on OA with the physical presence of the injected haMSCs in the OA model, and demonstrates that human adipose-derived mesenchymal stem cells persisted for 10 weeks locally in the rat joint, coinciding with the efficacy observed. (biomedcentral.com)
  • Human mesenchymal stem cells (MSCs) are therapeutic for clinical applications because of their excellent immunomodulatory and multiple lineage differentiation abilities at tissue injury sites. (biomedcentral.com)
  • Here, we demonstrated a preconditioning strategy with trophoblast stem cell-derived extracellular vesicles (TSC-EVs) to boost the proliferation and regenerative capacity of MSCs. (biomedcentral.com)
  • Human dental pulp-derived mesenchymal stem cells (hDP-MSCs), which include human dental pulp stem cells (hDPSCs) and stem cells from human exfoliated deciduous teeth (SHEDs), are promising cell sources for regenerative therapies. (biomedcentral.com)
  • hDP-MSCs includes human dental pulp stem cells (hDPSCs) and stem cells from human exfoliated deciduous teeth (SHEDs) which are isolated from the pulp tissue of permanent and deciduous teeth, respectively. (biomedcentral.com)
  • Stem cells are known to work via a variety of methods to heal tissue depending on where the stem cells come from and into which tissue it is being placed. (drcremers.com)
  • Here is a general list of all the Ways Stem Cells heal tissues or create new tissue. (drcremers.com)
  • 1. Stem cells have long been known to have the ability to differentiate (ie become/transform) into "good/normal" tissue. (drcremers.com)
  • Embryonic stem cells have been fraught with difficulties in coaxing them into "good/normal" tissue and there are major ethical issues. (drcremers.com)
  • These adult stem cells, such as from fat (adipose derived) or bone marrow, have the ability to transform into different cells. (drcremers.com)
  • To reduce possible xenobiotic contamination from 3T3s, primary human adipose-derived stem cells (ASCs) were examined as feeder cells to support the expansion of LSCs in vitro . (drcremers.com)
  • Mei H, González S, Nakatsu MN, Baclagon ER, Chen FV, Deng SX (2017) Human adipose-derived stem cells support the growth of limbal stem/progenitor cells. (drcremers.com)
  • The effects of erythropoietin (EPO) on the behaviors of bone marrow mesenchymal stem cells (BMSCs) subjected to mechanical stretch remain unclear. (hindawi.com)
  • Notably, it promotes the osteogenic differentiation of bone mesenchymal stem cells (BMSCs) [ 15 - 17 ]. (hindawi.com)
  • The bone marrow contains various populations of skeletal stem cells (SSCs) in the stromal compartment, which are important regulators of bone formation. (nature.com)
  • These Fgfr3 + stem/stromal cells with OCT identities are abundant in the young bone marrow and depleted in the old bone marrow, denoting their transitional nature. (nature.com)
  • Overall, our findings indicate that Fgfr3 + endosteal stem/stromal cells with OCT identities dictate active and aggressive osteogenesis, identifying these cells as an important regulator of long-term bone homeostasis. (nature.com)
  • Dr. Yang has extensive expertise in developing novel biomaterials and stem cell-based therapeutics for musculoskeletal tissue engineering, or engineering 3D in vitro cancer models for drug screening and mechanistic discovery. (stanford.edu)
  • The balance between osteogenesis and adipogenesis of bone marrow mesenchymal stem cells (BMSCs) plays a major role in the process of bone formation. (researchpad.co)
  • Bone marrow mesenchymal stem cells (BMSCs) are stromal stem cells that are derived from bone marrow and possess multiplex differentiation potential ( 3 ). (researchpad.co)
  • A recent study suggested that human bone marrow mesenchymal stem cells showed stronger proliferation and osteogenic differentiation when cocultured with inactive human monocytes ( 12 ). (researchpad.co)
  • In vitro and in vivo results implied that Cbfa1-overexpressing ASCs may be an alternative cell source for BMSCs for bone tissue engineering. (jarde.jp)
  • Furthermore, mechanical stretch may induce the differentiation of BMSCs into mature osteoblasts and enhance the deposition of the bone matrix [ 18 - 20 ]. (hindawi.com)
  • In this experiment, we found that exosomes derived from M2 macrophages (M2D-Exos) could inhibit adipogenesis and promote osteogenesis of BMSCs. (researchpad.co)
  • Therefore, BMSCs play a critical role in bone formation ( 4 ). (researchpad.co)
  • Osteal macrophages are located on the bone surface and are tightly related to the osteogenesis of BMSCs ( 10 ). (researchpad.co)
