• Critical assessment of rhBMP-2 mediated bone induction: an in vitro and in vivo evaluation. (scilifelab.se)
  • Genetic toxicology studies were conducted in vitro in Salmonella typhimurium and cultured Chinese hamster ovary cells and in vivo in rat and mouse bone marrow and mouse peripheral blood cells. (nih.gov)
  • In vivo X-ray fluorescence of lead in bone: review and current issues. (nih.gov)
  • Fluorescence microscopy and confocal scanning laser microscopy were utilized with BioQuant image analysis to determine the bone mineral apposition rates and gross morphology. (boneandjoint.org.uk)
  • An X-ray fluorescence (XRF) technique for monitoring cumulative lead (7439921) exposure in-vivo was described. (cdc.gov)
  • Inhibition of rat vascular smooth muscle proliferation in vitro and in vivo by bone morphogenetic protein-2. (jci.org)
  • We found that bone morphogenetic protein-2 (BMP-2) inhibited serum-stimulated increases in DNA synthesis and cell number of cultured rat arterial SMCs in a fashion quite different from that in the case of transforming growth factor-beta1 (TGF-beta1). (jci.org)
  • Furthermore, osteoblastic differentiation induced by bone morphogenetic protein 2 (BMP2), as shown by ALP activity, mRNA expression of osteocalcin, Id1, Osterix and Runx2, and Sma- and Mad-related protein (Smad)1/5/8 phosphorylation, was also enhanced in POB from alylaly mice. (elsevierpure.com)
  • His group also studied the incorporation of drugs and growth factors such as Bone Morphogenetic Proteins (BMP) into such ceramics and coatings, as well as the use of calciumphosphate particles for plastic surgery, i.e. filling and augmenting soft and hard tissues for cosmetic reasons). (wikipedia.org)
  • Cytokine combinations were tested for their ability to expand murine bone marrow (BM) progenitors in short-term suspension cultures (delta-cultures) with the aim of providing an enriched source of progenitors for BM transplantation (BMT). (eurekamag.com)
  • Simvastatin significantly inhibits tumor growth and bone metastasis in lung cancer xenograft mouse model, simvastatin can inhibit the kinase phosphorylation inMAPK/ERK signaling parthway. (nih.gov)
  • Our research offers real hope in the future for patients with complex bone trauma or large defects following removal of a tumor. (3dprint.com)
  • This aggregation behavior was unequivocally ascertained by performing light scattering studies of the two BMPs, which revealed linear aggregation with time for BMP-R unlike BMP-P. The in vitro results were also reflected in the in vivo experiments, in a rat ectopic model with injectable hyaluronic acid (HA) hydrogel as BMP carrier. (scilifelab.se)
  • The ectopic bone formation in vivo that was induced by BMP2 was enhanced in alylaly mice compared with controls. (elsevierpure.com)
  • A CT-scan study by Takahashi et al found that different regions of the temporal bone mature at different ages, determining that the otic capsule demonstrates mature bone at birth, while the ages of maturation for the lateral surface of the mastoid cavity, the posterior cranial fossa, and the middle cranial fossa are 1.7, 3.9, and 10.8 years, respectively. (medscape.com)
  • The authors suggested that these differences in the timing of bone maturation may contribute to the fact that acute mastoiditis spreads laterally in infants and medially in older children. (medscape.com)
  • The hypothesis is that the VEP model can provide additional details over bone maturation process not directly accessible through the common OP analysis. (hindawi.com)
  • Moreover, 18 F-fluoride signaling at different stages of G6PI-induced arthritis was significantly correlated with the degree of bone destruction. (biomedcentral.com)
  • Proposed projects should focus on improving the resolution of current imaging techniques or developing new imaging techniques that can visualize inner ear structures in vivo with significantly greater detail and accuracy than currently possible. (nih.gov)
  • Our study demonstrated that administration of bone mesenchymal stem cell-derived extracellular vesicles (BMSC-EV) reduced brain cell death, enhanced neuronal survival and regeneration, and improved motor function compared with the administration of BMSC-EV free culture media (EV-free CM). Besides, the BSCB was attenuated and pericyte coverage was significantly decreased in vivo . (frontiersin.org)
  • In a comparative in vivo study, creos xenoprotect demonstrated significantly higher new bone formation in the central portion of the defect. (nobelbiocare.com)
  • This increase in bone formation was associated with significantly increased expression of the growth factor Bmp2, which has a strong role in osteogenesis. (nobelbiocare.com)
