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Bone Marrow TransplantationBone MarrowTransplantation, HomologousBone Marrow CellsBone and BonesTransplantation, AutologousGraft vs Host DiseaseLiver TransplantationHematopoietic Stem Cell TransplantationWhole-Body IrradiationTransplantation ConditioningKidney TransplantationGraft SurvivalTransplantation ChimeraTissue DonorsAnemia, AplasticLeukemiaBone RemodelingBusulfanHistocompatibility TestingHeart TransplantationTransplantation, IsogeneicBone Marrow PurgingHistocompatibilityStem Cell TransplantationHematopoietic Stem CellsLung TransplantationGraft RejectionBone DensityCyclophosphamideTransplantation ImmunologyBone Marrow DiseasesImmunosuppressive AgentsRecurrenceTreatment OutcomeHematopoiesisMice, Inbred C57BLOrgan TransplantationCombined Modality TherapyTime FactorsHematologic NeoplasmsRadiation ChimeraBone ResorptionLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLeukemia, Myeloid, AcuteImmunosuppressionBone Marrow ExaminationRemission InductionPrecursor Cell Lymphoblastic Leukemia-LymphomaHepatic Veno-Occlusive DiseaseRetrospective StudiesBone Marrow NeoplasmsPancreas TransplantationGraft vs Host ReactionLeukemia, MyeloidAcute DiseaseLymphocyte DepletionSurvival AnalysisIslets of Langerhans TransplantationLymphoma, Non-HodgkinCell TransplantationLeukocyte TransfusionTransplantationHLA AntigensCyclosporineBone NeoplasmsT-LymphocytesSevere Combined ImmunodeficiencyChimeraMyelodysplastic SyndromesBone DevelopmentFollow-Up StudiesColony-Forming Units AssayCord Blood Stem Cell TransplantationActuarial AnalysisHematologic DiseasesCell DifferentiationSurvival RateBone DiseasesLymphocyte TransfusionAntineoplastic Combined Chemotherapy ProtocolsLiving DonorsTransplantation ToleranceCytomegalovirus InfectionsPeripheral Blood Stem Cell TransplantationCarmustineGraft vs Tumor EffectNuclear FamilyGraft vs Leukemia EffectMelphalanSkin TransplantationCytarabineDisease-Free SurvivalPancytopeniaMultiple MyelomaMice, Inbred BALB CGranulocyte Colony-Stimulating FactorPostoperative ComplicationsLeukocyte CountBone Regeneration
Hematopoietic cell transplantationStromal cellsTransplantDonorProliferating cell nuDonorsDifferentiationHSCTChemotherapyStem CellPeripheral blood stem cellsFlow CytometryProgenitor cellsPediatricUnderwentPatient'sLymphocytesHematologicSpinal Cord IEfficacySpongy tissueAdultLung TransplantationFindingsAdults with sickleFetalIliac crestEngraftmentLong-term survivorsSevereTherapeuticTherapyBlood to clotOutcomeImmunePlateletsUmbilical cordTransgenicMobilizationTherapeuticsImmatureAntigensProcedureSickleMiceMononuclear cells
Hematopoietic cell transplantation7
  • Among 1462 patients who had allogeneic hematopoietic cell transplantation (HCT) between January 2000 and December 2005, 116 (7.9%) developed stage 3-4 gut GVHD. (nature.com)
  • An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens. (nature.com)
  • Reduced mortality after allogeneic hematopoietic-cell transplantation. (nature.com)
  • To stimulate and facilitate further research, the NCI and NHLBI held the First International Consensus Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation on April 28 and 29, 2011. (medscape.com)
  • Large registries of unrelated donors are needed because only about 30% of patients with diseases treatable with hematopoietic cell transplantation can find a fully HLA matched donor among their family members. (wikipedia.org)
  • Late mortality in survivors of autologous hematopoietic-cell transplantation: report from the Bone Marrow Transplant Survivor Study. (qxmd.com)
  • We assessed late mortality in 854 individuals who had survived 2 or more years after autologous hematopoietic cell transplantation (HCT) for hematologic malignancies. (qxmd.com)
Stromal cells11
Transplant31
  • high-risk patients included male subjects, recipients of stem cells from female donors, patients younger than 10 years, those with nonidentical donors, and those who received radiation therapy in the transplant preparative regimen. (medscape.com)
  • In a study from the United States, long-term survivors of pediatric bone marrow transplantation followed in the Bone Marrow Transplant Survivors Study were compared with survivors of childhood cancer treated without bone marrow transplant from the Childhood Cancer Survivor Study. (medscape.com)
  • A bone marrow transplant is a procedure that replaces a person's faulty bone marrow stem cells. (medlineplus.gov)
  • It also suppresses your body's immune system so that it won't attack the new stem cells after the transplant. (medlineplus.gov)