  • Bone tissue (osseous tissue), which is also called bone in the uncountable sense of that word, is hard tissue, a type of specialised connective tissue. (wikipedia.org)
  • We show here that adipose tissue ECM can, in fact, be electrospun into a nanofiberous mesh, histologically shown to contain connective tissue, collagens, elastic fibers/elastin, proteoglycans, and glycoproteins in the newly synthesized matrix. (vcu.edu)
  • A type of connective tissue that contains stored cellular fat. (w8mdspa.com)
  • A family of structurally related collagens that form the characteristic collagen fibril bundles seen in CONNECTIVE TISSUE. (lookformedical.com)
  • A non-fibrillar collagen that forms a network of MICROFIBRILS within the EXTRACELLULAR MATRIX of CONNECTIVE TISSUE. (lookformedical.com)
  • This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (lookformedical.com)
  • Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules. (lookformedical.com)
  • A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. (lookformedical.com)
  • The aim of this study was to conduct a literature review on the use and clinical viability of human bone morphogenetic protein (rhBMP-2) for grafting bone in Dentistry. (bvsalud.org)
  • Further, there are signaling pathways that participate in regulation, such as Wnt channel, mitogen-activated protein kinase (MAPK) channel, bone morphogenetic protein (BMPs) channel, peroxisome proliferator activated-receptors (PPARs) channel, and Notch channel. (frontiersin.org)
  • Interestingly Chinese medicine which could promote the secretion of osteogenic factors such as collagen type 1 (COL1) bone morphogenetic protein 2 (BMP-2) osteocalcin (OCN) and osteopontin (OPN) and the gene manifestation of BMP-4 runt-related transcription element 2 (Runx2) OCN and OPN has been increasingly applied in osteogenic induction study [18-20]. (researchassistantresume.com)
  • Bone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup of the TGF-beta superfamily. (novusbio.com)
  • This study aims to investigate the effects of high glucose on proliferation as well as adipogenic and osteogenic differentiation of human MSCs derived from bone marrow and several gestational tissues including chorion, placenta, and umbilical cord. (hindawi.com)
  • In contrast to adipogenic differentiation, high glucose suppressed osteogenic differentiation and downregulated the expression levels of osteogenic gene runt-related transcription factor 2 ( RUNX2 ), collagen type I ( COL1A1 ), osteonectin ( ON ), and osteocalcin ( OCN ) of mouse BM-MSCs and MG63 cells [ 7 , 9 ]. (hindawi.com)
  • On days 7, 14 and 21 of osteogenic differentiation, the cultures were submitted to evaluations of MTT conversion in formazan, of alkaline phosphatase activity (AP), of collagen and mineralized matrix synthesis, evaluation of the number of cells per field and there was quantification of the gene transcripts for osterix, bone sialoprotein (BSP), osteonectin (ON) and osteocalcin (OC). (scielo.br)
  • In order to synthesize bone ex-vivo, electrospun scaffolds of fibrinogen (Fg), polydioxanone (PDO), and Fg:PDO blends were seeded with early passage ASCs, fibroblasts, or osteosarcoma cells and were maintained for 21 days in osteogenic or regular growth media. (vcu.edu)
  • To confirm our gene expression results, osteogenic-induced ASCs on Fg scaffolds were also shown to secrete osteocalcin in the extracellular matrix, a key marker in osteoblastogenesis. (vcu.edu)
  • Thus, electrospun Fg is an excellent material for ASC growth, proliferation, and osteogenic differentiation, providing an ideal system for furthering basic bone model-based research and for advancing regenerative medicine. (vcu.edu)
  • Osteogenic effects of TSC-EVs on MSCs were assessed by alkaline phosphatase (ALP) activity, calcium assays, and calvarial bone defect animal models. (biomedcentral.com)
  • Here, we intend to investigate whether RESV counteracts senescence-associated bone loss via osteogenic improvement of MSCs and the underlying mechanism. (thno.org)
  • Bone mass, bone formation rates and osteogenic differentiation of BMMSCs were primarily evaluated. (thno.org)
  • Chronic intermittent application of RESV enhances bone formation and counteracts accelerated bone loss, with RESV improving osteogenic differentiation of senescent BMMSCs. (thno.org)
  • BMP-2 induces chondrocyte proliferation, endochondral bone formation, longitudinal bone growth, and bone and cartilage repair (6, 7). (novusbio.com)
  • abstract = "Adipose tissues hold great promise in bone tissue engineering since they are available in large quantities as a waste material. (utwente.nl)
