Bone cements contain gentamicin. Medical search. Frequent questions

In July 2012 (11 months after the accident), because of fistula persistence, the patient underwent ablation of a tibial sequestrum ( Figure ) and implantation of a temporary cement spacer containing gentamicin and vancomycin. (cdc.gov)
The Copal bone cements Copal G+C and Copal G+V, for instance, contain combinations of antibiotics (gentamicin and clindamycin and gentamicin and vancomycin respectively) that tackle most of the microorganisms responsible for PJI. (healthcare-in-europe.com)
This contains the antibiotic gentamicin combined with vancomycin which, as a reserve antibiotic, is an option for use with known bacterial resistance to MRSA/MRSE, for example. (healthcare-in-europe.com)
Crowther GS, Callaghan N, Bayliss M, Noel A, Morley R, Price B. Efficacy of Topical Vancomycin- and Gentamicin-Loaded Calcium Sulfate Beads or Systemic Antibiotics in Eradicating Polymicrobial Biofilms Isolated from Diabetic Foot Infections within an In Vitro Wound Model. (kerrier.com)
Stravinskas M, Nilsson M, Vitkauskiene A, Tarasevicius S, Lidgren L. Vancomycin elution from a biphasic ceramic bone substitute. (boneandjoint.org.uk)
An injectable ceramic bone substitute, with hydroxyapatite in a calcium sulphate matrix, containing 66 mg of vancomycin per millilitre, was inserted to augment the fixation. (boneandjoint.org.uk)
This is the first long-term pharmacokinetic study that reports vancomycin release from a biphasic injectable ceramic bone substitute. (boneandjoint.org.uk)

Objectives To examine mortality and revision rates among patients with osteoarthritis undergoing hip arthroplasty and to compare these rates between patients undergoing cemented or uncemented procedures and to compare outcomes between men undergoing stemmed total hip replacements and Birmingham hip resurfacing. (bmj.com)
Our eMail-newsletter "Heraeus Medical Update" alerts you to product launches and newest information, webinars, tutorials, and focus topics related to cemented arthroplasty, infection management, interviews with experts from science and practice and more. (heraeus-medical.com)
Mr Reed presented recent data from the National Joint Registry (NJR) of England, Wales and Northern Ireland (the largest arthroplasty registry worldwide) supporting the efficacy of antibiotic-loaded bone cements in the prevention of revision surgery. (opnews.com)
Of those, 47 per cent and 59 per cent of primary hip and knee arthroplasties respectively were performed using PALACOS® R+G. Results showed a statistically significant reduction in the number of both hip and knee arthroplasty revisions when using antibiotic-loaded bone cement, specifically PALACOS® R+G, as compared to other bone cements. (opnews.com)
The NJR data are consistent with reports from other joint registries, including the Norwegian Arthroplasty Register and the Swedish National Hip Arthroplasty Register, which demonstrate that PALACOS® (R+G) displays the lowest risk of an implant failure among all bone cements analysed. (opnews.com)
Polymethylmethacrylate (PMMA) bone cement, which is primarily used to fix prosthetic implants, can support effective infection management in primary arthroplasty, revision and the treatment of periprosthetic infections. (healthcare-in-europe.com)
In primary arthroplasty patients, who are particularly at a high risk of infection, are recommended for combinations of antibiotics for antibiotic prophylaxis, and thus the use of Copal G+C bone cement. (healthcare-in-europe.com)
The purpose of this study was to compare the survivorship of cemented versus cementless tibial baseplate in primary total knee arthroplasty. (sicot-j.org)
The use of cefuroxime-impregnated cement was shown to be effective in the prevention of early to intermediate deep infection after primary total knee arthroplasty (TKA) performed with perioperative systemic antibiotic prophylaxis but without any so-called clean-air measures. (medscape.com)