  • What Is a Bone Marrow Transplant? (medlineplus.gov)
  • In this video you will find the costs of bone marrow transplant in India and benefits of going to Mumbai India for bone marrow stem cell transplant. (globalstemcelltherapy.com)
  • Successfully treated by Bone Marrow Transplant in India. (globalstemcelltherapy.com)
  • A bone marrow transplant is a procedure to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. (globalstemcelltherapy.com)
  • Connor needed a Bone Marrow Transplant but he didn't have enough money for the treatment. (globalstemcelltherapy.com)
  • When chemotherapy or radiation therapy is unable to eliminate all cancerous cells, or when the bone marrow fails to function properly, a stem cell transplant may be considered as a treatment option. (globalstemcelltherapy.com)
  • Hematopoietic cells from NMDP donors or cord blood units are used to transplant patients with a variety of blood, bone marrow or immune system disorders. (wikipedia.org)
  • Patients needing a hematopoietic cell transplant but who lack a suitably matched donor in their family can search the Be The Match Registry for a matched unrelated donor or cord blood unit. (wikipedia.org)
  • Hematopoietic cells are used to transplant patients with life-threatening disorders such as leukemia, lymphoma, aplastic anemia, as well as certain immune system and metabolic disorders. (wikipedia.org)
  • The remaining 70% require an unrelated hematopoietic cell donor as a transplant source. (wikipedia.org)
  • The transplant physician evaluating the patient considers a number of clinical factors to decide whether to use an adult donor's marrow or PBSC, or cord blood for a particular patient. (wikipedia.org)
  • Are you scheduled for a stem cell transplant with cord blood? (nih.gov)
  • Responsibilities would also include supporting the Bone Marrow Transplant Unit, as well as the expansion of clinical trials across the RWJBH health system as well as contribute to phase 1 clinical trials research group. (globalhealth.org)
  • Infl uenza is a major cause of illness and death in patients zanamivir, use of concomitant antimicrobial therapy, and with hematologic malignancy and in hematopoietic cell intravenous immunoglobulin was determined by the treat- transplant (HCT) recipients. (cdc.gov)
  • Mount Sinai Transplant offers a wide range of transplantation services, including procedures related to the bone marrow , cornea , heart , intestinal , kidney , liver , and pancreas . (mountsinai.org)
  • A new study published in the American Journal of Transplantation reports there is no evidence of children between 6 and 11 years of age being at a disadvantage if they are seeking deceased donor lung transplant in the current US lung allocation system. (medindia.net)
  • A vaccine that stimulates CD8 T regulatory cells helps to prevent self-destructive immune reactions in autoimmune diseases and organ transplant rejection. (medindia.net)
  • A 22-yr-old man with acute myelocytic leukemia received a bone marrow transplant from a genotypically HLA-identical female sibling after cyclophosphamide preparation. (notifylibrary.org)
  • At 34 mo after transplant, marrow relapse and chloroma were documented. (notifylibrary.org)
  • All metaphase cells and karyotypes from peripheral blood and marrow samples showed no evidence of host cells from 3 wk after transplant through the time of marrow relapse. (notifylibrary.org)
  • The patient received a second bone marrow transplant from the same donor after preparation with busulfan and cyclophosphamide and attained a complete remission with full hematologic engraftment. (notifylibrary.org)
  • Methods Center for International Blood and Marrow Transplant Research data from 184 adults who completed the Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) before undergoing alloHCT and at day 100 were used. (cdc.gov)
  • Regret was measured using a FACT-BMT item not included in scoring: "I regret having the bone marrow transplant. (cdc.gov)
  • These cells inhibited T cell proliferation in a standard in vitro mixed lymphocyte assay and, moreover, attenuated the development of vasculopathy mediated by autologous peripheral blood mononuclear cells in a functionally relevant humanized mouse transplant model. (lu.se)
  • One possible therapeutic approach for this disease is bone marrow transplant. (bvsalud.org)
  • Under immunosuppression conditions, all infectious foci can be activated and, for this reason, all active infections in hematopoietic stem cell pre-transplant patients must be eradicated prior to transplant so as to prevent or reduce the risk of systemic complications in these patients. (bvsalud.org)