  • This type of customized, patient-specific care in repairing bone would also eliminate the need for donors as cartilage templates are made in the customized shape of the patient's bone and then used in place of what typically would have been a bone graft. (3dprint.com)
  • Here, regeneration is of course the key as in with a traditional bone graft-and this is exactly what makes repairing bones so possible. (3dprint.com)
  • Development of nano-hydroxyapatite graft with silk fibroin scaffold as a new bone substitute. (thejcdp.com)
  • Molecular basis for action of bioactive glasses as bone graft substitute. (thejcdp.com)
  • A clinical comparison of nano-crystalline hydroxyapatite (Ostim) and autogenous bone graft in the treatment of periodontal intrabony defects. (thejcdp.com)
  • The recent article by van Koppen and colleagues [ 1 ] in Stem Cell Research & Therapy reports an interesting ex vivo approach aimed at overcoming the regenerative impairment of bone marrow stem cells (BMCs) isolated from CKD rats (CKD BMCs). (biomedcentral.com)
  • The authors provide evidence that an ex vivo short-term pre-treatment (2 hours) with the cholesterol-lowering drug pravastatin is able to revert the loss of regenerative properties of CKD BMCs [ 1 ]. (biomedcentral.com)
  • Therefore, here we compared the ability of OP and VEP models to catch the evolution of mechanical properties of bone tissue during the regenerative process, by analyzing the mechanical characteristics of preexistent and newly formed bone tissue regenerated at 4 and 12 weeks from the implantation of a macroporous hydroxyapatite (HA) scaffold in a preclinical model of critical-size defect. (hindawi.com)
  • The researchers hope to develop the tissue regenerative procedure for human application so that craniofacial injuries could be treated with bony tissue grown alongside natural bone rather than removing bone from elsewhere in the body for grafting and implantation. (nih.gov)
  • In this study, we characterize the alterations in bone marrow (BM) lymphocytes after influenza virus infection in mice. (nih.gov)
  • Therefore, we systematically examined the use of 18 F-NaF positron emission tomography/computed tomography (PET/CT) in mice with glucose-6-phosphate isomerase (G6PI)-induced arthritis for quantification of pathological bone metabolism. (biomedcentral.com)
  • Although several studies have suggested that the Keap1-Nrf2 system contributes to bone formation besides the maintenance of redox homeostasis, how Nrf2 hyperactivation by Keap1 deficiency affects the bone formation remains to be explored, as the Keap1-null mice are juvenile lethal. (elsevierpure.com)
  • We found that the NEKO mice exhibit small body size and low bone density. (elsevierpure.com)
  • Experiments with primary culture cells derived from Keap1-null mice showed that differentiation of both osteoclasts and osteoblasts was attenuated, showing that impaired differentiation of osteoblasts rather than osteoclasts is responsible for bone hypoplasia caused by Nrf2 hyperactivation. (elsevierpure.com)
  • Mechanical loading of tibial bone increased cortical bone mass and mechanical properties in wild-type and gap junction-impaired R76W mice through increased PGE 2 , endosteal osteoblast activity, and decreased sclerostin. (elifesciences.org)
  • We previously reported that alymphoplasia (alylaly) mice, which have a natural loss-of-function mutation in the Nik gene, which encodes a kinase essential for the processing of p100 to p52 in the alternative nuclear factor-κB (NF-κB) pathway, show mild osteopetrosis with an increase in several parameters of bone formation: bone formation rate, mineral apposition rate, and osteoblast number. (elsevierpure.com)
  • Three weeks later, the mice with therapeutic bandages had greater healing than those without, showing better bone formation, higher bone volume, and better vascularization. (medgadget.com)
  • They were divided into two groups defined by the femur bone defect size: (i) 1 mm resulting in normal healing (NH), and (ii) a large sized 5 mm defect resulting in critical healing (CH). Callus formation, patterning, and mineralisation kinetics in both groups were examined in the periosteal and osteotomy gap regions using a novel longitudinal study setup. (nih.gov)
  • To investigate the influence of PT on growing bone, we exposed an organotypic rat ex vivo femur culture model to PT. (mdpi.com)
  • Human dental pulp stem cells (hDPSCs) are mesenchymal stem cells that have been successfully used in human bone tissue engineering. (portlandpress.com)