  • A prior study within a rabbit calvarial defect model additional revealed that there is seductive spatial and temporal relationship between newly produced blood vessels and further skeletal bone tissue development [12]. (researchassistantresume.com)
  • A fibrillar collagen consisting of three identical alpha1(III) chains that is widely distributed in many tissues containing COLLAGEN TYPE I. It is particularly abundant in BLOOD VESSELS and may play a role in tissues with elastic characteristics. (lookformedical.com)
  • An increase in adipogenic differentiation levels was accompanied by an upregulation of the expression levels of several adipogenic genes including peroxisome proliferator-activated receptor gamma ( PPAR γ ), adipocyte protein 2 ( AP2 ), adipose tissue-specific secretory factor ( ADSF ), sterol regulatory element-binding protein 1C ( SREBP1C ), lipoprotein lipase ( LPL ), adiponectin ( ADIPOQ ), and glucose transporter type 4 ( GLUT4 ) [ 8 , 9 , 11 ]. (hindawi.com)
  • Wild-type (WT) AAV serotypes exhibit different tissue tropism due to different capsid protein sequences or variable regions interacting with disparate cell surface receptors, and thus can be utilized for different target tissues 3 . (nature.com)
  • mRNA and protein expressions of Ngb and HIF-1α showed positive in different tissues of the yak and cattle telencephalon. (bvsalud.org)
  • A group of synthetic hormones that promote the storage of protein and the growth of tissue, sometimes used by athletes to increase muscle size and strength. (w8mdspa.com)
  • Leptin (from Greek λεπτός leptos , 'thin' or 'light' or 'small') is a protein hormone predominantly made by adipose cells and its primary role is likely to regulate long-term energy balance . (cloudfront.net)
  • The results revealed that the osteoblastic markers, such as ALP activity, the osteocalcin expression, and calcium content, in Cbfa1-overexpressing ASCs were markedly greater than those of control ASCs. (jarde.jp)
  • Taken together, experiments using ASCs cultured on extracellular matrices of electrospun Fg or adipose ECM present an excellent framework for future advances in regenerative medicine therapeutics and research. (vcu.edu)
  • These cells, which can be derived from liposuction fat and lipoaspirate saline, are sources for patient-derivable extracellular matrix (ECM), fibrinogen (Fg) and adipose tissue extracellular matrix, and may prove useful for synthesizing new bone tissue analogues in vitro. (vcu.edu)
  • The population of MSC in human tissues is insufficient, and obtaining a high cellular yield and maintaining biological capacity during in vitro expansion remains challenging [ 4 ]. (biomedcentral.com)
  • Biomaterials can be defined as any material that acts replacing a lost bone defect and its function. (bvsalud.org)
  • Biomaterials can be defined as "any material, natural or synthetic, that acts in tissues/organs in order to replace the bone defect lost and s function" 13 . (bvsalud.org)
  • Electrospun biomaterials for bone tissue engineering. (dokumen.pub)
  • Cancellous bone, or spongy bone, also known as trabecular bone, is the internal tissue of the skeletal bone and is an open cell porous network that follows the material properties of biofoams. (wikipedia.org)
  • Moreover, AAV9-NEM localized strongly in vivo to cells lining the calcified trabecular bone and transduced primary murine osteoblasts in culture, while WT AAV9 transduced undifferentiated bone marrow stromal cells as well as osteoblasts. (nature.com)
  • Challenges in organ transplantation such as high organ demand and biocompatibility issues have led scientists in the field of tissue engineering and regenerative medicine to work on the use of scaffolds as an alternative to transplantation. (mdpi.com)
  • Among different types of scaffolds, polymeric hydrogel scaffolds have received considerable attention because of their biocompatibility and structural similarity to native tissues. (mdpi.com)
  • Pronounced mineralization was found throughout bone-induced ASC scaffolds, while control scaffolds (BJ foreskin fibroblasts) showed no mineral deposition (although they did demonstrate excellent cellularity). (vcu.edu)
  • 8 nm).Ppy NPs effectively augment the conductivity, surface roughness, andthickness of BC composites despite reducing scaffolds' transparency.BC-Ppy composites were flexible (up to 10 mM Ppy), maintained theirintricate 3D extracellular matrix-like mesh structure in all Ppy concentrationstested, and displayed electrical conductivities in the range of nativecardiac tissue. (ibecbarcelona.eu)