  • Aim: Present a case report of dental care provided to a non-Hodgkin lymphoma patient with an urgent need for hematopoietic stem cell transplant. (bvsalud.org)
Donor28
  • Our experiments demonstrate that the donor bone marrow cells in the host scid mice repopulate to form single (primary) follicles and aggregates of lymphoid nodules, the Peyer's patches. (nih.gov)
  • Or you can get cells from a donor. (medlineplus.gov)
  • In this case, healthy stem cells are taken from a donor or the patient themselves and then put back into the patient's bloodstream. (globalstemcelltherapy.com)
  • This can be from a relative, an unrelated donor, or even the patient's own stem cells if they are healthy. (globalstemcelltherapy.com)
  • In such cases, the transplantation procedure is prioritized during the early stages, provided a suitable donor is identified. (medistateinternational.com)
  • The decision to proceed with stem cell transplantation for these conditions hinges on a comprehensive evaluation of the disease's course, severity, donor-related attributes, and procedural risks. (medistateinternational.com)
  • The success of stem cell transplantation pivots on the identification of a donor possessing either a fully-matched or partially-matched tissue group with the patient. (medistateinternational.com)
  • The National Marrow Donor Program (NMDP) is a nonprofit organization founded in 1986 and based in Minneapolis, Minnesota, that operates the Be The Match Registry of volunteer hematopoietic cell donors and umbilical cord blood units in the United States. (wikipedia.org)
  • Bone marrow is extracted from the donor's pelvic bones while the donor is under general or local anesthesia. (wikipedia.org)
  • When an adult volunteer donor (marrow or PBSC) registers with the NMDP, their HLA and contact information is sent to the NMDP, which stores it in their computers. (wikipedia.org)
  • Physicians look for donor material on behalf of a patient by submitting the patient's HLA tissue type to the NMDP, which then searches its computerized database for matching donor (marrow or PBSC) or cord blood units. (wikipedia.org)
  • If the potential donor meets all requirements, the NMDP collects their bone marrow or peripheral blood stem cells and sends them by courier to the patient. (wikipedia.org)
  • The NMDP cooperates with World Marrow Donor Association (WMDA), an organization that coordinates communications among the world's registries. (wikipedia.org)
  • Bone marrow transplantation from a pediatric donor with a high frequency of cytomegalovirus-specific T-cells. (ox.ac.uk)
  • Tetramer assay showed that the frequency of CMV-specific CD8+ T cells of the donor in the peripheral blood was 5.3%, higher than average amongst young children. (ox.ac.uk)
  • The frequency of CMV-specific CD8+ T cells of the donor in the graft was 3.7% of CD8+ T-cells. (ox.ac.uk)
  • Although the phenotypic pattern of the CMV-specific T cells of the recipient was different from those of the donor before transplantation, the phenotype of the donor-derived cells retained their original phenotype in the recipient after transplantation. (ox.ac.uk)
  • Thus, we studied the safety, efficacy, and feasibility of transfer of gene modified donor T-cells shortly after allo-HSCT in two clinical trials between 2002 and 2007 and here we compare the results to unmodified donor leukocyte infusion (DLI). (frontiersin.org)
  • The aim of these trials was to provide patients with the protection of T-cells after T-cell-depleted allo-HSCT in the matched or mismatched donor setting with an option to delete transduced T-cells, if severe aGvHD occurred within the trial period. (frontiersin.org)
  • Donor-T-cells were transduced with the replication-deficient retrovirus SFCMM-3, expressing HSV-TK and the truncated ΔLNGFR for selection of transduced cells. (frontiersin.org)
  • Donor chimerism was stabilized after transfusion of the transduced cells in all patients treated. (frontiersin.org)
  • Thus, prophylactic transfusion of donor T-cells has been included in many protocols, despite the increased risk for acute GvHD ( Kolb, 2008 ). (frontiersin.org)
  • Data from autosomal and sex chromosome studies indicate that the marrow relapse occurred in cells of donor origin. (notifylibrary.org)
  • q22)] was observed in a majority of donor cells. (notifylibrary.org)
  • The lack of donor availability is a major limitation to the widespread use of allogeneic hematopoietic stem cell transplantation, and therefore it would be beneficial to identify less immunogenic HLA mismatches. (elsevierpure.com)