  • Restoring bone structure lost to injury or disease is an important target for tissue engineering research," said Šeila Selimović, director of the NIBIB program in Technologies for Tissue Chips, Engineered Tissues, and Biosensors and Physiological Detectors. (nih.gov)
  • Nosouhian S, Davoudi A, Rismanchian M, Razavi SM, Sadeghiyan H. Comparing Three Different Three-dimensional Scaffolds for Bone Tissue Engineering: An in vivo Study. (thejcdp.com)
  • This review provides theoretical references and evidences for further exploration of exosomes as noncoding RNA carriers to regulate bone tissue recovery through the following aspects: (1) basic characteristics of exosomes, (2) research progress of exosomal noncoding RNA in bone tissue engineering, (3) current status and advantages of engineering exosomes as nanocarriers for noncoding RNA delivery, and (4) problems and application prospects of exosome therapy in the field of orthopedics. (hindawi.com)
  • Sensitivity was defined using HR-pQCT images from women with fracture versus non-fracture, and low versus high bone volume fraction, expecting similar and different loading histories, respectively. (tue.nl)
  • Subjects with different bone volume fraction were clearly distinguished but not subjects with and without fracture. (tue.nl)
  • Injuries to the growth plate happen when a break or fracture develops near or at the end of a long bone. (nih.gov)
  • Image: Healing progress of a fracture in a mouse treated with a new type of bone bandage that traps native adenosine (top), is preloaded with external adenosine (middle), and has no adenosine at all. (medgadget.com)
  • As a proof-of-principal, multiple-tool biofabrication is used to engineer a mechanically reinforced cartilaginous template mimicking the geometry of a vertebral body, which in vivo supported the development of a vascularized bone organ containing trabecular-like endochondral bone with a supporting marrow structure," state the researchers in their paper. (3dprint.com)
  • Reproducibility was calculated with repeated in vitro as well as in vivo HR-pQCT measurements at 82 mm. (tue.nl)
  • This allows it to form a permanent bond to the bone and take measurements over long periods of time. (311institute.com)
  • For validation of bone metabolism quantified by 18 F-fluoride PET, bone surface parameters of high-resolution μCT measurements were used. (biomedcentral.com)
  • Furthermore, the possibility to perform repeated noninvasive measurements in vivo allows longitudinal study of therapeutical intervention monitoring. (biomedcentral.com)
  • In vivo bone lead measurements: a rapid monitoring method for cumulative lead exposure. (cdc.gov)
  • The authors suggest that in- vivo XRF measurements of tibial lead content may serve as an acceptable indicator of lead body burden, and may be useful for lead screening purposes. (cdc.gov)
  • Thus, we propose that the appropriate control of Nrf2 activity by Keap1 is essential for maintaining bone homeostasis. (elsevierpure.com)
  • The researchers implanted four bioreactors in each sheep, next to rib bones with exposed periosteum, a layer of vascularized connective tissue that surrounds bones. (nih.gov)
  • The dogs were sacrificed in 4 time intervals (15, 30, 45 and 60 days after) and the percentage of different types of regenerated bones (lamellar and woven) and connective tissue were recorded in histological process. (thejcdp.com)
  • This study demonstrates a bone reconstruction approach that works in large animals with materials known to be safe. (nih.gov)
  • Osteogenic scaffolds for bone reconstruction. (thejcdp.com)
  • Recent studies reported that the key factor for bone reconstruction was exosome [ 13 ]. (hindawi.com)
  • In addition, we focused on elaborating the feasible clinical application of bone exosomes and the characteristics of exosomal noncoding RNAs in the regulation of bone reconstruction. (hindawi.com)
  • Knowing how quickly and how well the bone is healing could also inform clinical treatment decisions, such as when to remove temporary hardware like plates, rods, or screws. (311institute.com)
  • This is facilitated by the distribution and use of three-dimensional PET scanners with high spatial resolution in clinical medicine and advantages over 99m Tc-labeled bone agents used for skeletal scintigraphy, such as higher diagnostic accuracy and reduced scanning time. (biomedcentral.com)
  • This notice of funding opportunity announcement (NOFO) also supports investigator initiated low-risk clinical trials addressing the development or improvement of human in vivo structural and functional imaging technologies. (nih.gov)