  • Our results highlight the remarkablepotential use of BC-Ppy scaffolds as a cardiac patch in tissue regenerativetherapies. (ibecbarcelona.eu)
  • The MEW scaffolds supported the development of a fibrocartilaginous tissue with compressive mechanical properties similar to that of native meniscus, while the anisotropic tensile properties of these constructs could be tuned by altering the fibre network aspect ratio. (regenhu.com)
  • This MEW framework was then used to generate scaffolds with spatially distinct fibre patterns, which in turn supported the development of heterogenous tissues consisting of isotropic and anisotropic collagen networks. (regenhu.com)
  • The architecture of MEW scaffolds can be tailored to not only modulate the directionality of the collagen fibres laid down by cells, but also to tune the anisotropic tensile mechanical properties of the resulting constructs, thereby enabling the engineering of biomimetic meniscal-like tissues. (regenhu.com)
  • Further, it regulates osteoblastic extracellular matrix such as osteopontin (OPN), osteocalcin (OCN), bone sialoprotein (BSP) in late differentiation. (frontiersin.org)
  • OB mediates bone formation through runt-related transcription factor 2(Runx2). (frontiersin.org)
  • osteoclasts are involved in the resorption of bone tissue. (wikipedia.org)
  • Other evidence supports that ferroptosis is participated osteoporotic bone remodeling, predominantly affecting the interaction between bone formation and bone resorption, explicitly bone resorption exceeded bone formation. (frontiersin.org)
  • The mutual restriction between bone formation and bone resorption is a critical factor to ensure bones healthy and integrity during the life cycle. (frontiersin.org)
  • The imbalance of bone formation and resorption is considered the main mechanism of osteoporosis. (frontiersin.org)
  • Bone resorption occurs mainly on the bone surface, by the osteoclasts (OC) on bone metabolism in continuous absorption. (frontiersin.org)
  • Aspirin (with antiestrogenic and vitamin E-like actions) is protective against bone resorption and hypercalcemia. (raypeat.com)
  • Although the effects of high glucose on the proliferation and differentiation of rat and mouse BM-MSCs have been previously reported, the effects of high glucose on biological properties of human MSCs derived from gestational tissues which, due to their ease of isolation by noninvasive procedure, are considered more suitable sources of MSCs for clinical applications have yet to be determined. (hindawi.com)
  • In addition to its classical role in the regulation of RBC proliferation, EPO has been shown to exert protective and regenerative capabilities in a variety of nonhematopoietic tissues [ 14 ]. (hindawi.com)
  • OB release bone matrix rich in collagen type I and participate in the hydroxyapatite crystal formation in collagen fiber deposition process, namely bone mineralization process, eventually forming new bone. (frontiersin.org)
  • Most processed food contains highly refined carbohydrates that alter insulin physiology and promote adipose tissue deposition [17,18] . (diabeets.com)
  • It really is proven that angiogenesis takes place before osteogenesis in the recovery of bone tissue defects. (researchassistantresume.com)
  • MSCs derived from bone marrow (BMMSCs) and the bone-specific, senescence-accelerated, osteoblastogenesis/osteogenesis-defective mice (the SAMP6 strain) were used as experimental models. (thno.org)
  • Moreover, Mitofilin is revealed to be indispensable for mitochondrial homeostasis and osteogenesis of BMMSCs, and that insufficiency of Mitofilin leads to BMMSC senescence and bone loss. (thno.org)
  • In this study, we report a novel population of SSCs with osteoblast-chondrocyte transitional (OCT) identities in the bone marrow endosteal space, which highly expresses Fgfr3 and contributes to both normal and aberrant osteogenesis. (nature.com)
  • Taken together, the results of our study indicate that exosomes isolated from M2 macrophages could facilitate osteogenesis and reduce adipogenesis through the miR-690/IRS-1/TAZ axis and might be a therapeutic tool for bone loss diseases. (researchpad.co)
  • Thus, regulating the balance between osteogenesis and adipogenesis may be a potential treatment strategy for bone loss diseases. (researchpad.co)
  • The low endogenous regenerative capacity of the heart,added tothe prevalence of cardiovascular diseases, triggered the advent ofcardiac tissue engineering in the last decades. (ibecbarcelona.eu)