Radiograph of left leg of patient with Clostridium tetani infection, showing delayed bone consolidation 11 months after fracture. (cdc.gov)
Heraeus Medical) had significantly reduced surgical site infection rate compared to those receiving standard antibiotic-loaded cement. (opnews.com)
Chen AF, Parvizi J. Antibiotic-loaded bone cement and periprosthetic joint infection. (jefferson.edu)
In a satellite symposium sponsored by Heraeus Medical at the 35th Annual Meeting of the European Bone and Joint Infection Society, the latest knowledge of biofilms and local methods of overcoming the challenge of infection in clinical practice was discussed. (opnews.com)
The Spacer ® by Tecres is a Gentamicin-enriched femorotibial interim prosthesis which is implanted temporarily during two-stage revision procedures performed due to infection. (merete.de)
For septic loosening or chronic infections, a spacer made of antibiotic-loaded bone cement is often inserted as a temporary joint replacement to eliminate infection. (healthcare-in-europe.com)
Bone cements containing antibiotics for infection prophylaxis - quo vadis? (healthcare-in-europe.com)
This study shows that in the management of open long bone fractures in low-resource settings, the use of local aqueous gentamycin administration as an adjunct to conventional management is effective in lowering the infection rates, reducing the number of operations, reducing length of hospital stay and non-union rates. (ecronicon.net)
The infecting organism may reach bone through blood or as a consequence of events such as trauma, surgery, the presence of foreign bodies, or the placement of prostheses that disrupt bony integrity and predispose to the onset of bone infection. (medscape.com)
Management of osteomyelitis requires systemic treatment with antibiotics and local treatment at the site of bone infection to eradicate infection, and reconstruction is often required for the sequelae of bone and joint infection. (medscape.com)
Hematogenous osteomyelitis most commonly involves the vertebrae, but infection may also occur in the metaphysis of the long bones, pelvis, and clavicle. (medscape.com)
Bone is normally resistant to infection. (medscape.com)
Bone infection may result from the treatment of trauma, which allows pathogens to enter bone and proliferate in the traumatized tissue. (medscape.com)
When bone infection persists for months, the resulting infection is referred to as chronic osteomyelitis and may be polymicrobial. (medscape.com)
Although all bones are subject to infection, the lower extremity is most commonly involved. (medscape.com)
The goals of osteomyelitis therapy are successful control of infection and reconstruction of the bone. (copernicus.org)
Bioactive glass appears to be a suitable bone substitute not only for successful control of infection and defect filling but also for bone healing in cases of infected non-union. (copernicus.org)
A randomized, controlled study to investigate the efficacy and safety of a topical gentamicin-collagen sponge in combination with systemic antibiotic therapy in diabetic patients with a moderate or severe foot ulcer infection. (ijsurgery.com)
The plain ceramic bone substitute has been proven to regenerate bone but should also be useful in preventing bone infection. (boneandjoint.org.uk)
The aim of this study was to investigate a new commercially available bone substitute that elutes antibiotics, combining an initial high local release with a sustainable antibiotic level for a sufficiently long time to eradicate or prevent infection effectively. (boneandjoint.org.uk)
Does a Prefabricated Gentamicin-impregnated, Load-bearing Spacer Control Periprosthetic Hip Infection? (wheelessonline.com)

It is now accepted that cementless implantation of the femoral component provides equivalent results to cemented one, however, the optimal fixation method of the tibial component remains controversial. (sicot-j.org)
We carried out a retrospective, monocentric study, including 109 TKA (Zimmer ® Natural Knee II ultra-congruent mobile-bearing) implanted between 2004 and 2010 for primary osteoarthritis, comparing 2 groups depending on tibial component fixation method, one cemented ( n = 68) and one cementless ( n = 41). (sicot-j.org)
Mean follow-up were 8.14 [5.31-12.7] and 8.06 [5.22-12.02] years, respectively, in cemented and cementless groups. (sicot-j.org)
The tibial component survival rate was 100% [95CI: 91.4-100] in the cementless group and 97.1% [95CI: 89.78-99.42] in the cemented group (2 aseptic loosenings) ( p = 0.27). (sicot-j.org)
Radiolucent lines were present in 31.7% ( n = 13) of the cementless and 44.1% ( n = 30) of the cemented baseplates ( p = 0.2). (sicot-j.org)
Mean range of flexion was 120 ± 10° in the cementless group and 122.5 ± 15° in the cemented group ( p = 0.37). (sicot-j.org)
The implant fixation method, either cemented or cementless, remains controversial, mainly on the tibial side [ 1 - 5 ]. (sicot-j.org)
However, cementless tibial components have a greater micromotion during the first 3 postoperative months, then a stabilization of the component in radiostereometric analysis is achieved, whereas cemented tibial components have an initially lower migration, but over time have a continuously increasing micromotion [ 11 , 12 ]. (sicot-j.org)
2011) Hybrid cemented / cementless total hip replacement in dogs: seventy-eight consecutive joint replacements. (uk.net)