  • High-risk clinical trials not meeting all the criteria above are referred to the companion U01 Cooperative Agreement for In Vivo High-Resolution Imaging for Inner Ear Visualization (Clinical Trial required) NOFO RFA-DC-24-005 . (nih.gov)
  • Through this combined translational and clinical strategy, Dr. Barrett's group is working toward optimizing the tremendous potential that stem cell transplantation holds in curing leukemia and other serious blood and bone marrow disorders. (nih.gov)
  • Clinical situations that require techniques to fill defects of bone are common in the surgical care of Orthopaedic patients. (elsevierpure.com)
  • The results demonstrated that viable bone tissue that could substitute for grafts taken from one's leg, the current clinical procedure, could be made from bony materials grown with 3D printed bioreactors. (nih.gov)
  • Tissue engineers have been developing ways to replace bone using tissue grown in devices called bioreactors. (nih.gov)
  • A team of researchers led by Dr. Antonios G. Mikos of Rice University set out to use 3D printing to create bioreactors that could form bone tissue into precise shapes to heal jaw defects. (nih.gov)
  • They filled 15 bioreactors with crushed rib bone and nine with a synthetic bone matrix. (nih.gov)
  • They used a spacer, which temporarily preserved the shape of the jaw at the defect site, and produced 3D printed molds, called bioreactors, used to grow replacement bone tissue. (nih.gov)
  • They filled the bioreactors with either a biocompatible ceramic or with crushed bone, anticipating that each material would be a good medium for growth of replacement tissue. (nih.gov)
  • Researchers found that the two materials grown in the bioreactors that were initially filled with either the ceramic or crushed bone were sufficient for implantation, however, the tissue grown from crushed bone had mechanical properties more similar to natural bone so they used these in the ultimate implantation procedure. (nih.gov)
  • Additional knowledge on the therapeutic mechanisms of BMCs and on the molecular alterations induced by uremic toxins is of interest, as it could provide clinically relevant information to assess stem cell potency before injection and to identify strategies to manipulate stem cells ex vivo . (biomedcentral.com)
  • A noninvasive imaging technology allowing objective quantification of pathophysiological alterations of bone structure in rodents could substantially extend the methods used to date in preclinical arthritis research for staging of autoimmune disease severity or efficacy of therapeutical intervention. (biomedcentral.com)
  • Specific inhibition of Cx43 hemichannels by Cx43(M1) antibody suppressed PGE 2 secretion and impeded loading-induced endosteal osteoblast activity, bone formation and anabolic gene expression. (elifesciences.org)
  • Destructive osteopathy is mainly due to the failure of the bone remodeling process, including enhanced osteoclast activity or reduced osteoblast generation [ 1 , 2 ]. (hindawi.com)
  • However, the viscoelastoplastic (VEP) model may be preferred being envisaged to provide additional insights into the regeneration process, as it allows evaluating also the viscous content of bone tissue. (hindawi.com)
  • The reported results confirmed the higher ability of VEP model compared to the more diffused OP model to provide important insights into bone mechanical properties, also during the bone regeneration process. (hindawi.com)
  • However, to date, the application of the VEP model has been almost exclusively limited to the analysis of native (i.e., not engineered) bone tissue, whereas reports of VEP analysis of bone mechanical properties during tissue regeneration are lacking. (hindawi.com)
  • A resorbable collagen membrane for guided bone regeneration and guided tissue regeneration procedures. (nobelbiocare.com)
  • I use the creos xenoprotect membrane combined with creos xenogain particularly in cases of guided bone regeneration. (nobelbiocare.com)
  • Three-dimensional Scaffold structure of synthetic biomaterials with their interconnected spaces seem to be a safe and effective option in supporting bone regeneration. (thejcdp.com)
  • Sponges stimulate alveolar bone, cementum and periodontal ligament regeneration in a canine class II furcation defect model. (thejcdp.com)
  • Bioactive glass scaffolds for bone regeneration and their hierarchical characterisation. (thejcdp.com)
  • 18 F-fluoride not only can be used to label glucose and other molecules of physiologic relevance but also has favorable properties in the form of sodium 18 F-fluoride ( 18 F-NaF) as a radiotracer per se in noninvasive in vivo imaging to investigate musculoskeletal diseases[ 4 ]. (biomedcentral.com)