  • Regenerative Medicine works as it takes a sample of your own blood, bone marrow, and other tissues, and then it goes through a process in which to take out a certain material known as Platelet-Rich Plasma. (benitonovas.com)
  • The buccal fatpad (BFP) is a specialized mass of adipose tissue that can be easily obtained via the oral cavity without injury to the external body surface.Another advantage of BFP over subcutaneous fat is that its size appears to be similar among different people, independent of body weight andfat distribution. (utwente.nl)
  • Adipocytes in the accumulated fat tissues, especially around waist area and visceral organs, release several cytokines which reduce the sensitivity of several cell types to insulin leading to insulin resistant and type 2 diabetes [ 4 , 5 ]. (hindawi.com)
  • The bone formation was markedly increased by the overexpression, compared to the control which partially dedifferentiated into adipocytes by 8 weeks after implantation. (jarde.jp)
  • Bone tissue is made up of different types of bone cells. (wikipedia.org)
  • Bone is not uniformly solid, but consists of a flexible matrix (about 30%) and bound minerals (about 70%) which are intricately woven and endlessly remodeled by a group of specialized bone cells. (wikipedia.org)
  • The columns are metabolically active, and as bone is reabsorbed and created the nature and location of the cells within the osteon will change. (wikipedia.org)
  • Cancellous bone is highly vascular and often contains red bone marrow where hematopoiesis, the production of blood cells, occurs. (wikipedia.org)
  • The number of cells per field, the AP activity, the collagen and mineralized matrix synthesis were higher in AT-MSC en differentiation, in relation to BM-MSC under the same conditions in all evaluated times. (scielo.br)
  • In the bone marrow, AAV9-NEM transduced Cd31, Cd34, and Cd90 expressing cells at a higher percentage than unmodified AAV9. (nature.com)
  • As demonstrated in previous studies many approaches have been applied to stimulate angiogenesis in the process of bone healing including the combination with endothelial cells the application of vascular growth factors vascular redesigning by microsurgery and gene transfection techniques [14-17]. (researchassistantresume.com)
  • However, it can be challenging to differentiate when they are connected with wounded tissue, opposed to when they instruct tissue-specific progenitor cells responsible for the redevelopment of damaged tissue. (techscience.com)
  • Bone marrow mononuclear cells have been isolated applying Ficoll solution inside two h just after bone marrow samples harvested and instantly subjected for that ex traction of total RNA. (micrornainhibitors.com)
  • Erythropoietin is a glycoprotein hormone that stimulates red blood cell (RBC) production in bone marrow via binding to the cell-surface receptor on hematopoietic progenitor cells, and it has been widely used for treating anemia [ 13 ]. (hindawi.com)
  • The term "transitional" emphasizes the unique feature of these cells that are particularly abundant in the young bone marrow. (nature.com)
  • Scaffold architecture was found to influence the spatial organization of the collagen network laid down by the jetted cells, with higher aspect ratios (1:4 and 1:16) supporting the formation of structurally anisotropic tissues. (regenhu.com)
  • Condition characterized by accumulation in body tissues of deposits of abnormal proteins (amyloids) produced by cells. (w8mdspa.com)
  • Recently, intercellular communication between bone cells and surrounding cells has been gradually recognized, and macrophages on the surface of bone have been proven to regulate bone metabolism. (researchpad.co)
  • Recently, our understanding of the bone system has moved beyond bone cells. (researchpad.co)
  • The crosstalk between bone cells and surrounding cells as well as the relationship between the bone and bone microenvironment has been gradually recognized and regarded as a relatively important factor in bone metabolism ( 9 ). (researchpad.co)
  • Predominantly, the 'energy expenditure hormone' leptin is made by adipose cells , and is thus labeled fat cell-specific . (cloudfront.net)
  • Multiple studies have made use of RGD hydrogel in different tissue and cell types. (thewellbio.com)
  • However, the effect of high glucose on adipogenic differentiation of human bone marrow and gestational tissue-derived MSCs is still poorly characterized. (hindawi.com)
  • The cortical bone gives bone its smooth, white, and solid appearance, and accounts for 80% of the total bone mass of an adult human skeleton. (wikipedia.org)
