ThrombocytopeniaNeutropeniaPancytopeniaAplastic AnemiaInfantile genetic agranulEosinophiliaSevereNeutrophilsDisordersDrug-inducedPronePatientsBiopsyAnemiaMarrow TransplantationSymptomsGranulocyteMegakaryocytesBloodBacteriaLiverRarelyInflammationInfectionTreatmentConditionDiseasesRiskChemicalsOccursSideCompletePeople
Thrombocytopenia1
- Colchicine may cause severe bone marrow depression (agranulocytosis, aplastic anaemia, thrombocytopenia). (medthority.com)
Neutropenia6
- Also called Kostmann disease, Kostmann neutropenia, congenital neutropenia and infantile genetic agranulocytosis. (cancer.ca)
- And yes, this will appear very similar to a neutropenia because agranulocytosis is a blood disorder in which the body is unable to make neutrophils. (coastdental.com)
- Neutropenia is sometimes called agranulocytosis or granulocytopenia because neutrophils make up about 60% of white blood cells and have granules inside their cell walls. (wordinfo.info)
- A variety of drugs can cause acquired agranulocytosis and neutropenia by destroying special cells in the bone marrow that later mature and become granulocytes (precursors). (orthopedicshealth.com)
- Neutropenia was diagnosed three days after the introduction of parenteral fosfomycin and agranulocytosis four days later. (bvsalud.org)
- The summary of product characteristics mentions that only a few cases of transient neutropenia and agranulocytosis have been reported. (bvsalud.org)
Pancytopenia2
- Aplastic anemia (AA) is a hematologic condition characterized by bone marrow hypoplasia or aplasia resulting in pancytopenia. (haematologica.org)
- Diagnosis requires demonstration of peripheral pancytopenia and a bone marrow biopsy revealing a hypocellular marrow. (msdmanuals.com)
Aplastic Anemia4
- Design and Methods This was a case-control, multicenter, multinational study, designed to identify risk factors for agranulocytosis and aplastic anemia. (haematologica.org)
- The cases were patients with diagnosis of aplastic anemia confirmed through biopsy or bone marrow aspiration, selected through an active search of clinical laboratories, hematology clinics and medical records. (haematologica.org)
- Aplastic anemia is a disorder of the hematopoietic stem cell that results in a loss of blood cell precursors, hypoplasia or aplasia of bone marrow, and cytopenias in two or more cell lines (red blood cells, white blood cells, and/or platelets). (msdmanuals.com)
- The term aplastic anemia commonly implies a panhypoplasia of the bone marrow with cytopenias in at least two hematopoietic lineages. (msdmanuals.com)
Infantile genetic agranul5
- And this week we're talking about Infantile Genetic Agranulocytosis. (coastdental.com)
- So we're talking about Infantile Genetic Agranulocytosis and this, for our listeners, is going to sound relatively similar to the previous episode where we talked about neutropenias. (coastdental.com)
- You see, an individual who has Infantile Genetic Agranulocytosis is an individual who is born, present at birth with this congenital or genetic disorder. (coastdental.com)
- So if an individual has Infantile Genetic Agranulocytosis, these are individuals who absolutely are going to be prone to infection and periodontitis, of course, is no exception. (coastdental.com)
- It absolutely means that individuals who may be experiencing oral infection associated with their Infantile Genetic Agranulocytosis are individuals who must be treated right away and then maintained consistently in order to continue to reduce the threat or vulnerability that they have to infection. (coastdental.com)
Eosinophilia2
- A bone marrow aspiration was performed showing a disappearance of the neutrophil granulocyte line and a significant eosinophilia. (bvsalud.org)
- In our case, the results of the bone marrow aspiration, the sudden drop of the neutrophil count with concomitant eosinophilia and the absence of improvement despite the dose decrease, point towards an immuno-allergic mechanism. (bvsalud.org)
Severe2
- Several cases of severe drug-induced skin disorders like agranulocytosis were reported in cocaine users. (clearbrookinc.com)
- Acquired agranulocytosis is a rare, drug-induced blood disorder that is characterized by a severe reduction in the number of white blood cells (granulocytes) in the circulating blood. (checkorphan.org)
Neutrophils4
- most of the neutrophils in the body are contained in the bone marrow, either as mitotically active (one third) or postmitotic mature cells (two thirds). (medscape.com)
- Vulnerability to infection is extremely high in patients with agranulocytosis, which is the virtual absence of neutrophils in peripheral blood, with ANC typically lower than 100/μL. (medscape.com)
- Neutrophils are white blood cells (WBCs) produced in the bone marrow that ingest bacteria. (wordinfo.info)
- The most common side effect of levamisole cocaine is agranulocytosis, a rare condition in which your bone marrow doesn't make a sufficient amount of a certain kind of white cell, most often ones called neutrophils. (clearbrookinc.com)
Disorders2
- Although available in many countries, one third of the patients developed signs of iron overload, such as delayed or absent puberty, growth disorders, hypothyroidism, hypogonadism, bone abnormalities, cirrhosis and heart disease (main cause of death in transfusion dependent patients with TM). (scielo.br)
- Kostmann syndrome is associated with an increased risk of acute myelogenous leukemia (AML) or bone marrow disorders. (cancer.ca)
Drug-induced1
- You can also have Acquired Agranulocytosis in which an individual could be exposed to chemicals, some prescription medications, cancer medications, antipsychotic medications, for example, that will develop a form of Drug-Induced Agranulocytosis. (coastdental.com)
Prone2
- A complicating factor is that several commonly used anti-cancer drugs are prone to cause agranulocytosis, thus interfering with treatment. (orthopedicshealth.com)
- Facial bones are prone to osteomyelitis due to various predisposing condition. (bvsalud.org)
Patients6
