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  • osteoblasts
  • Conditional disruption of calcineurin B1 in osteoblasts increases bone formation and reduces bone resorption," Journal of Biological Chemistry , vol. 282, no. 48, pp. 35318-35327, 2007. (hindawi.com)
  • The authors used oc/oc mice, which a loss of osteoclast (OCL) activity, to investigate the role of osteoblasts (OBLs) and OCLs in the development of the hematopoietic stem cell (HSC) niche. (asbmr.org)
  • resorption
  • Cytokine levels will increase rapidly in the first 3 weeks after HCT, preceding an increase in markers of bone resorption. (aamds.org)
  • Markers of bone resorption will increase in the first 100 days after HCT, will remain elevated until at least Day 180 in the Control Group, but will decrease after initiation of pamidronate at Day 100 in the Pamidronate Group. (aamds.org)
  • regulates
  • Calcineurin regulates bone formation by the osteoblast," Proceedings of the National Academy of Sciences of the United States of America , vol. 102, no. 47, pp. 17130-17135, 2005. (hindawi.com)
  • acute
  • Among those affected, the majority develops cancer, most often acute myelogenous leukemia, and 90% develop bone marrow failure (the inability to produce blood cells) by age 40. (wikipedia.org)
  • Specifically
  • Experimental design: Multiparameter flow cytometry was used to evaluate the proteolytic activation of caspase-3 and the phosphorylation of ERK1/2, p38 MAPK, and STAT5 specifically in defined CD34+, CD45+, or CD71+CD45- bone marrow (BM) cells from 60 MDS cases and normal controls, both at baseline and following stimulation with G-CSF and erythropoietin (EPO). (aacrjournals.org)
  • presence
  • Dyskeratosis congenita is characterized by a mucocutaneous triad, bone marrow failure (BMF), and presence of short telomeres because of mutations in telomerase. (semanticscholar.org)
  • metastatic
  • Bone is conducive to the metastatic process given its composition of many different kinds of cells and its ability to grow skeletal structures. (wikipedia.org)