• An aspirate needle is inserted through the skin using manual pressure and force until it abuts the bone. (wikipedia.org)
  • Then, with a twisting motion of clinician's hand and wrist, the needle is advanced through the bony cortex (the hard outer layer of the bone) and into the marrow cavity. (wikipedia.org)
  • Once the needle is in the marrow cavity, a syringe is attached and used to aspirate ("suck out") liquid bone marrow. (wikipedia.org)
  • The needle is then advanced with a twisting motion and rotated to obtain a solid piece of bone marrow. (wikipedia.org)
  • The bone marrow produces the cellular elements of the blood, including platelets, red blood cells and white blood cells. (wikipedia.org)
  • INNSBRUCK, Austria, Aug. 25-The presence of bone marrow micrometastases in women newly diagnosed with breast cancer is a highly significant predictor of poor outcome, according to a pooled analysis of data from nine breast cancer studies. (medpagetoday.com)
  • There are few contraindications to bone marrow examination. (wikipedia.org)
  • The aspirate yields semi-liquid bone marrow, which can be examined by a pathologist under a light microscope and analyzed by flow cytometry, chromosome analysis, or polymerase chain reaction (PCR). (wikipedia.org)
  • Bone marrow failure syndromes are relatively rare and universally complex disorders. (childrens.com)
  • We rely on a comprehensive panel of subspecialists with an express interest in bone marrow failure syndromes. (childrens.com)
  • We counsel families on the underlying genetic causes of bone marrow failure syndromes, and offer them carrier testing when appropriate. (childrens.com)
  • Given the increased risk of future cancers that occur in many bone marrow failure syndromes post-transplant, our team provides disease-specific recommendations for screening of at-risk patients and offers ongoing follow-up throughout childhood and adolescence. (childrens.com)
  • The chapter examines pathologic findings seen in the human bone marrow. (springer.com)
  • Adipocytes were identified in human bone marrow more than a century ago, yet until recently little has been known about their origin, development, function or interactions with other cells in the bone marrow. (nih.gov)
  • MDS syndromes are classified by how the cells in the bone marrow and blood smear look under the microscope. (news-medical.net)
  • Dunphy CH, O'Malley DP, Perkins SL, Chang CC. Analysis of immunohistochemical markers in bone marrow sections to evaluate for myelodysplastic syndromes and acute myeloid leukemias. (springer.com)
  • Replace the bone marrow and restore its normal function after high doses of chemotherapy or radiation are given to treat cancer. (childrensnational.org)
  • It starts in the bone marrow and spreads to the blood and other body tissues. (medicalnewstoday.com)
  • Yellow bone marrow serves primarily as a storehouse for fats but may be converted to red marrow under certain conditions, such as severe blood loss or fever. (britannica.com)
  • Bone marrow has a honeycomb or sponge-like structure, consisting of a fibrous network that is filled with liquid. (labtestsonline.org)
  • Donors who are not related to you, yet still match, may be found through national bone marrow registries. (medlineplus.gov)
  • In 1956 American physician E. Donnall Thomas performed the first successful syngeneic (genetically identical) bone marrow transplant between two humans. (britannica.com)
  • The researchers found that if they genetically engineered mice to be missing the Hoxb8 gene in their bone marrow only, they developed the excessive grooming behaviour but not the noxious chemical and temperature-sensing abnormalities. (www.nhs.uk)
  • In some restaurants, cooked pig tibia would be served with a drinking straw specifically for sucking out the semi-liquified marrow. (wikipedia.org)
  • There are a number of blood vessels and capillaries traversing through the marrow making it a very vascular organ. (news-medical.net)
  • Diagnosis of lymphoid disorders that involve the marrow are discussed. (springer.com)
  • The Bone Marrow Failure Program at the Gill Center has the breadth and depth of expertise needed to provide complete care to children and their families affected by these hematologic disorders. (childrens.com)
  • The sensitivity of marrow to damage by radiation therapy and some anticancer drugs accounts for the tendency of these treatments to impair immunity and blood production. (britannica.com)
  • Not only does it wipe out your bone marrow, but chemo and radiation also can be tough on your body. (webmd.com)
  • A fatigue fracture is caused by the prolonged cyclical application of abnormal mechanical stresses to a bone that has normal elastic resistance. (amazonaws.com)
  • These types of cancers can occur in many places in the body, including in the bone marrow. (medicalnewstoday.com)
  • Bone marrow involvement by marginal zone B-cell lymphomas of different types. (springer.com)