The two components are secured to the femur condyles and the tibia plateau with bone cement. (merete.de)
it is typically found in the tibia but can occur in any bone. (medscape.com)
Ninety-three studies were suitable for inclusion, describing 3701 patients (3711 fractures) with complex FRI. The population consisted predominantly of male patients (77%), with the tibia being the most commonly affected bone (64%), and a mean of three previous operations per patient. (sogacot.org)

The major appeal of incorporating antibiotics in bone cements is the higher local concentrations of antibiotic achievable when it is delivered in this way, compared with intravenous administration. (opnews.com)

conversely, there was a lower revision rate with cemented procedures (0.53, 0.50 to 0.57). (bmj.com)
For example, compared with the uncemented group, at eight years after surgery the predicted probability of death in the cemented group was 0.013 higher (0.007 to 0.019) and the predicted probability of revision was 0.015 lower (0.012 to 0.017). (bmj.com)
Both uncemented total hip replacements and Birmingham hip resurfacings had a higher revision rate than cemented total hip replacements. (bmj.com)
Conclusions There is a small but significant increased risk of revision with uncemented rather than cemented total hip replacement, and a small but significant increased risk of death with cemented procedures. (bmj.com)
Previously, only adjusted analyses of hip implant revision rates have been used to recommend and justify use of cheaper cemented total hip implants. (bmj.com)
In February 2012, because bone consolidation had not occurred, the patient underwent surgical revision to remove the locking plate, clean the wound, and insert an external fixator. (cdc.gov)
Preservation of the original femoral cement mantle during the management of infected cemented total hip replacement by two-stage revision. (wheelessonline.com)

A cemented femoral stem prosthesis. (orthopaediclist.com)

Al Thaher Y, Yang L, Jones SA, Perni S, Prokopovich P. LbL-assembled gentamicin delivery system for PMMA bone cements to prolong antimicrobial activity. (ucdenver.edu)

The risk factors that can increase the likelihood of infections include diabetes, osteoporosis, limited mobility, excess weight and dementia.When treating femoral neck fractures with a cemented hemiarthroplasty using Copal G+C, it can be verifiably demonstrated that the risk of deep infections (surgical site infections, SSI) can be considerably reduced by using dual antibiotic-loaded bone cement. (healthcare-in-europe.com)

It is particularly important to optimise strategies for reducing peri-prosthetic joint infections (PJIs) in high-risk patients, but which bone cement best overcomes the current challenges in PJI prevention? (opnews.com)

Heraeus Medical is a leader in the field of bone cements and biomaterials for surgical orthopaedics and trauma surgery. (heraeus-medical.com)
Heraeus Medical focuses on products for use in bone and joint surgery, spinal surgery as well as modern cementing technique. (heraeus-medical.com)
PALACOS® R+G (Heraeus Medical), which includes gentamicin, has been in use for over 40 years. (opnews.com)

A concern regarding the use of antibiotic-loaded bone cements is whether they cause antibiotic resistance. (opnews.com)
Silica-gentamicin nanohybrids: combating antibiotic resistance, bacterial biofilms, and in vivo toxicity Introduction Antibiotic resistance is a rising concern in well being care. (gentatest.com)

The humerus is the second most common long bone affected by metastatic diseases, following the femur, and the incidence of pathologic fractures has been reported to range from 16 to 27% [ 1 , 2 , 3 ]. (biomedcentral.com)