- In using VASOTEC consideration should be given to the fact that another angiotensin converting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen vascular disease, and that available data are insufficient to show that VASOTEC does not have a similar risk (see WARNINGS ). (rxlist.com)
- 4 Although bone marrow transplants have increased the survival rate of patients with AA, most people do not have access to this therapy, and fatality rates of the disease remain high. (haematologica.org)
- 5.15) Bone marrow depression: Use with caution in patients with bone marrow depression. (drugcentral.org)
- As neutrophil levels decrease, the susceptibility of patients with acquired agranulocytosis to bacterial infections becomes even greater. (orthopedicshealth.com)
- In the coming time, the hospital will continue to carry out autologous stem cell transplantation for pediatric patients with solid tumors and to implement allogeneic stem cell transplantation in the treatment of bone marrow failure, blood cancer or Thalassemia. (baothuathienhue.vn)
- An analysis of the FDA Adverse Event Reporting System Database highlighted a higher than expected frequency of agranulocytosis in patients treated with fosfomycin. (bvsalud.org)
Biopsy1
- In this setting, immediately perform a bone marrow aspiration and obtain a biopsy from the posterior iliac crest. (medscape.com)
Anemia1
- The risk of developing anemia or agranulocytosis is increased during treatment. (ziprx.ca)
Marrow Transplantation1
- Treatment usually involves immunosuppression with equine antithymocyte globulin and cyclosporine , or bone marrow transplantation. (msdmanuals.com)
Symptoms3
- The symptoms of this disorder come about as the result of interference in the production of granulocytes in the bone marrow. (orthopedicshealth.com)
- The first symptoms of acquired agranulocytosis are usually those associated with a bacterial infection such as general weakness, chills, fever, and/or extreme exhaustion. (orthopedicshealth.com)
- As unhealthy sinuses can disseminate the infection to remaining bone and to relieve the symptoms of sinusitis, sinus lining was removed which was completely thickened followed with nasal antrostomy on left side. (bvsalud.org)
Granulocyte2
- One important type of white blood cell is the granulocyte, which is made in the bone marrow and travels in the blood throughout the body. (medlineplus.gov)
- Other drugs that interfere with, or inhibit, granulocyte colony formation may induce agranulocytosis. (orthopedicshealth.com)
Megakaryocytes2
- It is so named because the level of large bone marrow cells that produce platelets, called megakaryocytes, are significantly lower or absent. (checkorphan.org)
- Thrombopoietin helps control the number of circulating platelets by stimulating the bone marrow to produce megakaryocytes. (msdmanuals.com)
Blood3
- Typically, this is diagnosed via a blood test, and it's typically managed through a combination of antibiotics, maybe even injections of a drug which are going to introduce white blood cells into the bloodstream, immunosuppressant drugs, a bone marrow transplant, and, of course, very important, the prevention of infection. (coastdental.com)
- If you are having treatment or taking medicine that could cause agranulocytosis, your health care provider will use blood tests to monitor you. (medlineplus.gov)
- In rare cases of acute acquired agranulocytosis, destructive action of certain white blood cell antibodies (leukocyte isoantibodies) may be induced by certain drugs such as phenylbutazone, gold salts, sulfapyridine, aminopyrine, meralluride, and dipyrine. (orthopedicshealth.com)
Bacteria1
- People with acquired agranulocytosis are susceptible to a variety of bacterial infections, usually caused by otherwise benign bacteria found in the body. (orthopedicshealth.com)
Liver1
- A 35-year-old woman with liver and bone marrow granulomas associated with agranulocytosis induced by chlorpromazine treatment is described. (biu.ac.il)
Rarely1
- We describe a case of agranulocytosis, a rarely described side effect that may be fatal. (bvsalud.org)
Inflammation1
- Osteomyelitis is an inflammation of medullary portion of bone along with cortex and periosteum. (bvsalud.org)
Infection2
- Individuals with agranulocytosis must be very careful to avoid infection. (coastdental.com)
- It is defined as inflammatory condition of bone which begins as an infection of medullary cavity, rapidly involves the periosteum of the affected area 12 . (bvsalud.org)
Treatment4
- Hypoplastic bone marrow associated with agranulocytosis is a well-known side effect of chlorpromazine treatment. (biu.ac.il)
- and it has become a standard treatment for acquired agranulocytosis. (orthopedicshealth.com)
- The treatment of acquired agranulocytosis includes the identification and elimination of drugs or other agents that induce this disorder. (orthopedicshealth.com)
- After the course of treatment, he had a partial response and was indicated for a bone marrow transplant. (baothuathienhue.vn)
Condition1
- When the body has too few granulocytes, the condition is called agranulocytosis. (medlineplus.gov)
Diseases1
- The LATIN study is an international case-control study designed to identify risk factors for agranulocytosis and AA, including drugs, other diseases, and environmental factors, using a methodological approach similar to that used in previous studies. (haematologica.org)
Risk1
- The child was diagnosed with high-risk neuroblastoma with tumor in the retroperitoneal space, bone metastases. (baothuathienhue.vn)
Chemicals1
- Acquired agranulocytosis is almost invariably caused by exposure to drugs and/or chemicals. (orthopedicshealth.com)
Occurs1
- discontinue if significant bone marrow suppression occurs. (ziprx.ca)
Side1
- It has some side effects such as Cholestatic jaundice,Agranulocytosis,Blurred vision,Bone marrow depression. (medibuddy.in)
Complete1
- Under sedation complete loose necrotic and lytic bone which was extending to involve the left antral floor, anterior wall of left antrum, and maxillary alveolar ridge from left canine to first molar was completely removed with through curettage of underlying bone. (bvsalud.org)
People1
- Clinicians do not understand why some people are susceptible to agranulocytosis and others are not. (orthopedicshealth.com)