As many as 30% of myeloma patients may present with a pathologic fracture, and up to two-thirds with bone pain alone as the initial symptom of disease [7]. (crimsonpublishers.com)
The bone fracture probabilities were obtained from a cohort study of 3614 women from USA with PMO treated with RIS-GR (1807) or ALN (1807) (Thomasius, 2022). (bvsalud.org)
This expert opinion discussed the current level I evidence on the experimental pharmacological agents used to favor bone fracture healing. (bvsalud.org)
All the randomized clinical trials investigating pharmacological agents for bone fracture healing were accessed. (bvsalud.org)
EXPERT OPINION: Calcitonin could favor bone fracture healing. (bvsalud.org)
Risk of a fat embolism is greatest in the first 48 hours after the fracture of a long bone. (rnpedia.com)
The case of a patient with Paget's disease of the pelvis ( acetabulum ) who had an intraoperative posterior wall fracture during the insertion of a noncemented acetabular component into an under-reamed acetabular bed of sclerotic Pagetoid bone is reported. (lookfordiagnosis.com)
Resorption5
Osteomalacia is a disease characterized by the softening of the bones caused by impaired bone metabolism primarily due to inadequate levels of available phosphate, calcium, and vitamin D, or because of resorption of calcium. (wikipedia.org)
However, while bone is continuously remodeling by resorption/neoformation during life, tooth's hard tissues are not. (bvsalud.org)
On conventional skeletal survey, 10% had minimal subperiosteal bone resorption limited to the phalanges. (rsna.org)
By absorptometric analysis and fine-detail radiography, a majority were found to have demineralization and excessive bone resorption. (rsna.org)
Low doses of IGF-I constituted a real replacement therapy that normalized IGF-I serum levels improving the expression of most of these proteins closely involved in bone-forming, and reducing bone resorption by mechanisms related to osteoprotegerin, RANKL and PTH receptor. (biomedcentral.com)
Density6
In a double-blind study comparing oral prednisolone (7.5 mg/d for 2 years) with placebo, hand bone density assessed with digital x-ray radiogrammetry was examined in 95 patients with rheumatoid arthritis with disease duration of less than 2 years. (nih.gov)
The mean loss of hand bone density was less in prednisolone-treated patients compared with placebo-treated patients at the 1-year follow-up (-0.011 vs -0.022 g/cm(2)) (P = .005) and at the 2-year follow-up (-0.026 vs -0.039 g/cm(2)) (P = .03). (nih.gov)
The mean percentage group difference in loss of hand bone density was 2.8% (P = .004) at the 1-year follow-up and 3.5% (P = .01) at the 2-year follow-up. (nih.gov)
To our knowledge, this is the first double-blind randomized study to show that disease-related loss of hand bone density in rheumatoid arthritis can be decelerated by prednisolone. (nih.gov)
Stored samples from a prior clinical trial aimed at analyzing the effect of alendronate on bone mineral density, provided further evidence of alendronate-mediated latency reversal and activation of immune effector cells. (bvsalud.org)
RESULTS: Computed tomographic scans disclosed osseous changes of the temporal and frontal bones, with areas of high density consistent with Paget disease . (lookfordiagnosis.com)
Fractures2
Pathologic fractures due to weight bearing may develop. (wikipedia.org)
patients with sclerotic bone, like those with osteoporotic bone, may also be at risk for periprosthetic acetabular fractures when an under-reaming technique is used. (lookfordiagnosis.com)
Marrow6
Clinical definitions of the various myeloma subtypes have been updated, as have the imaging definitions of what constitutes bone marrow disease and individual bony involvement. (medscape.com)
[ 8 ] Patients suspected of having multiple myeloma based on bone marrow aspirate results or hypergammaglobulinemia should undergo a radiographic skeletal survey. (medscape.com)
[ 9 ] MRI is the gold-standard imaging modality for detection of bone marrow involvement and the preferred imaging technique to rule out spinal cord compression in patients with multiple myeloma, whereas PET/CT provides valuable prognostic data and aids in assessment of response to therapy. (medscape.com)
range, 44-83 years) with multiple myeloma proven by bone marrow biopsy. (medscape.com)
About half of chemotherapy patients experience oral complications, particularly those being treated for leukemia and those who receive bone marrow transplants. (1stdentist.com)
Hemorrhage or bleeding of the oral cavity can occur when clotting factors are affected and during bone marrow suppression. (1stdentist.com)
Lesions4
Radiologically, multiple destructive lytic lesions of the skeleton, as well as severe demineralization, characterize multiple myeloma. (medscape.com)
Primary bone lesions are more commonly identified in patients under the age of 40, and can be subdivided into benign and malignant lesions. (crimsonpublishers.com)
The presence of multiple osteolytic bone lesions is a defining trademark of the disease. (crimsonpublishers.com)
Much less common are soft tissue lesions adjoining the pagetic bone that clinically and radiologically simulate sarcoma but histologically represent exaggerated periosteal bone formation as a manifestation of the basic pathologic process. (lookfordiagnosis.com)
Tooth2
In addition to low systemic levels of circulating mineral ions (for example, caused by vitamin D deficiency or renal phosphate wasting) that result in decreased bone and tooth mineralization, accumulation of mineralization-inhibiting proteins and peptides (such as osteopontin and ASARM peptides), and small inhibitory molecules (such as pyrophosphate), can occur in the extracellular matrix of bones and teeth, contributing locally to cause matrix hypomineralization (osteomalacia/odontomalacia). (wikipedia.org)