2016) Cement plug technique for the management of disc-associated cervical spondylopathy in 52 Dobermann Pinscher dogs. (uk.net)

Impact of antibiotic impregnation time on the discharge of gentamicin from cryopreserved allograft bone chips: an in vitro research. (gentatest.com)
Massive bone allograft is a good functional choice of treatment missing metatarsal. (mycongressonline.net)

Despite advances in orthopaedic materials, the development of drug-eluting bone and joint implants that can sustain the delivery of the drug and maintain the necessary mechanical strength to withstand loading has remained elusive. (nature.com)
The different systems, however, are simply categorised by their mode of fixation as cemented or uncemented implants. (bmj.com)
This material is also used in tooth implants, bone cements, and hard corneal contact lenses. (ucdenver.edu)

comparing low-dose single antibiotic versus high-dose dual antibiotic impregnated cement. (opnews.com)
Antibiotic prophylaxis for hip fracture surgical procedure: three-dose cefuroxime versus single-dose gentamicin and amoxicillin. (gentatest.com)
We compared the outcome of using bioactive glass (BAG) versus autologous bone graft (AB) in patients with infected non-union. (copernicus.org)

After 7 months a reconstruction procedure was performed with removal of the spacer and using a suitable first metatarsal fresh frozen from the bone bank stabilized with plates on the 1cuneiform and the head of the metatarsal. (mycongressonline.net)

Intramedullary nailing (IMN) can be carried out by a closed or open procedure [ 12 ], but it may cause rotator cuff injury, whereas plate fixation (PF) requires extensive stripping of the soft tissues from the bone [ 16 ]. (biomedcentral.com)

Mr Reed discussed how, in his institution, all lower limb joint replacements are carried out using antibiotic-loaded cement, using high dose dual antibiotic cement for patients with a hip fracture requiring joint replacement. (opnews.com)
Commenting on whether cost may be an issue, Reed said: "We've done a significant cost analysis and it shows that even though high dose dual antibiotic cement is more expensive, the cost to the hospital and the NHS is reduced, because of the infections prevented. (opnews.com)
69% reduction in the rate of deep infections following femoral neck fracture when using high-dose antibiotic-loaded bone cement. (healthcare-in-europe.com)

The use of antibiotic-loaded bone cements is a widely practised method of reducing orthopaedic infections. (opnews.com)

The local release of the antibiotic from the bone cement supplements standard systemic antibiotic prophylaxis. (healthcare-in-europe.com)

Primary hematogenous osteomyelitis is more common in infants and children, usually occurring in the long-bone metaphysis. (medscape.com)

2010) Treatment of lumbosacral discospondylitis by surgical stabilisation and application of a gentamicin-impregnated collagen sponge. (uk.net)
Varga M, Sixta B, Bem R, Matia I, Jirkovska A, Adamec M. Application of gentamicin-collagen sponge shortened wound healing time after minor amputations in diabetic patients- a prospective, randomised trial. (ijsurgery.com)

Among them, collagen membranes have attracted great interest due to their excellent biological properties and desired bone regeneration results to non-absorbable membranes even without a second surgery for removal. (encyclopedia.pub)

0.05) when irrigated with gentamicin solution than merely with saline solution. (ac.ir)

Unlike conventional methods, such as amputations, antibiotic impregnated cement space (ACS) was recently introduced and perceived as a substitute for amputation. (mdpi.com)

Antibiotic-loaded bone cement is an important element in a prevention strategy. (healthcare-in-europe.com)

However, when microorganisms are introduced into bone hematogenously from surrounding structures or from direct inoculation related to surgery or trauma, osteomyelitis can occur. (medscape.com)

Osteomyelitis is inflammation of the bone caused by an infecting organism. (medscape.com)
Contiguous-focus osteomyelitis often occurs in the bones of the feet in patients with diabetes mellitus and vascular compromise. (medscape.com)
Patients with chronic osteomyelitis and infected non-union who received either bioactive glass or autologous bone grafts between 2013 and 2017 were analyzed retrospectively. (copernicus.org)