  • Sodium 18 F-fluoride ( 18 F-NaF) is a bone-seeking tracer well-suited for molecular imaging. (biomedcentral.com)
  • The use of 18 F-NaF as a bone imaging probe was established by Blau et al . (biomedcentral.com)
  • This funding opportunity aims to support the development of in vivo high-resolution structural and functional imaging technologies for the living human inner ear. (nih.gov)
  • The advent of high-resolution computed tomography (CT) scanning in the 1980s revolutionized diagnostic imaging of the temporal bone. (medscape.com)
  • The article reviews the anatomy of the middle ear space and surrounding bone and presents radiographic imaging in both axial and coronal views, with labeled salient features and relevant text. (medscape.com)
  • A team led by Rice University bioengineers with support from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) used bone engineered in a shape defined by a 3D-printed mold and grown alongside the ribs of sheep to successfully replace a portion of the animals' jaw bones. (nih.gov)
  • In bone engineering context, it is still common practice to utilize the well-known Oliver and Pharr (OP) model [ 8 ] to analyze indentation data in terms of elastic/plastic contribution, which however overlooks the viscous behavior of bone tissue [ 9 ]. (hindawi.com)
  • In the course of experimental autoimmune disease, 18 F-fluoride bone uptake was increased at sites of enhanced bone metabolism caused by pathophysiological processes of autoimmune disease. (biomedcentral.com)
  • The results of this study suggest that small-animal PET/CT using 18 F-fluoride as a tracer is a feasible method for quantitative assessment of pathophysiological bone metabolism in experimental arthritis. (biomedcentral.com)
  • Bone growth and metabolism are mainly regulated by a series of intracellular molecules and extracellular stimuli. (hindawi.com)
  • The recent article by van Koppen and colleagues in Stem Cell Research & Therapy provides evidence that an ex vivo short-term pre-treatment with statins reverts the dysfunction of bone marrow stem cells isolated from rats with renal impairment. (biomedcentral.com)
  • Moreover, the ex vivo manipulation of stem cells with statins followed an easily applicable procedure. (biomedcentral.com)
  • In vivo generation of bone marrow from embryonic stem cells in interspecies chimeras. (bvsalud.org)
  • Generation of bone marrow (BM) from embryonic stem cells (ESCs) promises to accelerate the development of future cell therapies for life -threatening disorders. (bvsalud.org)
  • Stem cell transplants are used to put blood stem cells back into the body after the bone marrow has been destroyed by disease, chemotherapy (chemo), or radiation. (cancer.org)
  • This treatment also kills the stem cells in the bone marrow. (cancer.org)
  • Your stem cells are removed from either your bone marrow or your blood, and then frozen. (cancer.org)
  • In their research paper, the scientists point out that while the bioprinting of human organs is not yet possible with the technology at hand, they have come up with a 'precursor' that allows for a more immediate way to create biomaterials to repair bone, using cartilage templates to be 'engineered' in the lab with stem cells. (3dprint.com)
  • It is common practice to implement the elastoplastic Oliver and Pharr (OP) model to investigate the spatial and temporal variations of mechanical properties of engineered bone. (hindawi.com)
  • On the other hand, instrumented indentation (or "nanoindentation") is a widely accepted method to investigate the mechanical properties of bone tissue at the micro- and nanoscale [ 5 - 7 ]. (hindawi.com)
  • The objective of this in vivo study was to investigate the early stability and subsequent bone response adjacent to an all polymer TDR implant over a period of six months in an animal model. (boneandjoint.org.uk)
  • Flourochrome markers (which contain molecules that bind to mineralization fronts) were injected at specified intervals in order to investigate bone remodeling with time. (boneandjoint.org.uk)
  • The bony framework of the temporal bone contains multiple air spaces. (medscape.com)
  • There were no significant differences between the materials in bone density, bone height, bony surface area, or mineralized surface area. (nih.gov)
  • An axial view through the superior portion of the temporal bone, which demonstrates the anterior (a) and posterior (b) crura of the superior semicircular canal. (medscape.com)
  • The formation of degradation products (Fe-oxides and Fe-phosphate) on the implant surface, as well as a 30 40% loss of compressive strength after 3 months implantation indicated the degradation of β-TCP-30 (FeMg) in vivo. (abiodem.com)
