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  • RUNX2
  • RUNX2 is involved in development of both intramembraneous and endochondral bones through regulation of osteoblast differentiation and chondrocyte maturation, respectively. (reactome.org)
  • RUNX2 regulates expression of several genes implicated in cell migration during normal development and bone metastasis of breast cancer cells. (reactome.org)
  • Expression of osteogenesis markers BMP2 , Runx2 , Collagen I , and Osteocalcin was enhanced in OA-treated BMSCs. (mdpi.com)
  • Thus, OA confers an osteoinductive effect on BMSCs via induction of osteogenic marker gene expression, such as BMP2 and Runx2 expression and subsequently elevates ALP activity and mineralization, followed by enhanced trabecular bone formation in rat tibias. (mdpi.com)
  • Osteoprogenitor-enriched cell (OPEC) populations were found to express RUNX2, MSX2, SP7 (osterix), BGLAP (osteocalcin), SPARC (osteonectin), and SPP1 (osteopontin) in a temporally specific sequence. (biomedsearch.com)
  • human bone
  • Parfitt AM. Osteonal and hemi-osteonal remodeling: the spatial and temporal framework for signal traffic in adult human bone. (springer.com)
  • Indeed, key mechanisms involved in breast cancer osteotropism are still only partially understood due to the lack of suitable animal models to mimic metastasis of human tumor cells to a human bone microenvironment. (biologists.org)
  • The newly formed bone was largely humanized, as indicated by the incorporation of human bone cells and human-derived matrix proteins. (biologists.org)
  • Osteogenic
  • Although reports of multilineage engraftment by a single marrow-derived stem cell support this idea, more recent evidence has challenged claims of stem cell transdifferentiation and therefore the existence of a multipotent hematopoietic/osteogenic progenitor cell. (pnas.org)
  • Home Key Engineering Materials Bioceramics 16 In Vitro Osteogenic Activity of Rat Bone Marrow. (scientific.net)
  • findings
  • The findings suggest that osteocalcin, or perhaps a drug that targets bone, might hold promise in fighting the global epidemic of type 2 diabetes, according to the researchers. (preventdisease.com)
  • Our findings indicate that the bone marrow contains a primitive cell able to generate both the hematopoietic and osteocytic lineages. (pnas.org)
  • Marrow Cells
  • We tested this prediction in a murine transplantation model by using gene-marked bone marrow cells and retroviral integration site-specific PCR analysis. (pnas.org)
  • regulates bone
  • Ectonucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) is a factor that regulates bone mineralisation and is elevated in individuals with insulin resistance, a condition associated with type 2 and obesity-related diabetes. (biologists.org)
  • Fractures
  • Glucocorticoid induced osteoporosis, in common with other forms of osteoporosis such as that resulting from gonadal insufficiency and high intake of alcohol, is characterized by loss of bone mass and deterioration of the microarchitectural bone structure leading to an increased susceptibility to fractures [ 5 ]. (medsci.org)
  • Osteoporosis is a relatively widespread bone disorder, associated with low bone mass density (BMD) and increased risk of bone fractures. (springer.com)
  • Mineral
  • Endocrine Facts and Figures: Bone and Mineral. (endocrinefacts.org)
  • Body fat and lean mass are correlated with bone mineral density, with obesity apparently exerting protection against osteoporosis. (springer.com)
  • A multicenter study of the influence of fat and lean mass on bone mineral content: evidence for differences in their relative influence at major fracture sites. (springer.com)
  • Bone mineral density (BMD) and content (BMC) were reduced (0.061 ± 0.0046), (0.041 ± .0048) in all groups and increased (0.070 ± 0.0046), (0.063 ± 0.0045) upon adding flaxseed oil which have a ratio of 13.90 ± 0.01:21.10 ± 0.40 and there is correlation between bone marker and gene polymorphism after receiving flaxseed oil. (springer.com)
  • proteins
  • 1997), which encodes Osteocalcin, a bone-derived hormone which is one of the most abundant non-collagenous proteins of the bone extracellular matrix (reviewed in Karsenty and Olson 2016). (reactome.org)
  • The proteome map, that is, complete catalogue of the matrix and cellular proteins expressed in alveolar bone, cementum, periodontal ligament, and gingiva, is to be explored for more in-depth understanding of periodontium. (hindawi.com)
  • skeletal
  • Skeletal bone diseases such as multiple sclerosis (MS), osteoporosis, and vitamin D-dependent rickets type II were found to be affected by vitamin D receptor gene polymorphism (Rosset et al. (springer.com)
  • calcium
  • In order to carry out its functions (structural/locomotive, dynamic storage of calcium and phosphate, hematopoiesis), bone must adapt to endogenous (mainly hormonal and inflammatory) and exogenous (biomechanical load, diet, vitamin D) stimuli. (springer.com)
  • axis
  • No data are available regarding the bone-fat-pancreas axis in children. (clinicaltrials.gov)
  • Because the foundations of body composition trajectories and metabolic 'programming' are established early in the life course, childhood, particularly during early stages of growth and development, is an especially salient time period for evaluating the bone-fat-pancreas axis. (clinicaltrials.gov)