  • These tolerogenic NIMA effects were completely abolished by the depletion of CD4 + CD25 + cells from the donor inocula, thus suggesting the involvement of CD4 + CD25 + regulatory T cells in the tolerogenic NIMA effects. (elsevierpure.com)
  • Although it is possible to expand naturally occurring T(regs), an attractive alternative possibility, particularly suited to solid organ and bone marrow transplantation, is the stimulation of total T cell populations with defined allogeneic antigen-presenting cells (APCs) under conditions that lead to the generation or expansion of donor-reactive, adaptive T(regs). (lu.se)
  • Without further manipulation or selection, the resultant population delayed skin allograft rejection mediated by polyclonal CD4(+) effectors or donor-reactive CD8(+) T cell receptor transgenic T cells and inhibited both effector cell proliferation and T cell priming for interferon-γ production. (lu.se)
Proliferating cell nu1
  • Moreover, proliferating cell nuclear antigen (PCNA) and CD31 showed co-localization with α-SMA, suggesting the differentiation of hBMSCs into epithelial cells and myofibroblasts/fibroblasts. (ijbs.com)
Donors5
  • In cases where such donors are not available, the process can extend to non-related donors or even a patient's own cells, demonstrating the flexibility and innovation inherent in this field. (medistateinternational.com)
  • Bone marrow and PBSCs come from living adult donors. (wikipedia.org)
  • In both cases, recovery is usually swift and donors typically have fully restored marrow and blood cell counts in under two weeks. (wikipedia.org)
  • Transduced cells were transfused either after day +60 (matched donors) or on day +42 (haploidentical donors). (frontiersin.org)
  • Evaluate the feasibility and outcome of bone marrow transplantation using family or unrelated donors in infants with the 11q23 abnormality. (knowcancer.com)
Differentiation2
  • In order to eliminate the interference from the transplanted cells themselves, fetal stem cells were used for transplantation because the proliferation and differentiation potentials of fetal stem cells are superior to the adult ones ( 8 ). (ijbs.com)
  • The signal transducer and activator of transcription 5 (STAT5) regulates differentiation, survival, proliferation and transformation of hematopoietic cells. (nature.com)
HSCT8
  • Likewise, many children are now surviving hematopoietic stem-cell transplantation (HSCT) (see related histology slide below) and require structured long-term follow-up care. (medscape.com)
  • Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is applied successfully to the treatment of many hematopoietic malignancies, but remains limited by severe acute graft-versus-host-disease (aGvHD). (frontiersin.org)
  • 30,000 patients with blood-related malignancies receive HDC, which, if the response is satisfactory, could subsequently be followed by hematopoietic stem cell transplantation (HSCT). (bdbiosciences.com)
  • The hematopoietic stem cell transplantation units (HSCT) are recognized as places of high complexity treatments with relevant morbidity incidence. (bvsalud.org)
  • The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
  • This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (bvsalud.org)
  • The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
  • Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)
Chemotherapy12
  • In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to graft versus host disease (GVHD) and autoimmunity. (medscape.com)
  • Stem cell transplantation is a promising strategy for delayed wound healing caused by chemotherapy. (ijbs.com)
  • However, the fate of stem cells under chemotherapy has not been fully elucidated. (ijbs.com)
  • Treatment for this condition remains difficult and largely ineffective, because the growth of cells in the wound is inhibited ( 2 ) and chemotherapy usually leads to myelosuppression, the latter of which further compromises the migration of multipotent cells from the bone marrow ( 3 ). (ijbs.com)
  • Before the new stem cells are put in, the patient's own bone marrow is destroyed using chemotherapy or radiation therapy. (globalstemcelltherapy.com)
  • It permits the administration of exceedingly high doses of chemotherapy, a practice that becomes viable due to the subsequent infusion of the patient's own stem cells. (medistateinternational.com)
  • This twofold approach not only harnesses the power of potent chemotherapy but also safeguards against bone marrow deficiency by replenishing the patient's stem cell count following the chemotherapy phase. (medistateinternational.com)