  • Scanning electron microscopic (SEM) observation and energy-dispersive X-ray (EDX) microanalysis showed that the bone comes very close to the surface of the treated titanium. (elsevierpure.com)
  • The surrounding otic capsule is observed as dense white bone. (medscape.com)
  • It is a rare disorder that causes bones to grow abnormally and become too dense. (nih.gov)
  • He has developed two types of bioceramic, namely bulk ceramics (dense, porous, large and small) for mechanically unloaded bone fillers, and coatings for improving the bone bonding of strong, but less biocompatible, metallic orthopedic and dental implants. (wikipedia.org)
  • In order to better understand the mechanism of exosomes as noncoding RNA vectors regulating bone remodeling, we reviewed the newest findings on the feature and role of exosomes in bone formation. (hindawi.com)
  • Studies revealed that exosomes are also secreted from bone-related cells (osteoclasts, osteoclast precursors, osteoblasts, and MSCs) [ 31 - 33 ]. (hindawi.com)
  • 21.21 ± 0.96) were near to each, the FR Scaffold provided the highest amount of lamellar (29.71 ± 7.94) and woven bone (18.28 ± 2.35). (thejcdp.com)
  • Test and control specimens were retrieved, fixed and subjected to histological processing to assess the bone-implant-bone interface. (boneandjoint.org.uk)
  • Macroscopical, histological, and morphometric studies of porous bone-replacement materials in minipigs 8 months after implantation. (thejcdp.com)
  • Some patients are prescribed drugs designed to speed up bone healing or improve bone density, but these prescriptions can have side effects. (311institute.com)
  • The sequestered adenosine clearly helps the breaks heal faster to the naked eye up to 14 days, with cross sections of the bones showing more density and vascularization after 21 days. (medgadget.com)
  • A study by Shamshad et al using high-resolution CT scanning found pneumatization of the temporal bone to be more prevalent around the temporal mandibular joint (TMJ). (medscape.com)
  • Together, osteocytic Cx43 hemichannels could be a potential new therapeutic target for treating bone loss and osteoporosis. (elifesciences.org)
  • Learn more about what you can do to help keep your bones strong and healthy, what the risk factors are for osteoporosis, and how to live well if you have osteoporosis. (nih.gov)
  • Suppression of bone marrow myeloid and erythroid progenitor cells occurs after infection with a variety of different viruses. (nih.gov)
  • The ex vivo expansion of BM in IL-1 + KL-stimulated delta-cultures also greatly reduced the number of transplanted cells needed to provide radioprotection. (eurekamag.com)
  • In fact, pre-treated cells administered in a single dose to rats with an established CKD showed a therapeutic efficacy in vivo that was similar to that of BMCs isolated from healthy rats. (biomedcentral.com)
  • To address this challenge, co-author John Szivek, a professor of orthopedic surgery and biomedical engineering and BIO5 Institute member, developed an adhesive that contains calcium particles with an atomic structure similar to bone cells, which is used as to secure osseosurface electronics to the bone. (311institute.com)
  • The osteocytes embedded in the bone mineral matrix comprise over 90-95% of all bone cells and are thought to be a major mechanoreceptor in the adult skeleton ( Bonewald, 2011 ). (elifesciences.org)
  • The goal is that over time, the transplanted cells will settle in the bone marrow, where they will begin to grow and make healthy new blood cells. (cancer.org)
  • In vivo bone formation from human embryonic stem cell-derived osteogenic cells in poly(d,l-lactic-co-glycolic acid)/hydroxyapatite composite scaffolds. (musc.edu)
  • To form healthy bone tissue, a matrix, illustrated here, must provide support for cells to weave through. (nih.gov)
  • The team packed them to test both natural or synthetic materials as the matrix for cells to grow into precise 3D shapes of bone tissue. (nih.gov)
  • Ribs have a sleeve around them that's enriched with the cells and growth factors needed to generate bone. (nih.gov)
  • Osteogenic differentiation of human dental pulp stromal cells on 45S5 bioglass(R) based scaffolds in vitro and in vivo. (thejcdp.com)
  • One way of approaching new treatments for bone fractures involves delivering new bone cells, which can promote healing. (medgadget.com)
  • Funded by the Science Foundation Ireland at the AMBER Materials Science Centre , which is hosted at Trinity College Dublin , this work, amidst many other amazing projects they are working on, is meant to end the need in the future for bone grafts whether through autografting (moving the patient's own bone material) or allografting (transplanting bone from a donor). (3dprint.com)