  • The human MSCs were shown to engraft to the rat joint tissues and were proliferative. (biomedcentral.com)
  • Human FOXP2 gene was only detected in the knee joint tissue, suggesting limited biodistribution locally to the joints. (biomedcentral.com)
  • However, they are easy to obtain from human adult tissues without ethical issues and play an essential role in tissue repair and organ homeostasis [ 1 , 2 ]. (biomedcentral.com)
  • Our lab's mission is to develop therapies for regenerating human tissues lost due to diseases or aging, and to build tissue engineered 3D models for understanding disease progression and informing drug discovery. (stanford.edu)
  • Photobiomodulation reduces abdominal adipose tissue inflammatory infiltrate of diet-induced obese and hyperglycemic mice. (google.com)
  • We demonstrated that AAV9 capsid modified with N -ethyl Maleimide (NEM) increased its tropism more towards murine bone marrow (osteoblast lineage ) while decreased transduction of liver tissue compared to the unmodified capsid. (nature.com)
  • Before and after compatibility, the content of ligustrazine was highest in brain tissue and lowest in liver tissue, while the Danshensu content was highest in kidney tissue and lowest in brain tissue, indicating that ligustrazine could penetrate the blood-brain barrier more easily than Danshensu, and the main sites of accumulation were different. (alljournal.net.cn)
  • Osteoclast, derived from macrophage-mononuclear lineage, is a special myeloid cell. (frontiersin.org)
  • Many studies related to MSCs therapeutic potential in which MSCs derived extracellular vesicles accomplished a vital role. (techscience.com)
  • A recent study supports the pivotal role of trophoblast exosomes in that extracellular vesicles (EVs) derived from TSCs promote fertility by regulating endometrial cell receptivity [ 17 ]. (biomedcentral.com)
  • A bone is a rigid organ that constitutes part of the skeleton in most vertebrate animals. (wikipedia.org)
  • Cortical bone is covered by a periosteum on its outer surface, and an endosteum on its inner surface. (wikipedia.org)
  • A fibrillar collagen found widely distributed as a minor component in tissues that contain COLLAGEN TYPE I and COLLAGEN TYPE III. (lookformedical.com)
  • The amount of circulating leptin correlates with the amount of energy reserves, mainly triglycerides stored in adipose tissue. (cloudfront.net)
  • The primary function of the hormone leptin is the regulation of adipose tissue mass through central hypothalamus mediated effects on hunger , food energy use, physical exercise and energy balance . (cloudfront.net)
  • Among them, bone morphogenic proteins (BMPs) are thought to be the most potent osteoinductive factors and play a key role in the process of bone formation during DO. (hindawi.com)
  • The matrix is hardened by the binding of inorganic mineral salt, calcium phosphate, in a chemical arrangement known as bone mineral, a form of calcium apatite. (wikipedia.org)
  • Prolonged excitation and stress contribute to tissue inflammation and fibrosis. (raypeat.com)
  • Bone matrix is 90 to 95% composed of elastic collagen fibers, also known as ossein, and the remainder is ground substance. (wikipedia.org)
  • These form a complex network structure and precisely regulate bone formation ( 6 ). (frontiersin.org)
  • It remains a great challenge for orthopedic surgeons to achieve osseous reconstruction for nonunion and bone defects. (hindawi.com)
  • but the overall therapeutic process lasts for a relatively long period, and a variety of complications may arise, such as pin loss, infection around the transmucosal pin, bone fracture, and restriction in joint motion [ 8 ]. (hindawi.com)
  • Recently, M2 macrophages have been gradually recognized as a positive regulator of bone formation during fracture healing ( 13 ). (researchpad.co)
  • Bone is an active metabolism tissue, which constantly undergoes bone remodeling. (frontiersin.org)
  • Prof. Elisabeth Engel got her PhD in 2003 in bone metabolism diseases in medical school. (ibecbarcelona.eu)
  • Once the balance of bone metabolism is disrupted, a variety of bone disorders will develop. (researchpad.co)
  • The engineering of structurally organized meniscal grafts that mimic the anisotropy of the native tissue remains a significant challenge. (regenhu.com)
  • Such bioprinted tissues could potentially form the basis of new treatment options for damaged and diseased meniscal tissue. (regenhu.com)
  • Our approach could provide a promising platform for expanding clinical AAV development to treat bone pathologies such as cancer and osteoporosis. (nature.com)