  • TRANSPLANTATION: 2-Drug Combination Myeloablative Chemotherapy followed by Radiotherapy followed by Hematopoietic Rescue plus GVHD Prophylaxis. (knowcancer.com)
  • [ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
  • Stem cell transplantation is performed after high-dose chemotherapy (HDC) to restore a cancer patient's blood and immune cell production capacity. (bdbiosciences.com)
  • 3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
  • For many hematopoietic malignancies, collection and infusion of CD34+ hematopoietic stem/progenitor cells following chemotherapy is critical. (bdbiosciences.com)
Stem Cell40
Peripheral blood stem cells1
Flow Cytometry3
Progenitor cells4
  • Although engraftment of irradiated C.B-17 scid/scid (SCID) mice with human progenitor cells occurred after infusion with human pediatric bone marrow cells, significant engraftment of the mouse bone marrow with human cells was dependent upon continuous treatment with exogenous human cytokines. (elsevierpure.com)
  • Transplantation of nonhematopoietic adult bone marrow stem/progenitor cells isolated by p75 nerve growth factor receptor into the penis rescues erectile function in a rat model of cavernous nerve injury. (cellsurgicalnetwork.com)
  • CONCLUSIONS: Transplantation of adult stem/progenitor cells may provide an effective treatment for erectile dysfunction after radical prostatectomy. (cellsurgicalnetwork.com)
  • CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
Pediatric2
  • As one of the largest liver transplantation centers in the nation, Mount Sinai's surgeons treat adult and pediatric liver patients with innovative treatments and procedures. (mountsinai.org)
  • These finding suggested that active transferred immunity from the graft with a high frequency of CMV-specific CTL could induce a rapid reconstitution of CMV-specific T-cell mediated immunity in pediatric HLA-identical allogenetic bone marrow transplantation. (ox.ac.uk)
Underwent3
  • A 6-year-old girl underwent bone marrow transplantation from an HLA-identical sibling with a very high frequency of CMV specific tetramer-positive CD8+ T-cells. (ox.ac.uk)
  • The present report describes an incomplete atypical femoral fracture (AFF) patient who underwent simultaneous autogenous bone transplantation to the resected fracture region during intramedullary nail fixation. (hindawi.com)
  • Conclusions: Among patients who underwent alloHCT and lived to 100 days, the majority did not report regretting their transplantation. (cdc.gov)
Patient's4
Lymphocytes7
  • Most of the identifiable cells are lymphocytes or plasma cells. (medscape.com)
  • Evidence suggests that antigen priming of B-lymphocytes is responsible for the number and location of Peyer's patches during postnatal life, but little is known about the histogenesis of Peyer's patches and their overlying membranous (M) cells. (nih.gov)
  • To examine whether T- and B-lymphocytes in Peyer's patches have an influence on M-cell generation, we studied the development of Peyer's patches and M-cells in severe combined immunodeficient (SCID) mice reconstituted with bone marrow cells from normal syngeneic mice. (nih.gov)
  • Despite the return of normal numbers of T lymphocytes post-BMT phenotypic analysis reveals several long-term abnormalities, including an inverted T4:T8 ratio and a significant fraction of CD3+ T cells that do not co-express CD6. (ashpublications.org)
  • We conclude that despite the recovery of normal numbers of T lymphocytes early after engraftment of CD6-depleted marrow, these T cells exhibit several physiologic and functional abnormalities that persist for varying intervals post-BMT. (ashpublications.org)
  • T lymphocytes originate via lymphoid stem cells that migrate to the thymus and differentiate under the influence of the thymic hormones thymopoietin and thymosin. (medscape.com)
  • Lymphocytes, B and T cells, can respond selectively to thousands of non-self materials. (lu.se)
Hematologic1
  • From various cancer types like leukemia to congenital or acquired hematologic conditions leading to bone marrow insufficiency and immune system deficiencies, this method addresses diverse health concerns. (medistateinternational.com)
Spinal Cord I1
Efficacy1
  • This study aims to examine the efficacy and safety of ABM-MSC and ABM-MNC transplantation in T2DM and explores alterations in glucose-insulin homeostasis by metabolic studies. (drcalapai.com)
Spongy tissue3
Adult7
  • In an adult, roughly half of the bone marrow is still red. (medscape.com)
  • Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers. (cdc.gov)
  • TET2 Mutation in Adult T-Cell Leukemia/Lymphoma. (cdc.gov)
  • Adult T cell leukemia aggressivenness correlates with loss of both 5-hydroxymethylcytosine and TET2 expression. (cdc.gov)
  • Human T-cell leukemia virus type I Tax genotype analysis in Okinawa, the southernmost and remotest islands of Japan: Different distributions compared with mainland Japan and the potential value for the prognosis of aggressive adult T-cell leukemia/lymphoma. (cdc.gov)
  • Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma. (cdc.gov)
  • Absence of FLT3 mutations in Iranian adult T-cell leukemia/lymphoma patients. (cdc.gov)
Lung Transplantation1
Findings1
  • Methodology/Principal Findings: Autologous bone marrow was cultured in mesenchymal basal medium and adherent cells were harvested for transplantation to C57Bl6 mice, 24 and 72 hours after lethal whole body irradiation (10.4 Gy) or abdominal irradiation (16-20 Gy) in a single fraction. (elsevierpure.com)
Adults with sickle1
  • In 1999 there were 2 major obstacles for curing adults with sickle cell disease. (nih.gov)
Fetal3
  • Therefore, fetal stem cells are suitable cells for clarifying the influences of CTX on cell functions. (ijbs.com)
  • In the present study, after infusion of irradiated SCID mice with pre-cultured human fetal bone marrow cells (BM-SCID-hu mice), their bone marrow became significantly engrafted with human precursor cells and their peripheral lymphoid compartment became populated with human B cells and monocytes independently of the administration of extraneous human cytokines. (elsevierpure.com)
  • Bone marrow first appears in the clavicle near the end of fetal life and becomes active about 3 weeks later. (medscape.com)
Iliac crest2
Engraftment4
  • Furthermore, despite cytokine treatment, only minimal peripheral engraftment of these mice with human cells was observed. (elsevierpure.com)
  • Since engraftment occurs in the absence of exogenous cytokine treatment, the BM- SCID-hu mouse model described should provide a useful in vivo system for studying factors important in the maturation of human myeloid and lymphoid cells in the bone marrow and the behavior of the mature human cells after dissemination into the peripheral lymphoid tissue. (elsevierpure.com)
  • Patients who undergo allogeneic bone marrow transplantation (BMT) are clinically immunodeficient for a prolonged period after engraftment. (ashpublications.org)
  • We also found that, after CD2 stimulation, calcium flux in T cells was normal immediately after engraftment. (ashpublications.org)
Long-term survivors1
Severe3
  • [ 2 , 8 ] Survivors of bone marrow transplantation were more likely to have a severe or life threatening condition (relative risk [RR] = 3.9), more than one chronic condition (RR = 2.6), functional impairment (RR=3.5), and activity limitations (RR = 5.8) than conventionally treated patients. (medscape.com)
  • Our teams of specialists work with our patients to provide rehabilitation and transplantation services for people suffering from severe intestinal problems. (mountsinai.org)
  • T cell immunodeficiencies and severe combined immunodeficiencies (SCIDs) are marked with opportunistic infections caused by common environmental microorganisms. (lu.se)
Therapeutic1
  • In this study, we aimed to clarify whether combination therapy of intracerebral transplantation of human modified bone marrow-derived MSCs, SB623 cells, and voluntary exercise with running wheel (RW) could exert synergistic therapeutic effects on a rat model of ischemic stroke. (biomedcentral.com)
Therapy9
  • The decision to proceed with transplantation hinges on a thorough assessment of patients' chances for successful results, along with a comprehensive understanding of therapy-related risks. (medistateinternational.com)
  • Whereas, cell transplantation therapy is very desirable strategy for the treatment of CSPI, though much preclinical and clinical research work remains. (openveterinaryjournal.com)
  • Mesenchymal stromal cell (MSC) transplantation therapy is a promising therapy for stroke patients. (biomedcentral.com)
  • This study suggests that combination therapy of intracerebral transplantation SB623 cells and voluntary exercise with RW achieves robust neurological recovery and synergistically promotes endogenous neurogenesis and angiogenesis after cerebral ischemia, possibly through a mechanism involving the up-regulation of BDNF and VEGF. (biomedcentral.com)
  • Cell transplantation therapy has emerged as a potential candidate treatment for ischemic stroke. (biomedcentral.com)