Conservative treatment does not lead to significant bone healing because the tumor cells grow rapidly and overwhelm the bone's reparative process [ 4 ]. (biomedcentral.com)

are rare, and their outcomes are often unfavorable because of the persistence of the bacteria in bone ( 1 , 2 ). (cdc.gov)

Problems include low antibiotic concentrations due to inadequate perfusion of the bone and the surrounding soft tissues (van Vugt et al. (copernicus.org)

Compared with uncemented and cemented total hip replacements, Birmingham hip resurfacing has a significantly lower risk of death in men of all ages. (bmj.com)
Our investigations additionally consider mortality rates and suggest a potentially higher mortality rate with cemented total hip replacements, which merits further investigation. (bmj.com)

Barrier Membranes for Guided Bone Regeneration" Encyclopedia , https://encyclopedia.pub/entry/38111 (accessed December 07, 2023). (encyclopedia.pub)
Guided bone regeneration (GBR) has become a clinically standard modality for the treatment of localized jawbone defects. (encyclopedia.pub)

This is a prospective randomised controlled trial comparing topical antibiotic (aqueous gentamycin) and non-topical antibiotic groups. (ecronicon.net)

6 m&l for machine pressed precast conctete interlocking paver block any shape and size confirming to is 15658 2006 of 60 mm thickness, m 35 grade, with grey cement & no pigment, incl taking out existing old paver blocks and removingfrom sitecomplete all as specified and directed. (haryanatenders.net)
9 m&l for 15 mm thick plastering in two layers, 10 mm + 5 mm in cement mortar 1:4, top layer of 5 mm thickness mixed with with water proofing compound ( as per manufacturers instructions ) onbrick / stone walls or concrete surfaces finished even and fair ( upto any height ) for external surfacescomplete all as specified and directed.note : water proofing compound shall be measured and paid seperately as supply only. (haryanatenders.net)

Results As there were large baseline differences in the characteristics of patients receiving cemented, uncemented, or resurfacing procedures, unadjusted comparisons are inappropriate. (bmj.com)
it is indicated for lesions with substantial bone loss, or accompanied soft tissue mass, or for those patients with better prognosis. (biomedcentral.com)
Therefore, when possible, more radical treatment is needed for some patients with solitary bone lesions and a longer predicted life expectancy. (biomedcentral.com)
Patients with multidrug-resistant pathogens had a significantly higher rate of incomplete bone healing ( p =0 .033) and a 3-fold higher risk of complications in both groups. (copernicus.org)

The gold standard for filling defects is the autologous bone graft. (copernicus.org)
In our study, bioactive glass was neither superior nor inferior to autologous bone graft with regard to the primary and secondary endpoints. (copernicus.org)

Chimie et solubilité des phosphates ce calcium en milieux aqueux. (epfl.ch)
made of fully synthetic bone that correspond to the calcium phosphate component of natural bone in chemical composition and crystalline structure. (medicalexpo.com)

Conceivably, this may be a situation for routine use of antibiotic cement in all revisions. (medscape.com)

Bioactive glass S53P4 is an inorganic bone substitute. (copernicus.org)

The purpose of this study was to evaluate the effect of gentamicin irrigation solutions as a process to restrain septic arthritis following arthroscopic ACL reconstruction. (ac.ir)
Conclusion: Gentamicin irrigation solution has a preservative and protective effect against SA development following arthroscopic ACL reconstruction. (ac.ir)

Although bone is normally resistant to bacterial colonization, it can become infected in multiple ways. (medscape.com)

Pre-packed: bone cement pre-packed in a vacuum mixing system. (gopublic.work)

use of glass ampoules1 while the high contrast of blue pre-colored cement provides optimal visualization against bone and soft tissue. (medicalexpo.com)

The optimized UHMWPE eluted antibiotic at a higher concentration for longer than the clinical gold standard antibiotic-eluting bone cement, while retaining the mechanical and wear properties of clinically used UHMWPE joint prostheses. (nature.com)

characteristics of cement are markedly improved by centrifugation. (wheelessonline.com)

Anatomy15

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