  • Because the natural and synthetic materials formed similar bone tissue, future studies may use synthetic material as a source of bone matrix to avoid the need to harvest the patient's own bone. (nih.gov)
  • Researchers developed a technique to grow custom-fit bone implants to repair jawbone injuries from a patient's own rib. (nih.gov)
  • CT enabled identification of exact localization of 18 F-fluoride signaling in bone and soft tissue. (biomedcentral.com)
  • Twelve weeks after implantation of the bioreactor-grown tissues in the jaw, the researchers observed that the new bone knitted to the natural bone and that soft tissue grew to cover the wound site. (nih.gov)
  • 40 to 70% porous β-tricalcium phosphate (β-TCP) based bone scaffolds reinforced by FeMg metallic phase were produced by mixing precompacted nanocomposite granules (β-TCP with 30 vol % FeMg) of different size with salt particles followed by high pressure consolidation at room temperature and porogen dissolution. (abiodem.com)
  • Scaffolds with 50% porosity exhibited the best combination of compressive strength (8.5 10.5 MPa) and permeability (~3.5x10 10 m 2 ) falling within the range of trabecular bone. (abiodem.com)
  • The aim of this animal study was to compare the effectiveness of three different biocompatible scaffolds: bioglass (BG), demineralized bone matrix (DBM) and forstrite (FR). (thejcdp.com)
  • Also, FR Scaffold showed significant difference with BG (p = 0.026) and DBM Scaffolds (p = 0.032) in regenerated lamellar bone. (thejcdp.com)
  • With millions of people each year in need of bone grafts due to cancerous tumors, complex fractures, and even head traumas or dental issues after tooth loss or extenuating issues, obviously a less painful, more successful, and affordable method in replacing complex bone defects would be welcomed by both patients and medical professionals. (3dprint.com)
  • A bioactive 'self-fitting' shape memory polymer scaffold with potential to treat craniomaxillo facial bone defects. (thejcdp.com)
  • To explore the mechanism about how HMG-CoA reductase (HMGR) inhibitor inhibit proliferation and bone metastases of lung adenocarcinoma in vitro and in vivo. (nih.gov)
  • Evaluation of disease severity in experimental models of rheumatoid arthritis is inevitably associated with assessment of structural bone damage. (biomedcentral.com)
  • and able to maintain a specified minimum mechanical strength during degradation and bone growth. (elsevierpure.com)
  • Mechanical stimulation, such as physical exercise, is essential for bone formation and health. (elifesciences.org)
  • Here, we demonstrate the critical role of osteocytic Cx43 hemichannels in anabolic function of bone in response to mechanical loading. (elifesciences.org)
  • This study documents a key role for osteocyte-derived Cx43 hemichannels in the anabolic response of bone to mechanical stimulation, using transgenic mouse models and a Cx43 (M1) antibody. (elifesciences.org)
  • The studies shed new light on the molecular mechanisms that transduce mechanical loading into new bone formation, and identify Cx43 as an actionable target. (elifesciences.org)
  • Bone as a mechanosensitive tissue is adaptive to mechanical stimuli, which are essential for bone homeostasis, formation, and remodeling ( Bonewald, 2011 ). (elifesciences.org)
  • The mechanical stability is very high and when it is rehydrated it adapts very well to the underlying bone. (nobelbiocare.com)
  • This is the prerequisite for maintaining mass and mechanical strength of bone [ 8 ]. (hindawi.com)
  • 76-100% indicating relationship between DBM and newly formed bone. (medscape.com)
  • abstract = "A bone loading estimation algorithm was previously developed that provides in vivo loading conditions required for in vivo bone remodelling simulations. (tue.nl)
  • Protocols to generate and isolate mouse myogenic progenitors both in vitro and in vivo. (nih.gov)
  • This study addresses the hypothesis that callus formation, patterning, and mineralisation are impaired during the early phase of critical sized bone defect healing, and may relate to inter-fragmentary tissue strains within the bone defect area. (nih.gov)
  • Thus, the alternative the NF-κB pathway via the processing of p52 from p100 negatively regulates osteoblastic differentiation and bone formation by modifying BMP activity. (elsevierpure.com)
  • Apatite formation on implants is important in achieving a direct bonding to bone tissue. (elsevierpure.com)