  • 1 ] reported that long-term alendronate therapy could cause severely suppressed bone turnover (SSBT), resulting in delayed healing of nonspinal fractures. (hindawi.com)
  • It engaged a global discussion on sickle cell anemia, its perils and the advances in gene therapy that are showing great promise for this genetic disease. (acsh.org)
  • Did Gene Therapy Cure Sickle Cell Disease? (acsh.org)
  • A number of recent headlines imply that a new case study in the New England Journal of Medicine proves that gene therapy has cured sickle cell disease - a genetic disorder that causes tremendous pain, suffering and diminished life expectancy. (acsh.org)
Blood to clot2
Outcome2
  • 2002 until 2007), two were included in TK007 (2005-2009) and six serves as a control group for outcome after haploidentical transplantation without HSV-TK-transduced DLI. (frontiersin.org)
  • There is increasing evidence that malaria not only influences outcome but also changes the manifestations of sickle-cell anaemia in Africa. (who.int)
Immune6
  • It functions by slowing or blocking cell growth and compromising the immune system's response. (ijbs.com)
  • In various conditions like cancer or immune disorders, this marrow may need to be replaced. (globalstemcelltherapy.com)
  • In the present study, we examined immune function after BMT in a series of patients who had received HLA compatible sibling marrow grafts purged of T cells with anti-CD6 monoclonal antibody and complement. (ashpublications.org)
  • Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
  • A report suggests that there is accumulation of inclusion bodies in B-cells of individuals with I-cell disease, which may imply impairment of the immune system. (medscape.com)
  • 2) T cell deficiencies affect the function in killing infected cells or helping other immune cells. (lu.se)
Platelets3
Umbilical cord3
  • Cord blood cells are obtained from the umbilical cord and placenta of a newborn baby after the cord is clamped and cut as in a normal delivery. (wikipedia.org)
  • Stem cells from umbilical cords are usually used only in children because umbilical cord blood does not contain enough stem cells to use in adults. (msdmanuals.com)
  • Stem cells can be obtained from the blood in the umbilical cord or placenta after a baby is born. (msdmanuals.com)
Transgenic1
  • Myocardial infarctions were generated in mice and different cell populations including transgenic MSCs, unfractionated BM cells, or purified hematopoietic progenitors were injected. (ox.ac.uk)
Mobilization2
  • This pharmacologically induced egress of HSCs into peripheral blood, called mobilization, is utilized as the preferred strategy for generating HSCs for transplantation. (bdbiosciences.com)
  • Quantitating the CD34+ cell population can also be useful during mobilization as well as for determining the optimal timing of apheresis sessions to make sure that enough CD34+ cells have been harvested. (bdbiosciences.com)
Therapeutics1
  • Regulatory T cells (T(regs)) manipulated ex vivo have potential as cellular therapeutics in autoimmunity and transplantation. (lu.se)
Immature3
  • It contains immature cells, called stem cells. (medlineplus.gov)
  • Stem cells are immature cells in the bone marrow that give rise to all of your blood cells. (globalstemcelltherapy.com)
  • Here we demonstrate that stimulation of mouse CD4(+) T cells by immature allogeneic dendritic cells combined with pharmacological inhibition of phosphodiesterase 3 (PDE) resulted in a functional enrichment of Foxp3(+) T cells. (lu.se)
Antigens1
  • Luminal antigens are transported across the intestinal epithelium to stimulate the Peyer's patch pre-B-cells in the follicles that proliferate and migrate to distant sites. (nih.gov)
Procedure2
  • The present report shows a minimally invasive procedure, which could facilitate bone union in incomplete AFF. (hindawi.com)
  • Blood is preferred to bone marrow as a source because the procedure is less invasive and the number (count) of blood cells returns to normal more quickly. (msdmanuals.com)
Sickle22
  • Dr. Keith Hoots, the Division Director at the Division of Blood Diseases and Resources (DBDR) opened the meeting by greeting the Sickle Cell Disease Advisory committee (SCDAC) members. (nih.gov)
  • Sickle Cell Disease is an awful genetic disease that disproportionally affects black people. (acsh.org)
  • Sickle cell crises. (drugs.com)
  • Serious sickle cell crises have happened in people with sickle cell disorders receiving Nivestym that have sometimes led to death. (drugs.com)