Radiation dental caries is a term used for rapid tooth demineralization and severe cavities that occur with head and neck radiation, particularly when the parotid, submandibular, submental, or submaxillary salivary glands are in the radiation field. (1stdentist.com)
Mineral2
Removal of mineral constituents or salts from bone or bone tissue. (nih.gov)
Clinical manifestations, radiographic findings, and bone mineral measurements of 65 patients with primary hyperparathyroidism are reviewed. (rsna.org)
Metabolism1
The impairment of bone metabolism causes inadequate bone mineralization. (wikipedia.org)
Alveolar bone response to light-force tipping and bodily movement in maxillary incisor advancement: A prospective randomized clinical trial. (vcu.edu)
Malignancies1
Aminobisphosphonates (N-BPs) that include pamidronate, zoledronate, or alendronate, are the first-line treatment of bone-related diseases including osteoporosis and bone malignancies. (bvsalud.org)
Cortical1
In this condition MRI plays a fundamental role because it is the only imaging technique which can diagnose it and accurately assess its extent and any cortical bone and/or cartilage involvement. (cnr.it)
Cementum1
Dentin, cementum, and bone are mineralized hard tissues. (bvsalud.org)
Mineralization3
A relationship describing local, physiologic double-negative (inhibiting inhibitors) regulation of mineralization has been termed the Stenciling Principle of mineralization, whereby enzyme-substrate pairs imprint mineralization patterns into the extracellular matrix (most notably described for bone) by degrading mineralization inhibitors (e.g. (wikipedia.org)
Osteomalacia is a generalized bone condition in which there is inadequate mineralization of the bone. (wikipedia.org)
A condition marked by softening of the bones (due to impaired mineralization, with excess accumulation of osteoid), with pain, tenderness, muscular weakness, anorexia, and loss of weight, resulting from deficiency of vitamin D and calcium. (uams.edu)
Vertebral2
Spine infections are rare infections that can involve the intervertebral disc space (discitis), the vertebral bones, the spinal canal or adjacent soft tissues. (wheelessonline.com)
Vertebral osteomyelitis refers to an infection of the vertebral bones in the spine. (wheelessonline.com)
Osteomalacia1
Symptoms: Diffuse joint and bone pain (especially of spine, pelvis, and legs) Muscle weakness Difficulty walking, often with a waddling gait Hypocalcemia (positive Chvostek sign) Compressed vertebrae and diminished stature Pelvic flattening Weak, soft bones Easy fracturing Bending of bones Osteomalacia in adults starts insidiously as aches and pains in the lumbar (lower back) region and thighs before spreading to the arms and ribs. (wikipedia.org)
Radiographic2
MRI can provide information that is complementary to a skeletal survey and was recommended for use in patients with normal radiographic images and in all patients with an apparently solitary plasmacytoma of bone. (medscape.com)
Standard 99m Tc bone scintigraphy should play no role in the routine staging of myeloma, and sequential dual-energy radiographic absorptiometry (DXA) scans are not recommended, according to the authors. (medscape.com)
Tissues1
Bone is one of the major target tissues for Insulin-like Growth Factor I (IGF-I). Low doses of IGF-I were able to improve liver-associated osteopenia. (biomedcentral.com)
Spontaneous2
Most of the time, the only alleged symptom is chronic fatigue, while bone aches are not spontaneous but only revealed by pressure or shocks. (wikipedia.org)
Osteoradionecrosis (soft tissue and bone necrosis) can be spontaneous or secondary to trauma, extractions, or dental prostheses. (1stdentist.com)
Osteoporosis1
Bone damage in rheumatoid arthritis presents as osteoporosis and joint erosions. (nih.gov)
Inflammation1
In the first year, C-reactive protein, a marker of inflammation, was strongly correlated with hand bone loss in placebo-treated patients but not in prednisolone-treated patients, suggesting that prednisolone breaks the link between bone loss and inflammation. (nih.gov)
Sensitivity1
The pain is symmetrical, non-radiating and accompanied by sensitivity in the involved bones. (wikipedia.org)
Disease2
Extramedullary hematopoiesis usually occurs in hematological diseases but may also be found as an uncommon complication of Paget's disease , probably due to bone effraction mechanism. (lookfordiagnosis.com)
The appearance of a sarcoma of bone is a well-recognized complication of Paget's disease . (lookfordiagnosis.com)
Present1
In the present work, a model of partial IGF-I deficiency was used in order to provide insight into the mechanisms of the beneficial actions of IGF-I replacement therapy in bone. (biomedcentral.com)
Clinical1
Clinical features, incidence, and survivorship of malignant primary bone tumors [5-7]. (crimsonpublishers.com)
Joint1
Prednisolone has been shown to reduce the rate of hand joint destruction as seen on radiography but has not been shown to reduce the rate of hand bone loss. (nih.gov)
Primary2
Osteosarcoma, Ewing sarcoma and chondrosarcoma represent 70% of primary bone tumor diagnoses, and malignant primary bone tumors represent around 3,300 new cases annually in the United States [5,6]. (crimsonpublishers.com)
Technically considered a plasma cell dyscrasia, multiple myeloma is the most common primary malignancy of bone [7,8]. (crimsonpublishers.com)
Include1
Signs and symptoms can include diffuse body pains, muscle weakness, and fragility of the bones. (wikipedia.org)
INTRODUCTION1
INTRODUCTION: Pharmacological strategies might influence bone healing in terms of time to union or quality of mature bone. (bvsalud.org)
Effect1
This finding suggests that the deleterious effect of prednisolone on bone may be counteracted by its anti-inflammatory effect. (nih.gov)