  • Sickle-cell anaemia is a common genetic condition due to a haemoglobin disorder - inheritance of mutant haemoglobin genes from both parents. (who.int)
  • Such disorders, mainly thalassaemias and sickle-cell anaemia, are globally widespread. (who.int)
  • About 5% of the world's population carries genes responsible for haemoglobinopathies and each year about 300 000 infants are born with major haemoglobin disorders - in more than 200 000 cases sickle-cell anaemia in Africa. (who.int)
  • Sickle-cell anaemia is particularly common among people whose ancestors come from sub-Saharan Africa, India, Saudi Arabia and Mediterranean countries, and migration raised the frequency of the gene in the American continent. (who.int)
  • This distribution reflects the fact that sickle-cell trait confers a survival advantage against malaria and that selection pressure due to malaria has resulted in high frequencies of the mutant gene especially in areas of high malarial transmission. (who.int)
  • Frequencies of the carrier state determine the prevalence of sickle-cell anaemia at birth, which may thus be estimated and predicted. (who.int)
  • For example, in Nigeria, by far the most populous country in the subregion with about 120 million inhabitants, 24% of the population are carriers of the mutant gene and the prevalence of sickle-cell anaemia is about 20 per 1000 births. (who.int)
  • This means that in Nigeria alone, more than 100 000 children are born annually with sickle-cell anaemia. (who.int)
  • The sickle-cell gene has become common in Africa because the sickle-cell trait confers some resistance to falciparum malaria during a critical period of early childhood, favouring survival of the host and subsequent transmission of the abnormal haemoglobin gene. (who.int)
  • Although a single abnormal gene may protect against malaria, inheritance of two abnormal genes leads to sickle-cell anaemia and confers no such protection, and malaria is a major cause of ill-health and death in children with sickle-cell anaemia. (who.int)
  • The public health implications of sickle-cell anaemia are obvious as it causes either death or disability. (who.int)
  • When health impact is measured by under-five mortality, sickle-cell anaemia contributes the equivalent of 5% of under-five deaths on the African continent, more than 9% of such deaths in west Africa, and up to 16% of under-five deaths in individual west African countries. (who.int)
  • There are, however, no firm data on the survival of patients with sickle-cell anaemia on the African continent. (who.int)
  • In sub-Saharan Africa mortality will be much higher, and in some areas estimates derived from the age structure of populations attending clinics suggest that half of those with sickle-cell anaemia have died by the age of five years usually from infections including malaria and pneumococcal sepsis, and from the anaemia itself. (who.int)
  • Sickle-cell anaemia covers a wide spectrum of illness. (who.int)
  • The main problems arise from the tendency of the red blood cells to become sickle-shaped and block capillaries at low oxygen tension. (who.int)
  • In children, sickle-shaped red blood cells often become trapped in the spleen, leading to a serious risk of death before the age of seven years from a sudden profound anaemia associated with rapid splenic enlargement or because lack of splenic function permits an overwhelming infection. (who.int)
  • SCA, i.e. vaso-occlusive crisis and haemo- quently used in sickle-cell anaemia (SCA) lytic crisis [4,10]. (who.int)
Mice2
  • Use of the lectins Anguilla anguilla (AAA) and Ulex europaeus I (UEA-I) as positive markers of mouse Peyer's patch M-cells revealed that M-cells develop in the dome epithelium overlying the single primary follicles and Peyer's patches of reconstituted scid mice. (nih.gov)
  • Examination of the bone marrow of the BM-SCID-hu mice for human cytokine mRNA gene expression demonstrated human leukemia inhibitory factor mRNA and interleukin 7 mRNA in nine of nine BM-SCID-hu mice and macrophage-colony-stimulating factor mRNA in seven of eight BM-SCID-hu mice. (elsevierpure.com)
Mononuclear cells2
  • In contrast, the ability of unstimulated peripheral blood mononuclear cells (PBMC) to respond to recombinant interleukin-2 (rIL-2) is relatively intact, most likely reflecting early functional reconstitution of the NK cell population. (ashpublications.org)
  • The recent emergence of cell-based therapies such as autologous bone marrow-derived mesenchymal stem cells (ABM-MSCs) and mononuclear cells (ABM-MNCs) seems to offer a pragmatic approach to augment β-cell function/mass. (drcalapai.com)